Cited by 154MicroRNA in disease regulationMetabolism, Diabetes, and CancerPancreatic function and diabetes

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

MicroRNA 33 Regulates Glucose Metabolism

Open access

Ramírez, Cristina M., Goedeke, Leigh, Rotllan, Noemi, Yoon, Je-Hyun, Cirera-Salinas, Daniel, Mattison, Julie A., Suárez, Yajaira, de Cabo, Rafael, Gorospe, Myriam, Fernández-Hernando, Carlos·2013·Molecular and Cellular Biology

DOI 10.1128/mcb.00016-13PMC PMC3719675

Open this paper in CoChat — free account

Abstract

Metabolic diseases are characterized by the failure of regulatory genes or proteins to effectively orchestrate specific pathways involved in the control of many biological processes. In addition to the classical regulators, recent discoveries have shown the remarkable role of small noncoding RNAs (microRNAs [miRNAs]) in the posttranscriptional regulation of gene expression. In this regard, we have recently demonstrated that miR-33a and miR33b, intronic miRNAs located within the sterol regulatory element-binding protein (SREBP) genes, regulate lipid metabolism in concert with their host genes. Here, we show that miR-33b also cooperates with SREBP1 in regulating glucose metabolism by targeting phosphoenolpyruvate carboxykinase (PCK1) and glucose-6-phosphatase (G6PC), key regulatory enzymes of hepatic gluconeogenesis. Overexpression of miR-33b in human hepatic cells inhibits PCK1 and G6PC expression, leading to a significant reduction of glucose production. Importantly, hepatic SREBP1c/miR-33b levels correlate inversely with the expression of PCK1 and G6PC upon glucose infusion in rhesus monkeys. Taken together, these results suggest that miR-33b works in concert with its host gene to ensure a fine-tuned regulation of lipid and glucose homeostasis, highlighting the clinical potential of miR-33a/b as novel therapeutic targets for a range of metabolic diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/mcb.00016-13

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The functions of animal microRNAs
Ambros, V. (2004) · Nature · doi:10.1038/nature02871 · Cited by 10,728
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
Untitled work
(2008) · doi:10.1038/nrg2290 · Cited by 5,199
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834
A pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Yoon, J. C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Stafford, J., Kahn, C. R., Granner, D. K., et al. (2001) · Nature · doi:10.1038/35093050 · Cited by 1,821
Self-citation
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Puigserver, P., Rhee, J., Donovan, J., Walkey, C. J., Yoon, J. C., Oriente, F., Kitamura, Y., Altomonte, J., Dong, H., Accili, D., et al. (2003) · Nature · doi:10.1038/nature01667 · Cited by 1,487
Self-citation

Show all 46 references

Sorted by citations

Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935
MicroRNA Regulation of Atherosclerosis
Feinberg, M. W., & Moore, K. J. (2016) · Circulation Research · doi:10.1161/circresaha.115.306300 · Cited by 638
Metabolism of tissue macrophages in homeostasis and pathology
Wculek, S. K., Dunphy, G., Heras-Murillo, I., Mastrangelo, A., & Sancho, D. (2022) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00791-9 · Cited by 501
Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial
Rahmani, S., Asgary, S., Askari, G., Keshvari, M., Hatamipour, M., Feizi, A., & Sahebkar, A. (2016) · Phytotherapy Research · doi:10.1002/ptr.5659 · Cited by 472
MicroRNA-mediated regulation of glucose and lipid metabolism
Agbu, P., & Carthew, R. W. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00354-w · Cited by 376
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels
Goedeke, L., Rotllan, N., Canfrán-Duque, A., Aranda, J. F., Ramírez, C. M., Araldi, E., Lin, C.-S., Anderson, N. N., Wagschal, A., de Cabo, R., et al. (2015) · Nature Medicine · doi:10.1038/nm.3949 · Cited by 238
Self-citation
miRNAs and NAFLD: from pathophysiology to therapy
Gjorgjieva, M., Sobolewski, C., Dolicka, D., de Sousa, M. C., & Foti, M. (2019) · Gut · doi:10.1136/gutjnl-2018-318146 · Cited by 220
Macrophage mitochondrial energy status regulates cholesterol efflux and is enhanced by anti-miR33 in atherosclerosis
Karunakaran, D., Thrush, A. B., Nguyen, M.-A., Richards, L., Geoffrion, M., Singaravelu, R., Ramphos, E., Shangari, P., Ouimet, M., Pezacki, J. P., et al. (2015) · Circulation Research · doi:10.1161/circresaha.117.305624 · Cited by 188
Ogg1 -Dependent DNA Repair Regulates NLRP3 Inflammasome and Prevents Atherosclerosis
Tumurkhuu, G., Shimada, K., Dagvadorj, J., Crother, T. R., Zhang, W., Luthringer, D., Gottlieb, R. A., Chen, S., & Arditi, M. (2016) · Circulation Research · doi:10.1161/circresaha.116.308362 · Cited by 182
Non-coding RNAs: the new central dogma of cancer biology
Saw, P. E., Xu, X., Chen, J., & Song, E. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1700-9 · Cited by 180
Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice
Goedeke, L., Salerno, A., Ramírez, C. M., Guo, L., Allen, R. M., Yin, X., Langley, S. R., Esau, C., Wanschel, A., Fisher, E. A., et al. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404046 · Cited by 145
Self-citation
Micromanaging aerobic respiration and glycolysis in cancer cells
Orang, A., Petersen, J., McKinnon, R. A., & Michael, M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.01.014 · Cited by 117
microRNAs in lipoprotein metabolism and cardiometabolic disorders
Rotllan, N., Price, N., Pati, P., Goedeke, L., & Fernández-Hernando, C. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.01.025 · Cited by 100
Self-citation
Chlamydia preserves the mitochondrial network necessary for replication via microRNA-dependent inhibition of fission
Chowdhury, S. R., Reimer, A., Sharan, M., Kozjak‐Pavlovic, V., Eulálio, A., Prusty, B. K., Fraunholz, M. J., Rajeeve, K., & Rudel, T. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201608063 · Cited by 108
Mechanistic Role of MicroRNAs in Coupling Lipid Metabolism and Atherosclerosis
Novák, J., Olejníčková, V., Tkáčová, N., & Santulli, G. (2015) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-22380-3_5 · Cited by 95
Suitability of hepatocyte cell lines HepG2, AML12 and THLE-2 for investigation of insulin signalling and hepatokine gene expression
Sefried, S., Häring, H., Weigert, C., & Eckstein, S. S. (2018) · Open Biology · doi:10.1098/rsob.180147 · Cited by 113
miR-33a functions as a tumor suppressor in melanoma by targeting HIF-1α
Zhou, J., Xu, D., Xie, H., Tang, J., Liu, R., Li, J., Wang, S., Chen, X., Su, J., Zhou, X., et al. (2015) · Cancer Biology & Therapy · doi:10.1080/15384047.2015.1030545 · Cited by 97
MicroRNA-124 Reduces the Pentose Phosphate Pathway and Proliferation by Targeting PRPS1 and RPIA mRNAs in Human Colorectal Cancer Cells
Qiu, Z., Guo, W., Wang, Q., Chen, Z., Huang, S., Zhao, F., Yao, M., Zhao, Y., & He, X. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.050 · Cited by 94
