Cited by 4,935Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.

Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

Jang, Meishiang, Cai, Lining, Udeani, George O., Slowing, Karla V., Thomas, Cathy F., Beecher, Christopher W. W., Fong, Harry H. S., Farnsworth, Norman R., Kinghorn, A. Douglas, Mehta, Rajendra G., Moon, Richard C., Pezzuto, John M.·1997·Science

DOI 10.1126/science.275.5297.218

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Abstract

Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

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Background
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Background
Pflanzliche Polyphenole: chemische Eigenschaften, biologische Aktivität und Synthese
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Background
The natural alkaloid berberine targets multiple pathways to induce cell death in cultured human colon cancer cells
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Background
Recent Applications of Mass Spectrometry in the Study of Grape and Wine Polyphenols
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Mediterranean alcohol-drinking pattern and mortality in the SUN (Seguimiento Universidad de Navarra) Project: a prospective cohort study
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“Resveratrol (3,5,4′-trihydroxystilbene), a natural antioxidant present in grapes and many other plants (22), has anticarcinogenic effects in diverse in vitro and in vivo systems (23, 24).”
BackgroundResult
Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas
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“Resveratrol, a polyphenolic compound found in red wine [48], has been described to induce bona fide ACD in chronic myeloid leukemia [15] and induces cell death in prostate [49], ovarian [16], and endometrial cancer cells [50] that involves induction of autophagy, although the latter studies failed to provide complete…”
Background
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“…1999), estrogen receptor agonism (Gehm et al., 1997), and effects on cell signalling pathways, cell proliferation, tumour growth, and apoptosis (Jang et al., 1997; Carbo´ et al., 1999; ElAttar and Virji, 1999; Hsieh and Wu, 1999; Huang et al., 1999; MacCarrone et al., 1999; Miloso et al.,…”
Background
Forkhead Proteins Are Critical for Bone Morphogenetic Protein-2 Regulation and Anti-tumor Activity of Resveratrol
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Background
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Background
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“Stilbenes are not common in plants and are only produced upon pathogen invasion [29].”
Background
Chemoprevention of Colorectal Cancer by Dietary Compounds
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Background
Resveratrol and pterostilbene: A comparative overview of their chemistry, biosynthesis, plant sources and pharmacological properties
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“Since its first report by Jang et al. (1997), there are many reviews on the subject (Rauf et al., 2018; Varoni et al., 2016).”
Background
Human Sirtuin Regulators: The “Success” Stories
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“In addition to its effects on SIRT1, RSV was also shown to act on a wide range of enzymes, including COX-1, cAMP degrading phosphodiesterases, and nuclear factor-κB (NF-κB) (Jang et al., 1997; Manna et al., 2000; Pezzuto, 2011; Park et al., 2012).”
Background
Antiaging agents: safe interventions to slow aging and healthy life span extension
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“[51] published in Science, clarified the chemical protective effect of resveratrol, and subsequently reported that it activates sirtuin deacetylase and prolongs the life span of yeast, [52] researches on the effects and properties of this compound began to grow exponentially.”
Background
Antioxidant activity of extracts from Alpinia katsumadai seed
Lee, S. E., Shin, H., Hwang, H. J., & Kim, J. H. (2003) · Phytotherapy Research · doi:10.1002/ptr.1291 · Cited by 105
“Resveratrol, a constituent of grapes and other food products, has been shown to prevent carcinogenesis in murine models (Clement et al., 1998) and to protect the cell from oxidative damage and cell death (Jang et al., 1997; Chanvitayapongs et al., 1997).”
Background
Hypoxia enhances LPA-induced HIF-1α and VEGF expression: Their inhibition by resveratrol
Park, S. Y., Jeong, K. J., Lee, J., Yoon, D. S., Choi, W. S., Kim, Y. K., Han, J. W., Kim, Y. M., Kim, B. K., & Lee, H. Y. (2007) · Cancer Letters · doi:10.1016/j.canlet.2007.08.011 · Cited by 105
Inhibition of Pseudomonas aeruginosa and Escherichia coli O157:H7 Biofilm Formation by Plant Metabolite ε-Viniferin
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Mechanisms of resveratrol-induced platelet apoptosis
Lin, K., Hsiao, G., Shih, C.-M., Chou, D., & Sheu, J. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp139 · Cited by 105
“Resveratrol, a naturally occurring compound found in grapes and red wine, possesses chemotherapeutic potential through its ability to trigger apoptosis in several cancer types.(13,29) In this study, we demonstrate resveratrol also triggers platelet apoptosis by such mechanisms as caspase-8 cleavage and tBid formation.”
Background
Application of pulsed electric fields for improving the maceration process during vinification of red wine: influence of grape variety
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Deactivation of cultured human liver myofibroblasts by Trans -resveratrol, a grapevine-derived polyphenol
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“In 1997, Jang and colleagues published their seminal report on resveratrol’s ability to inhibit the three major stages of carcinogenesis (1).”
Background
Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1‐mediated nuclear factor‐κB pathway and subsequently downregulating expression of matrix metalloproteinases
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Background
Ellagic acid, a polyphenolic compound, selectively induces ROS-mediated apoptosis in cancerous B-lymphocytes of CLL patients by directly targeting mitochondria
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RETRACTED: Niosome-based hydrogel of resveratrol for topical applications: An effective therapy for pain related disorder(s)
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Identification and quantification of anthocyanins from the grains of black rice (Oryza sativa L.) varieties
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Resveratrol as an Inhibitor of Carcinogenesis
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Self-citation
Effect of resveratrol on herpes simplex virus vaginal infection in the mouse
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Resveratrol regulates cellular PKC α and δ to inhibit growth and induce apoptosis in gastric cancer cells
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“Resveratrol (3,4′,5-trihydroxystilbene) is a phytoalexin present in grape skin, red wine and peanuts and there is compelling evidence for its chemopreventive potential from studies showing (a) its ability to suppress each stage of experimental carcinogenesis [1], (b) its antiproliferative and pro-apoptotic action towa…”
Background
The Role of Natural Polyphenols in the Prevention and Treatment of Cervical Cancer—An Overview
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“The biological effects of these compounds are numerous, from reducing the risks of cancers and cardiovascular diseases, anti-inflammatory, chemoprotective and antioxidant properties [138,139].”
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Near-Infrared Light Dual-Promoted Heterogeneous Copper Nanocatalyst for Highly Efficient Bioorthogonal Chemistry in Vivo
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From Resveratrol to Its Derivatives: New Sources of Natural Antioxidant
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An innovative approach to grape metabolomics: stilbene profiling by suspect screening analysis
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“…show that resveratrol has anticancer, anti-oxidant and anti-inflammatory activities, confers cardioprotection, and inhibits platelet aggregation (Jang et al. 1997; Hung et al. 2000; Frankel et al. 1993; Frémont et al. 1999; Bertelli et al. 1995; Pace-Asciak et al. 1995; Bavaresco et al. 2012).”
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“Among these stilbenes, trans-resveratrol, which is mainly found in grapes and red wine, is one of the most important in terms of biological activities, since it has been reported to exert anticarcinogenic, antioxidant, and cardioprotective activities [1].”
Background
Sensitization of TRAIL-resistant LNCaP cells by resveratrol (3, 4', 5 tri-hydroxystilbene): molecular mechanisms and therapeutic potential
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“Resveratrol, a representative stilbene found in grapes and other food products, has attracted increasing interest due to its inhibitory activity, both in vitro and in vivo, of the initiation, promotion, and progression of carcinogenesis [12].”
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“In the past few years it has been discovered that resveratrol also has antitumor activity (8).”
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The World of Resveratrol
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“Nevertheless, the stilbene resveratrol found in red wine has received great attention for its anticarcinogenic properties [7], and its neuroprotective effect [8].”
Background
Resveratrol Inhibits Cancer Cell Metabolism by Down Regulating Pyruvate Kinase M2 via Inhibition of Mammalian Target of Rapamycin
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“Resveratrol is reported to exert antitumor activities at various stages of tumor initiation, promotion and progression [19].”
Background
Piceatannol Enhances Cisplatin Sensitivity in Ovarian Cancer via Modulation of p53, X-linked Inhibitor of Apoptosis Protein (XIAP), and Mitochondrial Fission
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“Resveratrol has been reported to inhibit the growth of a wide range of cancer cells, including OVCA (18).”
Background
Proto-oncogenic isoform A2 of eukaryotic translation elongation factor eEF1 is a target of miR-663 and miR-744
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BackgroundInfluential
Laccase‐Catalyzed Dimerization of Hydroxystilbenes
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Depurinating estrogen‐DNA adducts, generators of cancer initiation: their minimization leads to cancer prevention
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A current look at nutraceuticals – Key concepts and future prospects
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Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
Kuršvietienė, L., Kopustinskienė, D. M., Stanevičienė, I., Mongirdienė, A., Kubová, K., Masteiková, R., & Bernatonienė, J. (2023) · Antioxidants · doi:10.3390/antiox12122056 · Cited by 102
“…aggregation [50], its antioxidant effects [51], its anti-inﬂammatory properties [52], its capacity to lower blood glucose levels [53], its hep-atoprotective effects [54], its neuroprotective properties [55], its potential in anti-aging interventions [54], and its anti-cancer activities [9,56].”
Background
The traditional diet of Greece and cancer
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Background
Antitumor agents 200.1 cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives
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Antiproliferative effect of antioxidant polyphenols from grape in murine Hepa-1c1c7
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Diverse plant extracts andtrans-resveratrol inhibit biofilm formation and swarming ofEscherichia coliO157:H7
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“Trans-resveratrol, abundant in red wines, has received widespread attention and has anti-aging, anticarcinogenic, anti-inflammatory, and anti-oxidant properties in humans (Jang et al. 1997; Cottart et al. 2010).”
Background
A methoxy derivative of resveratrol analogue selectively induced activation of the mitochondrial apoptotic pathway in transformed fibroblasts
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“…present in grapes, peanuts, and pines, has antioxidant and antiinflammatory activities (Jeandet et al, 1991), and is the active ingredient in Leguminosae that inhibits cellular events associated with tumour initiation, promotion, and progression in mouse skin cancer model (Jang et al, 1997).”
Background
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“In addition, this compound exerts a potent chemopreventive effect in several carcinogenesis models (20).”
Influential
Peroxisome Proliferator–Activated Receptor γ as a Molecular Target of Resveratrol-Induced Modulation of Polyamine Metabolism
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Nonsteroidal anti-inflammatory drugs suppress T-cell activation by inhibiting p38 MAPK induction
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Authors: Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
Affiliations: University of Illinois Chicago (US)
Universidad Complutense de Madrid (ES)
M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Corresponding author: Cai, Lining
Pezzuto, John M.
ORCID: Udeani, George O.
Slowing, Karla V.
Kinghorn, A. Douglas
Mehta, Rajendra G.
Pezzuto, John M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-01-10
Volume: 275
Issue: 5297
Pages: 218-220
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.275.5297.218
OpenAlex: W2151089147
Cited by: 4,935
References: 33
Citations by year: 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
FWCI: 96.50
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
Funders: National Cancer Institute (P01CA048112)
Topics: Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords: resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions

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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

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