Deletion of ADA2 Increases Antifungal Drug Susceptibility and Virulence in Candida glabrata
Open accessAbstract
Candida glabrata , the second most frequent cause of candidiasis after Candida albicans , is an emerging human fungal pathogen that is intrinsically drug tolerant. Currently, studies of C. glabrata genes involved in drug tolerance are limited. Ada2, a component serving as a transcription adaptor of the Spt-Ada-Gcn5 acetyltransferase (SAGA) complex, is required for antifungal drug tolerance and virulence in C. albicans . However, its roles in C. glabrata remain elusive. In this study, we found that ada2 mutants demonstrated severe growth defects at 40°C but only mild defects at 37°C or 25°C. In addition, C. glabrata ada2 mutants exhibited pleiotropic phenotypes, including susceptibility to three classes of antifungal drugs (i.e., azoles, echinocandins, and polyenes) and cell wall-perturbing agents but resistance to the endoplasmic reticulum stressor tunicamycin. According to RNA sequence analysis, the expression of 43 genes was downregulated and the expression of 442 genes was upregulated in the ada2 mutant compared to their expression in the wild type. C. glabrata ADA2 , along with its downstream target ERG6 , controls antifungal drug tolerance and cell wall integrity. Surprisingly, ada2 mutants were hypervirulent in a murine model of systemic infection, possibly due to the upregulation of multiple adhesin-like genes, increased agar invasion, and overstimulation of murine tumor necrosis factor alpha production.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
EPA-family adhesins facilitate C. glabrata attachment to host epithelial cells and assist in macrophage entry.
“These adhesins facilitate C. glabrata attachment to host epithelial cells and assist in macrophage entry [25].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [25]
Deletion of the transcriptional co-activator CgAda2 conferred resistance to the ER stressor tunicamycin and hypervirulence in immunocompromised mice.
“Contrarily, deletion of the transcriptional co-activator CgAda2 conferred resistance to the ER stressor, tunicamycin, and hypervirulence in the immunocompromised mice [98].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Burnette, W. N. (1981) · Analytical Biochemistry · doi:10.1016/0003-2697(81)90281-5 · Cited by 8,432 · see citing works
Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
Pfaller, M. A., & Diekema, D. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-06 · Cited by 4,174 · cited 1× · see citing works
“glabrata is relatively high, partly due to its rapidly evolving resistance to antifungal drugs, especially azoles (3, 4).”
BackgroundImproved method for high efficiency transformation of intact yeast cells.
Gietz, D., Jean, A. S., Woods, R. A., & Schiestl, R. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.6.1425 · Cited by 3,379 · see citing works
Dujon, B., Sherman, D., Fischer, G., Durrens, P., Casaregola, S., Lafontaine, I., de Montigny, J., Marck, C., Neuvéglise, C., Talla, E., et al. (2004) · Nature · doi:10.1038/nature02579 · Cited by 1,623 · see citing works
Virulence factors of Candida albicans
Calderone, R. A., & Fonzi, W. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(01)02094-7 · Cited by 1,331 · see citing works
The SAT1 flipper, an optimized tool for gene disruption in Candida albicans
Reuß, O., Vik, Å., Kolter, R., & Morschhäuser, J. (2004) · Gene · doi:10.1016/j.gene.2004.06.021 · Cited by 744 · see citing works
Global trends in the distribution of Candida species causing candidemia
Guinea, J. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12539 · Cited by 680 · see citing works
Mechanisms of Antifungal Drug Resistance
Cowen, L. E., Sanglard, D., Howard, S. J., Rogers, P. D., & Perlin, D. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a019752 · Cited by 647 · see citing works
The Role of Toll‐like Receptor (TLR) 2 and TLR4 in the Host Defense against Disseminated Candidiasis
Netea, M. G., van der Graaf, C. A. A., Vonk, A. G., Verschueren, I., van der Meer, J. W. M., & Kullberg, B. J. (2002) · The Journal of Infectious Diseases · doi:10.1086/340511 · Cited by 486 · see citing works
Berger, S. L., Piña, B., Silverman, N., Marcus, G. A., Agapite, J., Regier, J. L., Triezenberg, S. J., & Guarente, L. (1992) · Cell · doi:10.1016/0092-8674(92)90100-q · Cited by 435 · see citing works
Method for antifungal disk diffusion susceptibility testing of yeasts : Approved guideline
Rex, J. H., & Clinical (2009) · Clinical and Laboratory Standards Institute eBooks · Cited by 425 · see citing works
Cormack, B. P., Ghori, N., & Falkow, S. (1999) · Science · doi:10.1126/science.285.5427.578 · Cited by 383 · see citing works
Redundant roles for the TFIID and SAGA complexes in global transcription
Lee, T. I., Causton, H. C., Holstege, F. C. P., Shen, W.-C., Hannett, N. M., Jennings, E. G., Winston, F., Green, M. R., & Young, R. A. (2000) · Nature · doi:10.1038/35015104 · Cited by 357 · see citing works
Hoyer, L. L., Green, C. B., Oh, S.-H., & Zhao, X. (2008) · Medical Mycology · doi:10.1080/13693780701435317 · Cited by 356 · see citing works
Complementary Adhesin Function in C. albicans Biofilm Formation
Nobile, C. J., Schneider, H. A., Nett, J. E., Sheppard, D. C., Filler, S. G., Andes, D. R., & Mitchell, A. P. (2008) · Current Biology · doi:10.1016/j.cub.2008.06.034 · Cited by 351 · see citing works
Hube, B., Sanglard, D., Odds, F. C., Hess, D., Monod, M., Schäfer, W., Brown, A. J. P., & Gow, N. A. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3529-3538.1997 · Cited by 311 · see citing works
Ferrari, S., Ischer, F., Calabrese, D., Posteraro, B., Sanguinetti, M., Fadda, G., Rohde, B., Bauser, C., Bader, O., & Sanglard, D. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000268 · Cited by 295 · see citing works
Kaur, R., Ma, B., & Cormack, B. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611195104 · Cited by 284 · see citing works
A yeast by any other name: Candida glabrata and its interaction with the host
Kaur, R., Domergue, R., Zupancic, M. L., & Cormack, B. P. (2005) · Current Opinion in Microbiology · doi:10.1016/j.mib.2005.06.012 · Cited by 271 · see citing works
Brunke, S., & Hube, B. (2013) · Cellular Microbiology · doi:10.1111/cmi.12091 · Cited by 239 · see citing works
Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylation.
Balasubramanian, R., Pray-Grant, M. G., Selleck, W., Grant, P. A., & Tan, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110849200 · Cited by 233 · see citing works
de Groot, P. W. J., Kraneveld, E. A., Yin, Q. Y., Dekker, H. L., Groß, U., Crielaard, W., de Koster, C. G., Bader, O., Klis, F. M., & Weig, M. (2008) · Eukaryotic Cell · doi:10.1128/ec.00284-08 · Cited by 232 · see citing works
Azie, N., Neofytos, D., Pfaller, M., Meier-Kriesche, H.-U., Quan, S.-P., & Horn, D. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.06.012 · Cited by 222 · see citing works
Pukkila-Worley, R., Peleg, A. Y., Tampakakis, E., & Mylonakis, E. E. (2009) · Eukaryotic Cell · doi:10.1128/ec.00163-09 · Cited by 192 · see citing works
Castaño, I., Pan, S., Zupancic, M., Hennequin, C., Dujon, B., & Cormack, B. P. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04465.x · Cited by 188 · see citing works
Bernardis, F. D., Arancia, S., Morelli, L., Hube, B., Sanglard, D., Schäfer, W., & Cassone, A. (1999) · The Journal of Infectious Diseases · doi:10.1086/314546 · Cited by 169 · see citing works
Wang, L. Y., Mizzen, C. A., Ying, C. Y., Candau, R., Barlev, N. A., Brownell, J., Allis, C. D., & Berger, S. L. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.519 · Cited by 169 · see citing works
Control of the C. albicans Cell Wall Damage Response by Transcriptional Regulator Cas5
Bruno, V. M., Kalachikov, S., Subaran, R., Nobile, C. J., Kyratsous, C., & Mitchell, A. P. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020021 · Cited by 157 · see citing works
Sinha, H., David, L., Pascon, R. C., Clauder‐Münster, S., Krishnakumar, S., Nguyen, M., Shi, G., Dean, J., Davis, R. W., Oefner, P. J., et al. (2008) · Genetics · doi:10.1534/genetics.108.092932 · Cited by 152 · see citing works
Ferrari, S., Sanguinetti, M., De Bernardis, F., Torelli, R., Posteraro, B., Vandeputte, P., & Sanglard, D. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01271-10 · Cited by 144 · see citing works
Piña, B., Berger, S. L., Marcus, G. A., Silverman, N. S., Agapite, J., & Guarente, L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.5981 · Cited by 119 · see citing works
Toward an Integrated Model of Capsule Regulation in Cryptococcus neoformans
Haynes, B. C., Skowyra, M. L., Spencer, S. J., Gish, S. R., Williams, M., Held, E. P., Brent, M. R., & Doering, T. L. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002411 · Cited by 102 · see citing works
Chen, Y.-L., Konieczka, J. H., Springer, D. J., Bowen, S. E., Zhang, J., Silao, F. G. S., Bungay, A. A. C., Bigol, U. G., Nicolas, M. G., Abraham, S. N., et al. (2012) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.112.002279 · Cited by 97 · see citing works
Self-citationSellam, A., Askew, C., Epp, E., Lavoie, H., Whiteway, M., & Nantel, A. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-11-1093 · Cited by 87 · see citing works
Dissection of Ire1 Functions Reveals Stress Response Mechanisms Uniquely Evolved in Candida glabrata
Miyazaki, T., Nakayama, H., Nagayoshi, Y., Kakeya, H., & Kohno, S. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003160 · Cited by 78 · see citing works
Kamran, M., Calcagno, A.-M., Findon, H., Bignell, E., Jones, M. D., Warn, P., Hopkins, P., Denning, D. W., Butler, G., Rogers, T., et al. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.2.546-552.2004 · Cited by 75 · see citing works
Miyazaki, T., Inamine, T., Yamauchi, S., Nagayoshi, Y., Saijo, T., Izumikawa, K., Seki, M., Kakeya, H., Yamamoto, Y., Yanagihara, K., et al. (2010) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2010.00611.x · Cited by 70 · see citing works
Calcineurin Controls Hyphal Growth, Virulence, and Drug Tolerance of Candida tropicalis
Chen, Y., Yu, S.-J., Huang, H., Chang, Y.-L., Lehman, V. N., Silao, F. G. S., Bigol, U. G., Bungay, A. A. C., Averette, A. F., & Heitman, J. (2014) · Eukaryotic Cell · doi:10.1128/ec.00302-13 · Cited by 68 · see citing works
Self-citationIncrease of Virulence and Its Phenotypic Traits in Drug-Resistant Strains of Candida albicans
Angiolella, L., Stringaro, A., Bernardis, F. D., Posteraro, B., Bonito, M., Toccacieli, L., Torosantucci, A., Colone, M., Sanguinetti, M., Cassone, A., et al. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01223-07 · Cited by 64 · see citing works
Reyes-Domínguez, Y., Narendja, F. M., Berger, H., Gallmetzer, A., Fernández-Martín, R., Garcia, I., Scazzocchio, C., & Strauss, J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00184-07 · Cited by 64 · see citing works
Brunke, S., Seider, K., Fischer, D., Jacobsen, I. D., Kasper, L., Jablonowski, N., Wartenberg, A., Bader, O., Angoulvant, A., Schaller, M., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004478 · Cited by 62 · see citing works
Differential virulence of Candida glabrata glycosylation mutants
West, L., Lowman, D. W., Mora-Montes, H. M., Grubb, S., Murdoch, C., Thornhill, M. H., Gow, N. A. R., Williams, D., & Haynes, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.478743 · Cited by 62 · see citing works
The SAGA complex in the rice pathogen F usarium fujikuroi: structure and functional characterization
Rösler, S. M., Kramer, K., Finkemeier, I., Humpf, H., & Tudzynski, B. (2016) · Molecular Microbiology · doi:10.1111/mmi.13528 · Cited by 62 · see citing works
Endoplasmic reticulum stress and fungal pathogenesis
Krishnan, K., & Askew, D. S. (2014) · Fungal Biology Reviews · doi:10.1016/j.fbr.2014.07.001 · Cited by 46 · see citing works
Initial treatment and outcome of Candida glabrata versus Candida albicans bloodstream infection
Klevay, M. J., Horn, D. L., Neofytos, D., Pfaller, M. A., & Diekema, D. J. (2009) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2009.03.007 · Cited by 40 · see citing works
Piña, B., Berger, S. L., Marcus, G. A., Silverman, N. S., Agapite, J., & Guarente, L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.5981-5989.1993 · Cited by 39 · see citing works
Kuhn, D. M., & Vyas, V. K. (2012) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2011.00785.x · Cited by 38 · see citing works
Sanz, A. B., García, R., Rodríguez-Peña, J. M., Nombela, C., & Arroyo, J. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw324 · Cited by 38 · see citing works
Church, M. C., Smith, K. C., Alhussain, M. M., Pennings, S., & Fleming, A. B. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx028 · Cited by 37 · see citing works
Santos, R., Costa, C., Mil‐Homens, D., Romão, D., de Carvalho, C. C. C. R., Pais, P., Mira, N. P., Fialho, A. M., & Teixeira, M. C. (2016) · Cellular Microbiology · doi:10.1111/cmi.12686 · Cited by 33 · see citing works
Ramírez-Zavala, B., Mogavero, S., Schöller, E., Sasse, C., Rogers, P. D., & Morschhäuser, J. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03065-14 · Cited by 25 · see citing works
Hoke, S. M. T., Genereaux, J. L., Liang, G., & Brandl, C. J. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.09.088 · Cited by 16 · see citing works
Chen, Y., Bernardis, F. D., Yu, S.-J., Sandini, S., Kauffman, S., Tams, R. N., Bethea, E. K., & Reynolds, T. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0116974 · Cited by 12 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [53]Clinical and Laboratory Standards Institute. 2008. Reference methods for broth dilution antifungal susceptibility testing of yeasts: approved standard, 2nd ed Document M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA. [Google Scholar] Associated Data This section collects any data citations, data availability statements, or supplementary materials included in this article. Supplementary Materials Supplemental material supp_62_3_e01924-17__index.html (801B, html)
Cited by
Sorted by citations
Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
Hassan, Y., Chew, S. Y., & Than, L. T. L. (2021) · Journal of Fungi · doi:10.3390/jof7080667 · Cited by 170 · see citing works
The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus
Furukawa, T., van Rhijn, N., Fraczek, M. G., Gsaller, F., Davies, E. A., Carr, P. D., Gago, S., Fortune‐Grant, R., Rahman, S., Gilsenan, J. M., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14191-1 · Cited by 133 · see citing works
Candida glabrata: A Lot More Than Meets the Eye
Kumar, K., Askari, F., Sahu, M. S., & Kaur, R. (2019) · Microorganisms · doi:10.3390/microorganisms7020039 · Cited by 128 · see citing works
Candida glabrata Antifungal Resistance and Virulence Factors, a Perfect Pathogenic Combination
León, M. G. F.-D., Hernández‐Castro, R., Conde-Cuevas, E., García-Coronel, I. H., Vázquez-Aceituno, V. A., Soriano-Ursua, M. A., Farfán‐García, E. D., Ocharan-Hernández, M. E., Rodríguez‐Cerdeira, C., Arenas, R., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101529 · Cited by 78 · see citing works
Ergosterol Biosynthesis and Regulation Impact the Antifungal Resistance and Virulence of Candida spp
Eliaš, D., Tóth Hervay, N., & Gbelská, Y. (2024) · Stresses · doi:10.3390/stresses4040041 · Cited by 63 · see citing works
Arias, L. S., Pessan, J. P., Neto, F. N. D. S., de Lima, B. H. R., Camargo, E. R., Ramage, G., Delbem, A. C. B., & Monteiro, D. R. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111080 · Cited by 59 · see citing works
Epigenetic Regulation of Antifungal Drug Resistance
Patra, S., Raney, M., Pareek, A., & Kaur, R. (2022) · Journal of Fungi · doi:10.3390/jof8080875 · Cited by 33 · see citing works
Baker, K. M., Hoda, S., Saha, D., Gregor, J. B., Georgescu, L., Serratore, N. D., Zhang, Y., Cheng, L., Lanman, N. A., & Briggs, S. D. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02250-21 · Cited by 30 · see citing works
Lin, C.-J., Hou, Y.-H., & Chen, Y.-L. (2019) · Medical Mycology · doi:10.1093/mmy/myz043 · Cited by 27 · see citing works
Self-citationHistone Acetylation Regulator Gcn5 Mediates Drug Resistance and Virulence of Candida glabrata
Yu, S., Paderu, P., Lee, A., Eirekat, S., Healey, K., Chen, L., Perlin, D. S., & Zhao, Y. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00963-22 · Cited by 23 · see citing works
Self-citationThe role of gene copy number variation in antimicrobial resistance in human fungal pathogens
Jay, A., Jordan, D., Gerstein, A. C., & Landry, C. R. (2025) · npj Antimicrobials and Resistance · doi:10.1038/s44259-024-00072-1 · Cited by 22 · see citing works
Vatanshenassan, M., Arastehfar, A. A., Boekhout, T., Berman, J. G., Lass‐Flörl, C., Sparbier, K., & Kostrzewa, M. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00554-19 · Cited by 21 · see citing works
Eliaš, D., Hervay, N. T., Jacko, J., Morvová, M., Valachovič, M., & Gbelská, Y. (2022) · FEMS Yeast Research · doi:10.1093/femsyr/foac045 · Cited by 21 · see citing works
Hsu, L.-H., Kwaśniewska, D., Wang, S.-C., Shen, T., Wieczorek, D., & Chen, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-59750-5 · Cited by 19 · see citing works
Self-citationRepurposing the thrombopoietin receptor agonist eltrombopag as an anticryptococcal agent
Ko, H.-T., Hsu, L.-H., Yang, S., & Chen, Y. (2019) · Medical Mycology · doi:10.1093/mmy/myz077 · Cited by 17 · see citing works
Self-citationde Sousa, I. P., Ferreira, A. G., Crotti, A. E. M., dos Santos, R. A., Kiermaier, J., Kraus, B., Heilmann, J., & Furtado, N. A. J. C. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103560 · Cited by 16 · see citing works
Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance
Su, Y., Li, Y., Yi, Q., Xu, Y., Sun, T., & Li, Y. (2025) · Journal of Fungi · doi:10.3390/jof11020143 · Cited by 18 · see citing works
“Yu et al. found that the ADA2 gene of Nakaseomyces glabrata (formerly Candida glabrata ) is associated with resistance to three classes of antifungals, as evidenced by ∆ ada2 knockout strains having significantly reduced MIC values [51].”
Kounatidis, I., Ames, L., Mistry, R., Ho, H.-L., Haynes, K., & Ligoxygakis, P. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200182 · Cited by 13 · see citing works
Antifungal Activity of Natural Thymol: Advances on Molecular Mechanisms and Therapeutic Potential
Chen, C., Liu, L., Tang, S., Li, D., & Dai, C. (2026) · Biomolecules · doi:10.3390/biom16010149 · Cited by 14 · see citing works
Wang, Y., Xu, J., Abid, F. B., Salah, H., Sundararaju, S., Ismail, K. A., Wang, K., Matthew, L. S., Taj‐Aldeen, S. J., Ibrahim, E. B., et al. (2024) · Microbial Genomics · doi:10.1099/mgen.0.001179 · Cited by 13 · see citing works
Filler, E. E., Liu, Y., Solis, N. V., Wang, L., Diaz, L. F., Edwards, J. E., Filler, S. G., & Yeaman, M. R. (2020) · Infection and Immunity · doi:10.1128/iai.00146-20 · Cited by 13 · see citing works
Naskar, S., Prajapati, A., & Kaur, R. (2025) · FEMS Yeast Research · doi:10.1093/femsyr/foaf025 · Cited by 11 · see citing works
The SAGA and NuA4 component Tra1 regulates Candida albicans drug resistance and pathogenesis
Razzaq, I., Berg, M. D., Jiang, Y., Genereaux, J. L., Uthayakumar, D., Kim, G. H., Agyare-Tabbi, M. R., Halder, V., Brandl, C. J., Lajoie, P., et al. (2021) · Genetics · doi:10.1093/genetics/iyab131 · Cited by 9 · see citing works
Roles of Elm1 in antifungal susceptibility and virulence in Candida glabrata
Ito, Y., Miyazaki, T., Tanaka, Y., Suematsu, T., Nakayama, H., Morita, A., Hirayama, T., Tashiro, M., Takazono, T., Saijo, T., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66620-7 · Cited by 8 · see citing works
Lin, C.-J., Yang, S.-Y., Hsu, L.-H., Yu, S.-J., & Chen, Y.-L. (2023) · Medical Mycology · doi:10.1093/mmy/myad004 · Cited by 7 · see citing works
Self-citationHuang, Y., Lee, Y.-H., Lin, C.-J., Hsu, L.-H., & Chen, Y. (2023) · Medical Mycology · doi:10.1093/mmy/myad099 · Cited by 7 · see citing works
Self-citationCandida albicans necrotizing fasciitis following elective surgery
Atallah, N. J., Scherer, A. K., Alexander, N. J., Dagher, Z., Viens, A. L., Muhammed, M., Branda, J. A., & Mansour, M. K. (2020) · Medical Mycology Case Reports · doi:10.1016/j.mmcr.2020.04.004 · Cited by 7 · see citing works
Marcet‐Houben, M., Księżopolska, E., & Gabaldón, T. (2024) · BMC Genomics · doi:10.1186/s12864-024-10979-8 · Cited by 6 · see citing works
Kumar, A., Francis, A., Hans, S., & Thakur, A. (2024) · Springer eBooks · doi:10.1007/978-981-97-4909-6_8 · Cited by 6 · see citing works
Teixeira, M. V. S., Fernandes, L. M., de Paula, V. S., Ferreira, A. G., & Furtado, N. A. J. C. (2022) · Letters in Applied Microbiology · doi:10.1111/lam.13648 · Cited by 6 · see citing works
Usher, J., Chaudhari, Y., Attah, V., Ho, H.-L., & Haynes, K. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.530915 · Cited by 5 · see citing works
Changes in nomenclature, virulence factors, and antifungal resistance of the genus Candida
Fernandes, M. A. A., de Aguiar, F. L. L., Coutinho, M. G. S., de Brito, É. H. S., Coelho, C. G. V., & Fontenelle, R. O. D. S. (2025) · Frontiers in Fungal Biology · doi:10.3389/ffunb.2025.1677892 · Cited by 4 · see citing works
Lima, R., Robles, Y. R., Oliva, I., Santos, A. L. O., Teixeira, J. G., Chellegatti, M. A. D. S. C., Furtado, N. A. J. C., Martins, C. H. G., Nardini, V., & Crotti, A. E. M. (2025) · Future Pharmacology · doi:10.3390/futurepharmacol5020023 · Cited by 3 · see citing works
Increased fungal burden in the gastrointestinal tract of brain-dead organ donors
Nachman, E. J., Ardis, C. K., Ardis, A. K. B., Nieto, J., Bresson, M. M., Robertson, C. M., Seale, M. N., Villafuerte, N. M., Lyu, Z., Preisner, E. C., et al. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.03341-24 · Cited by 2 · see citing works
Chou, Y. Y., Lee, Y.-H., Hsu, L.-H., Huang, Y., & Chen, Y. (2025) · Medical Mycology · doi:10.1093/mmy/myaf126 · Cited by 1 · see citing works
Self-citationLee, Y.-H., Hsu, L.-H., Yu, Z.-H., Leong, K.-Q., Chiang, H.-S., & Chen, Y. (2025) · Journal of Infection · doi:10.1016/j.jinf.2025.106595 · Cited by 1 · see citing works
Self-citationHsu, L.-H., Chou, Y. Y., Shen, T., Wieczorek, D., & Chen, Y. (2025) · Virulence · doi:10.1080/21505594.2025.2609407 · Cited by 1 · see citing works
Self-citationEssential anticandidal targets
Kumar, A., & Jha, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18744-5.00009-5 · Cited by 1 · see citing works
Cervicofacial Necrotizing Fasciitis and Candida spp
Giselle, J.-R. A. (2021) · SOJ Dental and Oral Disorder · doi:10.53902/sojdod.2021.01.000508
Wang, Y., Guo, X., Zhang, X., Chen, P., Wang, W., Hu, S., Ma, T., Zhou, X., Li, D., & Yang, Y. (2023) · Journal of Fungi · doi:10.3390/jof9080815
Angela, T., Wahyuni, S., & Halim, S. (2024) · F1000Research · doi:10.12688/f1000research.152800.1
Angela, T., Wahyuni, S., & Halim, S. (2024) · F1000Research · doi:10.12688/f1000research.152800.2
- Authors
- Yu, S.-J., Chang, Y.-L., & Chen, Y.-L.
- Affiliations
- National Taiwan University (TW)
- ORCID
- Chen, Ying-Lien
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2018-03
- Volume
- 62
- Issue
- 3
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC5826168
- OpenAlex
- W2782285131
- Cited by
- 43
- References
- 53
- Citations by year
- 2026: 1 · 2025: 9 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 1
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology, Taiwan (102-2320-B-002-041-MY2, 104-2320-B-002-063-MY3, 106-2923-B-002-001-MY3)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida glabrata, ADA2, antifungal drug tolerance, virulence, SAGA complex, ERG6, cell wall integrity, tunicamycin resistance, endoplasmic reticulum stress, gene expression profiling, TNF-α, systemic candidiasis, temperature sensitivity
- MeSH terms
- Animals, Antifungal Agents, Candidiasis, Cell Wall, Fungal Proteins, Male, Mice, Inbred ICR, Virulence, Drug Resistance, Fungal, Candida glabrata, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
