Cited by 1,076Biosensors and Analytical DetectionInnovation and Socioeconomic DevelopmentSARS-CoV-2 detection and testing

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Point-of-Care Diagnostics for Global Health

Yager, Paul, Domingo, Gonzalo J., Gerdes, John·2008·Annual Review of Biomedical Engineering

DOI 10.1146/annurev.bioeng.10.061807.160524

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Abstract

Biomedical engineers have traditionally developed technologies in response to the needs of the developed world's medical community. As a result, the diagnostic systems on which they have worked have met the requirements of well-funded laboratories in highly regulated and quality-assessed environments. However, such approaches do not address the needs of the majority of the world's people afflicted with infectious diseases, who have, at best, access to poorly resourced health care facilities with almost no supporting clinical laboratory infrastructure. A major challenge for the biomedical engineering community is to develop diagnostic tests to meet the needs of these people, the majority of whom are in the developing world. We here review the context in which the diagnostics must operate, some of the appropriate diagnostic technologies already in distribution, and some emerging technologies that promise to address this challenge. However, there is much room for innovation, adaptation, and cost reduction before these technologies can impact health care in the developing world.

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Authors: Yager, P., Domingo, G. J., & Gerdes, J.
Affiliations: University of Washington (US)
Program for Appropriate Technology in Health (US)
Redmond Fire Department (US)
ORCID: Yager, Paul
Domingo, Gonzalo J.
Venue: Annual Review of Biomedical Engineering
Publisher: Annual Reviews
Published: 2008-08-01
Volume: 10
Issue: 1
Pages: 107-144
ISSN: 1523-9829 (ISSN-L)
1545-4274
DOI: 10.1146/annurev.bioeng.10.061807.160524
OpenAlex: W2170895924
Cited by: 1,076
References: 217
Citations by year: 2026: 34 · 2025: 43 · 2024: 47 · 2023: 58 · 2022: 55 · 2021: 55 · 2020: 89 · 2019: 56 · 2018: 65 · 2017: 73 · 2016: 72 · 2015: 87 · 2014: 79 · 2013: 78 · 2012: 51
FWCI: 3.35
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
Social Sciences › Business, Management and Accounting › Business and International Management › Innovation and Socioeconomic Development
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
Keywords: point-of-care testing, global health, resource-limited settings, infectious diseases, diagnostic technology development, cost reduction, emerging diagnostic technologies
MeSH terms: Monitoring, Physiologic, Technology Assessment, Biomedical, Global Health, Point-of-Care Systems, Diagnostic Techniques and Procedures

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Point-of-Care Diagnostics for Global Health

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