MicroRNA 7 Impairs Insulin Signaling and Regulates A β Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway
Fernández-de Frutos, M., Galán-Chilet, I., Goedeke, L., Kim, B., Pardo-Marqués, V., Pérez-García, A., Herrero, J. I., Fernández-Hernando, C., Kim, J., & Ramírez, C. M. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00170-19 · Cited by 82
Self-citation
MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4
Li, K., Zhang, J., Yu, J., Liu, B., Guo, Y., Deng, J., Chen, S., Wang, C., & Guo, F. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.633990 · Cited by 81
Non-coding RNA regulation of endothelial and macrophage functions during atherosclerosis
Aryal, B. K., & Suárez, Y. (2018) · Vascular Pharmacology · doi:10.1016/j.vph.2018.03.001 · Cited by 78
Self-citation
Changes in microRNA abundance may regulate diapause in the flesh fly, Sarcophaga bullata
Reynolds, J. A., Peyton, J. T., & Denlinger, D. L. (2017) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2017.03.002 · Cited by 77
Elevated Hepatic miR-22-3p Expression Impairs Gluconeogenesis by Silencing the Wnt-Responsive Transcription Factor Tcf7
Kaur, K., Vig, S., Srivastava, R., Mishra, A., Singh, V. P., Srivastava, R., & Datta, M. (2015) · Diabetes · doi:10.2337/db14-1924 · Cited by 75
Micro RNA s: the fine modulators of liver development and function
Chen, Y., & Verfaillie, C. M. (2014) · Liver International · doi:10.1111/liv.12496 · Cited by 74
MicroRNA modulation of lipid metabolism and oxidative stress in cardiometabolic diseases
Aranda, J. F., Madrigal‐Matute, J., Rotllán, N., & Fernandez-Hernando, C. F. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.014 · Cited by 67
Noncoding RNAs: the shot callers in tumor immune escape
Liu, L., Wang, Q., Qiu, Z., Kang, Y., Liu, J., Ning, S., Yin, Y., Pang, D., & Xu, S. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0194-y · Cited by 66
MicroRNAs in obesity-associated disorders
Abente, E. J., Subramanian, M., Ramachandran, V., & Najafi-Shoushtari, S. H. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.09.018 · Cited by 63
Pathophysiological understanding of HFpEF: microRNAs as part of the puzzle
Rech, M., Aizpurua, A. B., van Empel, V. P. M., van Bilsen, M., & Schroen, B. L. M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy049 · Cited by 61
Cholesterol cholelithiasis: part of a systemic metabolic disease, prone to primary prevention
Ciaula, A. D., Wang, D. Q. ‐., & Portincasa, P. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2019.1549988 · Cited by 61
Promising Directions in Atherosclerosis Treatment Based on Epigenetic Regulation Using MicroRNAs and Long Noncoding RNAs
Skuratovskaia, D., Vulf, M. A., Komar, A., Кириенкова, Е. В., & Litvinova, L. S. (2019) · Biomolecules · doi:10.3390/biom9060226 · Cited by 59
SREBP-1c/MicroRNA 33b Genomic Loci Control Adipocyte Differentiation
Price, N. L., Holtrup, B., Kwei, S. L., Wabitsch, M., Rodeheffer, M. S., Bianchini, L., Suárez, Y., & Fernandez-Hernando, C. F. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00745-15 · Cited by 61
Self-citation
microRNAs and HDL life cycle
Canfrán‐Duque, A., Ramírez, C. M., Goedeke, L., Lin, C., & Fernandez-Hernando, C. F. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu140 · Cited by 59
Self-citation
Evidence that microRNAs are part of the molecular toolkit regulating adult reproductive diapause in the mosquito, Culex pipiens
Meuti, M. E., Bautista-Jimenez, R., & Reynolds, J. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203015 · Cited by 56
Relevance of microRNA in metabolic diseases
Price, N. L., Ramírez, C. M., & Fernandez-Hernando, C. F. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2014.937522 · Cited by 55
Self-citation
Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep
Lie, S., Morrison, J. L., Williams-Wyss, O., Suter, C. M., Humphreys, D. T., Ozanne, S. E., Zhang, S., MacLaughlin, S. M., Kleemann, D. O., Walker, S. K., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00553.2013 · Cited by 55
RNA sequencing of db/db mice liver identifies lncRNA H19 as a key regulator of gluconeogenesis and hepatic glucose output
