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DNA Methylation and Gene Function
Abstract
In most higher organisms, DNA is modified after synthesis by the enzymatic conversion of many cytosine residues to 5-methylcytosine. For several years, control of gene activity by DNA methylation has been recognized as a logically attractive possibility, but experimental support has proved elusive. However, there is now reason to believe, from recent studies, that DNA methylation is a key element in the hierarchy of control mechanisms that govern vertebrate gene function and differentiation.
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Metadata
- Authors
- Razin, A., & Riggs, A. D.
- Venue
- Science
- Published
- 1980-11-07
- Volume
- 210
- Issue
- 4470
- Pages
- 604-610
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091602444
- Cited by
- 2,071
- References
- 2
- FWCI
- 55.94
- Type
- journal article
- Language
- en
- Open access
- closed
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