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Cited by 292

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Fatty acid oxidation is directly regulated by carbohydrate metabolism during exercise

Coyle, E. F., Jeukendrup, A. E., Wagenmakers, A. J., Saris, W. H.·1997·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.1997.273.2.e268
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Abstract

We determined whether increased glycolytic flux from hyperglycemia and hyperinsulinemia directly reduces fatty acid oxidation during exercise. Fatty acid oxidation rates were measured during constant-rate intravenous infusion of trace amounts of a long-chain fatty acid ([1-13C]palmitate; Pal) vs. a medium-chain fatty acid ([1-13C]octanoate; Oct). Six endurance-trained men cycled for 40 min at 50% of maximal O2 uptake 1) after an overnight fast (“fasting”) and 2) after ingestion of 1.4 g/kg of glucose at 60 min and again 10 min before exercise (Glc). Glc caused hyperinsulinemia, a preexercise blood glucose of 6 mM, and a 34% reduction in total fat oxidation during exercise due to an approximately equal reduction in oxidation of plasma-free fatty acids (FFA) and intramuscular triglycerides (all P < 0.05). Oxidation of Pal was significantly reduced during Glc compared with fast (i.e., 70.0 +/- 4.1 vs. 86.0 +/- 1.9% of tracer infusion rate; P < 0.05). However, Glc had no effect on Oct oxidation, which is apparently not limited by mitochondrial transport. Furthermore, Glc reduced plasma FFA appearance 36% (P < 0.05), indicating a coordination of effects on adipose tissue and muscle. In summary, substrate oxidation during exercise can be regulated by increased glycolytic flux that is accompanied by a direct inhibition of long-chain fatty acid oxidation. These observations indicate that carbohydrate availability can directly regulate fat oxidation during exercise.

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Metadata

Authors
Coyle, E. F., Jeukendrup, A. E., Wagenmakers, A. J., & Saris, W. H.
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
1997-08-01
Volume
273
Issue
2
Pages
E268-E275
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.1997.273.2.e268
OpenAlex
W1783564712
Cited by
292
References
5
FWCI
4.23
Type
journal article
Language
en
Open access
closed

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