Cited by 4,935Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.

Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

Jang, Meishiang, Cai, Lining, Udeani, George O., Slowing, Karla V., Thomas, Cathy F., Beecher, Christopher W. W., Fong, Harry H. S., Farnsworth, Norman R., Kinghorn, A. Douglas, Mehta, Rajendra G., Moon, Richard C., Pezzuto, John M.·1997·Science

DOI 10.1126/science.275.5297.218

Open this paper in CoChat — free account

Abstract

Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

Integrity signals

Registry

Crossref · 10.1126/science.275.5297.218

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Aspirin Use and Reduced Risk of Fatal Colon Cancer
Thun, M. J., Namboodiri, M. M., & Heath, C. W. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112053252301 · Cited by 1,685
Prospective study of alcohol consumption and risk of coronary disease in men.
Rimm, E. B., Giovannucci, E. L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B., & Stampfer, M. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)90542-w · Cited by 1,239
The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease
Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G. J., & Goldberg, D. M. (1995) · Clinica Chimica Acta · doi:10.1016/0009-8981(95)06045-1 · Cited by 877
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.
Zhang, Y., Kensler, T. W., Cho, C., Posner, G. H., & Talalay, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3147 · Cited by 746
Alcohol and Mortality
Klatsky, A. L., Armstrong, M. A., & FRIEDMAN, G. D. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-8-646 · Cited by 541
Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers
Prochaska, H. J., & Santamaria, A. B. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90292-8 · Cited by 495
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
Gierse, J. K., Hauser, S. D., Creely, D., Koboldt, C. M., Rangwala, S. H., Isakson, P. C., & Seibert, K. (1995) · Biochemical Journal · doi:10.1042/bj3050479 · Cited by 412
Sulindac for polyposis of the colon
Waddell, W. R., Ganser, G. F., Cerise, E. J., & Loughry, R. W. (1989) · The American Journal of Surgery · doi:10.1016/0002-9610(89)90442-x · Cited by 409
The Production of Resveratrol (3,5,4'-trihydroxystilbene) by Grape Berries in Different Developmental Stages
Jeandet, P., Bessis, R., & Gautheron, B. (1991) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1991.42.1.41 · Cited by 401
Chemoprevention of cancer with retinoids
Peck, G. L. (1981) · Gynecologic Oncology · doi:10.1016/0090-8258(81)90086-x · Cited by 366

Show all 33 references

Research works printed but not linked: 11

Sporn M. B., Newton D. L., Fed. Proc. 38, 2528 (1979).
Kudo T., Narisawa T., Abo S., Gann 71 260 (1980);
Zenser T. V., et al., J. Pharmacol. Exp. Ther. 227 545 (1983);
Wattenberg L. W., Cancer Res. 53, 5890 (1993).
Sharma S., Stutzman J. D., Kelloff G. J., Steele V. E., Cancer Res. 54 5848 (1994);
Shamon L. A., et al., Anticancer Res. 14 1775 (1995).
Suh N., Luyengi L., Fong H. H. S., Kinghorn A. D., Pezzuto J. M., Anticancer Res. 15, 233 (1995).
Moon R. C., Mehta R. G., in Chemistry and Biology of Retinoids, , Dawson M. I., Okamura W. H., Eds. (CRC Press, Boca Raton, FL, 1990), pp. 501-518.
Dercks W., Creasy L. L., Physiol. Mol. Plant Pathol. 34, 289 (1989).
Siemann E. H. and , Creasy L. L., ibid. 43, 49 (1992);
Goldberg D. M., et al., ibid. 46, 159 (1995).

