Cited by 681Gut microbiota and healthGastrointestinal motility and disordersMicrobial Metabolites in Food Biotechnology

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Diets that differ in their FODMAP content alter the colonic luminal microenvironment

Open access

Halmos, Emma P, Christophersen, Claus T, Bird, Anthony R, Shepherd, Susan J, Gibson, Peter R, Muir, Jane G·2015·Gut

DOI 10.1136/gutjnl-2014-307264

Open this paper in CoChat — free account Open PDF

Abstract

Objective: A low FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols) diet reduces symptoms of IBS, but reduction of potential prebiotic and fermentative effects might adversely affect the colonic microenvironment. The effects of a low FODMAP diet with a typical Australian diet on biomarkers of colonic health were compared in a single-blinded, randomised, cross-over trial. Design: Twenty-seven IBS and six healthy subjects were randomly allocated one of two 21-day provided diets, differing only in FODMAP content (mean (95% CI) low 3.05 (1.86 to 4.25) g/day vs Australian 23.7 (16.9 to 30.6) g/day), and then crossed over to the other diet with ≥21-day washout period. Faeces passed over a 5-day run-in on their habitual diet and from day 17 to day 21 of the interventional diets were pooled, and pH, short-chain fatty acid concentrations and bacterial abundance and diversity were assessed. Results: Faecal indices were similar in IBS and healthy subjects during habitual diets. The low FODMAP diet was associated with higher faecal pH (7.37 (7.23 to 7.51) vs 7.16 (7.02 to 7.30); p=0.001), similar short-chain fatty acid concentrations, greater microbial diversity and reduced total bacterial abundance (9.63 (9.53 to 9.73) vs 9.83 (9.72 to 9.93) log 10 copies/g; p<0.001) compared with the Australian diet. To indicate direction of change, in comparison with the habitual diet the low FODMAP diet reduced total bacterial abundance and the typical Australian diet increased relative abundance for butyrate-producing Clostridium cluster XIVa (median ratio 6.62; p<0.001) and mucus-associated Akkermansia muciniphila (19.3; p<0.001), and reduced Ruminococcus torques . Conclusions: Diets differing in FODMAP content have marked effects on gut microbiota composition. The implications of long-term reduction of intake of FODMAPs require elucidation. Trial registration number: ACTRN12612001185853.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/gutjnl-2014-307264

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511
Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091
Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
Manichanh, C., Rigottier-Gois, L., Bonnaud, E., Gloux, K., Pelletier, E., Frangeul, L., Nalin, R., Jarrin, C., Chardon, P., Marteau, P., et al. (2006) · Gut · doi:10.1136/gut.2005.073817 · Cited by 2,277
Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium
Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094
Improved extraction of PCR-quality community DNA from digesta and fecal samples
Yu, Z., & Morrison, M. (2004) · BioTechniques · doi:10.2144/04365st04 · Cited by 1,663
Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria
Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364
A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome
Halmos, E. P., Power, V. A., Shepherd, S. J., Gibson, P. R., & Muir, J. G. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.09.046 · Cited by 1,249
Self-citation
Utilization of Nutrients by Isolated Epithelial Cells of the Rat Colon
Roediger, W. E. W. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80339-9 · Cited by 1,187
Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives
Joossens, M., Huys, G., Cnockaert, M., De Preter, V., Verbeke, K., Rutgeerts, P., Vandamme, P., & Vermeire, S. (2011) · Gut · doi:10.1136/gut.2010.223263 · Cited by 1,063
Relevance of protein fermentation to gut health
Windey, K., De Preter, V., & Verbeke, K. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100542 · Cited by 692

Show all 37 references

Sorted by citations

Gut microbiota functions: metabolism of nutrients and other food components
Rowland, I., Gibson, G., Heinken, A., Scott, K., Swann, J., Thiele, I., & Tuohy, K. (2018) · European Journal of Nutrition · doi:10.1007/s00394-017-1445-8 · Cited by 2,878
Influence of diet on the gut microbiome and implications for human health
Singh, R. K., Chang, H.-W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1175-y · Cited by 2,599
Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health
Ríos-Covián, D., Ruas‐Madiedo, P., Margollés, A., Gueimonde, M., Reyes‐Gavilán, C. G. D. L., & Salazar, N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00185 · Cited by 2,300
Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology
Dao, M. C., Everard, A., Aron-Wisnewsky, J., Sokolovska, N., Prifti, E., Verger, E. O., Kayser, B. D., Levenez, F., Chilloux, J., Hoyles, L., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308778 · Cited by 1,931
The gut microbiome in health and in disease
Shreiner, A. B., Kao, J. Y., & Young, V. B. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000139 · Cited by 1,764
Gut Microbiome: Profound Implications for Diet and Disease
Hills, R. D., Pontefract, B., Mishcon, H. R., Black, C. A., Sutton, S. C., & Theberge, C. R. (2019) · Nutrients · doi:10.3390/nu11071613 · Cited by 1,143
Akkermansia muciniphila and its role in regulating host functions
Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044
Irritable bowel syndrome
Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,102
Irritable bowel syndrome
Ford, A. C., Sperber, A. D., Corsetti, M., & Camilleri, M. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31548-8 · Cited by 818
Microbiota-Brain-Gut Axis and Neurodegenerative Diseases
Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804
Review article: dietary fibre-microbiota interactions
Simpson, H. L., & Campbell, B. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13248 · Cited by 602
Global burden of irritable bowel syndrome: trends, predictions and risk factors
Black, C. J., & Ford, A. C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0286-8 · Cited by 666
Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome as Well as Traditional Dietary Advice: A Randomized Controlled Trial
Böhn, L., Störsrud, S., Liljebo, T. M., Collin, L., Lindfors, P., Törnblom, H., & Simrén, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.07.054 · Cited by 628
Irritable Bowel Syndrome
Ford, A. C., Lacy, B. E., & Talley, N. J. (2017) · New England Journal of Medicine · doi:10.1056/nejmra1607547 · Cited by 626
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
Vasant, D. H., Paine, P. A., Black, C. J., Houghton, L. A., Everitt, H. A., Corsetti, M., Agrawal, A., Aziz, I., Farmer, A. D., Eugenicos, M. P., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-324598 · Cited by 592
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota
Karl, J. P., Hatch‐McChesney, A., Arcidiacono, S. M., Pearce, S., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 563
FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial
McIntosh, K., Reed, D. E., Schneider, T., Dang, F., Keshteli, A. H., Palma, G. D., Madsen, K. L., Berčík, P., & Vanner, S. J. (2016) · Gut · doi:10.1136/gutjnl-2015-311339 · Cited by 495
Randomised clinical trial: gut microbiome biomarkers are associated with clinical response to a low FODMAP diet in children with the irritable bowel syndrome
Chumpitazi, B. P., Cope, J. L., Hollister, E. B., Tsai, C. M., McMeans, A. R., Luna, R. A., Versalovic, J., & Shulman, R. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13286 · Cited by 436
A diet low in FODMAPs reduces symptoms in patients with irritable bowel syndrome and a probiotic restores bifidobacterium species: a randomized controlled trial
Staudacher, H. M., Lomer, M. C. E., Farquharson, F. M., Louis, P., Fava, F., Franciosi, E., Scholz, M., Tuohy, K. M., Lindsay, J. O., Irving, P. M., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.06.010 · Cited by 430
Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity
Skodje, G. I., Sarna, V. K., Minelle, I. H., Rolfsen, K. L., Muir, J. G., Gibson, P. R., Veierød, M. B., Henriksen, C., & Lundin, K. E. A. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.10.040 · Cited by 425
Self-citation
American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome
Ford, A. C., Moayyedi, P., Chey, W. D., Harris, L. A., Lacy, B. E., Saito, Y. A., & Quigley, E. M. M. (2018) · American Journal of Gastroenterology · doi:10.1038/s41395-018-0084-x · Cited by 388
Systematic review: exercise‐induced gastrointestinal syndrome—implications for health and intestinal disease
Costa, R. J. S., Snipe, R. M. J., Kitic, C. M., & Gibson, P. R. (2017) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14157 · Cited by 450
Self-citation
Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation
Parthasarathy, G., Chen, J., Chen, X., Chia, N., O'Connor, H. M., Wolf, P. G., Gaskins, H. R., & Bharucha, A. E. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.10.005 · Cited by 396
Stress and the Microbiota–Gut–Brain Axis in Visceral Pain: Relevance to Irritable Bowel Syndrome
Moloney, R. D., Johnson, A. C., O’Mahony, S. M., Dinan, T. G., Meerveld, B. G., & Cryan, J. F. (2015) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12490 · Cited by 412
The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS
Staudacher, H. M., & Whelan, K. (2017) · Gut · doi:10.1136/gutjnl-2017-313750 · Cited by 420
Does a diet low in FODMAPs reduce symptoms associated with functional gastrointestinal disorders? A comprehensive systematic review and meta-analysis
Marsh, A., Eslick, E. M., & Eslick, G. D. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0922-1 · Cited by 385
Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial
Cox, S. R., Lindsay, J. O., Fromentin, S., Stagg, A. J., McCarthy, N. E., Galleron, N., Ibraim, S. B., Roume, H., Levenez, F., Pons, N., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.09.024 · Cited by 386
A Randomized Controlled Trial Comparing the Low FODMAP Diet vs. Modified NICE Guidelines in US Adults with IBS-D
Eswaran, S., Chey, W., Han-Markey, T., Ball, S., & Jackson, K. (2016) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.434 · Cited by 369
Diet as a Trigger or Therapy for Inflammatory Bowel Diseases
Lewis, J. D., & Abreu, M. T. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.10.019 · Cited by 396
Intestinal microbiota and diet in IBS: causes, consequences, or epiphenomena?
Rajilić-Stojanović, M., Jonkers, D. M., Salonen, A., Hanevik, K., Raes, J., Jalanka, J., de Vos, W. M., Manichanh, C., Golic, N., Enck, P., et al. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.427 · Cited by 359
Efficacy of a low FODMAP diet in irritable bowel syndrome: systematic review and network meta-analysis
Black, C. J., Staudacher, H. M., & Ford, A. C. (2021) · Gut · doi:10.1136/gutjnl-2021-325214 · Cited by 380
The influence of the brain–gut axis in inflammatory bowel disease and possible implications for treatment
Gracie, D. J., Hamlin, P. J., & Ford, A. C. (2019) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(19)30089-5 · Cited by 362
British Dietetic Association systematic review and evidence‐based practice guidelines for the dietary management of irritable bowel syndrome in adults (2016 update)
McKenzie, Y. A., Bowyer, R. K., Leach, H., Gulia, P., Horobin, J., O'Sullivan, N.-A., Pettitt, C., Reeves, L., Seamark, L., Williams, M., et al. (2016) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12385 · Cited by 374
Systematic review: dietary fibre and FODMAP‐restricted diet in the management of constipation and irritable bowel syndrome
Rao, S. S. C., Yu, S., & Fedewa, A. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13167 · Cited by 343
Lactose Intolerance in Adults: Biological Mechanism and Dietary Management
Deng, Y., Misselwitz, B., Dai, N., & Fox, M. R. (2015) · Nutrients · doi:10.3390/nu7095380 · Cited by 349
The Intestinal Microenvironment and Functional Gastrointestinal Disorders
Barbara, G., Feinle-Bisset, C., Ghoshal, U. C., Santos, J., Vanner, S. J., Vergnolle, N., Zoetendal, E. G., & Quigley, E. M. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.02.028 · Cited by 335
Nonceliac Gluten Sensitivity
Fasano, A., Sapone, A., Zevallos, V. F., & Schuppan, D. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.049 · Cited by 331
Gut microbiota role in irritable bowel syndrome: New therapeutic strategies
Distrutti, E., Monaldi, L., Ricci, P., & Fiorucci, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i7.2219 · Cited by 320
The Role of Gut Microbiota in Intestinal Inflammation with Respect to Diet and Extrinsic Stressors
Lobionda, S., Sittipo, P., Kwon, H. Y., & Lee, Y. K. (2019) · Microorganisms · doi:10.3390/microorganisms7080271 · Cited by 326
Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies
Zhou, K. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.03.045 · Cited by 309
Irritable Bowel Syndrome
Phillips, S. F., Camilleri, M., & Talley, N. J. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-0790-4.00038-x · Cited by 298
Interindividual variability in gut microbiota and host response to dietary interventions
Healey, G. R., Murphy, R., Brough, L., Butts, C. A., & Coad, J. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux062 · Cited by 306
Irritable bowel syndrome: a gut microbiota-related disorder?
Bhattarai, Y., Muniz Pedrogo, D. A., & Kashyap, P. C. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2016 · Cited by 294
The low FODMAP diet in the management of irritable bowel syndrome: an evidence‐based review of FODMAP restriction, reintroduction and personalisation in clinical practice
Whelan, K., Martin, L. D., Staudacher, H. M., & Lomer, M. C. E. (2018) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12530 · Cited by 322
Microbiota in the Gastrointestinal Tract
Dieterich, W., Schink, M., & Zopf, Y. (2018) · Medical Sciences · doi:10.3390/medsci6040116 · Cited by 292
Effects of high doses of vitamin D3 on mucosa-associated gut microbiome vary between regions of the human gastrointestinal tract
Bashir, M., Prietl, B., Tauschmann, M., Mautner, S., Kump, P. K., Treiber, G. M., Wurm, P., Gorkiewicz, G., Högenauer, C., & Pieber, T. R. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-0966-2 · Cited by 262
Irritable bowel syndrome, the microbiota and the gut-brain axis
Raskov, H., Burcharth, J., Pommergaard, H.-C., & Rosenberg, J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1218585 · Cited by 243
The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update
Catassi, C., Alaedini, A., Bojarski, C., Bonaz, B. L., Bouma, G., Carroccio, A., Castillejo, G., de Magistris, L., Dieterich, W., Liberto, D. D., et al. (2017) · Nutrients · doi:10.3390/nu9111268 · Cited by 249
FODMAPs: food composition, defining cutoff values and international application
Varney, J. E., Barrett, J. S., Scarlata, K., Catsos, P., Gibson, P. R., & Muir, J. G. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13698 · Cited by 232
Self-citation
Multivariate modelling of faecal bacterial profiles of patients with IBS predicts responsiveness to a diet low in FODMAPs
Bennet, S. M. P., Böhn, L., Störsrud, S., Liljebo, T., Collin, L., Lindfors, P., Törnblom, H., Öhman, L., & Simrén, M. (2018) · Gut · doi:10.1136/gutjnl-2016-313128 · Cited by 225
The role of the gut microbiota in dietary interventions for depression and anxiety
Bear, T. L. K., Dalziel, J. E., Coad, J., Roy, N. C., Butts, C. A., & Gopal, P. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa016 · Cited by 229
Polysaccharides: bowel health and gut microbiota
Do, M. H., Seo, Y.-S., & Park, H. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1755949 · Cited by 231
Low fermentable, oligo-, di-, mono-saccharides and polyol diet in the treatment of irritable bowel syndrome: A systematic review and meta-analysis
Schumann, D., Klose, P., Lauche, R., Dobos, G., Langhorst, J., & Cramer, H. (2017) · Nutrition · doi:10.1016/j.nut.2017.07.004 · Cited by 228
Effects of varying dietary content of fermentable short‐chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome
Hustoft, T. N., Hausken, T., Ystad, S. O., Valeur, J., Brokstad, K. A., Hatlebakk, J. G., & Lied, G. A. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12969 · Cited by 220
A Review of Microbiota and Irritable Bowel Syndrome: Future in Therapies
Rodiño‐Janeiro, B. K., Vicario, M., Alonso, C., Pascua-García, R., & Santos, J. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0673-5 · Cited by 223
Low FODMAP Diet: Evidence, Doubts, and Hopes
Bellini, M., Tonarelli, S., Nagy, A., Pancetti, A., Costa, F., Ricchiuti, A., de Bortoli, N., Mosca, M., Marchi, S., & Rossi, A. (2020) · Nutrients · doi:10.3390/nu12010148 · Cited by 239
Fecal Microbiota Transplantation Reduces Symptoms in Some Patients With Irritable Bowel Syndrome With Predominant Abdominal Bloating: Short- and Long-term Results From a Placebo-Controlled Randomized Trial
Holvoet, T., Joossens, M., Vázquez-Castellanos, J. F., Christiaens, E., Heyerick, L., Boelens, J., Verhasselt, B., van Vlierberghe, H., De Vos, M., Raes, J., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.07.013 · Cited by 201
Consistent Prebiotic Effect on Gut Microbiota With Altered FODMAP Intake in Patients with Crohn's Disease: A Randomised, Controlled Cross-Over Trial of Well-Defined Diets
Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S., Muir, J. G., & Gibson, P. R. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.22 · Cited by 212
Self-citation
Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease
Pedersen, N. K., Ankersen, D. V., Felding, M., Wachmann, H., Végh, Z., Molzen, L., Burisch, J. M., Andersen, J. R., & Munkholm, P. S. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i18.3356 · Cited by 210
Dietary Factors and Modulation of Bacteria Strains of Akkermansia muciniphila and Faecalibacterium prausnitzii: A Systematic Review
Verhoog, S., Taneri, P. E., Roa‐Díaz, Z. M., Marques-Vidal, P. M., Troup, J. P., Bally, L., Franco, O. H., Glišić, M., & Muka, T. (2019) · Nutrients · doi:10.3390/nu11071565 · Cited by 212
FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction
Zhou, S.-Y., Gillilland, M. G., Wu, X., Leelasinjaroen, P., Zhang, G., Zhou, H. R., Ye, B., Lu, Y., & Owyang, C. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92390 · Cited by 215
Gut microbiota and colorectal cancer
Gao, R., Gao, Z., Huang, L., & Qin, H. (2017) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-016-2881-8 · Cited by 205
Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Irritable Bowel Syndrome (IBS)
Moayyedi, P., Andrews, C. N., MacQUEEN, G. M., Korownyk, C. S., Marsiglio, M., Graff, L. A., Kvern, B. L., Lazarescu, A., Liu, L., Paterson, W. G., et al. (2019) · Journal of the Canadian Association of Gastroenterology · doi:10.1093/jcag/gwy071 · Cited by 216
Food Components and Irritable Bowel Syndrome
Gibson, P. R., Varney, J. E., Malakar, S., & Muir, J. G. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.005 · Cited by 194
Self-citation
Efficacy of the low FODMAP diet for treating irritable bowel syndrome: the evidence to date
Gearry, R. B., Skidmore, P. M. L., O’Brien, L., WILKINSON, T. J., & Nanayakkara, W. (2016) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s86798 · Cited by 195
The gluten-free/casein-free diet: a double-blind challenge trial in children with autism
Hyman, S. L., Stewart, P. A., Foley, J., Cain, U., Peck, R., Morris, D. D., Wang, H., & Smith, T. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2564-9 · Cited by 192
Sensitivity to wheat, gluten and FODMAPs in IBS: facts or fiction?
GIORGIO, R. D., Volta, U., & Gibson, P. R. (2015) · Gut · doi:10.1136/gutjnl-2015-309757 · Cited by 199
Self-citation
Fermentable Carbohydrate Restriction (Low FODMAP Diet) in Clinical Practice Improves Functional Gastrointestinal Symptoms in Patients with Inflammatory Bowel Disease
Prince, A. C., Myers, C. E., Joyce, T., Irving, P. M., Lomer, M. C. E., & Whelan, K. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000708 · Cited by 190
Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns
Gargano, D., Appanna, R., Santonicola, A., Bartolomeis, F. D., Stellato, C., Cianferoni, A., Casolaro, V., & Iovino, P. (2021) · Nutrients · doi:10.3390/nu13051638 · Cited by 207
Crosstalk at the mucosal border: importance of the gut microenvironment in IBS
Öhman, L., Törnblom, H., & Simrén, M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.200 · Cited by 185
Host-microbial Cross-talk in Inflammatory Bowel Disease
Nagao‐Kitamoto, H., & Kamada, N. (2017) · Immune Network · doi:10.4110/in.2017.17.1.1 · Cited by 185
The gut microbiota as a novel regulator of cardiovascular function and disease
Battson, M. L., Lee, D. M., Weir, T. L., & Gentile, C. L. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.12.010 · Cited by 191
Dietary interventions for induction and maintenance of remission in inflammatory bowel disease
Limketkai, B. N., Iheozor‐Ejiofor, Z., Gjuladin-Hellon, T., Parian, A. M., Matarese, L. E., Bracewell, K., MacDonald, J. K., Gordon, M. A., & Mullin, G. E. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012839.pub2 · Cited by 182
Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?
Jian, H., Liu, Y., Wang, X., Dong, X., & Zou, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043900 · Cited by 186
Pathogenic role of the gut microbiota in gastrointestinal diseases
Nagao‐Kitamoto, H., Kitamoto, S., Kuffa, P., & Kamada, N. (2016) · Intestinal Research · doi:10.5217/ir.2016.14.2.127 · Cited by 178
Recent findings in Akkermansia muciniphila-regulated metabolism and its role in intestinal diseases
Liu, M., Yang, J.-Y., Yan, Z.-H., Hu, S., Li, J.-Q., Xu, Z., & Jian, Y. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.08.029 · Cited by 176
The gut microbiome and irritable bowel syndrome
Menees, S., & Chey, W. (2018) · F1000Research · doi:10.12688/f1000research.14592.1 · Cited by 159
“Recent studies have demonstrated reductions in potentially beneficial fecal bifidobacteria and butyrate levels in IBS patients on a low-FODMAP diet 61 .”
Background
Probiotics, fibre and herbal medicinal products for functional and inflammatory bowel disorders
Currò, D., Ianiro, G., Pecere, S., Bibbò, S., & Cammarota, G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13632 · Cited by 160
The gut Microbiome in adult and pediatric functional gastrointestinal disorders
Shin, A., Preidis, G. A., Shulman, R., & Kashyap, P. C. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.08.054 · Cited by 163
Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule: influence of age, gender, study country and testing protocol
Wang, Y., Mohammed, S. D., Farmer, A. D., Wang, D., Zárate-López, N., Hobson, A. R., Hellström, P. M., Semler, J. R., Kuo, B., Rao, S. S. C., et al. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13329 · Cited by 162
A Systematic Review of the Effects of Polyols on Gastrointestinal Health and Irritable Bowel Syndrome
Lenhart, A., & Chey, W. D. (2017) · Advances in Nutrition · doi:10.3945/an.117.015560 · Cited by 160
How to Test and Treat Small Intestinal Bacterial Overgrowth: an Evidence-Based Approach
Rezaie, A. R., Pimentel, M., & Rao, S. S. C. (2016) · Current Gastroenterology Reports · doi:10.1007/s11894-015-0482-9 · Cited by 160
Randomised clinical trial: the efficacy of gut‐directed hypnotherapy is similar to that of the low FODMAP diet for the treatment of irritable bowel syndrome
Peters, S. L., Yao, C. K., Philpott, H., Yelland, G. W., Muir, J. G., & Gibson, P. R. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13706 · Cited by 158
Self-citation
Dietary and pharmacological treatment of abdominal pain in IBS
Camilleri, M., & Boeckxstaens, G. E. (2017) · Gut · doi:10.1136/gutjnl-2016-313425 · Cited by 165
Diet in irritable bowel syndrome: What to recommend, not what to forbid to patients!
Cozma-Petruț, A. P., Loghin, F., Miere, D., & Dumitrascu, D. L. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i21.3771 · Cited by 158
Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis
Person, H., & Keefer, L. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110209 · Cited by 158
Behavioral and Diet Therapies in Integrated Care for Patients With Irritable Bowel Syndrome
Chey, W. D., Keefer, L., Whelan, K., & Gibson, P. R. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.06.099 · Cited by 154
Self-citation
Review article: the aetiology, diagnosis, mechanisms and clinical evidence for food intolerance
Lomer, M. C. E. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13041 · Cited by 152
Diet, Microbiota, and Metabolic Health: Trade-Off Between Saccharolytic and Proteolytic Fermentation
Korpela, K. (2018) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-030117-012830 · Cited by 161
Controversies and Recent Developments of the Low-FODMAP Diet.
Hill, P., Muir, J. G., & Gibson, P. R. (2017) · PubMed · Cited by 155
Self-citation
Diet in Irritable Bowel Syndrome (IBS): Interaction with Gut Microbiota and Gut Hormones
El‐Salhy, M., Hatlebakk, J. G., & Hausken, T. (2019) · Nutrients · doi:10.3390/nu11081824 · Cited by 160
Non-Celiac Gluten Sensitivity Has Narrowed the Spectrum of Irritable Bowel Syndrome: A Double-Blind Randomized Placebo-Controlled Trial
Shahbazkhani, B., Sadeghi, A., Malekzadeh, R., Khatavi, F., Etemadi, M., Kalantri, E., Rostami‐Nejad, M., & Rostami, K. (2015) · Nutrients · doi:10.3390/nu7064542 · Cited by 149
Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs
Harvie, R. M., Chisholm, A. W., Bisanz, J. E., Burton, J. P., Herbison, P., Schultz, K., & Schultz, M. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i25.4632 · Cited by 143
Involvement of Reduced Microbial Diversity in Inflammatory Bowel Disease
Gong, D., Gong, X., Wang, L., Yu, X., & Dong, Q. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/6951091 · Cited by 144
Food Intolerances
Tuck, C. J., Biesiekierski, J. R., Schmid‐Grendelmeier, P., & Pohl, D. (2019) · Nutrients · doi:10.3390/nu11071684 · Cited by 156
Mechanistic Insights Into Probiotic Properties of Lactic Acid Bacteria Associated With Ethnic Fermented Dairy Products
Ghosh, T., Beniwal, A., Semwal, A., & Navani, N. K. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00502 · Cited by 148
Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis
van Lanen, A., de Bree, A., & Greyling, A. (2021) · European Journal of Nutrition · doi:10.1007/s00394-020-02473-0 · Cited by 151
Follow-up of patients with functional bowel symptoms treated with a low FODMAP diet
Maagaard, L., Ankersen, D. V., Végh, Z., Burisch, J. M., Jensen, L., Pedersen, N. K., & Munkholm, P. S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i15.4009 · Cited by 140
New treatments and therapeutic targets for IBS and other functional bowel disorders
Simrén, M., & Tack, J. F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0034-5 · Cited by 150
Alterations in fecal short-chain fatty acids in patients with irritable bowel syndrome
Sun, Q., Jia, Q., Song, L., & Duan, L. (2019) · Medicine · doi:10.1097/md.0000000000014513 · Cited by 141

Authors: Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S. J., Gibson, P. R., & Muir, J. G.
Affiliations: The Alfred Hospital (AU)
Commonwealth Scientific and Industrial Research Organisation (AU)
Eastern Health (AU)
Corresponding author: Halmos, Emma P
ORCID: Halmos, Emma P
Christophersen, Claus T
Bird, Anthony R
Shepherd, Susan J
Muir, Jane G
Venue: Gut
Publisher: BMJ
Published: 2014-07-12
Volume: 64
Issue: 1
Pages: 93-100
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gutjnl-2014-307264
OpenAlex: W2167428741
Cited by: 681
References: 37
Citations by year: 2026: 21 · 2025: 31 · 2024: 37 · 2023: 45 · 2022: 56 · 2021: 64 · 2020: 63 · 2019: 76 · 2018: 66 · 2017: 87 · 2016: 79 · 2015: 47 · 2014: 8
FWCI: 30.18
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed (publishedVersion)
Research Online (Edith Cowan University) (submittedVersion)
eSpace (Curtin University) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Commonwealth Scientific and Industrial Research Organisation
Monash University
Medical Research Council
National Health and Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: low FODMAP diet, FODMAPs, irritable bowel syndrome, gut microbiota, fecal pH, short-chain fatty acids, butyrate-producing bacteria, Clostridium cluster XIVa, Akkermansia muciniphila, Ruminococcus torques, dietary intervention, prebiotics
MeSH terms: Adult, Colon, Diet, Disaccharides, Feces, Female, Fermentation, Humans, Male, Middle Aged, Monosaccharides, Oligosaccharides, Single-Blind Method, Cross-Over Studies, Irritable Bowel Syndrome, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Diets that differ in their FODMAP content alter the colonic luminal microenvironment

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks