Cited by 4,935Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

Jang, Meishiang, Cai, Lining, Udeani, George O., Slowing, Karla V., Thomas, Cathy F., Beecher, Christopher W. W., Fong, Harry H. S., Farnsworth, Norman R., Kinghorn, A. Douglas, Mehta, Rajendra G., Moon, Richard C., Pezzuto, John M.·1997·Science

DOI 10.1126/science.275.5297.218

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Abstract

Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

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BackgroundInfluential
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Background
Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase
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Background
Antioxidant Effects of Resveratrol in Cardiovascular, Cerebral and Metabolic Diseases
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“Studies performed in vivo and in vitro have shown that resveratrol exerts pleiotropic effects and can prevent or slow the progression of several pathological conditions, including cardiovascular and metabolic diseases, ischemic brain injuries, and cancer (Jang et al., 1997; Inoue et al., 2003), as well as extend lifes…”
Background
Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1α and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells
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Background
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BackgroundMethod
Resveratrol-caused apoptosis of human prostate carcinoma LNCaP cells is mediated via modulation of phosphatidylinositol 3′-kinase/Akt pathway and Bcl-2 family proteins
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“Jang et al (1997) first reported the chemopreventive role of resveratrol in skin cancer in mice treated with a carcinogen.(10) In SKH-1 hairless mice, topically applied resveratrol showed greater inhi-”
BackgroundInfluential
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Background
Retracted
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“It is believed that two glasses of red wine could provide a 10–30 µM concentration of resveratrol in vivo, where most of the pharmacological effects of resveratrol are observed ( 2 ).”
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Cancer Chemoprevention: Progress and Promise
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Wine, Resveratrol and Health: A Review
Guerrero, R. F., García-Parrilla, M. C., Puertas, B., & Cantos‐Villar, E. (2009) · Natural Product Communications · doi:10.1177/1934578x0900400503 · Cited by 197
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GHOSH, D. K., & Scheepens, A. (2008) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200800182 · Cited by 194
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“Resveratrol was first found as a potential antitumor agent (21).”
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“Jang et al. (1997) reported that resveratrol inhibited a number of events associated with the initiation, promotion, and progression of cancer.”
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Wine and Health: A Review
Guilford, J. M., & Pezzuto, J. M. (2011) · American Journal of Enology and Viticulture · doi:10.5344/ajev.2011.11013 · Cited by 191
“Resveratrol has received a great deal of attention because it blocks the multistep process of carcinogenesis at various stages: carcinogen activation, tumor initiation, tumor promotion, and tumor progression (Jang et al. 1997).”
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Pharmacognosy in the 21st century
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“Resveratrol, which also occurs in grapes and red wine, was found to be active as an inhibitor of cyclooxygenase 1, and then to show significant activity in the mouse mammary organ culture assay and in a full-term mouse skin carcinogenesis study (Jang et al 1997).”
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Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo
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Pterostilbene, a New Agonist for the Peroxisome Proliferator-Activated Receptor α-Isoform, Lowers Plasma Lipoproteins and Cholesterol in Hypercholesterolemic Hamsters
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Resveratrol—Potential Antibacterial Agent against Foodborne Pathogens
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Authors: Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
Affiliations: University of Illinois Chicago (US)
Universidad Complutense de Madrid (ES)
M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Corresponding author: Cai, Lining
Pezzuto, John M.
ORCID: Udeani, George O.
Slowing, Karla V.
Kinghorn, A. Douglas
Mehta, Rajendra G.
Pezzuto, John M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-01-10
Volume: 275
Issue: 5297
Pages: 218-220
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.275.5297.218
OpenAlex: W2151089147
Cited by: 4,935
References: 33
Citations by year: 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
FWCI: 96.50
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
Funders: National Cancer Institute (P01CA048112)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions

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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

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