Sorted by citations

Items 501–600 of 1,018

Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway
Yong-na, Z., Li, W., Li, F. Y., Zhang, Z., Dai, Y.-D., Xu, A.-L., Cui, Q., Gao, J., & Gao, J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.025 · Cited by 187
Pterostilbene: Biomedical applications
Estrela, J. M., Ortega, Á., Mena, S., Rodríguez, M. L., & Asensi, M. A. (2013) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2013.805182 · Cited by 180
“Nevertheless, since the seminal article published by Jang et al.(94) on the cancer chemopreventive activity of Resv in a mouse skin cancer model, the role of natural polyphenols in cancer prevention has received substantial support(91,95).”
Background
Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases
Knutson, M. D., & Leeuwenburgh, C. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00109.x · Cited by 178
Exploring Recombinant Flavonoid Biosynthesis in Metabolically Engineered Escherichia coli
Watts, K. T., Lee, P. C., & Schmidt‐Dannert, C. (2004) · ChemBioChem · doi:10.1002/cbic.200300783 · Cited by 176
Lipoxygenases and their involvement in programmed cell death
Maccarrone, M., Melino, G., & Finazzi‐Agrò, A. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400908 · Cited by 176
Antioxidant effect of red wine polyphenols on red blood cells
Tedesco, I., Russo, M., Russo, P., Iacomino, G., Russo, G. L., Carraturo, A., Faruolo, C., Luigi Moio, B., & Palumbo, R. (2000) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(99)00080-7 · Cited by 175
Effect of resveratrol in experimental osteoarthritis in rabbits
Elmali, N., Esenkaya, İ., Harma, A., Ertem, K., Türköz, Y., & Mızrak, B. (2005) · Inflammation Research · doi:10.1007/s00011-004-1341-6 · Cited by 176
“The anti-inflammatory properties of resveratrol have been demonstrated by suppression of carrageenan- induced paw edema, an effect attributed to suppression of PG synthesis [ 20 ].”
Background
Pleiotropic mechanisms facilitated by resveratrol and its metabolites
Calamini, B., Ratia, K. M., Malkowski, M. G., Cuendet, M., Pezzuto, J. M., Santarsiero, B. D., & Mesecar, A. D. (2010) · Biochemical Journal · doi:10.1042/bj20091857 · Cited by 179
“These discrepancies could be attributed to the fact that these results, and those of others [4,45,46], are based on different kinetic assays, including those that measure the inhibition of the hydroperoxidase activity of the enzymes using high concentrations of H2O2 for enzymatic detection.”
BackgroundResultInfluentialSelf-citation
Resveratrol enhances GLUT‐4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium
Penumathsa, S. V., Thirunavukkarasu, M., Zhan, L., Maulik, G., Menon, V. P., Bagchi, D., & Maulik, N. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00251.x · Cited by 175
“It possesses many other biologic activities, including an oestrogenic activity [22], antioxidant activity [23], an anti-inflammatory function [24], and a cancer chemopreventive property [25].”
Background
Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells
Chen, Z. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh183 · Cited by 175
Phenolic Compounds and Antioxidant Activity in Grape Juices: A Chemical and Sensory View
Cosme, F., Pinto, T., & Vilela, A. (2018) · Beverages · doi:10.3390/beverages4010022 · Cited by 175
“Several clinical studies on grapes and their derivatives have demonstrated these properties, including protection against cardiovascular diseases [68,69], atherosclerosis [70], hypertension [71], cancer [72], diabetes [73] and neurological problems [74].”
Background
Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway
Chan, M. M.-Y., Mattiacci, J. A., Hwang, H. S., Shah, A., & Fong, D. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00471-8 · Cited by 175
Recent advances in the discovery and development of topoisomerase inhibitors as antitumor agents
Wang, H., Morris-Natschke, S. L., & Lee, K. (1997) · Medicinal Research Reviews · doi:10.1002/(sici)1098-1128(199707)17:4 · Cited by 157
Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves
Ashidi, J. S., Houghton, P. J., Hylands, P. J., & Efferth, T. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.01.009 · Cited by 174
Natural polyphenols in cancer therapy
Asensi, M., Ortega, A., Mena, S., Feddi, F., & Estrela, J. M. (2011) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2011.631268 · Cited by 174
The journey of resveratrol from yeast to human
Timmers, S., Auwerx, J. H., & Schrauwen, P. (2012) · Aging · doi:10.18632/aging.100445 · Cited by 180
“Five years later, in 1997, Jang and colleagues reported resveratrol to work as a chemo-preventive agent, by the ability to inhibit carcinogenesis at multiple stages [5].”
Background
Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling
Scarlatti, F., Sala, G., Somenzi, G., Signorelli, P., Sacchi, N., & Ghidoni, R. (2003) · The FASEB Journal · doi:10.1096/fj.03-0292fje · Cited by 174
“Moreover resveratrol was seen to inhibit both the activity and transcription of COX1 and COX2 (15, 25).”
Resveratrol Brain Delivery for Neurological Disorders Prevention and Treatment
Andrade, S., Ramalho, M. J., Pereira, M. D. C., & Loureiro, J. A. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01261 · Cited by 173
Study of Grape Polyphenols by Liquid Chromatography-High-Resolution Mass Spectrometry (UHPLC/QTOF) and Suspect Screening Analysis
Flamini, R., Rosso, M. D., & Bavaresco, L. (2015) · Journal of Analytical Methods in Chemistry · doi:10.1155/2015/350259 · Cited by 176
Resveratrol (trans-3,5,4′-Trihydroxystilbene) Ameliorates Experimental Allergic Encephalomyelitis, Primarily via Induction of Apoptosis in T Cells Involving Activation of Aryl Hydrocarbon Receptor and Estrogen Receptor
Singh, N. P., Hegde, V. L., Hofseth, L. J., Nagarkatti, M., & Nagarkatti, P. S. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.038984 · Cited by 174
“…-trihydroxystilbene), a nonflavinoid polyphenolic compound found in a large number of plant products including mulberries, peanuts, and red grapes (Jang et al., 1997), is a member of the class of plant antibiotic compounds produced as a part of a plant’s defense system against fungal infection…”
Background
Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates β-Catenin Signaling and NFκB-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells
Bourguignon, L., Xia, W., & Wong, G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806708200 · Cited by 175
Scientific Validation of the Medicinal Efficacy of Tinospora cordifolia
Mishra, A., Kumar, S., & Pandey, A. K. (2013) · The Scientific World JOURNAL · doi:10.1155/2013/292934 · Cited by 176
“6million people died fromcancer in the world during 2007 [8].”
Background
Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium
Ferrero, M. E., Bertelli, A. A. E., Fulgenzi, A., Pellegatta, F., Romanelli, M. M. C., Bonfrate, M., Ferrara, F., Caterina, R. D., Giovannini, L., & Bertelli, A. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/68.6.1208 · Cited by 173
“We showed previously that resveratrol [which is present in grape juice and wine and has anticancer (16), antiinflammatory, and antiaggregating (17) properties] is adsorbed after oral ingestion, quickly enters the bloodstream, and is detectable in different organs (18).”
trans- 3,4,5′-Trihydroxystibene Inhibits Hypoxia-Inducible Factor 1α and Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells
Cao, Z., Fang, J. S., Xia, C., Shi, X., & Jiang, B. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0588 · Cited by 177
“Resveratrol is present in more than 70 plant species and is especially abundant in food products such as grapes, peanuts, and mulberries (2).”
Background
Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components
Piver, B., Berthou, F., Dréano, Y., & Lucas, D. (2001) · Toxicology Letters · doi:10.1016/s0378-4274(01)00418-0 · Cited by 172
Total Synthesis of Resveratrol‐Based Natural Products: A Chemoselective Solution
Snyder, S. A., Zografos, A. L., & Lin, Y. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200703333 · Cited by 173
Antineoplastic Agents. 465. Structural Modification of Resveratrol: Sodium Resverastatin Phosphate
Pettit, G. R., Grealish, M. P., Jung, M. K., Hamel, E., Pettit, R. K., Chapuis, J.-C., & Schmidt, J. M. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm010119y · Cited by 171
Resveratrol neuroprotection in stroke and traumatic CNS injury
Lopez, M. S., Dempsey, R. J., & Vemuganti, R. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.009 · Cited by 172
“Resveratrol is well known for its pro-apoptotic role in cancer (Jang et al., 1997; Lin et al., 2011), but interestingly has an anti-apoptotic effect after acute CNS injury.”
Background
Postharvest Induction Modeling Method Using UV Irradiation Pulses for Obtaining Resveratrol-Enriched Table Grapes: A New “Functional” Fruit?
Cantos‐Villar, E., Espı́n, J. C., & Tomás-Barberán, F. A. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010366a · Cited by 170
Impact of Lifestyles (Diet and Exercise) on Vascular Health: Oxidative Stress and Endothelial Function
Man, A. W. C., Li, H., & Xia, N. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1496462 · Cited by 182
“Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a plant polyphenol found mainly in grape fruits and red wine [142, 143].”
Background
Piceatannol, a hydroxylated analog of the chemopreventive agent resveratrol, is a potent inducer of apoptosis in the lymphoma cell line BJAB and in primary, leukemic lymphoblasts
Wieder, T., Prokop, A., Bagci, B., Eßmann, F., Bernicke, D., Schulze‐Osthoff, K., Dörken, B., Schmalz, H.-G., Daniel, P., & Henze, G. (2001) · Leukemia · doi:10.1038/sj.leu.2402284 · Cited by 171
Resveratrol induces prostate cancer cell entry into s phase and inhibits DNA synthesis.
Kuwajerwala, N., Cifuentes-Pagano, E., Gautam, S. C., Menon, M., Barrack, E. R., & Reddy, G. P. V. (2002) · PubMed · Cited by 171
Resveratrol as a Pan-HDAC Inhibitor Alters the Acetylation Status of Jistone Proteins in Human-Derived Hepatoblastoma Cells
Venturelli, S., Berger, A., Böcker, A., Busch, C., Weiland, T., Noor, S., Leischner, C., Schleicher, S., Mayer, M., Weiß, T. S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073097 · Cited by 174
“Beside the protection from cardiovascular diseases [7] and antioxidant properties [8] resveratrol was described to possess antiinflammatory [9] and antiproliferative effects [10,11].”
Distribution of resveratrol and stilbene synthase in young grape plants (Vitis vinifera L. cv. Cabernet Sauvignon) and the effect of UV-C on its accumulation
Wang, W., Tang, K., Yang, H., Wen, P., Zhang, P., Wang, H., & Huang, W. (2009) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2009.12.002 · Cited by 170
A high-throughput chemically induced inflammation assay in zebrafish
d’Alençon, C., Peña, O. A., Wittmann, C., Gallardo, V. E., Jones, R. A., Loosli, F., Liebel, U., Grabher, C., & Allende, M. L. (2010) · BMC Biology · doi:10.1186/1741-7007-8-151 · Cited by 170
“Trans-resveratrol COX-1 inhibitor 1 [41]”
Plant natural compounds: targeting pathways of autophagy as anti‐cancer therapeutic agents
Zhang, X., Chen, L., Ouyang, L., Cheng, Y., & Liu, B. (2012) · Cell Proliferation · doi:10.1111/j.1365-2184.2012.00833.x · Cited by 175
Resveratrol: A Natural Polyphenol with Multiple Chemopreventive Properties (Review)
Brisdelli, F., D’Andrea, G., & Bozzi, A. (2009) · Current Drug Metabolism · doi:10.2174/138920009789375423 · Cited by 173
“tumor initiation, promotion and progression in a murine model [14].”
Background
A Review of Resveratrol as a Potent Chemoprotective and Synergistic Agent in Cancer Chemotherapy
Xiao, Q., Zhu, W., Feng, W., Lee, S. S., Leung, A. W., Shen, J., Gao, L., & Xu, C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01534 · Cited by 172
Mechanism-Based Cancer Prevention Approaches: Targets, Examples, and the Use of Transgenic Mice
Hursting, S. D., Slaga, T. J., Fischer, S. M., DiGiovanni, J., & Phang, J. M. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.3.215 · Cited by 168
Commentary: Bioavailability of Flavonoids and Polyphenols: Call to Arms
Hu, M. (2007) · Molecular Pharmaceutics · doi:10.1021/mp7001363 · Cited by 172
Cyclooxygenase‐deficient Mice: A Summary of Their Characteristics and Susceptibilities to Inflammation and Carcinogenesis
LANGENBACH, R., LOFTIN, C. D., LEE, C., & TIANO, H. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08723.x · Cited by 170
Endocrine Disruptors and the Breast: Early Life Effects and Later Life Disease
Macon, M. B., & Fenton, S. E. (2013) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-013-9275-7 · Cited by 171
“Moreover, in vitro studies have demonstrated that RES has antitumor initiation, promotion, and anti-mutagenic properties which were attributed to its inhibitory effects on cyclooxegenase [160].”
Effect of ozone on aflatoxins detoxification and nutritional quality of peanuts
Chen, R., Ma, F., Li, P., Zhang, W., Ding, X., Zhang, Q., Li, M., Wang, Y., & Xu, B. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.09.059 · Cited by 169
“Polyphenols, including resveratrol, play a role in the prevention of degenerative diseases, particularly cardiovascular diseases and cancers with their antioxidative properties (Chukwumah, Walker, & Verghese, 2009; Jang et al., 1997; Sgambato et al., 2001).”
Background
Cancer Chemoprevention by Targeting the Epigenome
Huang, P.-H., Plass, C., & Gerhäuser, C. (2011) · Current Drug Targets · doi:10.2174/138945011798184155 · Cited by 168
“Chemopreventive activity of resveratrol was first described in 1997 [266].”
Background
Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
Nonn, L., Duong, D. K., & Peehl, D. M. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl241 · Cited by 169
Changes in the Phytoalexin Content of Various Vitis Spp. in Response to Ultraviolet C Elicitation
Breuil, A.-C., Jeandet, P., Adrian, M., & Bessis, R. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9900478 · Cited by 169
Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol
Li, Z. (2002) · Carcinogenesis · doi:10.1093/carcin/23.9.1531 · Cited by 169
“It was indicated that resveratrol can block the process of multistep carcinogenesis ( 5 ).”
Background
Recent Advances in the Study on Resveratrol
Nakata, R., Takahashi, S., & Inoue, H. (2012) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.35.273 · Cited by 171
Plants, Diet, and Health
Martin, C. R., Zhang, Y., Tonelli, C., & Petroni, K. (2013) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-050312-120142 · Cited by 171
Clinical Pharmacokinetics of Antioxidants and Their Impact on Systemic Oxidative Stress
Schwedhelm, E., Maas, R., Troost, R., & ger, R. H. B. (2003) · Clinical Pharmacokinetics · doi:10.2165/00003088-200342050-00003 · Cited by 172
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells
Miranda, C. L., Aponso, G. L. M., Stevens, J. F., Deinzer, M. L., & Buhler, D. R. (2000) · Cancer Letters · doi:10.1016/s0304-3835(99)00328-6 · Cited by 168
Exploring the Relation of Alcohol Consumption to Risk of Breast Cancer
Ellison, R. C. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.8.740 · Cited by 171
Resveratrol-mediated chemoprevention of diethylnitrosamine-initiated hepatocarcinogenesis: Inhibition of cell proliferation and induction of apoptosis
Bishayee, A., & Dhir, N. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.11.015 · Cited by 169
Anti-inflammatory Effects of Resveratrol and Its Potential Use in Therapy of Immune-mediated Diseases
Švajger, U., & Jeras, M. (2012) · International Reviews of Immunology · doi:10.3109/08830185.2012.665108 · Cited by 170
“postulated to explain certain cardioprotective effects of red wine [112], as well as demonstrated to be cancer preventive in mouse models [29].”
Background
Determination of the Phytoalexin Resveratrol (3,5,4‘-Trihydroxystilbene) in Peanuts and Pistachios by High-Performance Liquid Chromatographic Diode Array (HPLC-DAD) and Gas Chromatography−Mass Spectrometry (GC-MS)
Tokuşoğlu, Ö., Ünal, M. K., & Yemiş, F. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050496+ · Cited by 183
Impact of atmospheric ozone-enrichment on quality-related attributes of tomato fruit
Tzortzakis, N., Borland, A. M., Singleton, I., & Barnes, J. (2007) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2007.03.004 · Cited by 167
Resveratrol accumulation and resveratrol synthase gene expression in response to abiotic stresses and hormones in peanut plants
Chung, I., Park, M. R., Chun, J., & Yun, S. J. (2002) · Plant Science · doi:10.1016/s0168-9452(02)00341-2 · Cited by 167
Antiangiogenic mechanisms of diet-derived polyphenols
Cao, Y., Cao, R., & Bråkenhielm, E. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00204-8 · Cited by 166
Herbals, Cancer Prevention and Health
Wargovich, M. J., Woods, C., Hollis, D. M., & Zander, M. E. S. (2001) · Journal of Nutrition · doi:10.1093/jn/131.11.3034s · Cited by 167
Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process
Lançon, A., Delma, D., Osman‐Ponchet, H., Thenot, J. P., & Latruffe, N. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.02.164 · Cited by 167
Antidepressant effects of resveratrol in an animal model of depression
Hurley, L. L., Akinfiresoye, L. R., Kalejaiye, O., & Tizabi, Y. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.03.052 · Cited by 166
“Resveratrol was initially studied for its potential for treating cancer [26], but also gained recognition for its ability to reduce cardiovascular disease [27].”
Background
Resveratrol-Loaded Nanoparticles Based on Poly(epsilon-caprolactone) and Poly( d , l -lactic-co-glycolic acid)–Poly(ethylene glycol) Blend for Prostate Cancer Treatment
Sanna, V., Siddiqui, I. A., Sechi, M., & Mukhtar, H. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400342f · Cited by 166
Resveratrol, an extract of red wine, inhibits lipopolysaccharide induced airway neutrophilia and inflammatory mediators through an NF‐κB‐independent mechanism
Birrell, M. A., McCluskie, K., Wong, S., Donnelly, L., Barnes, P. J., & Belvisi, M. G. (2005) · The FASEB Journal · doi:10.1096/fj.04-2691fje · Cited by 171
“(6) have suggested that it inhibits all three phases of tumor development: initiation, promotion, and progression.”
Background
New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds
Redondo-Blanco, S., Fernández, J., Gutiérrez-del-Río, I., Villar, C. J., & Lombó, F. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00109 · Cited by 113
“Since the publication in 1997 of the chemopreventive activity of topically applied resveratrol in a mouse model of skin cancer (Jang et al., 1997), this natural compound has been extensively studied for the prevention and also treatment of many diseases, including CRC.”
Background
Chemotherapeutic efficacy of curcumin and resveratrol against cancer: Chemoprevention, chemoprotection, drug synergism and clinical pharmacokinetics
Patra, S., Pradhan, B., Nayak, R., Behera, C., Rout, L., Jena, M., Efferth, T., & Bhutia, S. K. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.10.010 · Cited by 166
Food Phenolics, Pros and Cons: A Review
Lule, S. U., & Xia, W. (2005) · Food Reviews International · doi:10.1080/87559120500222862 · Cited by 166
“Resveratrol has been shown to inhibit ribonucleotide reductase and certain other cellular events associated with initiation, promotion, and progression of carcinogenesis ( Jang et al, 1997 ).”
Background
Waste Management for the Food Industries
(2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373654-3.x5001-9 · Cited by 166
Prevention of Ocular Inflammation in Endotoxin-Induced Uveitis with Resveratrol by Inhibiting Oxidative Damage and Nuclear Factor–κB Activation
Kubota, S., Kurihara, T., Mochimaru, H., Satofuka, S., Noda, K., Ozawa, Y., Oike, Y., Ishida, S., & Tsubota, K. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2666 · Cited by 168
Resveratrol inhibits TGF-β1-induced epithelial-to-mesenchymal transition and suppresses lung cancer invasion and metastasis
Wang, H., Zhang, H., Tang, L., Chen, H., Wu, C., Zhao, M., Yang, Y., Chen, X., & Liu, G. (2012) · Toxicology · doi:10.1016/j.tox.2012.09.017 · Cited by 164
Differential expression of genes induced by resveratrol in LNCaP cells: P53‐mediated molecular targets
Narayanan, B. A., Narayanan, N. K., Re, G. G., & Nixon, D. W. (2003) · International Journal of Cancer · doi:10.1002/ijc.10932 · Cited by 164
Comparison of the effects of the chemopreventive agent resveratrol and its synthetic analog trans 3,4,5,4′‐tetramethoxystilbene (DMU‐212) on adenoma development in the ApcMin+ mouse and cyclooxygenase‐2 in human‐derived colon cancer cells
Sale, S., Tunstall, R. G., Ruparelia, K. C., Potter, G. A., Steward, W. P., & Gescher, A. J. (2005) · International Journal of Cancer · doi:10.1002/ijc.20884 · Cited by 166
“It inhibits diverse cellular events associated with the initiation, promotion and progression of cancer,(3) proliferation of a variety of cancer cell lines,(4) formation of preneoplastic lesions in the dimethylbenzathracene-induced mouse mammary organ culture model(5) and benzo(a)pyrene-induced transformation of rat t…”
BackgroundMethod
Resveratrol- induced apoptosis is mediated by p53-dependent pathway in Hep G2 cells
Kuo, P., Chiang, L., & Lin, C. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02177-x · Cited by 167
Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research.
Alberts, D. S., Colvin, O. M., Conney, A. H., Ernster, V. L., Garber, J., Greenwald, P., Gudas, L. J., Hong, K. H. W. K., Kelloff, G. J., Kramer, R. A., et al. (1999) · PubMed · Cited by 165
Self-citation
Resveratrol: Twenty Years of Growth, Development and Controversy
Pezzuto, J. M. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2018.176 · Cited by 173
“Considering the data presented in our first publication regarding the cancer chemopreventive potential of resveratrol (Jang et al, 1997), it has been clear from the outset that resveratrol does not abide by the concept of ‘one drug, one target’.”
BackgroundMethodResultInfluentialSelf-citation
Phenolic compounds in agri-food by-products, their bioavailability and health effects
Shahidi, F., Vamadevan, V., Oh, W. Y., & Peng, H. (2019) · Journal of Food Bioactives · doi:10.31665/jfb.2019.5178 · Cited by 175
Biotransformation of resveratrol: synthesis of trans-dehydrodimers catalyzed by laccases from Myceliophtora thermophyla and from Trametes pubescens
Nicotra, S., Cramarossa, M. R., Mucci, A., PAGNONI, U. M., Riva, S., & Forti, L. (2003) · Tetrahedron · doi:10.1016/j.tet.2003.10.117 · Cited by 165
Resveratrol antibacterial activity against Escherichia coli is mediated by Z-ring formation inhibition via suppression of FtsZ expression
Hwang, D., & Lim, Y. (2015) · Scientific Reports · doi:10.1038/srep10029 · Cited by 165
Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK
Wang, J., Li, J., Cao, N., Li, Z., Han, J., & Li, L. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s159095 · Cited by 167
“Resveratrol (trans-3,4′,5-trihydroxystilbene) is a natural polyphenolic phytoalexin, which is found in red grape skins, red wine, and peanuts.(4) Accumulating evidence indicated that resveratrol exerted various biological effects including anti-oxidation, inhibition of tumorigenesis, and inhibition of angiogenesis.”
Background
Evidence for a Trade‐Off between Survival and Fitness Caused by Resveratrol Treatment of Caenorhabditis elegans
Gruber, J., Tang, S. Y., & Halliwell, B. B. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1395.059 · Cited by 167
Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies
Guengerich, F. P., Chun, Y., Kim, D., Gillam, E. M. J., & Shimada, T. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00333-0 · Cited by 163
Ursolic Acid fromPlantagomajor, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis
Ringbom, T., Segura, L., Noreen, Y., Perera, P., & Bohlin, L. (1998) · Journal of Natural Products · doi:10.1021/np980088i · Cited by 163
Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis
Jazirehi, A. R., & Bonavida, B. (2004) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.71.3.1 · Cited by 163
“In vivo , resveratrol inhibits three major steps of carcinogenesis: initiation, promotion, and progression (5).”
Resveratrol in Peanuts
Sales, J. M., & Resurreccion, A. V. A. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.606928 · Cited by 166
“Emerging literature, pointing to the low intestinal absorbance of polyphenols, suggests that the ability of polyphenols and their metabolites in vivo to interact with cell-signaling cascades, such as apoptosis and redox-sensitive cell-signaling pathways, may be a major mechanism of action (Jang et al., 1997).”
Background
Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary
Morita, Y., Wada‐Hiraike, O., Yano, T., Shirane, A., Hirano, M., Hiraike, H., Koyama, S., Oishi, H., Yoshino, O., Miyamoto, Y., et al. (2012) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-10-14 · Cited by 165
“It can be found in berries, nuts and some medicinal plants, and mainly present in the skin of grapes and thus in red wine [3].”
Background
Inhibition of Breast Cancer Metastasis by Resveratrol-Mediated Inactivation of Tumor-Evoked Regulatory B Cells
Lee-Chang, C., Bodogai, M., Martín‐Montalvo, A., Wejksza, K., Sanghvi, M., Moaddel, R., de Cabo, R., & Biragyn, A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300606 · Cited by 167
Improved oral delivery of resveratrol from N-trimethyl chitosan-g-palmitic acid surface-modified solid lipid nanoparticles
Ramalingam, P., & Ko, Y. T. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.11.050 · Cited by 162
Resveratrol and Ophthalmic Diseases
Abu‐Amero, K. K., Kondkar, A. A., & Chalam, K. V. (2016) · Nutrients · doi:10.3390/nu8040200 · Cited by 166
“[33], demonstrating chemo-preventive activity of resveratrol and subsequently from reports that it activates sirtuin deacetylases, which extends the life-span in yeast [34], that studies on the effects and properties of this compound started accumulating exponentially.”
Background
Isolation, Identification, and Antioxidant Activity of Three Stilbene Glucosides Newly Extracted from Vitis vinifera Cell Cultures
Téguo, P. W., Fauconneau, B., Deffieux, G., Huguet, F., Vercauteren, J., & Mérillon, J. (1998) · Journal of Natural Products · doi:10.1021/np9704819 · Cited by 162
Resveratrol induces colon tumor cell apoptosis independently of p53 and precede by epithelial differentiation, mitochondrial proliferation and membrane potential collapse
Mahyar-Roemer, M., Katsen, A. D., Mestres, P., & Roemer, K. (2001) · International Journal of Cancer · doi:10.1002/ijc.1516 · Cited by 162
Pterostilbene and 3′-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells
Tolomeo, M., Grimaudo, S., Cristina, A. D., Roberti, M., Pizzirani, D., Meli, M., Dusonchet, L., Gebbia, N., Abbadessa, V., Crosta, L., et al. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2005.03.004 · Cited by 162
“Indeed, several in vitro and in vivo studies have shown that resveratrol inhibits cellular events associated with cancer initiation, promotion, and progression (Jang et al., 1997).”
Background
Perspectives for production and application of resveratrol
Kiselev, K. V. (2011) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-011-3184-8 · Cited by 162
“The anticancerogenic properties of this substance were first found in 1997 (Jang et al. 1997); since then, there have been numerous publications on the ability of transK.”
Background
Resveratrol and breast cancer chemoprevention: Molecular mechanisms
Corre, L. L., Chalabi, N., Delort, L., Bignon, Y., & Bernard-Gallon, D. J. (2005) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200400094 · Cited by 162
Convenient Preparation of trans-Arylalkenes via Palladium(II)-Catalyzed Isomerization of cis-Arylalkenes
Yu, J., Gaunt, M. J., & Spencer, J. B. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo015880u · Cited by 161
Targeting the AMP-Activated Protein Kinase for Cancer Prevention and Therapy
Kim, I., & He, Y. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00175 · Cited by 163
“One of the earliest findings of its anticancer effects was in 1997, in which topical resveratrol applications prevented skin cancer development in mice treated with a carcinogen (72).”
Background
Resveratrol suppresses prostate cancer progression in transgenic mice
Harper, C., Patel, B. B., Wang, J., Arabshahi, A., Eltoum, I. A., & Lamartiniere, C. A. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm144 · Cited by 160
“ability to halt carcinogenesis at the initiation, promotion, and progression stages [ 12 ].”
Background
Potential Anticancer Properties of Grape Antioxidants
Zhou, K., & Raffoul, J. J. (2012) · Journal of Oncology · doi:10.1155/2012/803294 · Cited by 160
“Melanoma is the leading cause of death from skin disease, and treatment of human melanoma A375 and Hs294t cells with GSPs resulted in a concentration-dependent inhibition of invasion or cell migration of these cells, which was related to a significant reduction in the levels of COX-2 expression and PGE(2) production […”
BackgroundInfluential
Association between Pterostilbene and Quercetin Inhibits Metastatic Activity of B16 Melanoma
Ferrer, P., Asensi, M. A., Segarra, R., Ortega, Á., Benlloch, M., Obrador, E., Varea, T., Asensio, G., Jordá, L., & Estrela, J. M. (2005) · Neoplasia · doi:10.1593/neo.04337 · Cited by 159
“investigation [3] and may include, for example: 1) inhibition of ribonucleotide reductase [5], DNA polymerase [6], protein kinase C [7], or cyclooxygenase-2 [8] activities; 2) inhibition of reactive oxygen species–mediated carcinogenesis [4] or cell proliferation [9]; and 3) apoptotic cell death activation [10–13].”
Background
In silico polypharmacology of natural products
Fang, J., Liu, C., Wang, Q., Lin, P., & Cheng, F. (2017) · Briefings in Bioinformatics · doi:10.1093/bib/bbx045 · Cited by 168
Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice
Hecht, S. S., Kenney, P. M. J., Wang, M., Trushin, N., Agarwal, S., Rao, A. V., & Upadhyaya, P. (1999) · Cancer Letters · doi:10.1016/s0304-3835(98)00326-7 · Cited by 159
Resveratrol and life extension
Agarwal, B., & Baur, J. A. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05850.x · Cited by 163

Authors: Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
Affiliations: University of Illinois Chicago (US)
Universidad Complutense de Madrid (ES)
M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Corresponding author: Cai, Lining
Pezzuto, John M.
ORCID: Udeani, George O.
Slowing, Karla V.
Kinghorn, A. Douglas
Mehta, Rajendra G.
Pezzuto, John M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-01-10
Volume: 275
Issue: 5297
Pages: 218-220
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.275.5297.218
OpenAlex: W2151089147
Cited by: 4,935
References: 33
Citations by year: 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
FWCI: 96.50
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
Funders: National Cancer Institute (P01CA048112)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks