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Adhesins in human fungal pathogens: glue with plenty of stick.
Open accessAbstract
Understanding the pathogenesis of an infectious disease is critical for developing new methods to prevent infection and diagnose or cure disease. Adherence of microorganisms to host tissue is a prerequisite for tissue invasion and infection. Fungal cell wall adhesins involved in adherence to host tissue or abiotic medical devices are critical for colonization leading to invasion and damage of host tissue. Here, with a main focus on pathogenic Candida species, we summarize recent progress made in the field of adhesins in human fungal pathogens and underscore the importance of these proteins in establishment of fungal diseases.
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“According to our analysis, we proposed a list of 101 adhesin-like proteins in DSY562 (File S5 and File S6), which well exceeds the number of deduced adhesins in CBS138 (66) according to de Groot et al. (2013).”
From Comparative Genomics of Two Sequential Candida glabrata Clinical Isolates (2017) · cites this paper as de Groot et al. (2013)
In the citing paper
“It is estimated that C. glabrata contains 63 ORFs with adhesin properties (de Groot et al. 2013).”
From Comparative Genomics of Two Sequential Candida glabrata Clinical Isolates (2017) · cites this paper as de Groot et al. 2013
In the citing paper
“DSY562 and DSY565 each contained a large set of adhesin-like genes (101 and 107, respectively), which exceed by far the number of reported adhesins (63) in the CBS138 genome.”
From Comparative Genomics of Two Sequential Candida glabrata Clinical Isolates (2017) · cites this paper as de Groot et al. 2013
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Metadata
- Authors
- de Groot, P. W. J., Bader, O., de Boer, A. D., Weig, M., & Chauhan, N.
- Affiliations
- Regional Center for Biomedical Research, Albacete Science and Technology Park, University of Castilla—La Mancha, Albacete, Spain
- Universitätsmedizin Göttingen (DE)
- Rutgers New Jersey Medical School (US)
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2013-04
- Volume
- 12
- Issue
- 4
- Pages
- 470-481
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- PMC
- PMC3623432
- OpenAlex
- W2141294282
- Cited by
- 319
- References
- 126
- Citations by year
- 2026: 17 · 2025: 23 · 2024: 33 · 2023: 32 · 2022: 25 · 2021: 30 · 2020: 29 · 2019: 22 · 2018: 21 · 2017: 25 · 2016: 22 · 2015: 21 · 2014: 16 · 2013: 3
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eukaryotic Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- GRO (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- fungal adhesins, Candida, fungal cell wall, microbial adhesion, medical device colonization, fungal pathogenesis, fungal virulence factors
- MeSH terms
- Amino Acid Sequence, Candida, Candidiasis, Cell Adhesion, Cell Wall, Fungal Proteins, Multigene Family, Humans, Membrane Glycoproteins, Molecular Sequence Data, Cell Adhesion Molecules, Gene Expression Regulation, Fungal, Protein Structure, Secondary, Protein Structure, Tertiary, Host-Pathogen Interactions
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