Microglial Physiology: Unique Stimuli, Specialized Responses

Alternative activation of macrophages

Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827

Monocyte and macrophage heterogeneity

Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514

Microglia: a sensor for pathological events in the CNS

Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., et al. (1999) · Nature · doi:10.1038/22124 · Cited by 3,160

Dendritic Cell and Macrophage Heterogeneity In Vivo

Hashimoto, D., Miller, J. C., & Mérad, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.007 · Cited by 378

Microglia: Architects of the Developing Nervous System

Frost, J. L., & Schafer, D. P. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.02.006 · Cited by 385

Factors regulating microglia activation

Kierdorf, K., & Prinz, M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00044 · Cited by 360

Schizophrenia and autism: both shared and disorder-specific pathogenesis via perinatal inflammation?

MEYER, U., FELDON, J., & DAMMANN, O. (2011) · Pediatric Research · doi:10.1203/pdr.0b013e318212c196 · Cited by 357

Microglia in ALS: The Good, The Bad, and The Resting

Henkel, J. S., Beers, D. R., Zhao, W., & Appel, S. H. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9171-5 · Cited by 353

Microglia Function in Central Nervous System Development and Plasticity

Schafer, D. P., & Stevens, B. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020545 · Cited by 353

Genome-wide pleiotropy between Parkinson disease and autoimmune diseases

Witoelar, A., Jansen, I. E., Wang, Y., Desikan, R. S., Gibbs, J. R., Blauwendraat, C., Thompson, W. K., Hernandez, D. G., Djurovic, S., Schork, A. J., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.0469 · Cited by 352

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

González, H., Elgueta, D., Montoya, A., & Pacheco, R. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.07.012 · Cited by 352

Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome

Tejera, D., Mercan, D., Sanchez‐Caro, J. M., Hanan, M., Greenberg, D., Soreq, H., Latz, E., Golenbock, D., & Heneka, M. T. (2019) · The EMBO Journal · doi:10.15252/embj.2018101064 · Cited by 351

Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease

Mildner, A., Schlevogt, B., Kierdorf, K., Böttcher, C., Erny, D., Kummer, M. P., Quinn, M., Brück, W., Bechmann, I., Heneka, M. T., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.6209-10.2011 · Cited by 351

Phagocytosis executes delayed neuronal death after focal brain ischemia

Neher, J. J., Emmrich, J., Fricker, M., Mander, P. K., Théry, C., & Brown, G. C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308679110 · Cited by 357

Microglia Function in Alzheimer’s Disease

Solito, E., & Sastre, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00014 · Cited by 361

The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood

Mizutani, M., Pino, P. A., Saederup, N., Charo, I. F., Ransohoff, R. M., & Cardona, A. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100421 · Cited by 346

Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines

Cao, P., Chen, C., Liu, A., Shan, Q., Zhu, X., Jia, C.-H., Peng, X., Zhang, M., Farzinpour, Z., Zhou, W., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.06.012 · Cited by 348

Microglial Dynamics and Role in the Healthy and Diseased Brain: A Paradigm of Functional Plasticity

Gomez-Nicola, D., & Perry, V. H. (2015) · The Neuroscientist · doi:10.1177/1073858414530512 · Cited by 340

Neuron–glia crosstalk in health and disease: fractalkine and CX 3 CR1 take centre stage

Sheridan, G. K., & Murphy, K. J. (2013) · Open Biology · doi:10.1098/rsob.130181 · Cited by 358

Microglial Morphology and Dynamic Behavior Is Regulated by Ionotropic Glutamatergic and GABAergic Neurotransmission

Fontainhas, A. M., Wang, M., Liang, K. J., Chen, S., Mettu, P., Damani, M., Fariss, R. N., Li, W., & Wong, W. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015973 · Cited by 334

Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity

Kraft, A. D., & Harry, G. J. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8072980 · Cited by 340

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

Jordão, J. F., Thévenot, E., Markham-Coultes, K., Scarcelli, T., Weng, Y.-Q., Xhima, K., O'Reilly, M., Huang, Y., McLaurin, J., Hynynen, K., et al. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.05.008 · Cited by 326

In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis

Siffrin, V., Radbruch, H., Glumm, R., Niesner, R., Paterka, M., Herz, J., Leuenberger, T., Lehmann, S. M., Luenstedt, S., Rinnenthal, J. L., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.08.018 · Cited by 325

Current Challenges in Glia-Pain Biology

McMahon, S. B., & Malcangio, M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.033 · Cited by 324

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

Kirkley, K. S., Popichak, K. A., Afzali, M. F., Legare, M. E., & Tjalkens, R. B. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0871-0 · Cited by 331

GABA-Receptive Microglia Selectively Sculpt Developing Inhibitory Circuits

Favuzzi, E., Huang, S., Saldi, G.-A., Binan, L., Ibrahim, L. A., Fernández-Otero, M., Cao, Y., Zeine, A., Sefah, A., Zheng, K., et al. (2020) · Cell · doi:10.1016/j.cell.2021.06.018 · Cited by 327

Homeostatic and injury‐induced microglia behavior in the aging brain

Hefendehl, J. K., Neher, J. J., Sühs, R. B., Kohsaka, S., Skodras, A., & Jucker, M. (2014) · Aging Cell · doi:10.1111/acel.12149 · Cited by 319

Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

Chen, Z., Jalabi, W., Hu, W., Park, H.-J., Gale, J. T., Kidd, G. J., Bernatowicz, R., Gossman, Z. C., Chen, J. T., Dutta, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5486 · Cited by 319

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Zheng, H., Jia, L., Liu, C.-C., Rong, Z., Zhong, L., Yang, L., Chen, X.-F., Fryer, J. D., Wang, X., Zhang, Y.-W., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2459-16.2017 · Cited by 317

An Effector-Reduced Anti- -Amyloid (A ) Antibody with Unique A Binding Properties Promotes Neuroprotection and Glial Engulfment of A

Adolfsson, O., Pihlgren, M., Toni, N., Varisco, Y., Buccarello, A. L., Antoniello, K., Lohmann, S., Piorkowska, K., Gafner, V., Atwal, J. K., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4742-11.2012 · Cited by 317

Function of microglia and macrophages in secondary damage after spinal cord injury

Ren, Y., Zhou, X., & He, X. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.143423 · Cited by 328

Inflammation in Anxiety

Salim, S., Chugh, G., & Asghar, M. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-398314-5.00001-5 · Cited by 331

HMGB1: A Common Biomarker and Potential Target for TBI, Neuroinflammation, Epilepsy, and Cognitive Dysfunction

Paudel, Y. N., Shaikh, M. F., Chakraborti, A., Kumari, Y., Aledo-Serrano, Á., Aleksovska, K., Alvim, M. K. M., & Othman, I. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00628 · Cited by 311

Sexual dimorphism in the inflammatory response to traumatic brain injury

Villapol, S., Loane, D. J., & Burns, M. P. (2017) · Glia · doi:10.1002/glia.23171 · Cited by 320

How microglia kill neurons

Brown, G. C., & Vilalta, A. (2015) · Brain Research · doi:10.1016/j.brainres.2015.08.031 · Cited by 322

Prior exposure to glucocorticoids sensitizes the neuroinflammatory and peripheral inflammatory responses to E. coli lipopolysaccharide

Frank, M. G., Miguel, Z. D., Watkins, L. R., & Maier, S. F. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.07.008 · Cited by 303

Neuroglia in neurodegeneration

Heneka, M. T., Rodriguez, J. J., & Verkhratsky, A. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.11.004 · Cited by 316

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

Dudvarski Stankovic, N., Teodorczyk, M., Ploen, R., Zipp, F., & Schmidt, M. H. H. (2016) · Acta Neuropathologica · doi:10.1007/s00401-015-1524-y · Cited by 301

Developmental neuroinflammation and schizophrenia

Meyer, U. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.11.003 · Cited by 307

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

Collins, L. M., Toulouse, A., Connor, T. J., & Nolan, Y. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.028 · Cited by 306

Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities

Hemonnot, A.-L., Hua, J., Ulmann, L., & Hirbec, H. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00233 · Cited by 298

TREM2 regulates microglial cell activation in response to demyelination in vivo

Cantoni, C., Bollman, B., Licastro, D., Xie, M., Mikesell, R., Schmidt, R., Yuede, C. M., Galimberti, D., Olivecrona, G., Klein, R. S., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1388-1 · Cited by 296

Immunometabolism in the Brain: How Metabolism Shapes Microglial Function

Bernier, L., York, E. M., & MacVicar, B. A. (2020) · Trends in Neurosciences · doi:10.1016/j.tins.2020.08.008 · Cited by 308

When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

Roesch, S., Rapp, C., Dettling, S., & Herold‐Mende, C. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020436 · Cited by 305

Role of Microglia TLRs in Neurodegeneration

Fiebich, B. L., Batista, C. R. A., Saliba, S. W., Yousif, N. M., & de Oliveira, A. C. P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00329 · Cited by 291

An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation

Saijo, K., Collier, J. G., Li, A. C., Katzenellenbogen, J. A., & Glass, C. K. (2011) · Cell · doi:10.1016/j.cell.2011.03.050 · Cited by 295

Microglia–Neuron Communication in Epilepsy

Eyo, U. B., Murugan, M., & Wu, L. (2016) · Glia · doi:10.1002/glia.23006 · Cited by 300

Microglia and the brain: Complementary partners in development and disease

Hammond, T. R., Robinton, D., & Stevens, B. (2018) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060509 · Cited by 288

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

Hooten, K. G., Beers, D. R., Zhao, W., & Appel, S. H. (2015) · Neurotherapeutics · doi:10.1007/s13311-014-0329-3 · Cited by 294

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

Bachstetter, A. D., Xing, B., de Almeida, L., Dimayuga, E. R., Watterson, D. M., & Van Eldik, L. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-79 · Cited by 282

Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair

London, A., Cohen, M., & Schwartz, M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00034 · Cited by 282

Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity

Patterson, S. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.020 · Cited by 291

Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes

Holder, M. K., & Blaustein, J. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.10.004 · Cited by 279

Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner

Birbrair, A., Zhang, T., Files, D. C., Mannava, S., Smith, T. L., Wang, Z., Messi, M. L., Mintz, A., & Delbono, O. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt512 · Cited by 291

HDAC inhibitor sodium butyrate-mediated epigenetic regulation enhances neuroprotective function of microglia during ischemic stroke

Patnala, R., Arumugam, T. V., Gupta, N., & Dheen, S. T. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0149-z · Cited by 278

Contribution of systemic inflammation to chronic neurodegeneration

Perry, V. H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0722-x · Cited by 286

The choreography of neuroinflammation in Huntington's disease

Crotti, A., & Glass, C. K. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.04.007 · Cited by 276

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β

Cho, S.-H., Chen, J. A., Sayed, F., Ward, M. E., Gao, F., Nguyen, T. A., Krabbe, G., Sohn, P. D., Lo, I., Minami, S., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2939-14.2015 · Cited by 275

The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders

Pawelec, P., Ziemka‐Nałęcz, M., Sypecka, J., & Zalewska, T. (2020) · Cells · doi:10.3390/cells9102277 · Cited by 284

Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

Lacagnina, M. J., Rivera, P. D., & Bilbo, S. D. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.121 · Cited by 271

Mitochondrial dynamics modulate the expression of pro‐inflammatory mediators in microglial cells

Park, J., Choi, H., Min, J., Park, S., Kim, J., Park, H., Kim, B., Chae, J., Yim, M., & Lee, D. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12361 · Cited by 270

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

Cho, S.-H., Sun, B., Zhou, Y., Kauppinen, T. M., Halabisky, B., Wes, P., Ransohoff, R. M., & Gan, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254268 · Cited by 268

Microglia in CNS development: Shaping the brain for the future

Mosser, C., Baptista, S., Arnoux, I., & Audinat, É. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.01.002 · Cited by 289

Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target

Du, L., Zhang, Y., Chen, Y., Zhu, J., Yang, Y., & Zhang, H.-L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0245-0 · Cited by 280

Anti-inflammatory activities of resveratrol in the brain: Role of resveratrol in microglial activation

Zhang, F., Liu, J., & Shi, J. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.03.043 · Cited by 270

Microglia and neuroprotection: From in vitro studies to therapeutic applications

Polazzi, E., & Monti, B. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.06.009 · Cited by 269

Cellular and Molecular Mediators of Neuroinflammation in the Pathogenesis of Parkinson’s Disease

More, S. V., Kumar, H., Kim, I. S., Song, S.-Y., & Choi, D.-K. (2013) · Mediators of Inflammation · doi:10.1155/2013/952375 · Cited by 264

Microglia and aging: the role of the TREM2-DAP12 and CX3CL1-CX3CR1 axes

Mecca, C., Giambanco, I., Donato, R., & Arcuri, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010318 · Cited by 258

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

Appel, S. H., Beers, D. R., & Henkel, J. S. (2010) · Trends in Immunology · doi:10.1016/j.it.2009.09.003 · Cited by 256

Inflammatory processes in schizophrenia: A promising neuroimmunological target for the treatment of negative/cognitive symptoms and beyond

Meyer, U., Schwarz, M., & Müller, N. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.003 · Cited by 262

Neural circuitry and immunity

Pavlov, V. A., & Tracey, K. J. (2015) · Immunologic Research · doi:10.1007/s12026-015-8718-1 · Cited by 254

AMPK: Potential Therapeutic Target for Ischemic Stroke

Jiang, S., Li, T. X., Ji, T., Yi, W., Yang, Z. P., Wang, S., Yang, Y., & Gu, C. (2018) · Theranostics · doi:10.7150/thno.25674 · Cited by 256

Microglia Phenotype Diversity

Olah, M., Biber, K. P. H., Vinet, J., & Boddeke, H. W. G. M. (2011) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152711794488575 · Cited by 260

Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration

Labandeira-García, J. L., Rodriguez-Perez, A. I., Garrido‐Gil, P., Rodríguez‐Pallares, J., Lanciego, J. L., & Guerra, M. J. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00129 · Cited by 259

Microglia in the developing brain: a potential target with lifetime effects

Harry, G. J., & Kraft, A. D. (2012) · NeuroToxicology · doi:10.1016/j.neuro.2012.01.012 · Cited by 250

Emptying the stores: lysosomal diseases and therapeutic strategies

Platt, F. M. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.214 · Cited by 257

Sex, glia, and development: Interactions in health and disease

Schwarz, J. M., & Bilbo, S. D. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.018 · Cited by 247

Influenza Infection Induces Neuroinflammation, Alters Hippocampal Neuron Morphology, and Impairs Cognition in Adult Mice

Jurgens, H. A., Amancherla, K., & Johnson, R. W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6389-11.2012 · Cited by 243

Youth and environmental enrichment generate serum exosomes containing miR‐219 that promote CNS myelination

Pusic, A. D., & Kraig, R. P. (2013) · Glia · doi:10.1002/glia.22606 · Cited by 243

Pathogenesis of multiple sclerosis: insights from molecular and metabolic imaging

Ciccarelli, O., Barkhof, F., Bodini, B., Stefano, N. D., Golay, X., Nicolay, K., Pelletier, D., Pouwels, P. J. W., Smith, S. A., Wheeler‐Kingshott, C. A. M. G., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70101-2 · Cited by 253

The Role of Microglia and Astrocytes in Huntington’s Disease

Palpagama, T. H., Waldvogel, H. J., Faull, R. L. M., & Kwakowsky, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00258 · Cited by 246

TNF-alpha-induced microglia activation requires miR-342: Impact on NF-kB signaling and neurotoxicity

Brás, J. P., Bravo, J., Freitas, J., Barbosa, M. A., Santos, S. G., Summavielle, T., & Almeida, M. I. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-2626-6 · Cited by 236

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

Morris, G. P., Clark, I. A., Zinn, R., & Vissel, B. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.002 · Cited by 236

Microglia and mast cells: two tracks on the road to neuroinflammation

Skaper, S. D., Giusti, P., & Facci, L. (2012) · The FASEB Journal · doi:10.1096/fj.11-197194 · Cited by 235

Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS

Illés, P., Rubini, P., Ulrich, H., Zhao, Y., & Tang, Y. (2020) · Cells · doi:10.3390/cells9051108 · Cited by 249

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

Bodea, L.-G., Wang, Y., Linnartz-Gerlach, B., Kopatz, J., Sinkkonen, L., Musgrove, R., Kaoma, T., Muller, A., Vallar, L., Di Monte, D. A., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5002-13.2014 · Cited by 234

Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system

Yang, S., Qin, C., Hu, Z.-W., Zhou, L.-Q., Yu, H.-H., Chen, M., Bosco, D. B., Wang, W., Wu, L.-J., & Tian, D.-S. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105290 · Cited by 232

Glial Cells Shape Pathology and Repair After Spinal Cord Injury

Gaudet, A. D., & Fonken, L. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0630-7 · Cited by 242

Brain-immune interactions in perinatal hypoxic-ischemic brain injury

Li, B., Concepcion, K. R., Meng, X., & Zhang, L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.006 · Cited by 236

Harnessing monocyte‐derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’

Shechter, R., & Schwartz, M. (2012) · The Journal of Pathology · doi:10.1002/path.4106 · Cited by 237

The mechanisms of microgliosis and pain following peripheral nerve injury

Calvo, M., & Bennett, D. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.018 · Cited by 227

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

Goldmann, T., Zeller, N., Raasch, J., Kierdorf, K., Frenzel, K., Ketscher, L., Basters, A., Staszewski, O., Brendecke, S. M., Spiess, A., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201490791 · Cited by 223

Microglia function during brain development: New insights from animal models

Bilimoria, P. M., & Stevens, B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.11.032 · Cited by 237

High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons

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