Goyal, N., Sivadas, A., Vellarikkal, S. K., Jayarajan, R., Verma, A., Sivasubbu, S., Scaria, V., & Datta, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-08281-7 · Cited by 56
Perspective: Milk microRNAs as Important Players in Infant Physiology and Development
Leroux, C., Chervet, M., & German, J. B. (2021) · Advances in Nutrition · doi:10.1093/advances/nmab059 · Cited by 55
Distinct microRNA and mRNA responses elicited by ecdysone, diapause hormone and a diapause hormone analog at diapause termination in pupae of the corn earworm, Helicoverpa zea
Reynolds, J. A., Nachman, R. J., & Denlinger, D. L. (2018) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2018.09.013 · Cited by 52
The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells
Shi, H., Fang, R., Li, Y., Li, L., Zhang, W., Wang, H., Chen, F., Zhang, S., Zhang, X., & Ye, L. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.08.025 · Cited by 52
miR-33 Silencing Reprograms the Immune Cell Landscape in Atherosclerotic Plaques
Afonso, M. S., Sharma, M., Schlegel, M., van Solingen, C., Koelwyn, G. J., Shanley, L. C., Beckett, L., Peled, D., Rahman, K., Giannarelli, C., et al. (2021) · Circulation Research · doi:10.1161/circresaha.120.317914 · Cited by 53
MicroRNAs Involved in the Lipid Metabolism and Their Possible Implications for Atherosclerosis Development and Treatment
Novák, J., Vašků, J. B., Kára, T., & Novák, M. (2014) · Mediators of Inflammation · doi:10.1155/2014/275867 · Cited by 53
MicroRNA-33a-3p suppresses cell migration and invasion by directly targeting PBX3 in human hepatocellular carcinoma
Han, S.-Y., Han, H.-B., Tian, X.-Y., Sun, H., Xue, D., Zhao, C., Jiang, S.-T., He, X.-R., Zheng, W.-X., Wang, J., et al. (2016) · OncoTarget · doi:10.18632/oncotarget.9886 · Cited by 53
MicroRNA-33b knock-in mice for an intron of sterol regulatory element-binding factor 1 (Srebf1) exhibit reduced HDL-C in vivo
Horie, T., Nishino, T., Baba, O., Kuwabara, Y., Nakao, T., Nishiga, M., Usami, S., Izuhara, M., Nakazeki, F., Ide, Y., et al. (2014) · Scientific Reports · doi:10.1038/srep05312 · Cited by 49
Insight into miRNAs related with glucometabolic disorder
Zhang, B., Shen, C., Zhu, B.-W., An, H., Zheng, B. J., Xu, S., Sun, J., Sun, P.-C., Zhang, W., Wang, J., et al. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.12.123 · Cited by 48
Role of microRNAs (miRNAs) in the pathophysiology of diabetes mellitus
Tiwari, J., Gupta, G., Pinto, T. D. J. A., Sharma, R., Pabreja, K., Matta, Y., Arora, N., Mishra, A., Sharma, R. K., & Dua, K. (2018) · Panminerva Medica · doi:10.23736/s0031-0808.17.03382-1 · Cited by 45
Nanomedicine Meets microRNA
Gadde, S., & Rayner, K. J. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307481 · Cited by 44
Non-alcoholic fatty liver disease and microRNAs expression, how it affects the development and progression of the disease
López-Sánchez, G. N., Domínguez‐Pérez, M., Uribe, M., Chávez-Tapia, N. C., & Nuño‐Lámbarri, N. (2020) · Annals of Hepatology · doi:10.1016/j.aohep.2020.04.012 · Cited by 43
MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking
Peng, H., Hsiao, J., Chou, S.-T., Hsu, Y.-M., Wu, G.-H., Shieh, Y., & Shiah, S. (2020) · Neoplasia · doi:10.1016/j.neo.2020.08.005 · Cited by 45
MicroRNA regulation of cholesterol metabolism
Citrin, K. M., Fernandez-Hernando, C. F., & Suárez, Y. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14566 · Cited by 45
Self-citation
Liver MicroRNA-291b-3p Promotes Hepatic Lipogenesis through Negative Regulation of Adenosine 5′-Monophosphate (AMP)-activated Protein Kinase α1
Meng, X., Guo, J., Fang, W., Dou, L., Li, M., Huang, X., Zhou, S., Man, Y., Tang, W., Yu, L., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.713768 · Cited by 42
Noncoding RNAs in Regulation of Cancer Metabolic Reprogramming
Yang, D., Sun, L., Li, Z., & Gao, P. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-1498-7_7 · Cited by 42
MicroRNA regulation and analytical methods in cancer cell metabolism
Zhang, L.-F., Jiang, S., & Liu, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2508-y · Cited by 41
