Cited by 319Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

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Adhesins in human fungal pathogens: glue with plenty of stick.

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de Groot, Piet W. J., Bader, Oliver, de Boer, Albert D., Weig, Michael, Chauhan, Neeraj·2013·Eukaryotic Cell

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Abstract

Understanding the pathogenesis of an infectious disease is critical for developing new methods to prevent infection and diagnose or cure disease. Adherence of microorganisms to host tissue is a prerequisite for tissue invasion and infection. Fungal cell wall adhesins involved in adherence to host tissue or abiotic medical devices are critical for colonization leading to invasion and damage of host tissue. Here, with a main focus on pathogenic Candida species, we summarize recent progress made in the field of adhesins in human fungal pathogens and underscore the importance of these proteins in establishment of fungal diseases.

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10.1080/mmy.39.1.1.8-0 · DOI · Paper page
KlisFMRamAFJDe GrootPWJ. 2007. A molecular and genomic view of the fungal cell wall, p 95–117. HowardRJGowNAR (ed), The mycota, vol 8. Springer-Verlag, Berlin, Germany.

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Authors: de Groot, P. W. J., Bader, O., de Boer, A. D., Weig, M., & Chauhan, N.
Affiliations: Regional Center for Biomedical Research, Albacete Science and Technology Park, University of Castilla—La Mancha, Albacete, Spain
Universitätsmedizin Göttingen (DE)
Rutgers New Jersey Medical School (US)
ORCID: Bader, Oliver
Weig, Michael
Chauhan, Neeraj
Venue: Eukaryotic Cell
Publisher: American Society for Microbiology
Published: 2013-04
Volume: 12
Issue: 4
Pages: 470-481
ISSN: 1535-9778 (ISSN-L)
1535-9786
DOI: 10.1128/ec.00364-12
PMC: PMC3623432
OpenAlex: W2141294282
Cited by: 319
References: 126
Citations by year: 2026: 17 · 2025: 23 · 2024: 33 · 2023: 32 · 2022: 25 · 2021: 30 · 2020: 29 · 2019: 22 · 2018: 21 · 2017: 25 · 2016: 22 · 2015: 21 · 2014: 16 · 2013: 3
FWCI: 2.68
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Eukaryotic Cell (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Rutgers University Community Repository (Rutgers University) (submittedVersion)
GRO (submittedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: fungal adhesins, Candida, fungal cell wall, microbial adhesion, medical device colonization, fungal pathogenesis, fungal virulence factors
MeSH terms: Amino Acid Sequence, Candida, Candidiasis, Cell Adhesion, Cell Wall, Fungal Proteins, Multigene Family, Humans, Membrane Glycoproteins, Molecular Sequence Data, Cell Adhesion Molecules, Gene Expression Regulation, Fungal, Protein Structure, Secondary, Protein Structure, Tertiary, Host-Pathogen Interactions

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Adhesins in human fungal pathogens: glue with plenty of stick.

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