Pulse transit time measured from the ECG: an unreliable marker of beat-to-beat blood pressure
Abstract
The arterial pulse-wave transit time can be measured between the ECG R-wave and the finger pulse ( rPTT), and has been shown previously to have a linear correlation with blood pressure (BP). We hypothesized that the relationship between rPTT, preejection period (PEP; the R-wave/mechanical cardiac delay), and BP would vary with different vasoactive drugs. Twelve healthy men (mean age 22 yr) were studied. Beat-to-beat measurements were made of rPTT (using ECG and photoplethysmograph finger probe), intra-arterial radial pressure, PEP (using cardiac bioimpedance), and transit time minus PEP ( pPTT). Four drugs (glyceryl trinitrate, angiotensin II, norepinephrine, salbutamol) were administered intravenously over 15 min, with stepped dosage increase every 5 min and a 25-min saline washout between agents. All subjects in all conditions had a negative linear correlation ( R 2 = 0.39) between rPTT and systolic BP (SBP), generally constant between different drugs, apart from four subjects who had a positive rPTT/SBP correlation with salbutamol. The 95% limits of agreement between measured and rPTT-predicted SBP were ±17.0 mmHg. Beat-to-beat variability of rPTT showed better coherence with SBP variability than it did with heart rate variability ( P < 0.001). PEP accounted for a substantial and variable proportion of rPTT (12–35%). Diastolic (DBP) and mean arterial BP (MAP) correlated poorly with rPTT ( R 2 = 0.02 and 0.08, respectively) but better with pPTT ( rPTT corrected for PEP, R 2 = 0.41 and 0.45, respectively). The 95% limits of agreement between measured and pPTT-predicted DBP were ± 17.3 mmHg. In conclusion, the negative correlation between rPTT and SBP is generally constant, even with marked hemodynamic perturbations. However, the relationship is not reliable enough for rPTT to be used as a surrogate marker of SBP, although it may be useful in assessing BP variability. DBP and MAP cannot be predicted from rPTT without correction for PEP. The significant contribution of PEP to rPTT means that rPTT should not be used as a marker of purely vascular function.
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The results for HR and SpO2 are within FDA regulatory guidelines, which require errors less than ±10% or ±5 bpm for HR and less than 3.5% for Arms for reflectance mode SpO2.
“The results for HR and SpO2 are within the regulatory guidelines set by the US Food and Drug Administration (FDA), which require errors less than ± 10 % or ± 5 bpm for HR and less than 3.5 % for Arms for reflectance mode SpO226,27.”
From Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units (2020) · cites this paper as [27]
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- Authors
- Payne, R. A., Symeonides, C. N., Webb, D. J., & Maxwell, S. R. J.
- Affiliations
- Western General Hospital (GB)
- University of Edinburgh (GB)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2006-01
- Volume
- 100
- Issue
- 1
- Pages
- 136-141
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2059208589
- Cited by
- 418
- References
- 41
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 15 · 2023: 18 · 2022: 16 · 2021: 25 · 2020: 39 · 2019: 32 · 2018: 40 · 2017: 28 · 2016: 31 · 2015: 18 · 2014: 19 · 2013: 13 · 2012: 16
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Explore Bristol Research (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
- Keywords
- pulse transit time, beat-to-beat blood pressure, pre-ejection period, systolic blood pressure, diastolic blood pressure, mean arterial pressure, vasoactive drugs, nitroglycerin, angiotensin II, norepinephrine, salbutamol, photoplethysmography, blood pressure variability, heart rate variability
- MeSH terms
- Adolescent, Adult, Blood Pressure, Blood Pressure Determination, Diagnosis, Computer-Assisted, Electrocardiography, Heart Rate, Humans, Male, Manometry, Pulsatile Flow, Sensitivity and Specificity, Reproducibility of Results, Photoplethysmography
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