Effects of miR-33 Deficiency on Metabolic and Cardiovascular Diseases: Implications for Therapeutic Intervention
Ortega, R., Liu, B., & Persaud, S. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310777 · Cited by 45
Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links?
Beck, R., Stýblo, M., & Sethupathy, P. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0845-8 · Cited by 39
Downregulation of miR‐33b promotes non‐small cell lung cancer cell growth through reprogramming glucose metabolism miR‐33b regulates non‐small cell lung cancer cell growth
Zhai, S., Zhao, L., Lin, T. C., & Wang, W. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27961 · Cited by 38
Overexpression of miR‐329‐3p sensitizes osteosarcoma cells to cisplatin through suppression of glucose metabolism by targeting LDHA
Li, G., Li, Y., & Wang, D. (2020) · Cell Biology International · doi:10.1002/cbin.11476 · Cited by 39
miRNAs in Heart Development and Disease
Lozano-Velasco, E., Inácio, J. M., Sousa, I., Guimarães, A. R., Franco, D., Moura, G. R., & Belo, J. A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031673 · Cited by 42
Control of very low-density lipoprotein secretion by N-ethylmaleimide-sensitive factor and miR-33
Allen, R. M., Marquart, T. J., Jesse, J. J., & Baldán, Á. (2014) · Circulation Research · doi:10.1161/circresaha.115.303100 · Cited by 38
Modulation of microRNA Expression in Subjects with Metabolic Syndrome and Decrease of Cholesterol Efflux from Macrophages via microRNA-33-Mediated Attenuation of ATP-Binding Cassette Transporter A1 Expression by Statins
Chen, W., Sheu, W. H., Tseng, P., Lee, T., Lee, W., Chang, P., & Chiang, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154672 · Cited by 37
miR‐33 in cardiometabolic diseases: lessons learned from novel animal models and approaches
Price, N. L., Goedeke, L., Suárez, Y., & Fernández‐Hernando, C. (2021) · EMBO Molecular Medicine · doi:10.15252/emmm.202012606 · Cited by 36
“In addition to controlling fatty acid metabolism, miR-33 also regulates insulin signaling and glucose metabolism (Gerin et al, 2010; Davalos et al, 2011; Ramirez et al, 2013).”
BackgroundInfluentialSelf-citation
Downregulation of microRNA-33a promotes cyclin-dependent kinase 6, cyclin D1 and PIM1 expression and gastric cancer cell proliferation
Wang, Y., Zhou, X., Shan, B., Han, J., Wang, F., Fan, X., Lv, Y., Chang, L., & Liu, W. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4296 · Cited by 36
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity
Horie, T., Nakao, T., Miyasaka, Y., Nishino, T., Matsumura, S., Nakazeki, F., Ide, Y., Kimura, M., Tsuji, S., Rodriguez, R. R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21107-5 · Cited by 49
miRNA Regulation of Glucose and Lipid Metabolism in Relation to Diabetes and Non-alcoholic Fatty Liver Disease
Suksangrat, T., Phannasil, P., & Jitrapakdee, S. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12668-1_7 · Cited by 34
Potential role for microRNA in regulating hypoxia-induced metabolic suppression in jumbo squids
Hadj‐Moussa, H., Logan, S. M., Seibel, B. A., & Storey, K. B. (2018) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2018.04.007 · Cited by 30
miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression
Benito‐Vicente, A., Uribe, K. B., Rotllán, N., Ramírez, C. M., Jebari‐Benslaiman, S., Goedeke, L., Canfrán‐Duque, A., Galicia-García, U., de Urturi, D. S., Aspichueta, P., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228675 · Cited by 34
Self-citation
Non-Coding RNAs: Novel Players in Insulin Resistance and Related Diseases
Formichi, C., Nigi, L., Grieco, G. E., Maccora, C., Fignani, D., Brusco, N., Licata, G., Sebastiani, G., & Dotta, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147716 · Cited by 34
The role of noncoding RNAs in metabolic reprogramming of cancer cells
Safi, A., Saberiyan, M., Sanaei, M., Adelian, S., Asl, F. D., Zeinaly, M., Shamsi, M., & Ahmadi, R. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00447-8 · Cited by 36
MicroRNA-33/33* inhibit the activation of MAVS through AMPK in antiviral innate immunity
Liu, D., Tan, Q., Zhu, J., Zhang, Y., Xue, Y., Song, Y., Liu, Y., Wang, Q., & Lai, L. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0326-x · Cited by 32
The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma
Liao, W., Du, J., Wang, Z., Feng, Q., Liao, M., Liu, H., Yuan, K., & Zeng, Y. (2022) · International Journal of Cancer · doi:10.1002/ijc.34040 · Cited by 31
Chronic hyperinsulinemia induced miR-27b is linked to adipocyte insulin resistance by targeting insulin receptor
Srivastava, A., Shankar, K., Beg, M., Rajan, S., Gupta, A., Varshney, S., Kumar, D., Gupta, S., Mishra, R. K., & Gaikwad, A. N. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1623-z · Cited by 31
Cellular and Molecular Mechanisms Underlying Glioblastoma and Zebrafish Models for the Discovery of New Treatments
Reimunde, P., Pensado‐López, A., Crende, M. C., Iglesias, V. L., Sanchez, L. E., Torrecilla-Parra, M., Ramírez, C. M., Anfray, C., & Torres, F. (2021) · Cancers · doi:10.3390/cancers13051087 · Cited by 31
Self-citation
MMAB promotes negative feedback control of cholesterol homeostasis
Goedeke, L., Canfrán‐Duque, A., Rotllán, N., Chaube, B., Thompson, B. M., Lee, R. G., Cline, G. W., McDonald, J. G., Shulman, G. I., Lasunción, M. A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26787-7 · Cited by 32
Self-citation
Analysis of MicroRNA Expression in Newborns with Differential Birth Weight Using Newborn Screening Cards
Rodil-García, P., Arellanes-Licea, E. D. C., Montoya-Contreras, A., & Salazar‐Olivo, L. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122552 · Cited by 30
Decoding microRNA drivers in atherosclerosis
Vartak, T., Kumaresan, S., & Brennan, E. P. (2022) · Bioscience Reports · doi:10.1042/bsr20212355 · Cited by 29
Metabolic and epigenetic regulation of macrophage polarization in atherosclerosis: Molecular mechanisms and targeted therapies.
Yang, P.-L., Rong, X.-L., Gao, Z., Wang, J.-J., & Liu, Z. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107588 · Cited by 29
miR-194 Promotes Burn-Induced Hyperglycemia via Attenuating IGF-IR Expression
Yu, Y., Chai, J., Zhang, H., Chu, W., Liu, L., Ma, L., Duan, H., Li, B., & Li, D. (2014) · Shock · doi:10.1097/shk.0000000000000258 · Cited by 29
MicroRNA‑24 inhibits the proliferation and migration of endothelial cells in patients with atherosclerosis by targeting importin‑α3 and regulating inflammatory responses
Ye, Z., Li, Y., Liu, G., Qi, X., & Cao, X. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5355 · Cited by 29
A post-weaning obesogenic diet exacerbates the detrimental effects of maternal obesity on offspring insulin signaling in adipose tissue
de Almeida-Faria, J., Duque-Guimaraes, D. E., Carpenter, A. A. M., Loche, E., & Ozanne, S. E. (2017) · Scientific Reports · doi:10.1038/srep44949 · Cited by 32
Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism
Arif, W., Datar, G. K., & Kalsotra, A. (2017) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2017.01.004 · Cited by 28
Hepatocellular carcinoma cell-derived extracellular vesicles encapsulated microRNA-584-5p facilitates angiogenesis through PCK1-mediated nuclear factor E2-related factor 2 signaling pathway
Shao, Z., Pan, Q., & Zhang, Y. (2020) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2020.105789 · Cited by 28
Epigenetic regulation of inflammatory factors in adipose tissue
Jung, B. C., & Kang, S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159019 · Cited by 28
MicroRNA-33a promotes cell proliferation and inhibits apoptosis by targeting PPARα in human hepatocellular carcinoma
Chang, W., Zhang, L., Xian, Y., & Yu, Z. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4236 · Cited by 27
The role of microRNAs in liver injury at the crossroad between hepatic cell death and regeneration
Lauschke, V. M., Mkrtchian, S., & Ingelman-Sundberg, M. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.10.084 · Cited by 29
Correlation of circulating miRNA-33a and miRNA-122 with lipid metabolism among Egyptian patients with metabolic syndrome
Refeat, M. M., Hassan, N. A.-M., Ahmad, I. H., Mostafa, E. R. M., & Amr, K. S. (2021) · Journal of Genetic Engineering and Biotechnology · doi:10.1186/s43141-021-00246-8 · Cited by 25
Ageing influences the relationship of circulating miR-33a and miR - 33b levels with insulin resistance and adiposity
Corona-Meraz, F.-I., Mercado, M. V.-D., Ortega, F. J., Ruíz-Quezada, S. L., Guzmán-Ornelas, M.-O., & Navarro-Hernández, R. E. (2018) · Diabetes and Vascular Disease Research · doi:10.1177/1479164118816659 · Cited by 22
Noncoding RNAs Carried by Extracellular Vesicles in Endocrine Diseases
Pomatto, M. A. C., Gai, C., Deregibus, M. C., Tetta, C., & Camussi, G. (2018) · International Journal of Endocrinology · doi:10.1155/2018/4302096 · Cited by 26
miR-33 deletion in hepatocytes attenuates MASLD-MASH-HCC progression
Fernández-Tussy, P., Cardelo, M. P., Zhang, H., Sun, J., Price, N. L., Boutagy, N. E., Goedeke, L., Cadena-Sandoval, M., Xirouchaki, C. E., Brown, W., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.168476 · Cited by 21
“These results prompted us to characterize additional post-transcriptional mechanisms regulating AMPK in our model.”
BackgroundInfluentialSelf-citation
MicroRNA-33a downregulation is associated with tumorigenesis and poor prognosis in patients with hepatocellular carcinoma.
Xie, R.-T., Cong, X.-L., Zhong, X., Luo, P., Yang, H., Lu, G., Luo, P., Chang, Z.-Y., Sun, R., Wu, T.-M., et al. (2018) · Oncology Letters · doi:10.3892/ol.2018.7892 · Cited by 21
“MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression”
Frutos, M. F.-D., Pardo, V., Torrecilla-Parra, M., Rada, P., Pérez-García, A., Martín-Martín, Y., de la Peña, G., Gómez, A., Toledano‐Zaragoza, A., Gómez‐Coronado, D., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2023.194938 · Cited by 21
Self-citation
3′-UTR SNP rs2229611 in G6PC1 affects mRNA stability, expression and Glycogen Storage Disease type-Ia risk
Karthi, S., Rajeshwari, M., Francis, A., Matheshwaran, S., Varalakshmi, P., Houlden, H., Kumarasamy Thangaraj, K., & Ashokkumar, B. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.05.016 · Cited by 23
Nutriepigenomics and Malnutrition
Luca, A. D., Hankard, R., Borys, J.-M., Sinnett, D., Marcil, V., & Levy, E. H. (2017) · Epigenomics · doi:10.2217/epi-2016-0168 · Cited by 22
In low protein diets, microRNA-19b regulates urea synthesis by targeting SIRT5
Sun, R.-P., Xi, Q., Sun, J., Cheng, X., Zhu, Y., Ye, D.-Z., Chen, T., Wei, L.-M., Ye, R.-S., Jiang, Q., et al. (2016) · Scientific Reports · doi:10.1038/srep33291 · Cited by 20
Novel Role of miR-33 in Regulating of Mitochondrial Function
Price, N. L., & Fernandez-Hernando, C. F. (2015) · Circulation Research · doi:10.1161/circresaha.117.306949 · Cited by 19
MicroRNA-Management of Lipoprotein Homeostasis
Sun, X., & Feinberg, M. W. (2014) · Circulation Research · doi:10.1161/circresaha.114.304228 · Cited by 19
microRNAs involved in psoriasis and cardiovascular diseases
Sileno, S., Beji, S., D'Agostino, M., Carassiti, A., Melillo, G., & Magenta, A. (2021) · Vascular Biology · doi:10.1530/vb-21-0007 · Cited by 17
MiR-570 inhibits cell proliferation and glucose metabolism by targeting IRS1 and IRS2 in human chronic myelogenous leukemia.
Zhao, H., Liu, F., Jia, R., Chang, H., Li, H., Miao, M., Wang, H., & Yang, Z. (2017) · Europe PMC (PubMed Central) · doi:10.22038/ijbms.2017.8671 · Cited by 18
miR-19b-3p regulated by estrogen controls lipid synthesis through targeting MSMO1 and ELOVL5 in LMH cells
Jia, Q., Cao, Y., Zhang, M., Xing, Y., Xia, T., Guo, Y., Yue, Y.-X., Li, X., Liu, X., Zhang, Y., et al. (2023) · Poultry Science · doi:10.1016/j.psj.2023.103200 · Cited by 17
ΔNp63 intronic miR-944 is implicated in the ΔNp63-mediated induction of epidermal differentiation
Kim, K., Cho, E., Yu, S. J., Kang, H., Kim, Y.-J., Kim, S. H., & Lee, T. R. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv735 · Cited by 17
miRNAs and High-Density Lipoprotein metabolism
Baldán, Á., & Vallim, T. Q. D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.01.021 · Cited by 18
miR-1224-5p Enhances Hepatic Lipogenesis by Targeting Adenosine Monophosphate–Activated Protein Kinase α1 in Male Mice
Chen, T., Yan, D., Cheng, X., Ji, X., Bian, J., & Yin, W. (2018) · Endocrinology · doi:10.1210/en.2017-03231 · Cited by 16

Authors: Ramírez, C. M., Goedeke, L., Rotllan, N., Yoon, J.-H., Cirera-Salinas, D., Mattison, J. A., Suárez, Y., de Cabo, R., Gorospe, M., & Fernández-Hernando, C.
Affiliations: New York University (US)
Departments of Medicine and Cell Biology, Leon H. Charney Division of Cardiology and Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, New York, USA
National Institutes of Health (US)
ORCID: Ramírez, Cristina M.
Goedeke, Leigh
Yoon, Je-Hyun
Mattison, Julie A.
Suárez, Yajaira
de Cabo, Rafael
Gorospe, Myriam
Venue: Molecular and Cellular Biology
Publisher: Informa UK Limited
Published: 2013-08-01
Volume: 33
Issue: 15
Pages: 2891-2902
ISSN: 0270-7306 (ISSN-L)
1098-5549
DOI: 10.1128/mcb.00016-13
PMC: PMC3719675
OpenAlex: W2148995089
Cited by: 154
References: 46
Citations by year: 2026: 3 · 2025: 7 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 19 · 2020: 12 · 2019: 11 · 2018: 15 · 2017: 16 · 2016: 18 · 2015: 14 · 2014: 13 · 2013: 1
FWCI: 5.40
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Molecular and Cellular Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (F31AG043318)
National Heart, Lung, and Blood Institute (R01HL105945, R01HL106063, R01HL107953)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: miR-33b, miR-33a, SREBP-1c, SREBP1, glucose metabolism, gluconeogenesis, PCK1, glucose-6-phosphatase, hepatic glucose production, post-transcriptional regulation, lipid metabolism, metabolic disorders, therapeutic target
MeSH terms: Animals, Gene Expression Regulation, Gluconeogenesis, Glucose, Glucose-6-Phosphatase, Glycogen, Humans, Macaca mulatta, Male, Phosphoenolpyruvate Carboxykinase (GTP), Hepatocytes, MicroRNAs, Intracellular Signaling Peptides and Proteins, Sterol Regulatory Element Binding Protein 1, Hep G2 Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

MicroRNA 33 Regulates Glucose Metabolism

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks