Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering

Nie, Shuming, Emory, Steven R.·1997·Science

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Optical detection and spectroscopy of single molecules and single nanoparticles have been achieved at room temperature with the use of surface-enhanced Raman scattering. Individual silver colloidal nanoparticles were screened from a large heterogeneous population for special size-dependent properties and were then used to amplify the spectroscopic signatures of adsorbed molecules. For single rhodamine 6G molecules adsorbed on the selected nanoparticles, the intrinsic Raman enhancement factors were on the order of 10 14 to 10 15 , much larger than the ensemble-averaged values derived from conventional measurements. This enormous enhancement leads to vibrational Raman signals that are more intense and more stable than single-molecule fluorescence.

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Authors: Nie, S., & Emory, S. R.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-02-21
Volume: 275
Issue: 5303
Pages: 1102-1106
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.275.5303.1102
OpenAlex: W2115797520
Cited by: 10,238
References: 0
FWCI: 36.58
Type: journal article
Language: en
Open access: closed

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Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering

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