Cited by 384Gut microbiota and healthInflammatory Bowel DiseaseMicroscopic Colitis

The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.

Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease

Open access

Conte, M P, Schippa, S, Zamboni, I, Penta, M, Chiarini, F, Seganti, L, Osborn, J, Falconieri, P, Borrelli, O, Cucchiara, S·2006·Gut

DOI 10.1136/gut.2005.078824PMC PMC1856471

Open this paper in CoChat — free account Open PDF

Abstract

Background: Clinical and experimental observations in animal models indicate that intestinal commensal bacteria are involved in the initiation and amplification of inflammatory bowel disease (IBD). No paediatric reports are available on intestinal endogenous microflora in IBD. Aims: To investigate and characterise the predominant composition of the mucosa-associated intestinal microflora in colonoscopic biopsy specimens of paediatric patients with newly diagnosed IBD. Methods: Mucosa-associated bacteria were quantified and isolated from biopsy specimens of the ileum, caecum and rectum obtained at colonoscopy in 12 patients with Crohn’s disease, 7 with ulcerative colitis, 6 with indeterminate colitis, 10 with lymphonodular hyperplasia of the distal ileum and in 7 controls. Isolation and characterisation were carried out by conventional culture techniques for aerobic and facultative-anaerobic microorganisms, and molecular analysis (16S rRNA-based amplification and real-time polymerase chain reaction assays) for the detection of anaerobic bacterial groups or species. Results: A higher number of mucosa-associated aerobic and facultative-anaerobic bacteria were found in biopsy specimens of children with IBD than in controls. An overall decrease in some bacterial species or groups belonging to the normal anaerobic intestinal flora was suggested by molecular approaches; in particular, occurrence of Bacteroides vulgatus was low in Crohn’s disease, ulcerative colitis and indeterminate colitis specimens. Conclusion: This is the first paediatric report investigating the intestinal mucosa-associated microflora in patients of the IBD spectrum. These results, although limited by the sample size, allow a better understanding of changes in mucosa-associated bacterial flora in these patients, showing either a predominance of some potentially harmful bacterial groups or a decrease in beneficial bacterial species. These data underline the central role of mucosa-adherent bacteria in IBD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/gut.2005.078824

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,480
Commensal Host-Bacterial Relationships in the Gut
Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362
High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease
Darfeuille-Michaud, A., Boudeau, J., Bulois, P., Neut, C., Glasser, A.-L., Barnich, N., Bringer, M.-A., Swidsinski, A., Beaugerie, L., & Colombel, J.-F. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.061 · Cited by 1,566
Mucosal flora in inflammatory bowel disease
Swidsinski, A. V., Ladhoff, A., Pernthaler, A., Swidsinski, S., Loening-Baucke, V. A., Ortner, M., Weber, J., Hoffmann, U., Schreiber, S., Dietel, M., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.30294 · Cited by 1,344
Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease
Ott, S. J., Musfeldt, M., Wenderoth, D. F., Hampe, J., Brant, O., Fölsch, U. R., Timmis, K. N., & Schreiber, S. (2004) · Gut · doi:10.1136/gut.2003.025403 · Cited by 1,311
Experimental models of inflammatory bowel disease
Elson, C. O., Sartor, R. B., Tennyson, G. S., & Riddell, R. H. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90599-5 · Cited by 1,212
Human Fecal Flora: The Normal Flora of 20 Japanese-Hawaiians
Moore, W. E. C., & Holdeman, L. V. (1974) · Applied Microbiology · doi:10.1128/am.27.5.961-979.1974 · Cited by 1,144
Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon
Seksik, P., Rigottier‐Gois, L., Gramet, G., BRIEND‐SUTREN, M., Pochart, P., Marteau, P. R., Jian, R., & Dore, J. M. (2003) · Gut · doi:10.1136/gut.52.2.237 · Cited by 746
Dysbiosis in inflammatory bowel disease
Tamboli, C. P., Neut, C., Desreumaux, P., & Colombel, J. F. (2004) · Gut · doi:10.1136/gut.53.1.1 · Cited by 743

Show all 51 references

Research works printed but not linked: 5

10.1172/JCI200319545 · DOI
2004, Aliment Pharmacol Ther, 20, 18
2002, J Pediatr Gastroenterol Nutr, 34, 42
2004, J Pediatr Gastroenterol Nutr, 38, 123
1998, Infect Immun, 60, 3971

Sorted by citations

The Microbiota-Gut-Brain Axis
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Microbial Influences in Inflammatory Bowel Diseases
Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927
Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders
Magro, F., Gionchetti, P., Eliakim, R., Ardizzone, S., Armuzzi, A., Barreiro-de Acosta, M., Burisch, J., Gecse, K. B., Hart, A. L., Hindryckx, P., et al. (2017) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjx008 · Cited by 1,910
Inflammatory bowel disease
Kaser, A., Zeissig, S., & Blumberg, R. S. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101225 · Cited by 1,806
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota
Stecher, B., Robbiani, R., Walker, A. W., Westendorf, A. M., Barthel, M., Kremer, M., Chaffron, S., Macpherson, A. J., Buer, J., Parkhill, J., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050244 · Cited by 1,048
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024
Microbial genes and pathways in inflammatory bowel disease
Schirmer, M., Garner, A., Vlamakis, H. C., & Xavier, R. J. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0213-6 · Cited by 979
Intestinal microbiota in functional bowel disorders: a Rome foundation report
Simrén, M., Barbara, G., Flint, H. J., Spiegel, B. M. R., Spiller, R. C., Vanner, S., Verdu, E. F., Whorwell, P. J., & Zoetendal, E. G. (2013) · Gut · doi:10.1136/gutjnl-2012-302167 · Cited by 939
Probiotics and the gut microbiota in intestinal health and disease
Gareau, M. G., Sherman, P. M., & Walker, W. A. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.117 · Cited by 907
Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 1: Definitions and diagnosis
Dignass, A. U., Eliakim, R., Magro, F., Maaser, C., Chowers, Y., Geboes, K., Mantzaris, G. J., Reinisch, W., Colombel, J., Vermeire, S., et al. (2012) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2012.09.003 · Cited by 903
16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis
Wang, Y., Hoenig, J. D., Malin, K. J., Qamar, S., Petrof, E. O., Sun, J., Antonopoulos, D. A., Chang, E. B., & Claud, E. C. (2009) · The ISME Journal · doi:10.1038/ismej.2009.37 · Cited by 600
European evidence-based Consensus on the diagnosis and management of ulcerative colitis: Definitions and diagnosis
Stange, E. F., Travis, S. P. L., Vermeire, S., Reinisch, W., Geboes, K., Barakauskienė, A., Feakins, R. M., Fléjou, J., Herfarth, H. H., Hommes, D. W., et al. (2008) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2007.11.001 · Cited by 559
Increased Proportions of Bifidobacterium and the Lactobacillus Group and Loss of Butyrate-Producing Bacteria in Inflammatory Bowel Disease
Wang, W., Chen, L., Zhou, R., Wang, X., Song, L., Huang, S., Wang, G., & Xia, B. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.01500-13 · Cited by 509
Alterations of the Gut Microbiome in Hypertension
Yan, Q., Gu, Y., Li, X., Yang, W. Q., Jia, L., Chen, C., Han, X., Huang, Y., Zhao, L., Li, P., et al. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00381 · Cited by 511
Western diet induces a shift in microbiota composition enhancing susceptibility to adherent-invasive E. coli infection and intestinal inflammation
Agus, A., Denizot, J., Thévenot, J., Martinez-Medina, M., Massier, S., Sauvanet, P., Bernalier-Donadille, A., Denis, S., Hofman, P., Bonnet, R., et al. (2016) · Scientific Reports · doi:10.1038/srep19032 · Cited by 477
The Commensal Microbiota and Enteropathogens in the Pathogenesis of Inflammatory Bowel Diseases
Chassaing, B., & Darfeuille–Michaud, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.054 · Cited by 443
The role of the intestinal microbiota in the development of atopic disorders
Penders, J., Stobberingh, E. E., van den Brandt, P. A., & Thijs, C. T. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01462.x · Cited by 447
High prevalence of Escherichia coli belonging to the B2+D phylogenetic group in inflammatory bowel disease
Kotłowski, R., Bernstein, C. N., Sepehri, S., & Krause, D. O. (2006) · Gut · doi:10.1136/gut.2006.099796 · Cited by 422
Intestinal barrier in inflammatory bowel disease
Antoni, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i5.1165 · Cited by 446
Role of the gut microbiota in defining human health
Fujimura, K. E., Slusher, N. A., Cabana, M. D., & Lynch, S. V. (2010) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.10.14 · Cited by 421
The Dynamic Distribution of Porcine Microbiota across Different Ages and Gastrointestinal Tract Segments
Zhao, W., Wang, Y., Liu, S., Huang, J., Zhai, Z., He, C., Ding, J., Wang, J., Wang, H., Fan, W., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117441 · Cited by 430
The dormant blood microbiome in chronic, inflammatory diseases
Potgieter, M., Bester, J., Kell, D. B., & Pretorius, E. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv013 · Cited by 384
Role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years?
Hold, G. L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i5.1192 · Cited by 365
Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease
Collado, M. C., Donat, E., Ribes-Koninckx, C., Calabuig, M., & Sanz, Y. (2009) · Journal of Clinical Pathology · doi:10.1136/jcp.2008.061366 · Cited by 354
Why Is Initial Bacterial Colonization of the Intestine Important to Infants' and Children's Health?
Houghteling, P. D., & Walker, W. A. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000597 · Cited by 353
Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis
Ciccia, F., Guggino, G., Rizzo, A. G., Alessandro, R., Luchetti, M. M., Milling, S. W. F., Saieva, L., Cypers, H., Stampone, T., Benedetto, P. D., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-210000 · Cited by 357
Mechanisms of probiotic action: Implications for therapeutic applications in inflammatory bowel diseases
Vanderpool, C., Yan, F., & Polk, B. D. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20525 · Cited by 340
Inﬂammatory bowel disease
Teitelbaum, D. H., & Coran, A. G. (2006) · CRC Press eBooks · doi:10.1201/b13237-67 · Cited by 341
Hippurate: The Natural History of a Mammalian–Microbial Cometabolite
Lees, H., Swann, J. R., Wilson, I. D., Nicholson, J. K., & Holmes, E. C. (2013) · Journal of Proteome Research · doi:10.1021/pr300900b · Cited by 338
Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM
Carvalho, F. A., Barnich, N., Sivignon, A., Darcha, C., Chan, C. H. F., Stanners, C. P., & Darfeuille–Michaud, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090741 · Cited by 314
Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly
Lapaquette, P., Glasser, A.-L., Huett, A. S., Xavier, R. J., & Darfeuille–Michaud, A. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01381.x · Cited by 341
Adherent-invasive Escherichia coli in inflammatory bowel disease
Rolhion, N., & Darfeuille–Michaud, A. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20176 · Cited by 299
Microbiota of De-Novo Pediatric IBD: Increased Faecalibacterium Prausnitzii and Reduced Bacterial Diversity in Crohn's But Not in Ulcerative Colitis
Hansen, R., Russell, R. K., Reiff, C., Louis, P., McIntosh, F. M., Berry, S. H., Mukhopadhya, I., Bisset, W. M., Barclay, A. R., Bishop, J., et al. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.335 · Cited by 293
Untitled work
(2016) · PubMed · Cited by 287
Self-citation
Alterations in the gut microbiome of children with severe ulcerative colitis
Michail, S. K., Durbin, M. D., Turner, D., Griffiths, A. M., Mack, D. R., Hyams, J., LeLeiko, N. S., Kenche, H., Stolfi, A., & Wine, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22860 · Cited by 281
Randomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitis
Oliva, S., Nardo, G. D., Ferrari, F., Mallardo, S., Rossi, P., Patrizi, G., Cucchiara, S., & Stronati, L. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04939.x · Cited by 280
Self-citation
Dysbiosis of Gut Fungal Microbiota is Associated With Mucosal Inflammation in Crohn’s Disease
Li, Q., Wang, C., Tang, C. X., He, Q., Li, N., & Li, J. (2013) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000035 · Cited by 279
Cesarean Delivery Is Associated With Celiac Disease but Not Inflammatory Bowel Disease in Children
Decker, E., Engelmann, G., Findeisen, A., Gerner, P., Laass, M. W., Ney, D., Posovszky, C., Hoy, L., & Hornef, M. W. (2010) · PEDIATRICS · doi:10.1542/peds.2009-2260 · Cited by 284
Long‐term monitoring of the human intestinal microbiota composition
Rajilić-Stojanović, M. D., Heilig, H. G. H. J., Tims, S., Zoetendal, E. G., & de Vos, W. M. (2012) · Environmental Microbiology · doi:10.1111/1462-2920.12023 · Cited by 286
Gut Microbial Activity, Implications for Health and Disease: The Potential Role of Metabolite Analysis
Nyangale, E. P., Mottram, D. S., & Gibson, G. R. (2012) · Journal of Proteome Research · doi:10.1021/pr300637d · Cited by 275
Lower Level of Bacteroides in the Gut Microbiota Is Associated with Inflammatory Bowel Disease: A Meta-Analysis
Zhou, Y., & Zhi, F. (2016) · BioMed Research International · doi:10.1155/2016/5828959 · Cited by 266
A distinctive 'microbial signature' in celiac pediatric patients
Schippa, S., Iebba, V., Barbato, M., Nardo, G. D., Totino, V., Checchi, M. P., Longhi, C., Maiella, G., Cucchiara, S., & Conte, M. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-175 · Cited by 259
Self-citation
Mucosal Barrier Depletion and Loss of Bacterial Diversity are Primary Abnormalities in Paediatric Ulcerative Colitis
Alipour, M., Zaidi, D., Valcheva, R. S., Jovel, J., Martínez, I., Sergi, C. M., Walter, J., Mason, A. L., Wong, G. K., Dieleman, L. A., et al. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv223 · Cited by 257
Dysbiotic Events in Gut Microbiota: Impact on Human Health
Schippa, S., & Conte, M. (2014) · Nutrients · doi:10.3390/nu6125786 · Cited by 256
Self-citation
Importance of microbial colonization of the gut in early life to the development of immunity
Kelly, D., King, T. P., & Aminov, R. I. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2007.03.011 · Cited by 249
IBD across the age spectrum—is it the same disease?
Ruel, J., Ruane, D., Mehandru, S., Gower‐Rousseau, C., & Colombel, J. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.240 · Cited by 244
Fungal-Bacterial Interactions in Health and Disease
Krüger, W., Vielreicher, S., Kapitan, M., Jacobsen, I. D., & Niemiec, M. J. (2019) · Pathogens · doi:10.3390/pathogens8020070 · Cited by 234
Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiota
Noor, S. O., Ridgway, K., Scovell, L., Kemsley, E. K., Lund, E. K., Jamieson, C., Johnson, I. T., & Narbad, A. (2010) · BMC Gastroenterology · doi:10.1186/1471-230x-10-134 · Cited by 227
Proteus spp. as Putative Gastrointestinal Pathogens
Hamilton, A. L., Kamm, M. A., Ng, S. C., & Morrison, M. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00085-17 · Cited by 227
Disrupted Intestinal Microbiota and Intestinal Inflammation in Children with Cystic Fibrosis and Its Restoration with Lactobacillus GG: A Randomised Clinical Trial
Bruzzese, E., Callegari, M. L., Raia, V., Viscovo, S., Scotto, R., Ferrari, S., Morelli, L., Buccigrossi, V., Vecchio, A. L., Ruberto, E., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087796 · Cited by 217
Analysis of bacterial bowel communities of IBD patients: What has it revealed?
Sokol, H., Lay, C., Seksik, P., & Tannock, G. W. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20392 · Cited by 229
Cesarean section and offspringʼs risk of inflammatory bowel disease: A national cohort study
Bager, P., Simonsen, J., Nielsen, N. M., & Frisch, M. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21805 · Cited by 191
Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohnʼs disease
Man, S. M., Zhang, L., Day, A. S., Leach, S. T., Lemberg, D. A., & Mitchell, H. M. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21157 · Cited by 183
Complete Genome Sequence of Crohn's Disease-Associated Adherent-Invasive E. coli Strain LF82
Miquel, S., Peyretaillade, É., Claret, L., de Vallée, A., Dossat, C., Vacherie, B., Zineb, E. H., Segurens, B., Barbe, V., Sauvanet, P., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012714 · Cited by 181
The involvement of gut microbiota in inflammatory bowel disease pathogenesis: Potential for therapy
Cammarota, G., Ianiro, G., Cianci, R., Bibbò, S., Gasbarrini, A., & Currò, D. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.006 · Cited by 184
Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease
Orel, R. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i33.11505 · Cited by 177
Invasive Fusobacterium nucleatum may play a role in the carcinogenesis of proximal colon cancer through the serrated neoplasia pathway
Yu, J., Chen, Y., Fu, X., Zhou, X., Peng, Y., Shi, L., Chen, T., & Wu, Y. (2016) · International Journal of Cancer · doi:10.1002/ijc.30168 · Cited by 176
Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells
Alrafas, H. R., Busbee, P. B., Nagarkatti, M., & Nagarkatti, P. S. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3a1218-476rr · Cited by 174
Microbiota in Pediatric Inflammatory Bowel Disease
Schwiertz, A., Jacobi, M., Frick, J.-S., Richter, M., Rusch, K., & Köhler, H. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.02.046 · Cited by 166
Epidemiology of Inflammatory Bowel Disease in India: The Great Shift East
Kedia, S., & Ahuja, V. (2017) · Inflammatory Intestinal Diseases · doi:10.1159/000465522 · Cited by 165
The biodiversity and composition of the dominant fecal microbiota in patients with inflammatory bowel disease
Sha, S., Xu, B., Wang, X., Zhang, Y., Wang, H., Kong, X., Zhu, H., & Wu, K. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.11.022 · Cited by 165
Roles of intestinal bacteroides in human health and diseases
Wang, C., Zhao, J., Zhang, H., Lee, Y. K., Zhai, Q., & Chen, W. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1802695 · Cited by 169
The role of bacteria and pattern-recognition receptors in Crohn's disease
Man, S. M., Kaakoush, N. O., & Mitchell, H. M. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2011.3 · Cited by 166
Reduced mucosal antimicrobial activity in Crohn’s disease of the colon
Nuding, S., Fellermann, K., Wehkamp, J., & Stange, E. F. (2007) · Gut · doi:10.1136/gut.2006.118646 · Cited by 163
Metabolic Influences of Gut Microbiota Dysbiosis on Inflammatory Bowel Disease
Sultan, S., El‐Mowafy, M., Elgaml, A., Ahmed, T. A., Hassan, H., & Mottawea, W. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715506 · Cited by 170
Intestinal microbiota: A source of novel biomarkers in inflammatory bowel diseases?
Berry, D., & Reinisch, W. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.005 · Cited by 154
Metagenomics Reveals Dysbiosis and a Potentially Pathogenic N. flavescens Strain in Duodenum of Adult Celiac Patients
D’Argenio, V., Casaburi, G., Precone, V., Pagliuca, C., Colicchio, R., Sarnataro, D., Discepolo, V., Kim, S. M., Russo, I., Blanco, G. D. V., et al. (2016) · The American Journal of Gastroenterology · doi:10.1038/ajg.2016.95 · Cited by 154
Diagnosis and management of inflammatory bowel disease in children
Oliveira, S. B. D. C., & Monteiro, I. M. (2017) · BMJ · doi:10.1136/bmj.j2083 · Cited by 152
Probiotics and prebiotics in inflammatory bowel disease: microflora ‘on the scope’
Damaskos, D., & Kolios, G. C. (2008) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2008.03096.x · Cited by 151
Antibiotic Exposure and Juvenile Idiopathic Arthritis: A Case–Control Study
Horton, D. B., Scott, F. I., Haynes, K., Putt, M., Rosé, C. D., Lewis, J. D., & Strom, B. L. (2015) · PEDIATRICS · doi:10.1542/peds.2015-0036 · Cited by 151
Fecal Microbiota in Patients with Irritable Bowel Syndrome Compared with Healthy Controls Using Real-Time Polymerase Chain Reaction: An Evidence of Dysbiosis
Shukla, R., Ghoshal, U., Dhole, T. N., & Ghoshal, U. C. (2015) · Digestive Diseases and Sciences · doi:10.1007/s10620-015-3607-y · Cited by 147
Commensals, Bacterial Pathogens and Intestinal Inflammation: An Intriguing Ménage à Trois
Pédron, T., & Sansonetti, P. J. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.010 · Cited by 148
Mucosal bacterial microﬂora and mucus layer thickness inadolescents with inﬂammatory bowel disease
Fyderek, K., Strus, M., Kowalska‐Duplaga, K., Gosiewski, T., Wędrychowicz, A., Jedynak‐Wąsowicz, U., Sładek, M., Pieczarkowski, S., Adamski, P., Kochan, P., et al. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.5287 · Cited by 149
Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine
Matthies, A., Clavel, T., Gütschow, M., Engst, W., Haller, D., Blaut, M., & Braune, A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.00555-08 · Cited by 141
Intestinal dysbiosis in inflammatory bowel disease
Kaur, N. J., Chen, C.-C., Luther, J., & Kao, J. Y. (2011) · Gut Microbes · doi:10.4161/gmic.2.4.17863 · Cited by 145
Cathelicidin Signaling via the Toll-like Receptor Protects Against Colitis in Mice
Koon, H. W., Shih, D. Q., Chen, J., Bakirtzi, K., Hing, T. C., Law, I. K. M., Ho, S., Ichikawa, R., Zhao, D., Xu, H. J., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.079 · Cited by 136
From models to mechanisms: Odorant communication as a key determinant of social behavior in rodents during illness-associated states
Arakawa, H., Cruz, S., & Deak, T. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.03.007 · Cited by 131
Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention
Zhang, S.-L., Wang, S., & Miao, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01674 · Cited by 139
The microbiota and autoimmunity: Their role in thyroid autoimmune diseases
Köhling, H.-L., Plummer, S. F., Marchesi, J. R., Davidge, K. S., & Ludgate, M. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.07.001 · Cited by 139
Early Development of the Gut Microbiome and Immune-Mediated Childhood Disorders
Li, M., Wang, M., & Donovan, S. (2014) · Seminars in Reproductive Medicine · doi:10.1055/s-0033-1361825 · Cited by 131
Paneth cell defects in Crohn’s disease patients promote dysbiosis
Liu, T., Gurram, B., Baldridge, M. T., Head, R. D., Lam, V., Luo, C., Cao, Y., Simpson, P. M., Hayward, M., Holtz, M. L., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.86907 · Cited by 134
Role of nutrition and microbiota in susceptibility to inflammatory bowel diseases
Gentschew, L., & Ferguson, L. R. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100630 · Cited by 133
Crohnʼs disease-associated Escherichia coli LF82 aggravates colitis in injured mouse colon via signaling by flagellin
Carvalho, F. A., Barnich, N., Sauvanet, P., Darcha, C., Gelot, A., & Darfeuille–Michaud, A. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20423 · Cited by 130
Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive Escherichia coli invasion
Rolhion, N., Barnich, N., Bringer, M.-A., Glasser, A.-L., Ranc, J., Hébuterne, X., Hofman, P. M., & Darfeuille–Michaud, A. (2010) · Gut · doi:10.1136/gut.2010.207456 · Cited by 147
Metabolic adaptation of human pathogenic and related nonpathogenic bacteria to extra- and intracellular habitats
Fuchs, T. M., Eisenreich, W., Heesemann, J., & Goebel, W. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00301.x · Cited by 132
Higher Prevalence and Abundance of Bdellovibrio bacteriovorus in the Human Gut of Healthy Subjects
Iebba, V., Santangelo, F., Totino, V., Nicoletti, M., Gagliardi, A., Biase, R. V. D., Cucchiara, S., Nencioni, L., Conte, M. P., & Schippa, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061608 · Cited by 122
Self-citation
Real-Time Analysis of Mucosal Flora in Patients with Inflammatory Bowel Disease in India
Verma, R., Verma, A. K., Ahuja, V., & Paul, J. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01360-10 · Cited by 124
Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation
Wu, R., Xiong, R., Li, Y., Chen, J., & Yan, R. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103062 · Cited by 124
Relationship between gut microbiota and development of T cell associated disease
Kosiewicz, M. M., Dryden, G. W., Chhabra, A., & Alard, P. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.019 · Cited by 120
Cross-Sectional and Longitudinal Comparisons of the Predominant Fecal Microbiota Compositions of a Group of Pediatric Patients with Cystic Fibrosis and Their Healthy Siblings
Duytschaever, G., Huys, G., Bekaert, M., Boulanger, L., De Boeck, K., & Vandamme, P. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05933-11 · Cited by 114
Immune aspects of the pathogenesis of inflammatory bowel disease
Hisamatsu, T., Kanai∥, T., Mikami, Y., Yoneno∥, K., Matsuoka, K., & Hibi∥, T. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.10.008 · Cited by 117
Bacterial-mucosal interactions in inflammatory bowel disease—an alliance gone bad
Chichlowski, M., & Hale, L. P. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90516.2008 · Cited by 114
Terminal restriction fragment length polymorphism analysis of the diversity of fecal microbiota in patients with ulcerative colitis
Andoh, A., Sakata, S., Koizumi, Y., Mitsuyama, K., Fujiyama, Y., & Benno, Y. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20151 · Cited by 113
Understanding How Commensal Obligate Anaerobic Bacteria Regulate Immune Functions in the Large Intestine
Maier, E., Anderson, R. C., & Roy, N. C. (2014) · Nutrients · doi:10.3390/nu7010045 · Cited by 123
Microbial Factors Associated with Postoperative Crohn’s Disease Recurrence
Wright, E. K., Kamm, M. A., Wagner, J., Teo, S. M., Cruz, P. P. D., Hamilton, A. L., Ritchie, K. J., Inouye, M., & Kirkwood, C. D. (2016) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjw136 · Cited by 112
Crohn disease: A current perspective on genetics, autophagy and immunity
Stappenbeck, T. S., Rioux, J. D., Mizoguchi, A., Saitoh, T., Huett, A. S., Darfeuille–Michaud, A., Wileman, T., Mizushima, N., Carding, S. R., Parkes, M., et al. (2011) · Autophagy · doi:10.4161/auto.7.4.13074 · Cited by 113
Characterization of adherent-invasive Escherichia coli isolated from pediatric patients with inflammatory bowel disease
Negroni, A., Costanzo, M., Vitali, R., Superti, F., Bertuccini, L., Tinari, A., Minelli, F., Nardo, G. D., Nuti, F., Pierdomenico, M., et al. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21899 · Cited by 109
Self-citation
Characterization of Adherent Bacteroidales from Intestinal Biopsies of Children and Young Adults with Inflammatory Bowel Disease
Zitomersky, N. L., Atkinson, B. J., Franklin, S. W., Mitchell, P. D., Snapper, S. B., Comstock, L. E., & Bousvaros, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063686 · Cited by 112
Functional Metagenomics Reveals Novel Pathways of Prebiotic Breakdown by Human Gut Bacteria
Cecchini, D. A., Laville, É., Laguerre, S., Robe, P., Leclerc, M., Dore, J. M., Henrissat, B., Remaud‐Siméon, M., MONSAN, P. F., & Potocki-Véronèse, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072766 · Cited by 115
Characterization of bacterial community shift in human Ulcerative Colitis patients revealed by Illumina based 16S rRNA gene amplicon sequencing
Walujkar, S. A., Dhotre, D. P., Marathe, N. P., Lawate, P. S., Bharadwaj, R. S., & Shouche, Y. S. (2014) · Gut Pathogens · doi:10.1186/1757-4749-6-22 · Cited by 107

Authors: Conte, M. P., Schippa, S., Zamboni, I., Penta, M., Chiarini, F., Seganti, L., Osborn, J., Falconieri, P., Borrelli, O., & Cucchiara, S.
Affiliations: Policlinico Umberto I (IT)
Corresponding author: Cucchiara, S
ORCID: Conte, M P
Schippa, S
Borrelli, O
Cucchiara, S
Venue: Gut
Publisher: BMJ
Published: 2006-04-28
Volume: 55
Issue: 12
Pages: 1760-1767
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.2005.078824
PMC: PMC1856471
OpenAlex: W2152822836
Cited by: 383
References: 51
Citations by year: 2026: 4 · 2025: 7 · 2024: 8 · 2023: 15 · 2022: 14 · 2021: 23 · 2020: 13 · 2019: 23 · 2018: 12 · 2017: 17 · 2016: 19 · 2015: 25 · 2014: 27 · 2013: 23 · 2012: 20
FWCI: 9.51
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders: Ministero dell’Istruzione, dell’Università e della Ricerca
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
Keywords: inflammatory bowel disease, pediatric patients, gut microbiota, mucosa-associated bacteria, Crohn's disease, ulcerative colitis, indeterminate colitis, Bacteroides vulgatus, anaerobic bacteria, colonoscopic biopsy, 16S rRNA
MeSH terms: Adolescent, Bacteria, Aerobic, Bacteria, Anaerobic, Bacteroides, Cecum, Child, Child, Preschool, Colitis, Colitis, Ulcerative, Crohn Disease, DNA, Bacterial, Humans, Hyperplasia, Ileum, Intestinal Mucosa, Rectum, Inflammatory Bowel Diseases, Polymerase Chain Reaction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks