The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Stress- and Allostasis-Induced Brain Plasticity
Open accessAbstract
The brain is the key organ of stress processes. It determines what individuals will experience as stressful, it orchestrates how individuals will cope with stressful experiences, and it changes both functionally and structurally as a result of stressful experiences. Within the brain, a distributed, dynamic, and plastic neural circuitry coordinates, monitors, and calibrates behavioral and physiological stress response systems to meet the demands imposed by particular stressors. These allodynamic processes can be adaptive in the short term (allostasis) and maladaptive in the long term (allostatic load). Critically, these processes involve bidirectional signaling between the brain and body. Consequently, allostasis and allostatic load can jointly affect vulnerability to brain-dependent and stress-related mental and physical health conditions. This review focuses on the role of brain plasticity in adaptation to, and pathophysiology resulting from, stressful experiences. It also considers interventions to prevent and treat chronic and prevalent health conditions via allodynamic brain mechanisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“environmental conditions and interpersonal interactions, both positive and negative, are embedded biologically, shaping or canalizing the development of brain and behavior”
From School Readiness and Self-Regulation: A Developmental Psychobiological Approach (2015) · cites this paper as McEwen & Gianaros 2011
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Extensive literature links ELA to pervasive, quantifiable variation in brain structure and function [15, 21, 24, 25].”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [15]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Importantly, HPA hyper- and hypo-reactivity both represent prototypical patterns associated with excess allostatic load, and both predict human stress-related chronic illnesses, including cardiovascular, metabolic, and psychiatric diseases linked epidemiologically to ELA [15, 29, 48].”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [15]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Such an approach facilitates the synthesis of complex evidence for application, and is supported by observed dose–response effects linking cumulative early adversity to later outcomes [1, 3, 5], and by the “allostatic load” paradigm exploring pathogenic effects of cumulative all-cause stress [15].”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [15]
The cited source says what the claim attributes to it.
In the citing paper
“However, chronic or excessive activation contributes to the pathogenic physiological “wear and tear” described within the allostatic load paradigm [15, 29].”
From Biological embedding of childhood adversity: from physiological mechanisms to clinical implications (2017) · cites this paper as [15]
In the citing paper
“These experience-dependent mechanisms regulate the sensitivity and plasticity of the central nervous system and act at several biological levels (likely partly in parallel with each other): i) cellular changes such as neurogenesis, pruning and sprouting of synapses, myelination of axons and alterations to the number of dendritic spines9, 10, ii) subcellular changes, such as alterations to the”
From Resilience in mental health: linking psychological and neurobiological perspectives. (2013) · cites this paper as [9]
In the citing paper
“The shape of the inverted U differs by many factors including sex, strain, and behavioral domain in question (Fig. 2).”
From Neurobiology of resilience (2012) · cites this paper as [50]
In the citing paper
“McEwen and colleagues systematically measured the type, length, and quality of stress experience on multiple rat behaviors and found that stress affects most behavioral domains with an inverted U–shape curve, where low and high levels of stress both impair behavior, while intermediate levels actually promote positive coping responses (for review see50).”
From Neurobiology of resilience (2012) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Eysenck, H. J. (1985) · Behaviour Research and Therapy · doi:10.1016/0005-7967(85)90087-7 · Cited by 32,038
“Stress: appraisal and coping,”
Folkman, S. (2013) · Encyclopedia of Behavioral Medicine · doi:10.1007/978-1-4419-1005-9_215 · Cited by 27,833
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733
Self-citationPhysiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429
Self-citationTracey, K. J. (2002) · Nature · doi:10.1038/nature01321 · Cited by 3,728
Psychological Stress and Disease
Cohen, S., Janicki-Deverts, D., & Miller, G. E. (2007) · JAMA · doi:10.1001/jama.298.14.1685 · Cited by 3,168
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,343
Self-citationAerobic Exercise Training Increases Brain Volume in Aging Humans
Colcombe, S. J., Erickson, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., Elavsky, S., Marquez, D. X., Hu, L., & Kramer, A. F. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.11.1166 · Cited by 2,134
Research works printed but not linked: 3
- 10.1001/archinte.153.18.2093 · DOI · Paper page
- 10.1210/edrv-7-3-284 · DOI · Paper page
- Charney DS, 2004, Science's STKE, 225, 1
Cited by
Sorted by citations
The Lifelong Effects of Early Childhood Adversity and Toxic Stress
Shonkoff, J. P., Garner, A. S., THE COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, C. O. E. C., Siegel, B. S., Dobbins, M. I., Earls, M. F., Garner, A. S., McGuinn, L., Pascoe, J., & Wood, D. L. (2012) · Pediatrics · doi:10.1542/peds.2011-2663 · Cited by 5,164
The Neuroscience of Mindfulness Meditation
Tang, Y.-Y., Hölzel, B. K., & Posner, M. I. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn3916 · Cited by 2,889
Adverse childhood experiences, allostasis, allostatic load and age-related disease
Danese, A., & McEwen, B. S. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.019 · Cited by 2,140
Self-citationStress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574
Self-citationMechanisms of stress in the brain
McEwen, B. S., Bowles, N. P., Gray, J. D., Hill, M. N., Hunter, R. G., Karatsoreos, I. N., & Nasca, C. (2015) · Nature Neuroscience · doi:10.1038/nn.4086 · Cited by 1,386
Self-citationThe stressed synapse: the impact of stress and glucocorticoids on glutamate transmission
Popoli, M., Yan, Z., McEwen, B. S., & Sanacora, G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3138 · Cited by 1,393
Self-citationSchool Readiness and Self-Regulation: A Developmental Psychobiological Approach
Blair, C., & Raver, C. C. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015221 · Cited by 1,240
Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206
Brain on stress: how the social environment gets under the skin
McEwen, B. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121254109 · Cited by 1,200
Self-citationMore than a feeling: A unified view of stress measurement for population science
Epel, E. S., Crosswell, A. D., Mayer, S. E., Prather, A. A., Slavich, G. M., Puterman, E., & Mendes, W. B. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.03.001 · Cited by 1,077
“This latter finding is important because the hippocampus is replete with glucocorticoid receptors and thus renders the hippocampus at risk for atrophy when exposed to the high doses of glucocorticoids observed in response to prolonged stress in animal models (McEwen, 1999; Sapolsky, 1999), as well as excitatory amino…”
BackgroundThe Brain on Stress: Vulnerability and Plasticity of the Prefrontal Cortex over the Life Course
McEwen, B. S., & Morrison, J. H. (2013) · Neuron · doi:10.1016/j.neuron.2013.06.028 · Cited by 1,079
Self-citationChild Development in the Context of Disaster, War, and Terrorism: Pathways of Risk and Resilience
Masten, A. S., & Narayan, A. J. (2011) · Annual Review of Psychology · doi:10.1146/annurev-psych-120710-100356 · Cited by 1,173
The neuroendocrinology of social isolation
Cacioppo, J. T., Cacioppo, S., Capitanio, J. P., & Cole, S. W. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015240 · Cited by 977
Dynamic adaptation of large-scale brain networks in response to acute stressors
Hermans, E. J., Henckens, M. J. A. G., Joëls, M., & Fernández, G. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.03.006 · Cited by 988
Social influences on neuroplasticity: stress and interventions to promote well-being
Davidson, R. J., & McEwen, B. S. (2012) · Nature Neuroscience · doi:10.1038/nn.3093 · Cited by 892
Self-citationHostinar, C. E., Sullivan, R. M., & Gunnar, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0032671 · Cited by 739
Sex differences in stress-related psychiatric disorders: neurobiological perspectives
Bangasser, D. A., & Valentino, R. J. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.03.008 · Cited by 737
Biological embedding of childhood adversity: from physiological mechanisms to clinical implications
Berens, A. E., Jensen, S. K. G., & Nelson, C. A. (2017) · BMC Medicine · doi:10.1186/s12916-017-0895-4 · Cited by 657
“However, chronic or excessive activation contributes to the pathogenic physiological “wear and tear” described within the allostatic load paradigm [15, 29].”
BackgroundInfluentialUncertainty and stress: Why it causes diseases and how it is mastered by the brain
Peters, A., McEwen, B. S., & Friston, K. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.004 · Cited by 652
“Beliefs about the current states of the world/body, about the attainable states, and about the goal states are proposed to be represented in the lateral PFC, the pre-SMA and the vmPFC/OFC, respectively.”
InfluentialSelf-citationThe Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548
A Systematic Review of Allostatic Load, Health, and Health Disparities
Beckie, T. M. (2012) · Biological Research For Nursing · doi:10.1177/1099800412455688 · Cited by 475
REM sleep dysregulation in depression: state of the art
Palagini, L., Baglioni, C., Ciapparelli, A., Gemignani, A., & Riemann, D. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.11.001 · Cited by 513
Toward understanding how early-life stress reprograms cognitive and emotional brain networks
Chen, Y., & Baram, T. Z. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.181 · Cited by 474
Tol, W. A., Song, S., & Jordans, M. J. D. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12053 · Cited by 497
Social Structure, Adversity, Toxic Stress, and Intergenerational Poverty: An Early Childhood Model
McEwen, C. A., & McEwen, B. S. (2017) · Annual Review of Sociology · doi:10.1146/annurev-soc-060116-053252 · Cited by 472
Self-citationResilience in mental health: linking psychological and neurobiological perspectives.
Rutten, B. P. F., Hammels, C., Geschwind, N., Menne‐Lothmann, C., Pishva, E., Schruers, K., van den Hove, D., Kenis, G., van Os, J., & Wichers, M. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12095 · Cited by 418
LUPIEN, S. J., Juster, R., Raymond, C., & Marin, M. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.02.001 · Cited by 445
Yaffe, K., Falvey, C., Harris, T. B., Newman, A., Satterfield, S., Koster, A., Ayonayon, H., Simonsick, E., & Study, F. T. H. A. (2013) · BMJ · doi:10.1136/bmj.f7051 · Cited by 363
Computations of uncertainty mediate acute stress responses in humans
de Berker, A. O., Rutledge, R. B., Mathys, C., Marshall, L., Cross, G. F., Dolan, R. J., & Bestmann, S. (2016) · Nature Communications · doi:10.1038/ncomms10996 · Cited by 330
Stress and emotional memory: a matter of timing
Joëls, M., Fernández, G., & Roozendaal, B. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.04.004 · Cited by 386
Vella, S., & Pai, N. B. (2019) · Archives of Medicine and Health Sciences · doi:10.4103/amhs.amhs_119_19 · Cited by 450
Borsook, D., Maleki, N., Becerra, L. R., & McEwen, B. S. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.001 · Cited by 370
Self-citationEpigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions
Klengel, T., & Binder, E. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.036 · Cited by 353
Stress and the adolescent brain
Tottenham, N., & Galván, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.030 · Cited by 324
Pregnenolone Can Protect the Brain from Cannabis Intoxication
Vallée, M., Vitiello, S., Bellocchio, L., Hébert-Chatelain, É., Monlezun, S., Martín‐García, E., Kasanetz, F., Baillie, G. L., Panin, F., Cathala, A., et al. (2014) · Science · doi:10.1126/science.1243985 · Cited by 321
Psychological Stress and Mitochondria: A Conceptual Framework
Picard, M. A., & McEwen, B. S. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000544 · Cited by 328
Self-citationCurrent Psychosomatic Practice
Fava, G. A., Cosci, F., & Sonino, N. (2017) · Psychotherapy and Psychosomatics · doi:10.1159/000448856 · Cited by 302
Child and Family Resilience: A Call for Integrated Science, Practice, and Professional Training
Masten, A. S., & Monn, A. R. (2015) · Family Relations · doi:10.1111/fare.12103 · Cited by 357
In pursuit of resilience: stress, epigenetics, and brain plasticity
McEwen, B. S. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13020 · Cited by 329
Self-citationToxic Stress in Children and Adolescents
Bucci, M., Marques, S. S., Oh, D., & Harris, N. B. (2016) · Advances in Pediatrics · doi:10.1016/j.yapd.2016.04.002 · Cited by 295
Recognizing resilience: Learning from the effects of stress on the brain
McEwen, B. S., Gray, J. D., & Nasca, C. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2014.09.001 · Cited by 292
Self-citationYu, H., Wang, D.-D., Wang, Y., Liu, T., Lee, F. S., & Chen, Z.-Y. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5048-11.2012 · Cited by 275
de Kloet, E. R., Meijer, O. C., Nicola, A. F. D., Rijk, R. H. D., & Joëls, M. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.02.003 · Cited by 287
High anxiety trait: A vulnerable phenotype for stress-induced depression
Weger, M., & Sandi, C. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.01.012 · Cited by 289
Naturalistic rodent models of chronic early‐life stress
Molet, J., Maras, P. M., Avishai‐Eliner, S., & Baram, T. Z. (2014) · Developmental Psychobiology · doi:10.1002/dev.21230 · Cited by 282
Carroll, D., Ginty, A. T., Phillips, A. C., Lovallo, W. R., & de Rooij, S. R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.025 · Cited by 284
Associations between children's socioeconomic status and prefrontal cortical thickness
Lawson, G. M., Duda, J., Avants, B., Wu, J., & Farah, M. J. (2013) · Developmental Science · doi:10.1111/desc.12096 · Cited by 284
McEwen, B. S., Gray, J. D., & Nasca, C. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0121 · Cited by 253
Self-citationHow the brain connects in response to acute stress: A review at the human brain systems level
van Oort, J., Tendolkar, I., Hermans, E. J., Mulders, P. C. R., Beckmann, C. F., Schene, A. H., Fernández, G., & van Eijndhoven, P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.015 · Cited by 266
Stress and neurodevelopmental processes in the emergence of psychosis
Holtzman, C. W., Trotman, H. D., Goulding, S. M., Ryan, A. T., MacDonald, A. N., Shapiro, D. I., Brasfield, J. L., & Walker, E. F. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.017 · Cited by 262
Hippocampal gene expression changes underlying stress sensitization and recovery
Gray, J. D., Rubin, T. G., Hunter, R. G., & McEwen, B. S. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.175 · Cited by 242
Self-citationThe Brain on Stress: Toward an Integrative Approach to Brain, Body, and Behavior
McEwen, B. S. (2013) · Perspectives on Psychological Science · doi:10.1177/1745691613506907 · Cited by 237
Self-citationLactate Shuttles in Neuroenergetics—Homeostasis, Allostasis and Beyond
Mason, S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00043 · Cited by 240
Karatsoreos, I. N., & McEwen, B. S. (2013) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12054 · Cited by 247
Self-citationResilience in Development: Progress and Transformation
Masten, A. S., & Cicchetti, D. (2016) · Developmental Psychopathology · doi:10.1002/9781119125556.devpsy406 · Cited by 416
Wachs, T. D., Georgieff, M., Cusick, S. E., & McEwen, B. S. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12314 · Cited by 255
Self-citationGenomic and epigenomic mechanisms of glucocorticoids in the brain
Gray, J. D., Kogan, J. F., Marrocco, J., & McEwen, B. S. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.97 · Cited by 242
Self-citationFrom Receptor Balance to Rational Glucocorticoid Therapy
de Kloet, E. R. (2014) · Endocrinology · doi:10.1210/en.2014-1048 · Cited by 211
A culture-brain link: negative age stereotypes predict Alzheimer's disease biomarkers
Levy, B. R., Ferrucci, L., Zonderman, A. B., Slade, M. D., Troncoso, J., & Resnick, S. M. (2016) · Psychology and Aging · doi:10.1037/pag0000062 · Cited by 198
Kraan, T. C., Velthorst, E., Smit, F., de Haan, L., & van der Gaag, M. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.11.026 · Cited by 196
Evans, G. W., & Kim, P. (2012) · Psychological Science · doi:10.1177/0956797612441218 · Cited by 170
Resilience as a focus of suicide research and prevention
Sher, L. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13059 · Cited by 225
Stress-induced changes in human decision-making are reversible
Soares, J. M., Sampaio, A., Ferreira, L. M., Santos, N. C., Marques, F., Palha, J. A., Cerqueira, J. J., & Sousa, N. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.59 · Cited by 183
Stratified medicine for mental disorders
Schumann, G., Binder, E. B., Holte, A., de Kloet, E. R., Oedegaard, K. J., Robbins, T. W., Walker-Tilley, T. R., Bitter, I., Brown, V. J., Buitelaar, J., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.09.010 · Cited by 186
Environmental effects on fish neural plasticity and cognition
Ebbesson, L. O. E., & Braithwaite, V. A. (2012) · Journal of Fish Biology · doi:10.1111/j.1095-8649.2012.03486.x · Cited by 185
Cognitive Aging and the Promise of Physical Activity
Erickson, K. I., Donofry, S. D., Sewell, K. R., Brown, B. M., & Stillman, C. M. (2022) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-072720-014213 · Cited by 195
Sculpting the hippocampus from within: stress, spines, and CRH
Maras, P. M., & Baram, T. Z. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.005 · Cited by 183
Zalli, A., Carvalho, L. A., Lin, J., Hamer, M., Erusalimsky, J. D., Blackburn, E. H., & Steptoe, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322145111 · Cited by 186
Neuroendocrine mechanisms for immune system regulation during stress in fish
Nardocci, G., Navarro, C., Cortés, P. P., Imarai, M., Montoya, M., Valenzuela, B., Jara, P., Acuña‐Castillo, C., & Fernández, R. (2014) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2014.08.001 · Cited by 172
Shaltiel, G., Hanan, M., Wolf, Y., Barbash, S., Kovalev, E., Shoham, S., & Soreq, H. (2012) · Brain Structure and Function · doi:10.1007/s00429-011-0376-z · Cited by 173
Schmalzl, L., Powers, C., & Henje Blom, E. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00235 · Cited by 170
McEwen, B. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.10.029 · Cited by 179
Self-citationDisrupted default mode network connectivity in migraine without aura
Tessitore, A., Russo, A., Giordano, A., Conte, F., Corbo, D., Stefano, M. D., Cirillo, S., Cirillo, M., Esposito, F., & Tedeschi, G. (2013) · The Journal of Headache and Pain · doi:10.1186/1129-2377-14-89 · Cited by 171
Sripada, R. K., Swain, J. E., Evans, G. W., Welsh, R. C., & Liberzon, I. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.75 · Cited by 171
Common hippocampal structural and functional changes in migraine
Maleki, N., Becerra, L. R., Brawn, J., McEwen, B. S., Burstein, R., & Borsook, D. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0437-y · Cited by 170
Self-citationPeriodization Theory: Confronting an Inconvenient Truth
Kiely, J. (2017) · Sports Medicine · doi:10.1007/s40279-017-0823-y · Cited by 201
Brain systems for baroreflex suppression during stress in humans
Gianaros, P. J., Onyewuenyi, I. C., Sheu, L. K., Christie, I. C., & Critchley, H. D. (2012) · Human Brain Mapping · doi:10.1002/hbm.21315 · Cited by 166
Self-citationThe brain’s action-mode network
Dosenbach, N. U. F., Raichle, M. E., & Gordon, E. M. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00895-x · Cited by 224
Birth practices: Maternal‐neonate separation as a source of toxic stress
Bergman, N. (2019) · Birth Defects Research · doi:10.1002/bdr2.1530 · Cited by 186
Home Visiting and the Biology of Toxic Stress: Opportunities to Address Early Childhood Adversity
Garner, A. S. (2013) · PEDIATRICS · doi:10.1542/peds.2013-1021d · Cited by 163
Stress and alcohol interactions: animal studies and clinical significance
Spanagel, R., Noori, H. R., & Heilig, M. A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.02.006 · Cited by 175
The complex neurobiology of resilient functioning after childhood maltreatment
Ioannidis, K., Askelund, A. D., Kievit, R., & van Harmelen, A. (2020) · BMC Medicine · doi:10.1186/s12916-020-1490-7 · Cited by 175
Psychiatric resilience: longitudinal twin study
Amstadter, A. B., Myers, J., & Kendler, K. S. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.130906 · Cited by 169
Adverse childhood experiences and allostatic load: A systematic review
Finlay, S., Roth, C., Zimsen, T., Bridson, T. L., Sarnyai, Z., & McDERMOTT, B. M. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104605 · Cited by 164
Disconnection and reconnection: The morphological basis of (mal)adaptation to stress
Sousa, N., & Almeida, O. F. X. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.006 · Cited by 159
Remodeling of axo-spinous synapses in the pathophysiology and treatment of depression
Licznerski, P., & Duman, R. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.057 · Cited by 157
Better Safe Than Sorry: A Common Signature of General Vulnerability for Psychopathology
den Bergh, O. V., BROSSCHOT, J. F., Critchley, H., Thayer, J. F., & Ottaviani, C. (2020) · Perspectives on Psychological Science · doi:10.1177/1745691620950690 · Cited by 170
Hostinar, C. E., & Gunnar, M. R. (2013) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2013.804387 · Cited by 153
The Insula: A “Hub of Activity” in Migraine
Borsook, D., Veggeberg, R., Erpelding, N., Borra, R., Linnman, C., Burstein, R., & Becerra, L. (2016) · The Neuroscientist · doi:10.1177/1073858415601369 · Cited by 146
Swartz, J. R., Williamson, D. E., & Hariri, A. R. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14020195 · Cited by 144
Stress and Anxiety Across the Lifespan: Structural Plasticity and Epigenetic Regulation
Hunter, R. G., & McEwen, B. S. (2013) · Epigenomics · doi:10.2217/epi.13.8 · Cited by 142
Self-citationALL OUR SONS: THE DEVELOPMENTAL NEUROBIOLOGY AND NEUROENDOCRINOLOGY OF BOYS AT RISK
Schore, A. N. (2017) · Infant Mental Health Journal · doi:10.1002/imhj.21616 · Cited by 153
Epigenetic basis of the dark side of alcohol addiction
Pandey, S. C., Kyzar, E. J., & Zhang, H. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.02.002 · Cited by 149
Chen, Y., Feng, X., Hu, X., Sha, J., Li, B., Zhang, H., & Fan, H. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4035310 · Cited by 140
Rutherford, H. J. V., Williams, S. K., Moy, S., Mayes, L. C., & Johns, J. M. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00037 · Cited by 140
Cognition, emotion, and the central autonomic network
Quadt, L., Critchley, H., & Nagai, Y. (2022) · Autonomic Neuroscience · doi:10.1016/j.autneu.2022.102948 · Cited by 139
Psychosocial Job Stress and Immunity: A Systematic Review
Nakata, A. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-071-7_3 · Cited by 140
Ganguly, P., & Brenhouse, H. C. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.07.001 · Cited by 136
Systemic corazonin signalling modulates stress responses and metabolism in Drosophila
Kubrak, O. I., Lushchak, O. V., Zandawala, M., & Nässel, D. R. (2016) · Open Biology · doi:10.1098/rsob.160152 · Cited by 134
Stress Impact on Resting State Brain Networks
Soares, J. M., Sampaio, A., Ferreira, L. M., Santos, N. C., Marques, P., Marques, F., Palha, J. A., Cerqueira, J., & Sousa, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066500 · Cited by 137
Metadata
- Authors
- McEwen, B. S., & Gianaros, P. J.
- Affiliations
- Rockefeller University (US)
- University of Pittsburgh (US)
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 2011-02-18
- Volume
- 62
- Issue
- 1
- Pages
- 431-445
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- PMC
- PMC4251716
- OpenAlex
- W2116769635
- Cited by
- 1,171
- References
- 74
- Citations by year
- 2026: 96 · 2025: 100 · 2024: 78 · 2023: 55 · 2022: 98 · 2021: 81 · 2020: 81 · 2019: 86 · 2018: 60 · 2017: 83 · 2016: 79 · 2015: 64 · 2014: 73 · 2013: 54 · 2012: 58
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL089850)
- National Institute of Mental Health (5P01 MH58911, K01MH070616, R01 MH41256, P50MH058911, R01MH041256)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- allostasis, allostatic load, neuroplasticity, stress response, stress-related disorders, stress adaptation, stress coping
- MeSH terms
- Adaptation, Physiological, Adaptation, Psychological, Animals, Brain, Female, Humans, Male, Neuronal Plasticity, Stress, Physiological, Stress, Psychological, Mice, Rats, Allostasis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
