The DOI matches its Crossref record; 181 of the 181 references it cites were found in a registry or an index; 50 of the 149 sources its claims cite were checked for support.
Dietary Nitrate and Physical Performance
Open accessAbstract
Nitric oxide (NO) plays a plethora of important roles in the human body. Insufficient production of NO (for example, during older age and in various disease conditions) can adversely impact health and physical performance. In addition to its endogenous production through the oxidation of l-arginine, NO can be formed nonenzymatically via the reduction of nitrate and nitrite, and the storage of these anions can be augmented by the consumption of nitrate-rich foodstuffs such as green leafy vegetables. Recent studies indicate that dietary nitrate supplementation, administered most commonly in the form of beetroot juice, can ( a) improve muscle efficiency by reducing the O 2 cost of submaximal exercise and thereby improve endurance exercise performance and ( b) enhance skeletal muscle contractile function and thereby improve muscle power and sprint exercise performance. This review describes the physiological mechanisms potentially responsible for these effects, outlines the circumstances in which ergogenic effects are most likely to be evident, and discusses the effects of dietary nitrate supplementation on physical performance in a range of human populations.
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Claims the paper makes
52 No full text of the sources · 31 Own interpretation · 20 Supported · 10 Partly supported · 7 Supported so far · 1 Sources not found · 1 Not checked yet · accuracy not yet measured
Every source the paper cites for this claim was checked and supports it.
In the paper
“However, six days of NO 3 supplementation has been reported to improve high-intensity intermittent exercise performance in trained soccer players who consumed ∼13 mmol NO 3 -per day (110)”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Wylie et al. (166) tested the effect of dietary NO 3
What the sources say
- Supportedcites [110] source
The Discussion reports that six days of nitrate-rich beetroot juice supplementation improved high-intensity intermittent exercise performance in trained soccer players. It specifies a daily nitrate dose of 12.9 mmol, consistent with the citing sentence’s approximate 13 mmol. (LLM, conf=0.95)
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Indeed, seven days of NO 3 -supplementation increased the expression of the sarcoplasmic reticulum Ca 2+ -handling proteins, calsequestrin and dihydropyridine, in the type II skeletal muscle of NaNO 3 -supplemented mice (53).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Wylie et al. (166) tested the effect of dietary NO 3
What the sources say
- Supportedcites [53] source
The Results report significantly greater CASQ1 (calsequestrin 1) and DHPR (dihydropyridine receptor) expression in fast-twitch EDL muscle from nitrate-treated mice than controls. The Abstract specifies that the mice received sodium nitrate in drinking water for seven days. (LLM, conf=0.94)
plaindirect- Asserted: passes — The authors put it forward as true.
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- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Furthermore, an acute, high NO 3 -dose (∼10 mmol) did not alter 180-m sprint running performance compared to placebo in junior elite cross-country skiers (131).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Wylie et al. (166) tested the effect of dietary NO 3
What the sources say
- Supportedcites [131] source
The Participants section identifies the runners as junior-elite cross-country skiers. Experimental Tests gives the acute nitrate dose as 9.9 mmol and includes a placebo condition. The Results report 180-m sprint times of 24.1 seconds with nitrate alone and 24.3 seconds with placebo; the significant sprint difference reported was between nitrate alone and the combined L-arginine–nitrate treatment, not placebo. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
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- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“A single, high-NO 3 -bolus (11.2 mmol) has been shown to improve isokinetic knee extensor torque at very high angular velocities (360 • s -1 ) (28)”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Wylie et al. (166) tested the effect of dietary NO 3
What the sources say
- Partly supportedcites [28] sourceExperimental — accuracy not yet measured
The Methods describe a single 11.2 mmol nitrate dose and testing at 360°/s. The Results report that peak torque at that velocity only tended to increase (P=0.12); the increase was significant when torque was expressed relative to maximal isometric torque. The claim omits that distinction. (LLM, conf=0.88)
plaindirect- Asserted: passes — The authors put it forward as true.
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- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“A low dose of NO 3 -(∼5 mmol) administered acutely improved maximal power during 3-4-s inertial-load cycling sprints in trained athletes (128)”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Wylie et al. (166) tested the effect of dietary NO 3
What the sources say
- Partly supportedcites [128] sourceExperimental — accuracy not yet measured
The Abstract Methods and Results report that acute nitrate supplementation improved maximal power during 3–4-s inertial-load cycling trials in trained athletes. However, Methods > Methodology states that participants received two doses containing about 11.2 mmol nitrate in total, not a total dose of approximately 5 mmol. The indexed passages provide no page numbers. (LLM, conf=0.90)
plaindirect- Asserted: passes — The authors put it forward as true.
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- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Increased exposure to NO 3 -and NO 2 -has been reported to activate PGC1-α (peroxisome proliferator-activated receptor γ coactivator 1-α) (129) and adenosine monophosphate-activated protein kinase (AMPK) (101) in skeletal muscle.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 8. INTERACTION OF NITRATE SUPPLEMENTATION WITH EXERCISE TRAINING AND DAILY PHYSICAL ACTIVITY
What the sources say
- Partly supportedcites [129] sourceExperimental — accuracy not yet measured
The Abstract (p. 4) and Results (p. 11) report that nitrate increased PGC1α expression in rat skeletal muscle, supporting the PGC1α part attributed to this source. The passages do not establish that increased nitrite exposure has the same effect. AMPK is attached to a different citation in the citing sentence. (LLM, conf=0.83)
- Partly supportedcites [101] sourceExperimental — accuracy not yet measured
The Results section, “Nitrite mediates biogenesis through activation of PGC1, SIRT1, and AMPK” (page unavailable), supports nitrite-dependent AMPK activation. But the Methods identify the experimental cells as rat aortic smooth muscle cells, not skeletal muscle; this source also does not establish the claimed effect of nitrate. In the citing sentence, this citation is attached to AMPK, while the PGC1-α claim has a separate citation. (LLM, conf=0.88)
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“However, 5 days of NO 3 -supplementation did not improve repeated 30-s and 60-s sprint cycling performance (166).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Wylie et al. (166) tested the effect of dietary NO 3
What the sources say
- Supportedcites [166] source
The Methods (Experimental design; page not supplied) describe a five-day nitrate-rich beetroot juice supplementation period, with repeated 30-s and 60-s cycling tests on days 4 and 5. The Discussion conclusion reports no significant performance improvement in either protocol. (LLM, conf=0.92)
plain- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Following a very high dose of NO 3 -(29 mmol administered over 36 h), a 4.2% improvement in distance covered was observed in recreationally active team sport players during the Yo-Yo intermittent recovery test level 1 (Yo-Yo IR1), a well-established and ecologically valid test widely used to mimic the high-intensity running demands of football (10).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Wylie et al. (166) tested the effect of dietary NO 3
What the sources say
- Partly supportedcites [166] sourceExperimental — accuracy not yet measured
The Methods (Subjects and Experimental design) describe recreational team-sport players, and the Discussion reports improved intermittent-exercise performance after beetroot juice supplementation. But this paper tested cycling after five days of supplementation, not distance covered in the Yo-Yo IR1 after 29 mmol of nitrate over 36 hours. It does not report the claimed 4.2% improvement. (LLM, conf=0.83)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“This adaptation to several days of NO 3 -supplementation may underpin the reported increase in contractile force at low stimulation frequencies and faster rates of force development in isolated type II muscle fibers (53)”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Wylie et al. (166) tested the effect of dietary NO 3
What the sources say
- Supportedcites [53] source
The Discussion reports that seven days of nitrate supplementation altered calcium handling and increased force at low stimulation frequencies in fast-twitch muscle. The Results also report a markedly faster rate of force increase in isolated nitrate-treated fibres. These findings support the citing sentence’s hedged link between the adaptation and the reported contractile effects. (LLM, conf=0.93)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“and recent evidence suggests that dietary NO 3 -may also be important in the health of the aging brain (122).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 8. INTERACTION OF NITRATE SUPPLEMENTATION WITH EXERCISE TRAINING AND DAILY PHYSICAL ACTIVITY
What the sources say
- Supportedcites [122] source
The Conclusions report increased frontal-lobe white-matter perfusion in older adults after a high-nitrate diet and suggest potential benefits for cognitive health, while noting that further studies are needed. This supports the citing sentence’s cautious claim that dietary nitrate may be important for the aging brain. (LLM, conf=0.94)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
- Probably not a substantial claim. 6
- It may state two separate claims as one. 32
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Exercise is known to promote several mechanisms that maintain brain structure and function (29,40)”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 8. INTERACTION OF NITRATE SUPPLEMENTATION WITH EXERCISE TRAINING AND DAILY PHYSICAL ACTIVITY
What the sources say
- Not checked — no full text of the sourcecites [29] source
- Supportedcites [40] source
The Discussion describes several pathways by which exercise may support brain structure and function, including BDNF-associated cell proliferation, dendritic branching, and increased vascularization. It also reports increased hippocampal volume and improved memory after exercise, while noting that effects vary by brain region. Page numbers are not provided in our copy. (LLM, conf=0.90)
boosteddirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
Every source the paper cites for this claim was checked and supports it.
In the paper
“An early study showed that NO 3 -supplementation attenuated the muscle metabolic perturbation during high-intensity knee-extension exercise in hypoxia (14.5% O 2 ) and restored exercise tolerance to that observed in normoxia (152).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 9. EFFECTS OF NITRATE SUPPLEMENTATION IN HYPOXIA
What the sources say
- Supportedcites [152] source
The Abstract describes knee-extension exercise in 14.5% O₂ and reports that nitrate supplementation reduced muscle metabolic perturbation while restoring exercise tolerance to values observed in normoxia. The Discussion states the same principal finding specifically for high-intensity exercise. (LLM, conf=0.95)
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“It should be noted that evidence for enhanced O 2 delivery does not exclude the possibility that NO 3 --induced alterations in metabolic control (153) and mitochondrial efficiency (81) also contribute to increased Qmax in hypoxia.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 9. EFFECTS OF NITRATE SUPPLEMENTATION IN HYPOXIA
What the sources say
- Supportedcites [153] source
The Discussion says faster PCr recovery in hypoxia may be predominantly due to improved O2 delivery, while explicitly leaving open a contribution from altered metabolic control. It also reports higher Qmax after nitrate supplementation in hypoxia. The separate citation attached to mitochondrial efficiency is not needed to support the part attributed to this paper. (LLM, conf=0.94)
- Not checked — no full text of the sourcecites [81] source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“These studies suggest that the exercise capacity of physically active individuals is improved during hypoxic exercise (11-14.5% O 2 ) when NO 3 -supplementation is continued for 24 h-6 days (59, 69, 95, 152; cf.130), but not following acute NO 3 -ingestion (46).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 9. EFFECTS OF NITRATE SUPPLEMENTATION IN HYPOXIA
What the sources say
- Supportedcites [59] source
The Methods (Subjects; page unavailable) describe participants who exercised regularly. The Abstract reports that after four days of nitrate supplementation, time to exhaustion during exercise at 13.95% oxygen was significantly longer than with placebo. This source supports the multi-day supplementation finding; the sentence cites a different source for the acute-ingestion comparison. (LLM, conf=0.93)
- Not checked — no full text of the sourcecites [69] source
- Not checked — no full text of the sourcecites [95] source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Some studies indicate that acute NO 3 -supplementation (∼6-15 mmol) can improve exercise performance in a TT (106, 134, 135), but others have found no significant ergogenic effects (5,91,111).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 9. EFFECTS OF NITRATE SUPPLEMENTATION IN HYPOXIA
What the sources say
- Not checked — no full text of the sourcecites [106] source
- Supportedcites [134] source
The Methods (Overview; page unavailable) describe a single ~12.5 mmol nitrate dose before each trial, within the claimed range. The Results (TT performance; page unavailable) report significantly faster time-trial completion with nitrate-rich beetroot juice than placebo. The sentence cites other studies separately for the absence of ergogenic effects; that finding is not attributed to this source. (LLM, conf=0.93)
- Supportedcites [135] source
This paper supports the positive time-trial finding for which it is cited. The Methods (p. 5) describe a single dose of approximately 15.2 mmol nitrate three hours before exercise, and the Results (p. 10) report a 3.2% improvement in 1500 m time-trial performance versus placebo in moderate normobaric hypoxia. The citing sentence assigns the no-effect findings to other references. (LLM, conf=0.92)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
Every source the paper cites for this claim was checked and supports it.
In the paper
“Only one study has investigated the effects of chronic (three-day) NO 3 -supplementation and found that 15-km cycle TT performance was not improved in trained cyclists exercising in 11% O 2 (16).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 9. EFFECTS OF NITRATE SUPPLEMENTATION IN HYPOXIA
What the sources say
- Supportedcites [16] source
The Methods (Experimental design; page unavailable) describe three-day nitrate supplementation in trained cyclists and hypoxia at an inspired oxygen fraction of 0.11. The Results (Fifteen kilometers time-trial cycling; page unavailable) report no significant improvement in 15-km completion time with nitrate under hypoxia. The citation identifies this study; the paper does not establish the citing authors’ broader claim that it was the only such study. (LLM, conf=0.93)
plain- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“While the efficacy of dietary NO 3 -to reduce systemic blood pressure in older age has been extensively studied (reviewed in 140; see also 139, 142), relatively few studies have assessed the effects of NO 3 -supplementation on exercise capacity in healthy older individuals.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 10. EFFECTS OF NITRATE SUPPLEMENTATION IN OLDER AGE AND DISEASE STATES
What the sources say
- Partly supportedcites [140] sourceExperimental — accuracy not yet measured
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
- Not checked — no full text of the sourcecites [139] source
- Could not verifycites [142] sourceExperimental — accuracy not yet measured
Split into 2 atoms — 0 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 2 unverifiable. Expand the claim to see per-atom verdicts.
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Some studies have indicated that NO donors and NO 3 -supplementation may enhance cerebral perfusion (52, 122), particularly to areas responsible for executive functioning (122), and enhance coupling of cerebral blood flow to neuronal activity (1, 119).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 11. EFFECTS OF NITRATE SUPPLEMENTATION ON COGNITIVE FUNCTION AT REST AND DURING EXERCISE
What the sources say
- Not checked — no full text of the sourcecites [52] source
- Supportedcites [122] source
The Discussion reports that oral nitrate increased cerebral blood flow in the white matter of older adults and identifies the frontal-lobe deep white matter as important for cognitive function. The Conclusion describes the affected regions as involved in executive functioning. The separate claim about coupling blood flow to neuronal activity is cited to other sources, not this paper. (LLM, conf=0.92)
- Not checked — no full text of the sourcecites [1] source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In 2007, Larsen et al. (83) made the remarkable discovery that three days of sodium nitrate (NaNO 3 ) supplementation increased the plasma [NO 2 -] and reduced the O 2 cost of submaximal cycle exercise (83).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 3. INFLUENCE OF DIETARY NITRATE INTAKE ON INDICES OF NITRIC OXIDE BIOAVAILABILITY AND PHYSIOLOGICAL EFFECTS DURING EXERCISE
What the sources say
- Not checked — no full text of the sourcecites [83] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Following three days of beetroot juice supplementation, the plasma [NO 2 -] was doubled, and the increase in O 2 uptake ( V O 2 ) during exercise was reduced by approximately 5% (9).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 3. INFLUENCE OF DIETARY NITRATE INTAKE ON INDICES OF NITRIC OXIDE BIOAVAILABILITY AND PHYSIOLOGICAL EFFECTS DURING EXERCISE
What the sources say
- Not checked — no full text of the sourcecites [9] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Recent studies indicate that dietary nitrate supplementation, administered most commonly in the form of beetroot juice, can (a) improve muscle efficiency by reducing the O 2 cost of submaximal exercise and thereby improve endurance exercise performance and (b) enhance skeletal muscle contractile function and thereby improve muscle power and sprint exercise performance.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Abstract
hedgeddirect- Asserted: passes — The authors put it forward as true.
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- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“While many studies have confirmed the early observations described above, others have not, and it appears that the efficacy of NO 3 -supplementation depends on several factors, including the training status of the participants, the dose and duration of NO 3 supplementation, and the duration, intensity, and nature of the exercise task (63).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 3. INFLUENCE OF DIETARY NITRATE INTAKE ON INDICES OF NITRIC OXIDE BIOAVAILABILITY AND PHYSIOLOGICAL EFFECTS DURING EXERCISE
What the sources say
- Not checked — no full text of the sourcecites [63] source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In athletes or recreational exercise enthusiasts, improved exercise efficiency following NO 3 -ingestion would be expected to enable the same work rate to be sustained for longer or a higher work rate to be sustained for the same duration.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 3. INFLUENCE OF DIETARY NITRATE INTAKE ON INDICES OF NITRIC OXIDE BIOAVAILABILITY AND PHYSIOLOGICAL EFFECTS DURING EXERCISE
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Consistent with the experimental hypothesis, NO 3 -administration improved 4.0-km and 16.1-km TT performance by 2.8% and 2.7%, respectively (78).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 3. INFLUENCE OF DIETARY NITRATE INTAKE ON INDICES OF NITRIC OXIDE BIOAVAILABILITY AND PHYSIOLOGICAL EFFECTS DURING EXERCISE
What the sources say
- Not checked — no full text of the sourcecites [78] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These results imply that dietary nitrate ingestion permits more muscular work to be performed per unit time for the same energy cost, i.e., that the efficiency of skeletal muscle contraction is enhanced.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 3. INFLUENCE OF DIETARY NITRATE INTAKE ON INDICES OF NITRIC OXIDE BIOAVAILABILITY AND PHYSIOLOGICAL EFFECTS DURING EXERCISE
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“These results elegantly demonstrated that NO 3 -supplementation reduced mitochondrial proton leakage and uncoupled respiration.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Consistent with this notion, the changes in [ADP], [P i ], and [PCr] following NO 3
What the sources say
- Not checked — no full text of the sourcecites [81] source
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Taken together with the findings of Bailey et al. (8), those of Larsen et al. (81) suggest that NO 3 -supplementation improves exercise efficiency by improving the efficiency of both muscle contraction (reduced high-energy phosphate cost of force production) and mitochondrial oxidative phosphorylation (increased P/O ratio).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Consistent with this notion, the changes in [ADP], [P i ], and [PCr] following NO 3
What the sources say
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“In all, these findings suggest that while NO 3 -supplementation appears less effective at improving economy and performance in highly trained and elite athletes during cycling and running exercise, NO 3 -supplementation may provide an ergogenic effect for highly trained kayakers and rowers, although these improvements are dependent on a sufficient dose of NO 3 -being administered.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 6. INFLUENCE OF FITNESS ON THE EFFICACY OF NITRATE SUPPLEMENTATION
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In all, these reports suggest that extending the supplementation period (at least up to four weeks) does not improve (or reduce) the effects of NO 3 -consumption on exercise economy but that exercise performance may benefit from a chronic, rather than an acute, supplementation strategy.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 5. THE INFLUENCE OF DOSE AND DURATION OF NITRATE SUPPLEMENTATION ON THE PHYSIOLOGICAL EFFECTS OBSERVED
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Taken together, the findings from these acute NO 3 -consumption studies suggest that a NO 3 -dose of 5.0-8.5 mmol (310-527 mg) is likely to improve exercise economy, but to elicit an improvement in both exercise economy and performance, a NO 3 -dose of >8.5 mmol (>527 mg) might be necessary.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 5. THE INFLUENCE OF DOSE AND DURATION OF NITRATE SUPPLEMENTATION ON THE PHYSIOLOGICAL EFFECTS OBSERVED
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Although there is evidence that inorganic NO 3 -supplementation, particularly when administered chronically, can improve performance in moderately trained endurance athletes ( V O 2 peak < 60 mL/kg/min), the impact of NO 3 -on highly trained or elite endurance athletes ( V O 2 peak ≥ 60 mL/kg/min) is not promising and has been the topic of much debate (e.g., 66) (Figure 2).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 6. INFLUENCE OF FITNESS ON THE EFFICACY OF NITRATE SUPPLEMENTATION
What the sources say
- Not checked — no full text of the sourcecites [66] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Despite the discrepancy in the literature, recent meta-analyses indicate that NO 3 -supplementation both lowers the O 2 cost of exercise (114) and improves endurance exercise performance (98) in healthy volunteers.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 3. INFLUENCE OF DIETARY NITRATE INTAKE ON INDICES OF NITRIC OXIDE BIOAVAILABILITY AND PHYSIOLOGICAL EFFECTS DURING EXERCISE
What the sources say
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“It is possible that the NO-mediated signaling cascades generated by NO 3 -supplementation are synergistic to the molecular signaling processes stimulated by exercise training.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 8. INTERACTION OF NITRATE SUPPLEMENTATION WITH EXERCISE TRAINING AND DAILY PHYSICAL ACTIVITY
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“In another study, three days of NO 3 -supplementation increased the TOI of m. vastus lateralis during cycle exercise by 3.6% compared to placebo, although this effect did not reach statistical significance (69).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 9. EFFECTS OF NITRATE SUPPLEMENTATION IN HYPOXIA
What the sources say
- Not checked — no full text of the sourcecites [69] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“This observation indicates that NO 2 -is utilized by the active muscle, potentially facilitating distribution of O 2 to areas of high metabolic activity (145).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 9. EFFECTS OF NITRATE SUPPLEMENTATION IN HYPOXIA
What the sources say
- Not checked — no full text of the sourcecites [145] source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“As enzymatic production of NO requires the presence of O 2 and essential cofactors, it has been proposed that the NO 3 --NO 2 --NO reduction pathway might compensate for impaired NO production via NOS under conditions of reduced O 2 availability (88).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 9. EFFECTS OF NITRATE SUPPLEMENTATION IN HYPOXIA
What the sources say
- Not checked — no full text of the sourcecites [88] source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Dietary supplementation with NO 3 -may therefore represent a practical and cost-effective means to restore NO homeostasis and improve exercise tolerance in these populations (113).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 10. EFFECTS OF NITRATE SUPPLEMENTATION IN OLDER AGE AND DISEASE STATES
What the sources say
- Not checked — no full text of the sourcecites [113] source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“A characteristic feature of these populations is exercise intolerance that often occurs in concert with a reduced NO production during exercise (2, 84), suggesting a role for NO dysfunction in exercise intolerance.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 10. EFFECTS OF NITRATE SUPPLEMENTATION IN OLDER AGE AND DISEASE STATES
What the sources say
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“NO 3 -supplementation with 9.6 mmol/day for three days resulted in a reduction in systemic blood pressure at rest and a speeding of the V O 2 response (mean response time) across the transition from standing rest to treadmill walking in 60-70-year-old men and women (68).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 10. EFFECTS OF NITRATE SUPPLEMENTATION IN OLDER AGE AND DISEASE STATES
What the sources say
- Not checked — no full text of the sourcecites [68] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In contrast, Kelly et al. (68) found no effect of three days of NO 3 -supplementation on the ability of healthy older adults to complete cognitive tasks at rest, and found no changes in cerebral perfusion and metabolism, measured via 1 H-MRS and 31 P-MRS, respectively.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 11. EFFECTS OF NITRATE SUPPLEMENTATION ON COGNITIVE FUNCTION AT REST AND DURING EXERCISE
What the sources say
- Not checked — no full text of the sourcecites [68] source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“During intense exercise, as cerebral oxygenation diminishes (133), higher-order functions of the prefrontal cortex may be disengaged to avoid compromising optimal motor function (35), and cognitive abilities are compromised (44,126).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 11. EFFECTS OF NITRATE SUPPLEMENTATION ON COGNITIVE FUNCTION AT REST AND DURING EXERCISE
What the sources say
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“This manifests as a reduction in circulating [NO 3 -] and [NO 2 -] (73), which, as described in Section 2, can be recycled back into bioactive NO through the NO 3 --NO 2 --NO pathway.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 10. EFFECTS OF NITRATE SUPPLEMENTATION IN OLDER AGE AND DISEASE STATES
What the sources say
- Not checked — no full text of the sourcecites [73] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Chronic medication and/or multiple systemic and metabolic maladaptations associated with conditions such as type II diabetes, COPD, and obesity may limit NO production, NO bioavailability, and NO's ultimate bioactivity in target tissues.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 10. EFFECTS OF NITRATE SUPPLEMENTATION IN OLDER AGE AND DISEASE STATES
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
In the paper
“However, NO 3 -ingestion did not affect functional capacity assessed with a 6-min walk test, nor the muscle metabolic response to low-intensity knee-extension exercise measured by 31 P-MRS (68).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 10. EFFECTS OF NITRATE SUPPLEMENTATION IN OLDER AGE AND DISEASE STATES
What the sources say
- Not checked — no full text of the sourcecites [68] source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“Importantly, the greatest differences between the NO 3 -and placebo conditions were observed in the final third of each 40-min “half ” (148), when fatigue-related alterations in cerebral physiology/cognitive abilities may be greatest (44).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 11. EFFECTS OF NITRATE SUPPLEMENTATION ON COGNITIVE FUNCTION AT REST AND DURING EXERCISE
What the sources say
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“While the mechanisms responsible for the physiological effects observed remain unclear, the effects on muscle function and performance appear to be robust, at least in non-elite athlete subjects and when an appropriate supplementation regimen is followed.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Dietary NO 3
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“It is therefore essential that NO production is maintained at the appropriate rate to support activity, and there are certain circumstances in which it might limit muscular performance (for example, during intense exercise, in hypoxia, and in older age and specific disease conditions).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > Dietary NO 3
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Nitric oxide plays many important roles relevant to human physical activity, including regulation of neuromuscular activity and muscle excitation-contraction coupling (via Ca2+ activity), mitochondrial respiration, and blood flow and its intramuscular and/or cerebral distribution.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“To date, relatively few studies have investigated the influence of NO 3 -supplementation on cognitive performance during exercise.”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 11. EFFECTS OF NITRATE SUPPLEMENTATION ON COGNITIVE FUNCTION AT REST AND DURING EXERCISE
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Exercise in hypoxia is associated with reduced muscle oxidative function and impaired exercise tolerance.
“Exercise in hypoxia is associated with reduced muscle oxidative function and impaired exercise tolerance.”
The paper relies on this without support.
Athletes competing in both individual and team sports must make quick and accurate decisions while simultaneously performing exercise at varying intensities.
“athletes competing in both individual and team sports must make quick and accurate decisions while simultaneously performing exercise at varying intensities.”
The paper relies on this without support.
Nitric oxide plays many important roles relevant to human physical activity, including regulation of neuromuscular activity and muscle excitation-contraction coupling (via Ca2+ activity), mitochondrial respiration, and blood flow and its intramuscular and/or cerebral distribution.
“NO plays many important roles that are relevant to human physical activity, including regulation of neuromuscular activity and muscle excitation-contraction coupling (via Ca 2+ activity), mitochondrial respiration, and blood flow and its intramuscular and/or cerebral distribution.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Safety concerns regarding dietary nitrate primarily relate to its potential conversion into nitrosamines, also known as N-nitroso compounds (NOCs) [185,188].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [188]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“vegetables provide antioxidants and bioactive compounds that enhance NO bioavailability and inhibit nitrosamine formation [185,188].”
From Dietary Nitrate-Rich Vegetables as Natural Modulators of Health: Mechanisms and Benefits in Ageing Populations (2026) · cites this paper as [188]
Experimental — accuracy not yet measuredIn the citing paper
“In a large cohort of 1420 older women of ≥70 years of age, the relationship between total nitrate intake and muscle function measures was analyzed [33]. Each standard deviation higher nitrate intake (31.2 mg/kg) was associated with stronger grip strength and faster timed-up-and-go”
In the citing paper
“More recently, inorganic nitrate (NO3−) ingestion, often administered as concentrated NO3−-rich beetroot juice (BR), has been reported to confer ergogenic effects in various exercise modalities [35], including running [36,37,38,39,40,41,42,43,44,45,46,47], rowing [48,49], kayaking [50], knee extensions [37,51] and cycling [52,53,54,55,56,57,58,59,60,61,62,63,64].”
From Effects of Dietary Nitrate Supplementation on Weightlifting Exercise Performance in Healthy Adults: A Systematic Review (2020) · cites this paper as [35]
In the citing paper
“Dietary nitrate can be serially reduced to nitric oxide (NO), providing a complementary pathway to the nitric oxide synthase (NOS-)supported conversion of arginine to NO [19].”
From Neither beetroot juice supplementation nor increased carbohydrate oxidation enhance economy of prolonged exercise in elite race walkers (2021) · cites this paper as [19]
In the citing paper
“Although nitrate supplementation is more likely to benefit higher-intensity events [19]”
From Neither beetroot juice supplementation nor increased carbohydrate oxidation enhance economy of prolonged exercise in elite race walkers (2021) · cites this paper as [19]
In the citing paper
“nitrate supplementation is thought to reduce the oxygen cost of exercise via enhanced calcium handling and contractile efficiency [19]”
From Neither beetroot juice supplementation nor increased carbohydrate oxidation enhance economy of prolonged exercise in elite race walkers (2021) · cites this paper as [19]
In the citing paper
“The apparent lack of effect in elite endurance athletes may be a function of their athletic status (e.g., due to a superior background NO production or reduced number of Type II muscle fibres in which nitrate supplementation might be most suited to targeting conditions of hypoxia or acidosis [19,56,61,62]) as well as an interaction with the conditions of use.”
From Neither beetroot juice supplementation nor increased carbohydrate oxidation enhance economy of prolonged exercise in elite race walkers (2021) · cites this paper as [19]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > 3. INFLUENCE OF DIETARY NITRATE INTAKE ON INDICES OF NITRIC OXIDE BIOAVAILABILITY AND PHYSIOLOGICAL EFFECTS DURING EXERCISE
“In 2007, Larsen et al. (83) made the remarkable discovery that three days of sodium nitrate (NaNO 3 ) supplementation increased the plasma [NO 2 -] and reduced the O 2 cost of submaximal cycle exercise (83).”
§ Annual Review of Nutrition Dietary Nitrate and Physical Performance > References
“83. Lefferts WK, Hughes WE, White CN, Brutsaert TD, Heffernan KS. 2016. Effect of acute nitrate supplementation on neurovascular coupling and cognitive performance in hypoxia.”
Citations
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The L-Arginine-Nitric Oxide Pathway
Epstein, F. H., Moncada, S., & Higgs, A. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292706 · Cited by 6,678
Exercise training increases size of hippocampus and improves memory
Erickson, K. I., Voss, M. W., Prakash, R. S., Basak, C., Szabo, A., Chaddock, L., Kim, J. S., Heo, S., Alves, H., White, S. M., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015950108 · Cited by 4,855
Arginine metabolism: nitric oxide and beyond
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Skeletal muscle fatigue: cellular mechanisms
Allen, D. G., Lamb, G. D., & Westerblad, H. (2008) · Physiological Reviews · doi:10.1152/physrev.00015.2007 · Cited by 2,495
Aerobic Exercise Training Increases Brain Volume in Aging Humans
Colcombe, S. J., Erickson, K. I., Scalf, P. E., Kim, J. S., Prakash, R., McAuley, E., Elavsky, S., Marquez, D. X., Hu, L., & Kramer, A. F. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.11.1166 · Cited by 2,134
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
RESPIRATORY ENZYMES IN OXIDATIVE PHOSPHORYLATION
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Biosynthesis of nitric oxide from l-arginine
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RESPIRATORY ENZYMES IN OXIDATIVE PHOSPHORYLATION
Chance, B., & Williams, G. R. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)57191-5 · Cited by 1,125
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Cited by
Sorted by citations
Skeletal muscle energy metabolism during exercise
Hargreaves, M., & Spriet, L. L. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0251-4 · Cited by 1,408
Nitric oxide signaling in health and disease
Lundberg, J. O., & Weitzberg, E. (2022) · Cell · doi:10.1016/j.cell.2022.06.010 · Cited by 879
Contemporary Nutrition Strategies to Optimize Performance in Distance Runners and Race Walkers
Burke, L. M., Jeukendrup, A. E., Jones, A. M., & Mooses, M. (2019) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2019-0004 · Cited by 170
Self-citationJones, A. M., Vanhatalo, A., Seals, D. R., Rossman, M. J., Piknova, B., & Jonvik, K. L. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002470 · Cited by 156
Self-citationDiet for the prevention and management of sarcopenia
Calvani, R., Picca, A., Coelho‐Júnior, H. J., Tosato, M., Marzetti, E., & Landi, F. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155637 · Cited by 164
Ergogenic Effect of Nitrate Supplementation: A Systematic Review and Meta-analysis
Senefeld, J. W., Wiggins, C. C., Regimbal, R. J., Dominelli, P. B., Baker, S. E., & Joyner, M. J. (2020) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002363 · Cited by 146
Human skeletal muscle nitrate store: Influence of dietary nitrate supplementation and exercise
Wylie, L. J., Park, J. W., Vanhatalo, A., Kadach, S., Black, M. I., Stoyanov, Z., Schechter, A. N., Jones, A. M., & Piknova, B. (2019) · The Journal of Physiology · doi:10.1113/jp278076 · Cited by 116
“Nitrite is derived from the reduction of nitrate by commensal bacteria residing in the oral cavity (Govoni et al. 2008; Kapil et al. 2013), and, as only recently shown, by mammalian tissue nitrate reductases (Jansson et al. 2008; Piknova et al. 2016b).”
BackgroundSelf-citationHuertas, J. R., Casuso, R. A., Hernansanz‐Agustín, P., & Cogliati, S. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7058350 · Cited by 106
“In addition, much attention has been paid to dietary nitrate (NO3 ) supplementation, as it has been linked to improvements in human exercise performance in a wide range of physical activities [160].”
BackgroundBurke, L. M., Sharma, A. P., Heikura, I. A., Forbes, S. F., Holloway, M., McKay, A. K. A., Bone, J. L., Leckey, J. J., Welvaert, M., & Ross, M. L. (2020) · PLOS ONE · doi:10.1371/journal.pone.0234027 · Cited by 96
“Noting that nitrate/beetroot juice supplements are popularly used by athletes as a performance aid due to their demonstrated ability to decrease the oxygen cost of exercise [66], it is possible that the LCHF diet might achieve the reverse by reducing the operation of this pathway and its ability to produce NO under co…”
Background“Food First but Not Always Food Only”: Recommendations for Using Dietary Supplements in Sport
Close, G. L., Kasper, A. M., Walsh, N. P., & Maughan, R. J. (2022) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2021-0335 · Cited by 107
“Nitrate has become one of the most widely used ergogenic aids with extensive research literature to support this practice (Jones, 2014a; Jones, 2014b; Jones et al., 2018; Senefeld et al., 2020).”
Gonzalez, A. M., Townsend, J. R., Pinzone, A. G., & Hoffman, J. R. (2023) · Nutrients · doi:10.3390/nu15030660 · Cited by 94
“, smoking), and the use of antibacterial mouthwash which disrupts the commensal bacteria responsible for the reduction of NO3 to NO2 in the oral cavity [77,78].”
BackgroundOgden, H. B., Child, R. B., Fallowfield, J. L., Delves, S. K., Westwood, C. S., & Layden, J. D. (2020) · Nutrients · doi:10.3390/nu12020537 · Cited by 78
“No guidelines exist for L-arginine or L-citrulline supplementation in athletic populations [238], and consensus documents do not support its use to improve oxygen uptake kinetics or exercise performance [239].”
BackgroundWhat Is in Your Beet Juice? Nitrate and Nitrite Content of Beet Juice Products Marketed to Athletes
Gallardo, E. J., & Coggan, A. R. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0223 · Cited by 72
“Based on studies demonstrating that BRJ ingestion can enhance exercise performance (Jones et al., 2018), a large number of BRJbased supplements are now marketed to athletes.”
BackgroundInfluentialChatzinikolaou, P. N., Margaritelis, N. V., Paschalis, V., Theodorou, A. A., Vrabas, I. S., Kyparos, A., D’Alessandro, A., & Nikolaidis, M. G. (2024) · Acta Physiologica · doi:10.1111/apha.14081 · Cited by 79
“525 Collectively, the above data show that the erythrocyte can sense tissue oxygen levels and adjust nitric oxide production and release accordingly, ultimately, regulating its own flow in the micro-circulation with clear physiological 24,226,526,527 and clinical implications.”
BackgroundThe Fate of Nitrogen from Soil to Plants: Influence of Agricultural Practices in Modern Agriculture
Giordano, M., Petropoulos, S. A., & Rouphael, Y. (2021) · Agriculture · doi:10.3390/agriculture11100944 · Cited by 80
Wickham, K. A., & Spriet, L. L. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0063 · Cited by 78
“…years with dietary NO3- supplementation has challenged this basic tenet by demonstrating an ~3-5% reduction in the O2 cost of exercise at a given power output (exercise economy) during moderate intensity submaximal exercise in physically active males (Affourtit et al. 2015; Jones et al. 2018).”
BackgroundThe role of vascular function on exercise capacity in health and disease
Poole, D. C., Behnke, B. J., & Musch, T. I. (2020) · The Journal of Physiology · doi:10.1113/jp278931 · Cited by 77
Raubenheimer, K., Bondonno, C. P., Blekkenhorst, L. C., Wagner, K., Peake, J. M., & Neubauer, O. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz025 · Cited by 63
Jonvik, K. L., Hoogervorst, D., Peelen, H. B., de Niet, M., Verdijk, L. B., van Loon, L. J. C., & van Dijk, J. (2020) · European Journal of Sport Science · doi:10.1080/17461391.2020.1788649 · Cited by 62
Jagim, A. R., Harty, P. S., Erickson, J. L., Tinsley, G. M., Garner, D., & Galpin, A. J. (2023) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2023.1239121 · Cited by 66
“This list often includes protein (24), carbohydrates (25, 26), creatine (27), caffeine (28), nitrates (29), beta-alanine (30), and sports drinks (14).”
BackgroundNitrate: The Dr. Jekyll and Mr. Hyde of human health?
Bondonno, C. P., Zhong, L., Bondonno, N. P., Sim, M., Blekkenhorst, L. C., Liu, A. H., Rajendra, A., Pokharel, P., Erichsen, D. W., Neubauer, O., et al. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.03.014 · Cited by 58
d’Unienville, N. M. A., Blake, H. T., Coates, A. M., Hill, A. M., Nelson, M. J., & Buckley, J. D. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-021-00472-y · Cited by 56
“Improvements in exercise performance with NO3 intake are believed to be a result of improved mechanical efficiency and V ̇O2 kinetics that derive from effects on fast-twitch muscle fibres [8], such as enhancement of excitation-contraction coupling.”
BackgroundInfluentialNutritional approaches to counter performance constraints in high‐level sports competition
Burke, L. M. (2021) · Experimental Physiology · doi:10.1113/ep088188 · Cited by 51
Nutraceuticals and Dietary Supplements for Older Adults with Long COVID-19
Tosato, M., Ciciarello, F., Zazzara, M. B., Pais, C., Savera, G., Picca, A., Galluzzo, V., Coelho‐Júnior, H. J., Calvani, R., Marzetti, E., et al. (2022) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2022.04.004 · Cited by 51
“Dietary nitrate administration in the form of beetroot juice has been extensively studied in sport nutrition, owing to its purported beneficial effects on physical performance.(172) In this context, beetroot juice may improve both endurance and power exercise performance through increasing NO bioavailability, which in…”
BackgroundPavitt, M. J., Tanner, R., Lewis, A. P., Buttery, S. C., Mehta, B., Jefford, H., Curtis, K., BANYA, W. A. S., Husain, S., Satkunam, K., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2019-214278 · Cited by 44
Shannon, O. M., Allen, J. D., Bescós, R., Burke, L. M., Clifford, T., Easton, C., Gonzalez, J. T., JONES, A. M., Jonvik, K. L., Larsen, F. J., et al. (2022) · Sports Medicine · doi:10.1007/s40279-022-01701-3 · Cited by 56
“…ingestion does not enhance exercise performance under all conditions (e.g. [ 17–22]), and the different effects of nitrate reported between studies could be related to the nature of the exercise test/protocol, participant characteristics and supplementation strategy, amongst other factors [23–25].”
Self-citationWebster, J., Via, J. D., Langley, C. K., Smith, C., Sale, C., & Sim, M. (2023) · Bone Reports · doi:10.1016/j.bonr.2023.101684 · Cited by 49
“It has also been suggested that higher nitrate intake enhances nitric oxide production, thereby improving endothelial function ( e.g. , vasodilation), thus facilitating transport and uptake of oxygen by the muscle (see Jones et al., 2018 for review).”
BackgroundKadach, S., Piknova, B., Black, M. I., Park, J. W., Wylie, L. J., Stoyanov, Z., Thomas, S. M., McMahon, N. F., Vanhatalo, A., Schechter, A. N., et al. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.01.003 · Cited by 43
“, blood pressure and exercise performance) are complex and highly variable between individuals [11,23].”
BackgroundSelf-citationvan der Avoort, C. M. T., Jonvik, K. L., Nyakayiru, J., van Loon, L. J. C., Hopman, M. T. E., & Verdijk, L. B. (2020) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.02.014 · Cited by 42
López‐Samanes, Á., Parra, A. G., Moreno-Pérez, V., & Courel‐Ibáñez, J. (2020) · Nutrients · doi:10.3390/nu12010188 · Cited by 44
“NO3− supplementation improves vasodilation and increases blood flow in muscle [14,15] that appears to benefit muscle force and power production in rodents [16] and healthy adults [17].”
BackgroundRojas‐Valverde, D., Montoya-Rodríguez, J., Azofeifa-Mora, C., & Ureña, B. S. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1798351 · Cited by 42
“(Cuenca et al. 2018; Jones et al. 2018; Jonvik, Nyakayiru, et al. 2018; Kent et al. 2019; Reynolds et al. 2020); the preferred dosage was 70mL of BRJ in the morning and 70mL in the evening.”
BackgroundSan Juan, A. F., Dominguez, R., Lago-Rodríguez, Á., Montoya, J. J., Tan, R., & Bailey, S. J. (2020) · Nutrients · doi:10.3390/nu12082227 · Cited by 36
“More recently, inorganic nitrate (NO3−) ingestion, often administered as concentrated NO3−-rich beetroot juice (BR), has been reported to confer ergogenic effects in various exercise modalities [35], including running [36–47], rowing [48,49], kayaking [50], knee extensions [37,51] and cycling [52–64].”
BackgroundKadach, S., Park, J. W., Stoyanov, Z., Black, M. I., Vanhatalo, A., Burnley, M., Walter, P. J., Cai, H., Schechter, A. N., Piknova, B., et al. (2023) · Acta Physiologica · doi:10.1111/apha.13924 · Cited by 40
“49,50 The original finding that acutely elevated muscle [NO 3− ] is associated with greater muscle torque production may have implications for improving functional outcomes in a wide range of human populations, from those that may be compromised by senescence or disease through to elite athletes.”
BackgroundSelf-citationNitric oxide in exercise physiology: past and present perspectives
Mueller, B. J., Roberts, M. D., Mobley, C. B., Judd, R. L., & Kavazis, A. N. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2024.1504978 · Cited by 32
Rocha, B. S. (2021) · Frontiers in Aging · doi:10.3389/fragi.2021.778467 · Cited by 30
Pan, W., Hu, G., Li, S., Li, G., Feng, X., Wu, Z., Zhang, D., Qin, L., Wang, X., Hu, L., et al. (2023) · 中国科学通报：英文版 · doi:10.1016/j.scib.2023.03.043 · Cited by 29
Zingerone attenuates aortic banding‐induced cardiac remodelling via activating the eNOS/Nrf2 pathway
Liu, C., Wu, Q., Cai, Z., Xie, S., Duan, M., Xie, Q., Yuan, Y., Deng, W., & Tang, Q. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14540 · Cited by 28
Delleli, S., Ouergui, I., Messaoudi, H., Trabelsi, K., Glenn, J. M., Ammar, A., & Chtourou, H. (2023) · Nutrients · doi:10.3390/nu15020398 · Cited by 27
“It is well recognized that NO3supplementation may increase exercise tolerance in healthy young men following a single dose or multiday consumption [7,8].”
BackgroundHlinský, T., Kumstát, M., & Vajda, P. (2020) · Nutrients · doi:10.3390/nu12092734 · Cited by 26
“A more consistent positive change in performance is likely observed in athletes following a chronic supplementation protocol [1].”
BackgroundResultInfluentialTheodorou, A. A., Zinelis, P. T., Malliou, V. J., Chatzinikolaou, P. N., Margaritelis, N. V., Mandalidis, D. G., Geladas, N. D., & Paschalis, V. (2021) · Nutrients · doi:10.3390/nu13103311 · Cited by 25
Control of rat muscle nitrate levels after perturbation of steady state dietary nitrate intake
Park, J. W., Thomas, S. M., Schechter, A. N., & Piknova, B. (2021) · Nitric Oxide · doi:10.1016/j.niox.2021.03.003 · Cited by 24
Esen, Ö., Dobbin, N., & Callaghan, M. J. (2022) · Journal of the American Nutrition Association · doi:10.1080/07315724.2022.2037475 · Cited by 26
Carbohydrate supplementation: A critical review of recent innovations
Baur, D. A., & Saunders, M. J. (2021) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04534-y · Cited by 22
Pérez-Piñero, S., Ávila-Gandía, V., Rubio Arias, J. A., Muñoz-Carrillo, J. C., Losada-Zafrilla, P., & López-Román, F. J. (2021) · Nutrients · doi:10.3390/nu13124373 · Cited by 21
“In a large cohort of 1420 older women of ≥70 years of age, the relationship between total nitrate intake and muscle function measures was analyzed [33].”
l-Arginine and Beetroot Extract Supplementation in the Prevention of Sarcopenia
Córdova-Martínez, A., Caballero-García, A., Bello, H. J., Pons-Biescas, A., Noriega, D. C., & Roche, E. (2022) · Pharmaceuticals · doi:10.3390/ph15030290 · Cited by 21
“A possible explanation is that dietary supplementation with nitrate, administered in the form of beetroot extract, improves skeletal muscle contractile function and thereby improves muscle power and sprint performance [43].”
BackgroundReynolds, C. M. E., Evans, M., Halpenny, C., Hughes, C., Jordan, S., Quinn, A., Hone, M., & Egan, B. (2020) · Journal of Sports Sciences · doi:10.1080/02640414.2020.1770409 · Cited by 24
Protective roles of inorganic nitrate in health and diseases
Qin, L., & Wang, S. (2022) · Current Medicine · doi:10.1007/s44194-022-00002-1 · Cited by 20
“After swallowing, nitrate and nitrite are reabsorbed into the blood via the intestinal mucosa, and nitrite is either quickly oxidized to nitrate in the peripheral blood or reduced to NO (Jones et al., 2018; Lundberg et al., 2018).”
BackgroundDietary nitrite extends lifespan and prevents age-related locomotor decline in the fruit fly
Moretti, C. H., Schiffer, T. A., Montenegro, M. F., Larsen, F. J., Tsarouhas, V., Carlström, M., Samakovlis, C., Weitzberg, E., & Lundberg, J. O. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.09.018 · Cited by 21
León, V. M., & Luzardo, O. P. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111812 · Cited by 22
Behrens, C. E., Ahmed, K. A., Ricart, K. C., Linder, B. A., Fernández, J. R., Bertrand, B. M., Patel, R. P., & Fisher, G. (2020) · Physiological Reports · doi:10.14814/phy2.14574 · Cited by 16
Fernández-Elías, V. E., Courel‐Ibáñez, J., Pérez‐López, A., Jiménez, P. J., Moreno-Pérez, V., Coso, J. D., & López‐Samanes, Á. (2020) · Journal of the American Nutrition Association · doi:10.1080/07315724.2020.1835585 · Cited by 21
Esen, Ö., Faisal, A., Zambolin, F., Bailey, S. J., & Callaghan, M. J. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04946-y · Cited by 19
“Dietary nitrate (NO3) supplementation has been reported to increase plasma nitrite (NO2) concentration, which can be reduced to nitric oxide (NO) and subsequently enhance skeletal muscle perfusion, metabolism and endurance performance (Jones et al. 2018).”
Backgroundde Zevallos, J. O., Hogwood, A. C., Kruse, K., Guzman, J. D., Buckley, M., WELTMAN, A. L., & Allen, J. D. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00220.2023 · Cited by 23
Esen, Ö., Domínguez, R., & Karayiğit, R. (2022) · Nutrients · doi:10.3390/nu14142839 · Cited by 20
“8 mmol of NO3 have been consistently shown to enhance plasma NO2 by a magnitude that would be expected to enhance exercise performance [1,28].”
BackgroundMethodResultInfluentialRoux‐Mallouf, T. L., Pelen, F., Vallejo, A., Halimaoui, I., Doutreleau, S., & Vergès, S. (2019) · Aging · doi:10.18632/aging.101984 · Cited by 20
“Previous studies in healthy subjects showed a positive effect of citrulline [70] or nitrate [71,72] supplementation on exercise endurance performance.”
BackgroundPark, J. W., Piknova, B., Walter, P. J., Cai, H., Upanan, S., Thomas, S. M., Tunau-Spencer, K. J., & Schechter, A. N. (2023) · Scientific Reports · doi:10.1038/s41598-023-28190-2 · Cited by 20
van der Avoort, C. M. T., van Loon, L. J. C., Verdijk, L. B., Poyck, P. P. C., Thijssen, D. T. J., & Hopman, M. T. E. (2021) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2021-0054 · Cited by 19
Swartz, M. C., Allen, K., Deer, R., Lyons, E., Swartz, M. D., & Clifford, T. (2019) · Nutrients · doi:10.3390/nu11123003 · Cited by 19
“Because efficiency is a key determinant of aerobic exercise performance, it was reasonable to assume that this nitrate-induced reduction in work demand could enhance performance by increasing exercise tolerance and delaying the onset of fatigue [41].”
BackgroundResultInfluentialRoux‐Mallouf, T. L., Laurent, J., Besset, D., Marillier, M., Larribaut, J., Belaïdi, E., Corne, C., Doutreleau, S., & Vergès, S. (2019) · Experimental Physiology · doi:10.1113/ep087493 · Cited by 18
Tian, C., Jiang, Q., Han, M., Guo, L., Huang, R., Zhao, L., & Mao, S. (2025) · Nutrients · doi:10.3390/nu17121958 · Cited by 16
Tan, R., Pennell, A., Karl, S. T., Cass, J. K., Go, K., Clifford, T., Bailey, S. J., & Storm, C. P. (2023) · Nutrients · doi:10.3390/nu15112493 · Cited by 25
“Since resistance exercise encompasses lower and upper body exercise protocols, and that various upper body muscle groups are comprised of a greater proportion of type II muscle fibers [44], it was suggested that the efficacy of NO3 supplementation could be dependent on whether resistance exercise is being performed by…”
Zhou, J., Liu, H., Hu, L., Kagami, H., & Wang, S. (2024) · Medicine Plus · doi:10.1016/j.medp.2023.100003 · Cited by 17
Calvani, R., Giampaoli, O., Marini, F., CHIERICO, F. D., Rosa, M. D., Conta, G., Sciubba, F., Tosato, M., Picca, A., Ciciarello, F., et al. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.11.023 · Cited by 20
Effectiveness of Nitrate Intake on Recovery from Exercise-Related Fatigue: A Systematic Review
Gamonales, J. M., Rojas‐Valverde, D., Muñoz-Jiménez, J., Serrano-Moreno, W., & Ibáñez, S. J. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912021 · Cited by 16
Burgos, J., Viribay, A., Calleja-González, J., Fernández‐Lázaro, D., Olasagasti-Ibargoien, J., Seco‐Calvo, J., & Mielgo‐Ayuso, J. (2022) · Biology · doi:10.3390/biology11010075 · Cited by 16
“The placebo (cellulose) capsules were made of both 1 g and 700 mg being of the same color and shape as the other two supplements to avoid the placebo effect [45].”
BackgroundBenjamim, C. J. R., da Silva, L. S. L., Valenti, V. E., Gonçalves, L. D. S., Porto, A. A., Júnior, M. F. T., Walhin, J., Garner, D. M., Gualano, B., & Júnior, C. R. B. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.02.011 · Cited by 16
López‐Samanes, Á., Pérez‐López, A., Morencos, E., Muñoz, A., Kühn, A., Sánchez-Migallón, V., Moreno-Pérez, V., González, P., Bach-Faig, A., Roberts, J., et al. (2022) · European Journal of Nutrition · doi:10.1007/s00394-022-03052-1 · Cited by 21
“In fact, beetroot juice effect is mediated by its function as NO precursor [14] and may elicit performance enhancement due to different physiological mechanisms related to vasodilatation [11], skeletal muscle contractility or delaying fatigue development [13].”
BackgroundEsen, Ö., Mustafa, E. S. E. R., Abdioğlu, M., Benešová, D., Gabrys, T. T., & Karayiğit, R. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19084462 · Cited by 18
“While the literature has mostly focused on nitrate supplementation in the last decade [11], numerous NO-stimulating supplements in the sport nutrition market containing L-Arg claim performance and health benefits despite unclear and contrary findings of the effects of L-Arg supplementation on performance and health va…”
BackgroundBurke, L. M., Hall, R., Heikura, I. A., Ross, M. L., Tee, N., Kent, G. L., Whitfield, J., Forbes, S. F., Sharma, A. P., Jones, A. M., et al. (2021) · Nutrients · doi:10.3390/nu13082767 · Cited by 15
“Variability in findings around effects of nitrate supplementation on both economy and performance can be explained, in theory [19,56] and by meta-analysis, by a number of factors including the supplementation protocol (amount, type and timing) [58], the type of exercise [57] and the training status and aerobic fitness…”
BackgroundInfluentialSelf-citationBenjamim, C. J. R., Sousa, Y. B. A., Porto, A. A., Pontes, Y. M. D. M., Tavares, S. S., Rodrigues, G. D. S., da Silva, L. S. L., Gonçalves, L. D. S., Guimarães, C. S., Rebelo, M. A., et al. (2023) · Trials · doi:10.1186/s13063-023-07117-2 · Cited by 15
Tan, R., Black, M. I., Home, J., Blackwell, J. R., Clark, I. E., Wylie, L. J., Vanhatalo, A., & JONES, A. M. (2022) · Journal of Sports Sciences · doi:10.1080/02640414.2023.2176052 · Cited by 13
“Dietary nitrate (NO3 −) supplementation increases nitric oxide (NO) bioavailability and has been reported to enhance muscle contractility (Bailey et al., 2010; Hernández et al., 2012), oxygenation (Ferguson et al., 2013) and exercise performance (Jones et al., 2018).”
BackgroundSelf-citationMarshall, A., Rimmer, J. E., Shah, N., Bye, K., Kipps, C., Woods, D. R., O'Hara, J. P., Boos, C. J., & Barlow, M. (2021) · Nitric Oxide · doi:10.1016/j.niox.2021.05.002 · Cited by 15
Eriksson, K. E., Eidhagen, F., Liška, J., Franco‐Cereceda, A., Lundberg, J. O., & Weitzberg, E. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.06.046 · Cited by 13
Burgos, J., Viribay, A., Fernández‐Lázaro, D., Calleja-González, J., González‐Santos, J., & Mielgo‐Ayuso, J. (2021) · Nutrients · doi:10.3390/nu14010040 · Cited by 15
“Besides, the contractile characteristics of human muscle are improved by dietary NO3 [27].”
BackgroundDietary supplements for consideration in elite female footballers
Sheridan, H. C., Parker, L. J. F., & Hammond, K. M. (2021) · European Journal of Sport Science · doi:10.1080/17461391.2021.1988149 · Cited by 14
“to have more promising effects on performance in highly trained athletes compared to acute, low doses (Jones et al., 2018).”
BackgroundInfluentialKavcı, Z., Ozan, M., Buzdağlı, Y., Savaş, A., & Uçar, H. (2024) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2024.2445609 · Cited by 18
Task-Dependent Mechanisms Underlying Prolonged Low-Frequency Force Depression
Richards, A. J., Watanabe, D., Yamada, T., Westerblad, H., & Cheng, A. J. (2024) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000352 · Cited by 13
“The nitrate-nitrite-NO pathway has received a lot of attention due to its potential to improve exercise performance (47).”
Gutiérrez-Vargas, R., Pino‐Ortega, J., Ugalde-Ramírez, A., Ureña, B. S., Blanco-Romero, L., Trejos-Montoya, J. A., Gutiérrez-Vargas, J. C., & Rojas‐Valverde, D. (2021) · RICYDE Revista Internacional de Ciencias del Deporte · doi:10.5232/ricyde2022.06701 · Cited by 11
Rowland, S. N., James, L. J., O’Donnell, E., & Bailey, S. J. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05369-z · Cited by 15
“…needed to increase muscle [NO 2− ] (Kadach et al. 2023; Gilliard et al. 2018; Wylie et al. 2019) and subsequently impact skeletal muscle contractile function (Cermak et al. 2012; Jones et al. 2018), which may account for the lack of ergogenic effect of acute BR ingestion in the current study.”
BackgroundDietary Nitrate Supplementation and Exercise-Related Performance
Baranauskas, M. N., Coggan, A. R., Gruber, A. H., Altherr, C. A., Raglin, J. S., & Carter, S. J. (2020) · Nutrition Today · doi:10.1097/nt.0000000000000431 · Cited by 14
“The diverse role of NO in the regulation of blood flow, oxygen uptake, and skeletal muscle contractions has implications for athletic performance.(2,10,11) Accordingly, dietary NO3 − supplementation has been shown to result in small but nevertheless significant improvements in the performance of specific endurance and…”
BackgroundInfluentialOikawa, S. Y., Brisbois, T. D., van Loon, L. J. C., & Rollo, I. (2021) · GeroScience · doi:10.1007/s11357-021-00419-w · Cited by 13
“1 3 of inorganic nitrate cycling resulting in an augmented vasodilatory response above exercise alone [51].”
BackgroundRobinson, G. P., Killer, S. C., Stoyanov, Z., Stephens, H., Read, L., James, L. J., & Bailey, S. J. (2020) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2020-0198 · Cited by 11
“Keywords: beetroot juice, exercise performance, nitric oxide Dietary supplementation with inorganic nitrate (NO3 −), typically in the form of NO3 −-rich beetroot juice (BR), has emerged as a nutritional intervention to enhance exercise performance (Jones et al., 2018).”
BackgroundInfluentialCapó, X., Ferrer, M. D., Olek, R. A., Salaberry, E., Suau, R., Marí, B., Llompart, I., Tur, J. A., Sureda, A., & Pons, A. (2020) · Antioxidants · doi:10.3390/antiox9070596 · Cited by 11
Food for thought: Physiological considerations for nutritional ergogenic efficacy
Wickham, K. A., & Spriet, L. L. (2023) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14307 · Cited by 16
Influence of Sex and Acute Beetroot Juice Supplementation on 2 KM Running Performance
Casado, A., Domínguez, R., da Silva, S. F., & Bailey, S. J. (2021) · Applied Sciences · doi:10.3390/app11030977 · Cited by 15
“Importantly, the reduction of NO2 to NO is enhanced in acidosis and hypoxia [7], which is consistent with a lowering in plasma [NO2] during high-intensity exhaustive exercise which evokes acidosis, but not during lower intensity exercise that markedly perturbs acid–base balance [35].”
BackgroundInfluentialNeteca, J., Veseta, U., Liepina, I., Volgemute, K., Dzintare, M., & Babarykin, D. (2024) · Nutrients · doi:10.3390/nu17010063 · Cited by 13
Evangelista, J. F., Meirelles, C., Aguiar, G. S., Alves, R., & Matsuura, C. (2023) · Journal of the American Nutrition Association · doi:10.1080/27697061.2023.2211318 · Cited by 12
Nitrosative Stress in Astronaut Skeletal Muscle in Spaceflight
Blottner, D., Moriggi, M., Trautmann, G., Furlan, S., Block, K., Gutsmann, M., Torretta, E., Barbacini, P., Capitanio, D., Rittweger, J., et al. (2024) · Antioxidants · doi:10.3390/antiox13040432 · Cited by 11
“Skeletal muscle (taken together, forming the largest body organ) is a major source of NO in the human body [22].”
BackgroundDietary Nitrates, Nitrites, and Food Safety: Risks Versus Benefits
Martin, K. R. (2021) · Acta Scientifci Nutritional Health · doi:10.31080/asnh.2020.05.0884 · Cited by 10
“Accumulating evidence shows that dietary nitrate can markedly reduce the oxygen cost of exercise and enhance endurance around 15%, purportedly via modulation of mitochondrial efficiency mediated by improvement in the efficiency of oxidative phosphorylation [41,44].”
BackgroundSalem, A., Ammar, A., Kerkeni, M., Boujelbane, M. A., Uyar, A. M., Köbel, L. M., Selvaraj, S. A., Zare, R., Heinrich, K. M., Jahrami, H., et al. (2025) · Nutrients · doi:10.3390/nu17101720 · Cited by 16
“NO pathway, where NO 3 − is converted by oral bacteria and under hypoxia into NO, a potent vasodilator that enhances skeletal and coronary muscle perfusion, reduces systemic vascular resistance, and improves stroke volume [56,57].”
Macuh, M., Kojić, N., & Knap, B. (2023) · Nutrients · doi:10.3390/nu15173721 · Cited by 9
“Through the formation of nitric oxide (NO) via the nitrate–nitrite– nitric oxide metabolic pathway, nitrates augment endurance performance by decreasing oxygen cost during submaximal aerobic exercise and increase power output through enhanced muscle contractile function [5].”
BackgroundBerry, M. J., Miller, G. D., Kim‐Shapiro, D. B., Fletcher, M. S., Jones, C. G., Gauthier, Z. D., Collins, S. L., Basu, S., & Heinrich, T. M. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235047 · Cited by 9
Cramer, M. N., Hieda, M., Huang, M. R., Moralez, G., & Crandall, C. G. (2020) · Experimental Physiology · doi:10.1113/ep088834 · Cited by 9
Spleen contraction and Hb elevation after dietary nitrate intake
Engan, H. K., Patrician, A., Lodin‐Sundström, A., Johansson, H., Melin, M., & Schagatay, E. K. A. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00236.2020 · Cited by 10
“It should also be noted that studies investigating exercise performance following dietary NO (cid:1) 3 ingestion have reported both positive and null effects (30).”
BackgroundEffects of beetroot juice intake on repeated performance of competitive swimmers
Moreno-Heredero, B., Morencos, E., Vicente-Campos, D., Muñoz, A., González‐García, J., & Veiga, S. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2022.1076295 · Cited by 9
“Beetroot juice (BJ), which is included in the Class A group, has been found to have a high concentration of inorganic nitrate (NO3 ), and there is evidence that NO3 − supplementation improves vasodilation and increases blood flow in muscle (Jones et al., 2018; McDonagh et al., 2019), specifically on the type II muscle…”
BackgroundEffect of nitrite on the electroencephalographic activity in the healthy brain
Frankó, E., Ezra, M., Crockett, D. C., Joly, O., & Pattinson, K. T. S. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.06.002 · Cited by 7
Hennis, P. J., Cumpstey, A. F., O’Doherty, A. F., Fernandez, B. O., Gilbert-Kawai, E. T., Mitchell, K., Moyses, H. E., Cobb, A., Meale, P., Pöhnl, H., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.827235 · Cited by 8
Gonzalez, A. M., Pinzone, A. G., Lipes, S. E., Mangine, G. T., Townsend, J. R., Allerton, T. D., Sell, K. M., & Ghigiarelli, J. J. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-04940-4 · Cited by 10
Cumpstey, A. F., Hennis, P. J., Gilbert-Kawai, E. T., Fernandez, B. O., Grant, D., Jenner, W. J., Poudevigne, M., Moyses, H. E., Levett, D. Z. H., Cobb, A., et al. (2019) · Nitric Oxide · doi:10.1016/j.niox.2019.10.004 · Cited by 8
Metadata
- Authors
- Jones, A. M., Thompson, C., Wylie, L. J., & Vanhatalo, A.
- Affiliations
- University of Exeter (GB)
- Corresponding author
- Jones, Andrew M.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2018-08-21
- Volume
- 38
- Issue
- 1
- Pages
- 303-328
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2888009838
- Cited by
- 206
- References
- 168
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 21 · 2023: 39 · 2022: 33 · 2021: 24 · 2020: 29 · 2019: 15 · 2018: 1
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- dietary nitrate, nitric oxide, nitrate supplementation, beetroot juice, physical performance, endurance exercise, sprint performance, muscle efficiency, oxygen cost of exercise, skeletal muscle contractile function, nitrite, leafy vegetables, ergogenic aids
- MeSH terms
- Diet, Food Analysis, Humans, Nitrates, Nitric Oxide, Exercise
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