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Out of Eden: Stem Cells and Their Niches
Abstract
Stem cells are currently in the news for two reasons: the successful cultivation of human embryonic stem cell lines and reports that adult stem cells can differentiate into developmentally unrelated cell types, such as nerve cells into blood cells. Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified. Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy.
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Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
North, T., Gu, T.-L., Stacy, T., Wang, Q., Howard, L., Binder, M., Marín-Padilla, M., & Speck, N. A. (1999) · Development · doi:10.1242/dev.126.11.2563 · Cited by 662
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
Dyson, S., & Gurdon, J. B. (1998) · Cell · doi:10.1016/s0092-8674(00)81185-x · Cited by 204
Cited by
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951
Effector and memory T-cell differentiation: implications for vaccine development
Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology · doi:10.1038/nri778 · Cited by 1,865
Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine
Vizoso, F., Eiro, N., Cid, S., Schneider, J., & Perez-Fernandez, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091852 · Cited by 1,363
Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
Dalby, M. J., Gadegaard, N., & Oreffo, R. O. C. (2014) · Nature Materials · doi:10.1038/nmat3980 · Cited by 1,082
Multilineage differentiation from human embryonic stem cell lines
Odorico, J. S., Kaufman, D. S., & Thomson, J. A. (2001) · Stem Cells · doi:10.1634/stemcells.19-3-193 · Cited by 969
Role of the extracellular matrix in regulating stem cell fate
Watt, F. M., & Huck, W. T. S. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3620 · Cited by 861
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Nishimura, E. K., Granter, S. R., & Fisher, D. E. (2005) · Science · doi:10.1126/science.1099593 · Cited by 750
The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571
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Simons, B. D., & Clevers, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.033 · Cited by 489
Fully functional bioengineered tooth replacement as an organ replacement therapy
Ikeda, E., Morita, R., Nakao, K., Ishida, K., Nakamura, T., Takano-Yamamoto, T., Ogawa, M., Mizuno, M., Kasugai, S., & Tsuji, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902944106 · Cited by 447
Bianco, P., & Robey, P. G. (2015) · Development · doi:10.1242/dev.102210 · Cited by 402
Cell-Extracellular Matrix Interactions in Normal and Diseased Skin
Watt, F. M., & Fujiwara, H. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005124 · Cited by 384
Self-citationHost-reactive CD8+ memory stem cells in graft-versus-host disease
Zhang, Y., Joe, G., Hexner, E., Zhu, J., & Emerson, S. G. (2005) · Nature Medicine · doi:10.1038/nm1326 · Cited by 369
Arnold, I., & Watt, F. M. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00154-3 · Cited by 341
Self-citationSox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
Driskell, R. R., Giangreco, A., Jensen, K. B., Mulder, K. W., & Watt, F. M. (2009) · Development · doi:10.1242/dev.038620 · Cited by 331
Self-citationDeregulated expression of c-Myc depletes epidermal stem cells
Waikel, R. L., Kawachi, Y., Waikel, P. A., Wang, X.-J., & Roop, D. R. (2001) · Nature Genetics · doi:10.1038/88889 · Cited by 318
Schwab, K. E., Chan, R. W. S., & Gargett, C. E. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.02.056 · Cited by 249
Micro-bioreactor array for controlling cellular microenvironments
Figallo, E., Cannizzaro, C., Gerecht, S., Burdick, J. A., Langer, R., Elvassore, N., & Vunjak-Novakovic, G. (2007) · Lab on a Chip · doi:10.1039/b700063d · Cited by 220
Translational strategies and challenges in regenerative medicine
Dimmeler, S., Ding, S., Rando, T. A., & Trounson, A. (2014) · Nature Medicine · doi:10.1038/nm.3627 · Cited by 179
Radiation‐induced tissue damage and response
McBride, W. H., & Schaue, D. (2020) · The Journal of Pathology · doi:10.1002/path.5389 · Cited by 155
Ma, Z.-J., Yang, J.-J., Lu, Y.-B., Liu, Z.-Y., & Wang, X.-X. (2020) · World Journal of Stem Cells · doi:10.4252/wjsc.v12.i8.814 · Cited by 155
Khalturin, K., Anton-Erxleben, F., Milde, S., Plötz, C., Wittlieb, J., Hemmrich, G., & Bosch, T. C. G. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.06.013 · Cited by 125
Cellular modulation by the elasticity of biomaterials
Han, F., Zhu, C., Guo, Q., Yang, H., & Li, B. (2016) · Journal of Materials Chemistry B · doi:10.1039/c5tb02077h · Cited by 83
Hair organ regeneration via the bioengineered hair follicular unit transplantation
Asakawa, K., Toyoshima, K.-E., Ishibashi, N., Tobe, H., Iwadate, A., Kanayama, T., Hasegawa, T., Nakao, K., Toki, H., Noguchi, S., et al. (2012) · Scientific Reports · doi:10.1038/srep00424 · Cited by 81
β1 Integrin-Mediated Adhesion Signalling Is Essential for Epidermal Progenitor Cell Expansion
Piwko-Czuchra, A., Koegel, H., Meyer, H., Bauer, M., Werner, S., Brakebusch, C., & Fässler, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005488 · Cited by 52
Somatic Stem Cells in the Endometrium
Cervelló, I., & Simón, C. (2009) · Reproductive Sciences · doi:10.1177/1933719108329955 · Cited by 29
Lee, G., Han, S.-B., Kim, S. H., Jeong, S., & Kim, D.-H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1303688 · Cited by 6
Metadata
- Authors
- Watt, F. M., & Hogan, A. B. L. M.
- Venue
- Science
- Published
- 2000-02-25
- Volume
- 287
- Issue
- 5457
- Pages
- 1427-1430
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2039396493
- Cited by
- 1,758
- References
- 3
- FWCI
- 29.40
- Type
- journal article
- Language
- en
- Open access
- closed
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