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Domains, Motifs, and Scaffolds: The Role of Modular Interactions in the Evolution and Wiring of Cell Signaling Circuits

Bhattacharyya, Roby P., Reményi, Attila, Yeh, Brian J., Lim, Wendell A.·2006·Annual Review of Biochemistry
DOI 10.1146/annurev.biochem.75.103004.142710
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Abstract

Living cells display complex signal processing behaviors, many of which are mediated by networks of proteins specialized for signal transduction. Here we focus on the question of how the remarkably diverse array of eukaryotic signaling circuits may have evolved. Many of the mechanisms that connect signaling proteins into networks are highly modular: The core catalytic activity of a signaling protein is physically and functionally separable from molecular domains or motifs that determine its linkage to both inputs and outputs. This high degree of modularity may make these systems more evolvable—in principle, novel circuits, and therefore highly innovative regulatory behaviors, can arise from relatively simple genetic events such as recombination, deletion, or insertion. In support of this hypothesis, recent studies show that such modular systems can be exploited to engineer nonnatural signaling proteins and pathways with novel behavior.

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Citations

Cites

Research works printed but not linked: 138

  1. 10.1038/35057062 · DOI · Paper page
  2. 10.1038/35057277 · DOI
  3. 10.1038/35011540 · DOI · Paper page
  4. 10.1038/nsmb820 · DOI · Paper page
  5. Ptashne M, 2002, Genes and Signals
  6. 10.1126/science.1113833 · DOI
  7. 10.1073/pnas.95.15.8420 · DOI · Paper page
  8. 10.1016/S0022-2836(63)80091-1 · DOI
  9. 10.1038/scientificamerican1278-92 · DOI
  10. 10.1126/science.1083653 · DOI · Paper page
  11. 10.1038/nmeth731 · DOI · Paper page
  12. 10.1002/cber.18940270364 · DOI
  13. 10.1111/j.1538-7836.2004.01021.x · DOI
  14. 10.1385/MB:22:1:051 · DOI
  15. 10.1016/S0960-9822(99)80205-X · DOI
  16. 10.1073/pnas.72.9.3448 · DOI
  17. 10.1038/nmeth708 · DOI
  18. 10.1016/S0960-9822(00)00221-9 · DOI
  19. 10.1021/ar020116v · DOI
  20. 10.1126/science.278.5337.455 · DOI
  21. 10.1016/S0968-0004(00)01627-3 · DOI · Paper page
  22. 10.1101/gad.13.20.2678 · DOI · Paper page
  23. 10.1016/j.molcel.2005.10.030 · DOI · Paper page
  24. 10.1016/j.cellsig.2005.04.001 · DOI
  25. 10.1091/mbc.02-03-0043 · DOI
  26. 10.1093/emboj/20.3.466 · DOI · Paper page
  27. 10.1016/0968-0004(96)30032-7 · DOI
  28. 10.1074/jbc.M108145200 · DOI
  29. 10.1074/jbc.M102512200 · DOI
  30. 10.1074/jbc.M010271200 · DOI
  31. 10.1016/j.molcel.2005.04.001 · DOI
  32. 10.1093/emboj/cdg353 · DOI
  33. 10.1093/emboj/19.5.979 · DOI · Paper page
  34. 10.1093/emboj/19.12.2924 · DOI · Paper page
  35. 10.1093/emboj/cdf437 · DOI
  36. 10.1016/0003-9861(88)90089-6 · DOI
  37. 10.1016/S0092-8674(01)00374-9 · DOI · Paper page
  38. 10.1016/S1097-2765(01)00253-2 · DOI
  39. 10.1016/S0960-9822(01)00370-0 · DOI
  40. 10.1126/stke.2422004re10 · DOI
  41. 10.1016/S0014-5793(01)03294-X · DOI · Paper page
  42. 10.1016/j.tibs.2004.09.010 · DOI
  43. Harris BZ, 2001, J. Cell Sci., 114, 3219, 10.1242/jcs.114.18.3219 · DOI · Paper page
  44. 10.1042/0264-6021:3500001 · DOI · Paper page
  45. 10.1016/S0962-8924(01)02154-7 · DOI · Paper page
  46. 10.1126/stke.2003.191.re12 · DOI · Paper page
  47. 10.1016/j.cell.2005.04.001 · DOI
  48. 10.1126/stke.2003.179.re8 · DOI
  49. 10.1242/jcs.1994.Supplement_18.14 · DOI
  50. 10.1016/j.sbi.2004.10.004 · DOI
  51. 10.1016/S0959-440X(02)00290-7 · DOI · Paper page
  52. 10.1126/science.290.5492.801 · DOI · Paper page
  53. 10.1083/jcb.150.6.1299 · DOI
  54. 10.1038/385602a0 · DOI · Paper page
  55. 10.1006/jmbi.1997.1426 · DOI
  56. 10.1038/385595a0 · DOI · Paper page
  57. 10.1093/nar/gkh088 · DOI · Paper page
  58. 10.1073/pnas.95.11.5857 · DOI
  59. 10.1016/S0960-9822(02)01038-2 · DOI · Paper page
  60. 10.1093/emboj/cdg258 · DOI · Paper page
  61. 10.1016/S1097-2765(03)00046-7 · DOI · Paper page
  62. 10.1074/jbc.M402745200 · DOI · Paper page
  63. 10.1016/S0092-8674(03)00314-3 · DOI
  64. 10.1016/S0960-9822(00)80080-9 · DOI
  65. 10.1016/j.cell.2005.02.019 · DOI
  66. 10.1073/pnas.92.11.5106 · DOI
  67. 10.1126/science.7509083 · DOI · Paper page
  68. 10.1074/jbc.270.7.2897 · DOI · Paper page
  69. 10.1038/nature02178 · DOI · Paper page
  70. 10.1371/journal.pbio.0020014 · DOI
  71. 10.1126/science.278.5346.2075 · DOI · Paper page
  72. 10.1021/bi0268910 · DOI
  73. 10.1038/nature03329 · DOI · Paper page
  74. 10.1016/S0955-0674(99)00078-2 · DOI
  75. Elion EA, 2001, J. Cell Sci., 114, 3967, 10.1242/jcs.114.22.3967 · DOI
  76. 10.1016/S0955-0674(99)80028-3 · DOI · Paper page
  77. 10.1146/annurev.cellbio.19.111401.091942 · DOI · Paper page
  78. 10.1016/S0968-0004(98)01309-7 · DOI · Paper page
  79. 10.1016/j.molcel.2004.06.011 · DOI
  80. 10.1073/pnas.91.16.7762 · DOI
  81. 10.1126/science.276.5319.1702 · DOI · Paper page
  82. Printen JA, 1994, Genetics, 138, 609, 10.1093/genetics/138.3.609 · DOI · Paper page
  83. 10.1128/MCB.26.3.912-928.2006 · DOI
  84. 10.1016/S0960-9822(01)00567-X · DOI
  85. 10.1038/sj.onc.1204782 · DOI
  86. 10.1021/ar020210b · DOI
  87. 10.1006/jmbi.2001.4585 · DOI · Paper page
  88. 10.1128/MCB.20.15.5529-5539.2000 · DOI
  89. 10.1016/j.brainresrev.2004.06.002 · DOI
  90. 10.1016/S1074-7613(00)80422-7 · DOI
  91. 10.1074/jbc.M000404200 · DOI · Paper page
  92. 10.1016/S1097-2765(01)00383-5 · DOI · Paper page
  93. 10.1128/MCB.22.9.3035-3045.2002 · DOI · Paper page
  94. 10.1038/nature02237 · DOI
  95. 10.1074/jbc.M405681200 · DOI
  96. 10.1126/science.1120941 · DOI
  97. 10.1074/jbc.M207324200 · DOI
  98. 10.1074/jbc.M501926200 · DOI
  99. 10.1126/science.7528941 · DOI
  100. 10.1126/science.271.5255.1589 · DOI
  101. 10.1016/S0960-9822(99)80141-9 · DOI
  102. 10.1093/emboj/20.8.1921 · DOI · Paper page
  103. 10.1016/j.cellsig.2005.04.003 · DOI
  104. 10.1038/27448 · DOI
  105. 10.1038/40805 · DOI · Paper page
  106. 10.1054/ceca.1999.0070 · DOI
  107. 10.1016/j.febslet.2005.02.013 · DOI
  108. 10.1126/science.1076979 · DOI
  109. 10.1073/pnas.1934711100 · DOI
  110. 10.1126/science.1085945 · DOI · Paper page
  111. 10.1074/jbc.M301226200 · DOI
  112. 10.1126/science.2420005 · DOI
  113. 10.1016/0092-8674(87)90756-2 · DOI · Paper page
  114. 10.1016/0092-8674(87)90757-4 · DOI
  115. 10.1016/S0962-8924(00)01834-1 · DOI
  116. 10.1126/science.288.5463.88 · DOI · Paper page
  117. 10.1073/pnas.0503610102 · DOI
  118. 10.1016/j.tig.2005.02.008 · DOI
  119. 10.1038/nbt796 · DOI
  120. 10.1074/jbc.M102604200 · DOI · Paper page
  121. 10.1074/jbc.M506654200 · DOI
  122. 10.1006/jmbi.2000.4133 · DOI
  123. 10.1073/pnas.96.6.2758 · DOI · Paper page
  124. 10.1126/science.8303274 · DOI · Paper page
  125. 10.1006/jmbi.1999.3007 · DOI
  126. 10.1021/bi026806o · DOI
  127. 10.1073/pnas.95.25.14628 · DOI
  128. 10.1073/pnas.040552697 · DOI · Paper page
  129. 10.1073/pnas.0501162102 · DOI
  130. 10.1016/j.febslet.2004.10.104 · DOI
  131. 10.1074/jbc.M400349200 · DOI
  132. 10.1128/JVI.78.3.1301-1313.2004 · DOI
  133. 10.1038/nature03556 · DOI · Paper page
  134. 10.1016/S0969-2126(01)00679-7 · DOI
  135. 10.1093/emboj/cdg068 · DOI · Paper page
  136. 10.1016/S0092-8674(00)00043-X · DOI
  137. 10.1038/nature03650 · DOI · Paper page
  138. 10.1016/j.cub.2004.12.050 · DOI

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Metadata

Authors
Bhattacharyya, R. P., Reményi, A., Yeh, B. J., & Lim, W. A.
Venue
Annual Review of Biochemistry
Publisher
Annual Reviews
Published
2006-06-01
Volume
75
Issue
1
Pages
655-680
ISSN
  • 0066-4154 (ISSN-L)
  • 1545-4509
DOI
10.1146/annurev.biochem.75.103004.142710
OpenAlex
W2152854378
Cited by
454
References
20
FWCI
1.89
Type
journal article
Language
en
Open access
closed

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