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Cited by 236Visual perception and processing mechanismsNeural dynamics and brain functionNeural and Behavioral Psychology Studies

Dual Diffusion Model for Single-Cell Recording Data From the Superior Colliculus in a Brightness-Discrimination Task

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Ratcliff, Roger, Hasegawa, Yukako T., Hasegawa, Ryohei P., Smith, Philip L., Segraves, Mark A.·2007·Journal of Neurophysiology
DOI 10.1152/jn.00393.2006PMC PMC2394732
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Abstract

Monkeys made saccades to one of two peripheral targets based on the brightness of a central stimulus. Task difficulty was manipulated by varying the ratio of stimulus black-and-white pixels. Correct response probability for two monkeys varied directly with difficulty. Deep layer SC neurons exhibited robust presaccadic activity the magnitude of which was unaffected by task difficulty when the stimulus specified a saccade toward a target within the neuron's response field. Activity after stimuli specifying saccades to targets outside the response field was affected by task difficulty, increasing as the task became more difficult. A quantitative model derived from studies of human decision-making was fit to the behavioral data. The model assumes that information from the stimulus drives two independent diffusion processes. Simulated paths from the model were compared with neuron activity, assuming that firing rate is linearly related to position in the accumulation process. The firing rate data show delayed availability of discriminative information for fast, intermediate, and slow decisions when activity is aligned on the stimulus and very small differences in discriminative information when aligned on the saccade. The model produces exactly these patterns of results. The accumulation process is highly variable, allowing the process both to make errors, as is the case for the behavioral performance, and also to account for the firing rate results. Thus the dual diffusion model provides a quantitative account for both the behavior in a simple decision-making task as well as the patterns of activity in competing populations of neurons.

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  • The pattern of LIP activity in the 4-choice task is similar to the process underlying 2-choice decisions.

    “This pattern of LIP activity in the 4-choice task is similar to the process underlying 2-choice decisions1,2,16.”

    From Decision-making with multiple alternatives (2008) · cites this paper as [16]

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Authors
Ratcliff, R., Hasegawa, Y. T., Hasegawa, R. P., Smith, P. L., & Segraves, M. A.
Affiliations
  • The Ohio State University (US)
  • Northwestern University (US)
  • The University of Melbourne (AU)
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
2007-02
Volume
97
Issue
2
Pages
1756-1774
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.00393.2006
PMC
PMC2394732
OpenAlex
W2062322739
Cited by
236
References
104
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 15 · 2020: 8 · 2019: 5 · 2018: 11 · 2017: 10 · 2016: 13 · 2015: 25 · 2014: 21 · 2013: 15 · 2012: 14
FWCI
3.89
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R37MH044640, R01MH059893, K05MH001891, R37 MH 44640, R01-MH59893, K05 MH 01891)
  • National Eye Institute (R01-EY-08212, R01EY008212)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
superior colliculus, brightness discrimination, response fields, task difficulty, firing rate
MeSH terms
Animals, Discrimination, Psychological, Electrophysiology, Female, Fixation, Ocular, Macaca mulatta, Models, Neurological, Neurons, Photic Stimulation, Psychomotor Performance, Saccades, Stereotaxic Techniques, Superior Colliculi

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