Cited by 4,935Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

Jang, Meishiang, Cai, Lining, Udeani, George O., Slowing, Karla V., Thomas, Cathy F., Beecher, Christopher W. W., Fong, Harry H. S., Farnsworth, Norman R., Kinghorn, A. Douglas, Mehta, Rajendra G., Moon, Richard C., Pezzuto, John M.·1997·Science

DOI 10.1126/science.275.5297.218

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Abstract

Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

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Aspirin Use and Reduced Risk of Fatal Colon Cancer
Thun, M. J., Namboodiri, M. M., & Heath, C. W. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112053252301 · Cited by 1,685
Prospective study of alcohol consumption and risk of coronary disease in men.
Rimm, E. B., Giovannucci, E. L., Willett, W. C., Colditz, G. A., Ascherio, A., Rosner, B., & Stampfer, M. J. (1991) · The Lancet · doi:10.1016/0140-6736(91)90542-w · Cited by 1,239
The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease
Pace-Asciak, C. R., Hahn, S., Diamandis, E. P., Soleas, G. J., & Goldberg, D. M. (1995) · Clinica Chimica Acta · doi:10.1016/0009-8981(95)06045-1 · Cited by 877
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.
Zhang, Y., Kensler, T. W., Cho, C., Posner, G. H., & Talalay, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3147 · Cited by 746
Alcohol and Mortality
Klatsky, A. L., Armstrong, M. A., & FRIEDMAN, G. D. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-117-8-646 · Cited by 541
Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: A screening assay for anticarcinogenic enzyme inducers
Prochaska, H. J., & Santamaria, A. B. (1988) · Analytical Biochemistry · doi:10.1016/0003-2697(88)90292-8 · Cited by 495
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase
Gierse, J. K., Hauser, S. D., Creely, D., Koboldt, C. M., Rangwala, S. H., Isakson, P. C., & Seibert, K. (1995) · Biochemical Journal · doi:10.1042/bj3050479 · Cited by 412
Sulindac for polyposis of the colon
Waddell, W. R., Ganser, G. F., Cerise, E. J., & Loughry, R. W. (1989) · The American Journal of Surgery · doi:10.1016/0002-9610(89)90442-x · Cited by 409
The Production of Resveratrol (3,5,4'-trihydroxystilbene) by Grape Berries in Different Developmental Stages
Jeandet, P., Bessis, R., & Gautheron, B. (1991) · American Journal of Enology and Viticulture · doi:10.5344/ajev.1991.42.1.41 · Cited by 401
Chemoprevention of cancer with retinoids
Peck, G. L. (1981) · Gynecologic Oncology · doi:10.1016/0090-8258(81)90086-x · Cited by 366

Show all 33 references

Research works printed but not linked: 11

Sporn M. B., Newton D. L., Fed. Proc. 38, 2528 (1979).
Kudo T., Narisawa T., Abo S., Gann 71 260 (1980);
Zenser T. V., et al., J. Pharmacol. Exp. Ther. 227 545 (1983);
Wattenberg L. W., Cancer Res. 53, 5890 (1993).
Sharma S., Stutzman J. D., Kelloff G. J., Steele V. E., Cancer Res. 54 5848 (1994);
Shamon L. A., et al., Anticancer Res. 14 1775 (1995).
Suh N., Luyengi L., Fong H. H. S., Kinghorn A. D., Pezzuto J. M., Anticancer Res. 15, 233 (1995).
Moon R. C., Mehta R. G., in Chemistry and Biology of Retinoids, , Dawson M. I., Okamura W. H., Eds. (CRC Press, Boca Raton, FL, 1990), pp. 501-518.
Dercks W., Creasy L. L., Physiol. Mol. Plant Pathol. 34, 289 (1989).
Siemann E. H. and , Creasy L. L., ibid. 43, 49 (1992);
Goldberg D. M., et al., ibid. 46, 159 (1995).

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Background
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Rotondo, S., Rajtar, G., Manarini, S., Celardo, A., Rotilio, D., de Gaetano, G., Evangelista, V., & Cerletti, C. (1998) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701784 · Cited by 241
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Background
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Cyclooxygenase knockout mice
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Self-citation
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Background
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“The first report of the cancer chemoprotective activity of a phytoalexin is the study of the group of Pezzuto [119].”
Background
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“Resveratrol raised his importance as a chemopreventive agent after a paper published in 1997 [130].”
Background
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“Res has various biological activities, including antiinflammatory, antifungal, antimutagenic and anticancer effects (5).”
Background
Mass spectrometry in grape and wine chemistry. Part I: Polyphenols
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“In the last 10 years, it has become an important qualitative parameter because of the several beneficial effects on human health that were revealed by recent studies: anticancer activity, cardioprotection, antioxidant activity, inhibition of platelet aggregation, and anti-inflammatory activity (Frankel, Waterhouse, &…”
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Shin, N.-H., Ryu, S. Y., Choi, E. J., Kang, S.-H., Chang, I., Min, K. R., & Kim, Y. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8169 · Cited by 226
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“models, where it suppresses the initiation, promotion and progression of tumors [5].”
Background
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Bujanda, L., Hijona, E., Larzábal, M., Beraza, M., Aldazábal, P., García‐Urkía, N., Sarasqueta, C., Cosme, Á., Irastorza, B., González, A., et al. (2008) · BMC Gastroenterology · doi:10.1186/1471-230x-8-40 · Cited by 226
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Background
Resveratrol‐induced apoptosis in MCF‐7 human breast cancer cells involves a caspase‐independent mechanism with downregulation of Bcl‐2 and NF‐κB
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“Stilbenes Stilbenes are another class of phenylpropanoids that have gained much attention, particularly resveratrol, which is touted as an antioxidant [51] and for its ability to increase the lifespan of yeast, fruit fly, round worm [52], and fish [53] by activating siruin deacetylases [54].”
Background
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Lima, T., Waffo‐Téguo, P., Teissèdre, P., Pujolas, A., Vercauteren, J., Cabanis, J. C., & Mérillon, J. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9900884 · Cited by 220
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Background
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Human Cytochrome P450 Enzymes
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“demonstrated to have biological functions such as antiinflammatory and anti-oxidant activities, chemoprotection, and apoptosis induction, as well as other beneficial effects on human health, such as lowering risk of cardiovascular diseases and cancer [206–208].”
Phenolic fortification of yogurt using grape and callus extracts
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Tadolini, B., Juliano, C., Piu, L., Franconi, F., & Cabrini, L. (2000) · Free Radical Research · doi:10.1080/10715760000300661 · Cited by 220
Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease
Chang, J., Rimando, A. M., Pallàs, M., Camins, A., Porquet, D., Reeves, J., Shukitt‐Hale, B., Smith, M. A., Joseph, J. A., & Casadesús, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.08.015 · Cited by 219
“In vitro effects of resveratrol, through SIRT1 activation (Yeung et al., 2004), also include inhibition of proinflammatory nuclear factor-kappa B (NF B) transcription (HolmesMcNary and Baldwin, 2000; Jang et al., 1997; Manna et al., 2000).”
Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice
Sánchez‐Fidalgo, S., Cárdeno, A., Villegas, I., Talero, E., & Alarcón‐de‐la‐Lastra, C. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.01.025 · Cited by 220
“The last years, it has been the focus of numerous in vitro and in vivo studies where its biological attributes have been investigated, which include essentially antioxidant and anti-inflammatory activities, anti-platelet aggregation effect, anti-atherogenic property, oestrogen-like growth promoting effect, growth-inhi…”
Resveratrol Suppresses the Angiogenesis and Tumor Growth of Gliomas in Rats
Tseng, S.-H., Lin, S.-M., Chen, J.-C., Su, Y., Huang, H., Chen, C.-K., Lin, P.-Y., & Chen, Y. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0105 · Cited by 217
“In recent years, resveratrol was further demonstrated to be an antitumor and chemopreventive agent and found to affect cellular proliferation through its action on tumor initiation, promotion, and progression (11, 12).”
Background
Role of Natural Stilbenes in the Prevention of Cancer
Sirerol, J. A., Rodríguez, M. L., Mena, S., Asensi, M., Estrela, J., & Ortega, Á. L. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3128951 · Cited by 197
“The chemopreventive properties of Resv have been associated with its antioxidant activity since it was first published that its anticancer activity, affecting all steps in the carcinogenesis process, was linked to the inhibition of cyclooxygenase 2 (COX-2) [18].”
BackgroundInfluential
The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells
Wang, X., Li, Y.-B., Yao, H.-J., Ju, R.-J., Zhang, Y., Li, R., Yu, Y., Zhang, L., & Lü, W.-L. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.029 · Cited by 216
“Resveratrol has emerged as a potential antitumor agent having the ability to inhibit all three major stages of carcinogenesis, including initiation, promotion and progression [16].”
Synthesis and Biological Evaluation of Resveratrol and Analogues as Apoptosis-Inducing Agents
Roberti, M., Pizzirani, D., Simoni, D., Rondanin, R., Baruchello, R., Bonora, C., Buscemi, F., Grimaudo, S., & Tolomeo, M. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm030785u · Cited by 216
Nutritionally Improved Agricultural Crops
Newell‐McGloughlin, M. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.121947 · Cited by 214
“It was shown to have ‘‘chemopreventive’’ activity, preventing the formation of tumors in mouse skin bioassays, and, therefore, may help reduce cancer rates in humans (Jang et al., 1997).”
Background
Advances in phytochemical delivery systems for improved anticancer activity
Lagoa, R., Silva, J. S., Rodrigues, J. R., & Bishayee, A. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.04.004 · Cited by 215
Oxidative Stress and Neurodegenerative Disorders
Sun, A. Y., & Chen, Y. (1998) · Journal of Biomedical Science · doi:10.1007/bf02255928 · Cited by 214
Wine, Beer, and Mortality in Middle-aged Men From Eastern France
Renaud, S., Gueguen, R., Siest, G., & Salamon, R. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.16.1865 · Cited by 218
“Among these substances, resveratrol may even inhibit the 3 main stages of carcinogenesis.(9) We reported recently(10) that allcause mortality in middle-aged men from eastern France who consumed mostly wine (1-3 drinks per day) was 20% to 30% lower compared with abstainers.”
Background
SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells
Miyazaki, R., Ichiki, T., Hashimoto, T., Inanaga, K., Imayama, I., Sadoshima, J., & Sunagawa, K. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.166991 · Cited by 221
Effect of Resveratrol on Antioxidant Enzyme Activities in the Brain of Healthy Rat
Mokni, M., Elkahoui, S., Limam, F., Amri, M., & Aouani, E. (2007) · Neurochemical Research · doi:10.1007/s11064-006-9255-z · Cited by 215
“Resveratrol was also shown to inhibit cellular events associated with tumour initiation, promotion and progression [9], and due to its weak toxicity should be envisaged as a chemopreventive agent [10].”
Background
Metabolic engineering of for the synthesis of the wine-related antioxidant resveratrol
BECKER, J., Armstrong, G. O., VANDERMERWE, M., Lambrechts, M. G., Vivier, M. A., & Pretorius, I. S. (2003) · FEMS Yeast Research · doi:10.1016/s1567-1356(03)00157-0 · Cited by 213
“The antioxidant and anti-in£ammatory activities of resveratrol enable it to inhibit biochemical changes involved in tumour initiation, promotion and progression [10,11].”
Background
Molecular basis of chemoprevention by resveratrol: NF-κB and AP-1 as potential targets
Kundu, J. K., & Surh, Y. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.05.019 · Cited by 212
The Pharmacology of the Ductus Arteriosus
Smith, G. C. S. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01348-6 · Cited by 212
“drug has been described (Jang et al., 1997), it is likely to”
Resveratrol inhibition of herpes simplex virus replication
Docherty, J. J., Fu, M., Stiffler, B. S., Limperos, R. J., Pokabla, C. M., & DeLucia, A. L. (1999) · Antiviral Research · doi:10.1016/s0166-3542(99)00042-x · Cited by 212
“In addition, a recent report described it as a cancer chemo-preventative, affecting the three major stages of carcinogenesis (Jang et al., 1997).”
BackgroundInfluential
Raging the War Against Inflammation With Natural Products
Attiq, A., Jalil, J., Husain, K., & Ahmad, W. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00976 · Cited by 222
“In last two decades several reports have highlighted the anticancer activity of well-established chemo-preventive secondary metabolite resveratrol (31) (Figure 4) (Jang et al., 1997; Bhat and Pezzuto, 2002).”
Background
Effects of maternal xenoestrogen exposure on development of the reproductive tract and mammary gland in female CD-1 mouse offspring
Nikaido, Y., Yoshizawa, K., Danbara, N., Tsujita-Kyutoku, M., Yuri, T., Uehara, N., & Tsubura, A. (2004) · Reproductive Toxicology · doi:10.1016/j.reprotox.2004.05.002 · Cited by 251
A Stress-Inducible Resveratrol O -Methyltransferase Involved in the Biosynthesis of Pterostilbene in Grapevine
Schmidlin, L., Poutaraud, A., Claudel, P., Mestre, P., Prado, E., Santos-Rosa, M., Wiedemann‐Merdinoglu, S., Karst, F., Merdinoglu, D., & Hugueney, P. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.126003 · Cited by 211
“In addition, pterostilbene exhibits antioxidant and anticancer properties similar to those of resveratrol (Jang et al., 1997).”
Background
Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases
Pyo, I. S., Yun, S., Yoon, Y. E., Choi, J. W., & Lee, S. (2020) · Molecules · doi:10.3390/molecules25204649 · Cited by 221
“Inhibition of PKC by resveratrol in turn induces the inhibition of COX and LOX, which can induce the synthesis of proinflammatory molecules that are critical for the initiation of tumorigenesis.”
BackgroundInfluential
Engineering the plant cell factory for secondary metabolite production
Verpoorte, R., van der Heijden, R., & Memelink, J. (2000) · Transgenic Research · doi:10.1023/a:1008966404981 · Cited by 214
“Plants overproducing resveratrol are also of interest from nutritional point of view, as this stilbene is a strong antioxidant, which has among others been proposed as the compound involved in the health promoting effects of wine (French paradox) (Soleas et al., 1997; Jang et al., 1997).”
Background
Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells
Delmas, D., Rébé, C., Micheau, O., Athias, A., Gambert, P., Grazide, S., Laurent, G., Latruffe, N., & Solary, É. (2004) · Oncogene · doi:10.1038/sj.onc.1208086 · Cited by 211
“The polyphenol resveratrol (3, 5, 40-trihydroxystilbene) has demonstrated a cancer chemopreventive activity in animal models of carcinogenesis (Jang et al., 1997).”
Background
Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum.
Gescher, A. J., & Steward, W. P. (2003) · PubMed · Cited by 210
Antioxidant and apoptosis-inducing activities of ellagic acid.
Han, D. H., Lee, M. J., & Kim, J. H. (2006) · PubMed · Cited by 210
Suppression of Ultraviolet B Exposure-Mediated Activation of NF-κB in Normal Human Keratinocytes by Resveratrol
Adhami, V. M., Afaq, F., & Ahmad, N. (2003) · Neoplasia · doi:10.1016/s1476-5586(03)80019-2 · Cited by 209
“Studies have shown that resveratrol imparts skin cancer chemopreventive action by inhibiting cellular events at all the three stages ( initiation, promotion, and progression) of the process of carcinogenesis [16].”
Resveratrol and cancer: a review
Savouret, J., & Quesne, M. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(01)00158-5 · Cited by 207
Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cells
Jang, J., & Surh, Y. (2001) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00233-9 · Cited by 211
The pleiotropic neuroprotective effects of resveratrol in cognitive decline and Alzheimer’s disease pathology: From antioxidant to epigenetic therapy
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208
Complementary and alternative medicine: Herbs, phytochemicals and vitamins and their immunologic effects
Mainardi, T., Kapoor, S., & Bielory, L. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.12.023 · Cited by 209
Determination of Stilbenes (δ-viniferin, trans-astringin, trans-piceid, cis- and trans-resveratrol, ε-viniferin) in Brazilian Wines
Vitrac, X., Bornet, A., Vanderlinde, R., Valls, J., Richard, T., Delaunay, J.-C., Mérillon, J., & Teissèdre, P. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf050122g · Cited by 208
Resveratrol Induces Apoptosis in Thyroid Cancer Cell Lines via a MAPK- and p53-Dependent Mechanism
Shih, A., Davis, F. B., Lin, H., & Davis, P. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8345 · Cited by 204
Inhibition of Vascular Endothelial Growth Factor-Induced Angiogenesis by Resveratrol through Interruption of Src-Dependent Vascular Endothelial Cadherin Tyrosine Phosphorylation
Lin, M., Yen, M., Lin, C., & Kuo, M. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.5.1029 · Cited by 208
“Resveratrol has also been reported to inhibit the development of preneoplastic lesions in carcinogen-induced mammary carcinogenesis and the promotion stage of mouse skin carcinogenesis (Jang et al., 1997).”
Background
Synthesis of Stilbene and Distyrylbenzene Derivatives through Rhodium-Catalyzed Ortho-Olefination and Decarboxylation of Benzoic Acids
Mochida, S., Hirano, K., Satoh, T., & Miura, M. (2010) · Organic Letters · doi:10.1021/ol1027392 · Cited by 208
Regioselective reactions for programmable resveratrol oligomer synthesis
Snyder, S. A., Gollner, A., & Chiriac, M. I. (2011) · Nature · doi:10.1038/nature10197 · Cited by 207
“As indicated by the representative structures shown for compounds 16–20 (refs 9–13) derived from the pallidol (12) and ampelopsin F (14) cores, these new ring systems are added with inconsistent regio- and stereospecificity.”
Background
NF-κB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts
González‐Sarrías, A., Larrosa, M., Tomás-Barberán, F. A., Dolara, P., & Espı́n, J. C. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000826 · Cited by 207
“Res (30mM) was used as a selective COX1/2 inhibitor positive control((20,21)).”
Method

Authors: Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
Affiliations: University of Illinois Chicago (US)
Universidad Complutense de Madrid (ES)
M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Corresponding author: Cai, Lining
Pezzuto, John M.
ORCID: Udeani, George O.
Slowing, Karla V.
Kinghorn, A. Douglas
Mehta, Rajendra G.
Pezzuto, John M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-01-10
Volume: 275
Issue: 5297
Pages: 218-220
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.275.5297.218
OpenAlex: W2151089147
Cited by: 4,935
References: 33
Citations by year: 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
FWCI: 96.50
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
Funders: National Cancer Institute (P01CA048112)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions

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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

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