Matrix Metalloproteinases in Lung: Multiple, Multifarious, and Multifaceted

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

Vestbo, J., Hurd, S. S., Agustí, A. G., Jones, P. W., Vogelmeier, C., Anzueto, A., Barnes, P. J., Fabbri, L. M., Martinez, F. J., Nishimura, M., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201204-0596pp · Cited by 15,983

Inflammation and cancer

Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop Summary

PAUWELS, R. A., BUIST, A. S., CALVERLEY, P. M. A., JENKINS, C. R., & HURD, S. S. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.5.2101039 · Cited by 6,587

New functions for the matrix metalloproteinases in cancer progression

Egeblad, M., & Werb, Z. (2002) · Nature Reviews Cancer · doi:10.1038/nrc745 · Cited by 6,108

How Matrix Metalloproteinases Regulate Cell Behavior

Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959

Chronic Obstructive Pulmonary Disease

(2018) · Questions for the Final FFICM Structured Oral Examination · doi:10.1017/9781108233712.025 · Cited by 2,689

A matrix metalloproteinase expressed on the surface of invasive tumour cells

Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E., & Seiki, M. (1994) · Nature · doi:10.1038/370061a0 · Cited by 2,551

Smad transcription factors

Massagué, J., Seoane, J., & Wotton, D. (2005) · Genes & Development · doi:10.1101/gad.1350705 · Cited by 2,452

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

Yu, Q., & Stamenkovic, I. (2000) · PubMed · Cited by 1,995

Matrix metalloproteinases as modulators of inflammation and innate immunity

Parks, W. C., Wilson, C. L., & López-Boado, Y. S. (2004) · Nature Reviews Immunology · doi:10.1038/nri1418 · Cited by 1,929

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

Yu, Q., & Stamenkovic, I. (2000) · Genes & Development · doi:10.1101/gad.14.2.163 · Cited by 1,754

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

Vu, T. H., Shipley, J. M., Bergers, G., Berger, J. E., Helms, J. A., Hanahan, D., Shapiro, S. D., Senior, R. M., & Werb, Z. (1998) · Cell · doi:10.1016/s0092-8674(00)81169-1 · Cited by 1,750

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

Strongin, A. Y., Collier, I., Bannikov, G., Marmer, B. L., Grant, G. A., & Goldberg, G. I. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5331 · Cited by 1,593

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

Brooks, P. C., Strömblad, S., Sanders, L. C., von Schalscha, T. L., Aimes, R. T., Stetler-Stevenson, W. G., Quigley, J. P., & Cheresh, D. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81235-0 · Cited by 1,552

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

Hautamaki, R. D., Kobayashi, D. K., Senior, R. M., & Shapiro, S. D. (1997) · Science · doi:10.1126/science.277.5334.2002 · Cited by 1,469

COLLAGENOLYTIC ACTIVITY IN AMPHIBIAN TISSUES: A TISSUE CULTURE ASSAY

Gross, J., & Lapiere, C. M. (1962) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.48.6.1014 · Cited by 1,310

Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

Giannelli, G., Falk-Marzillier, J., Schiraldi, O., Stetler-Stevenson, W. G., & Quaranta, V. (1997) · Science · doi:10.1126/science.277.5323.225 · Cited by 1,221

Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy

Overall, C. M., & Kleifeld, O. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1821 · Cited by 1,214

Mammalian defensins in the antimicrobial immune response

Selsted, M. E., & Ouellette, A. J. (2005) · Nature Immunology · doi:10.1038/ni1206 · Cited by 1,203

Neutrophil granules and secretory vesicles in inflammation

Faurschou, M., & Borregaard, N. (2003) · Microbes and Infection · doi:10.1016/j.micinf.2003.09.008 · Cited by 1,162

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

Basset, P., Bellocq, J. P., Wolf, C., Stoll, I., Hutin, P., Limacher, J. M., Podhajcer, O. L., Chenard, M. P., Rio, M. C., & Chambon, P. (1990) · Nature · doi:10.1038/348699a0 · Cited by 1,131

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

Wilhelm, S. M., Collier, I. E., Marmer, B. L., Eisen, A. Z., Grant, G. A., & Goldberg, G. I. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71480-4 · Cited by 1,109

Regulation of matrix biology by matrix metalloproteinases

Mott, J. D., & Werb, Z. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.07.010 · Cited by 1,104

Chronic Obstructive Pulmonary Disease

Barnes, P. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007273430407 · Cited by 1,078

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,074

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.

Werb, Z., Tremble, P. M., Behrendtsen, O., Crowley, E., & Damsky, C. H. (1989) · The Journal of cell biology · doi:10.1083/jcb.109.2.877 · Cited by 1,059

Prognostic Significance of Histopathologic Subsets in Idiopathic Pulmonary Fibrosis

BJORAKER, J. A., RYU, J. H., EDWIN, M. K., MYERS, J. L., TAZELAAR, H. D., SCHROEDER, D. R., & OFFORD, K. P. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.1.9704130 · Cited by 1,039

Immunoregulatory functions of surfactant proteins

Wright, J. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1528 · Cited by 964

Induction of Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells by Transforming Growth Factor-β1

Willis, B. C., Liebler, J. M., Luby-Phelps, K., Nicholson, A. G., Crandall, E. D., du Bois, R. M., & Borok, Z. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62351-6 · Cited by 951

A Mutation in the Surfactant Protein C Gene Associated with Familial Interstitial Lung Disease

Nogee, L. M., Dunbar, A. E., Wert, S. E., Askin, F., Hamvas, A., & Whitsett, J. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102223440805 · Cited by 929

Remodeling in Asthma and Chronic Obstructive Lung Disease

JEFFERY, P. K. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.supplement_2.2106061 · Cited by 917

Dual Role of Matrix Metalloproteinases (Matrixins) in Intimal Thickening and Atherosclerotic Plaque Rupture

Newby, A. C. (2005) · Physiological Reviews · doi:10.1152/physrev.00048.2003 · Cited by 817

Matrix metalloproteinases: structures, evolution, and diversification

Massova, I., Kotra, L. P., Fridman, R., & Mobashery, S. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.12.1075 · Cited by 781

Role of the Matrix Metalloproteinase and Plasminogen Activator–Plasmin Systems in Angiogenesis

Pepper, M. S. (2001) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/hq0701.093685 · Cited by 777

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

McQuibban, G. A., Gong, J.-H., Tam, E. M., McCulloch, C. A. G., Clark-Lewis, I., & Overall, C. M. (2000) · Science · doi:10.1126/science.289.5482.1202 · Cited by 772

Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas

Freije, J. M., Díez-Itza, I., Balbín, M., Sánchez, L. M., Blasco, R., Tolivia, J., & López-Otín, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)89457-7 · Cited by 762

Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury

Li, Q., Park, P. W., Wilson, C. L., & Parks, W. C. (2002) · Cell · doi:10.1016/s0092-8674(02)01079-6 · Cited by 752

TGF-β1 induces human alveolar epithelial to mesenchymal cell transition (EMT)

Kasai, H., Allen, J. T., Mason, R. M., Kamimura, T., & Zhang, Z. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-56 · Cited by 744

The Membrane-Anchored MMP Inhibitor RECK Is a Key Regulator of Extracellular Matrix Integrity and Angiogenesis

Oh, J., Takahashi, R., Kondo, S., Mizoguchi, A., Adachi, E., Sasahara, R. M., Nishimura, S., Imamura, Y., Kitayama, H., Alexander, D. B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00597-9 · Cited by 728

The ABC protein turned chloride channel whose failure causes cystic fibrosis

Gadsby, D. C., Vergani, P., & Csanády, L. (2006) · Nature · doi:10.1038/nature04712 · Cited by 703

Generation of biologically active IL-1 beta by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1 beta processing.

Schönbeck, U., Mach, F., & Libby, P. (1998) · PubMed · Cited by 681

Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-α and leaves RANTES and MCP-2 intact

Van den Steen, P. E., Proost, P., Wuyts, A., Van Damme, J., & Opdenakker, G. (2000) · Blood · doi:10.1182/blood.v96.8.2673 · Cited by 680

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

Zhou, Z., Apte, S. S., Soininen, R., Cao, R., Baaklini, G. Y., Rauser, R. W., Wang, J., Cao, Y., & Tryggvason, K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.060037197 · Cited by 666

Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1

McQuibban, G. A., Butler, G. S., Gong, J.-H., Bendall, L., Power, C., Clark-Lewis, I., & Overall, C. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107736200 · Cited by 655

Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase– and cathepsin-dependent emphysema

Zheng, T., Zhu, Z., Wang, Z., Homer, R. J., Ma, B., Riese, R. J., Chapman, H. A., Shapiro, S. D., & Elias, J. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10458 · Cited by 646

Idiopathic Pulmonary Fibrosis: Relationship between Histopathologic Features and Mortality

KING, T. E., SCHWARZ, M. I., BROWN, K., TOOZE, J. A., COLBY, T. V., WALDRON, J. A., FLINT, A., THURLBECK, W., & CHERNIACK, R. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.6.2001056 · Cited by 628

Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans

Zuo, F., Kaminski, N., Eugui, E., Allard, J., Yakhini, Z., Ben-Dor, A., Lollini, L., Morris, D., Kim, Y., DeLustro, B., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092134099 · Cited by 620

Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo

McQuibban, G. A., Gong, J.-H., Wong, J. P., Wallace, J. L., Clark-Lewis, I., & Overall, C. M. (2002) · Blood · doi:10.1182/blood.v100.4.1160.h81602001160_1160_1167 · Cited by 611

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin

Wilson, C. L., Heppner, K. J., Labosky, P. A., Hogan, B. L. M., & Matrisian, L. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1402 · Cited by 609

Matrix Metalloproteinase-9 in Lung Remodeling

Atkinson, J. J., & Senior, R. M. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0166tr · Cited by 587

Determination of protease cleavage site motifs using mixture-based oriented peptide libraries

Turk, B. E., Huang, L. L., Piro, E. T., & Cantley, L. C. (2001) · Nature Biotechnology · doi:10.1038/90273 · Cited by 560

Loss of collagenase-2 confers increased skin tumor susceptibility to male mice

Balbín, M., Fueyo, A., Tester, A. M., Pendás, A. M., Pitiot, A. S., Astudillo, A., Overall, C. M., Shapiro, S. D., & López-Otín, C. (2003) · Nature Genetics · doi:10.1038/ng1249 · Cited by 536

Progression of Coronary Atherosclerosis Is Associated with a Common Genetic Variant of the Human Stromelysin-1 Promoter Which Results in Reduced Gene Expression

Ye, S., Eriksson, P., Hamsten, A., Kurkinen, M., Humphries, S. E., & Henney, A. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.13055 · Cited by 496

A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation

Weathington, N. M., van Houwelingen, A. H., Noerager, B. D., Jackson, P. L., Kraneveld, A. D., Galin, F. S., Folkerts, G., Nijkamp, F. P., & Blalock, J. E. (2006) · Nature Medicine · doi:10.1038/nm1361 · Cited by 496

Up-Regulation and Profibrotic Role of Osteopontin in Human Idiopathic Pulmonary Fibrosis

Pardo, A., Gibson, K., Cisneros, J., Richards, T. J., Yang, Y., Becerril, C., Yousem, S., Herrera, I., Ruiz, V., Selman, M., et al. (2005) · PLoS Medicine · doi:10.1371/journal.pmed.0020251 · Cited by 489

An Immune Basis for Lung Parenchymal Destruction in Chronic Obstructive Pulmonary Disease and Emphysema

Grumelli, S., Corry, D. B., Song, L.-Z., Song, L., Green, L., Huh, J., Hacken, J., Espada, R., Bag, R., Lewis, D. E., et al. (2004) · PLoS Medicine · doi:10.1371/journal.pmed.0010008 · Cited by 484 · cited 4×

Dysregulation of TGF-β1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice

Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asahi, M., Takahashi, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507375102 · Cited by 476

Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library

Takino, T., Sato, H., Shinagawa, A., & Seiki, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.39.23013 · Cited by 471

Elastin fragments drive disease progression in a murine model of emphysema

Houghton, A. M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25617 · Cited by 462

Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression

Overall, C. M., Wrana, J. L., & Sodek, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)92810-3 · Cited by 460

Gene Expression Profiles Distinguish Idiopathic Pulmonary Fibrosis from Hypersensitivity Pneumonitis

Selman, M., Pardo, A., Barrera, L., Estrada, A., Watson, S. R., Wilson, K., Aziz, N., Kaminski, N., & Zlotnik, A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200504-644oc · Cited by 458

Mitochondrial redox control of matrix metalloproteinases

Nelson, K. K., & Melendez, J. A. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.06.008 · Cited by 441

Interleukin-1β Causes Pulmonary Inflammation, Emphysema, and Airway Remodeling in the Adult Murine Lung

Lappalainen, U., Whitsett, J. A., Wert, S. E., Tichelaar, J. W., & Bry, K. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0309oc · Cited by 430

The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome

Pugin, J., Verghese, G., Widmer, M.-C., & Matthay, M. A. (1999) · Critical Care Medicine · doi:10.1097/00003246-199902000-00036 · Cited by 421

Interferon γ Induction of Pulmonary Emphysema in the Adult Murine Lung

Wang, Z., Zheng, T., Zhu, Z., Homer, R. J., Riese, R. J., Chapman, H. A., Shapiro, S. D., & Elias, J. A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1587 · Cited by 415

Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin

Wu, S., Lim, K.-C., Huang, J., Saidi, R. F., & Sears, C. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14979 · Cited by 408

Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice

Wert, S. E., Yoshida, M., LeVine, A. M., Ikegami, M., Jones, T., Ross, G. F., Fisher, J. H., Korfhagen, T. R., & Whitsett, J. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100448997 · Cited by 405

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.

Hasty, K. A., Pourmotabbed, T. F., Goldberg, G. I., Thompson, J. P., Spinella, D. G., Stevens, R. M., & Mainardi, C. L. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38413-3 · Cited by 401

Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions.

Sun, J., & Hemler, M. E. (2001) · PubMed · Cited by 397

Role of Rac1 and Oxygen Radicals in Collagenase-1 Expression Induced by Cell Shape Change

Kheradmand, F., Werner, E., Tremble, P., Symons, M., & Werb, Z. (1998) · Science · doi:10.1126/science.280.5365.898 · Cited by 391

Matrix Metalloproteinases and TlMPs

Woessner, J. F., & Nagase, H. (2000) · Oxford University Press eBooks · doi:10.1093/oso/9780198502685.002.0001 · Cited by 391

Transmembrane-deletion Mutants of the Membrane-type Matrix Metalloproteinase-1 Process Progelatinase A and Express Intrinsic Matrix-degrading Activity

Pei, D., & Weiss, S. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.15.9135 · Cited by 388

The Serpin α1-Proteinase Inhibitor Is a Critical Substrate for Gelatinase B/MMP-9 In Vivo

Liu, Z., Zhou, X., Shapiro, S. D., Shipley, J. M., Twining, S. S., Diaz, L. A., Senior, R. M., & Werb, Z. (2000) · Cell · doi:10.1016/s0092-8674(00)00087-8 · Cited by 388

Regulation of Matrix Metalloproteinases (MMP-2, -3, -9, and -13) by Interleukin-1 and Interleukin-6 in Mouse Calvaria: Association of MMP Induction with Bone Resorption

Kusano, K. (1998) · Endocrinology · doi:10.1210/en.139.3.1338 · Cited by 386

Matrix metalloproteinases and TIMPs

Woessner, J. F., & Nagase, H. (2000) · Medical Entomology and Zoology · Cited by 380

Matrix metalloproteinases in lung biology

Parks, W. C., & Shapiro, S. D. (2000) · Respiratory Research · doi:10.1186/rr33 · Cited by 380

Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema

D'Armiento, J., Dalal, S. S., Okada, Y., Berg, R. A., & Chada, K. (1992) · Cell · doi:10.1016/0092-8674(92)90391-o · Cited by 379

Macrophage Metalloelastase Mediates Acute Cigarette Smoke–induced Inflammation via Tumor Necrosis Factor-α Release

Churg, A., Wang, R. D., Tai, H., Wang, X., Xie, C., Dai, J., Shapiro, S. D., & Wright, J. L. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200212-1396oc · Cited by 367

Vascular Matrix Metalloproteinase-2 Cleaves Big Endothelin-1 Yielding a Novel Vasoconstrictor

Fernandez-Patron, C., Radomski, M. W., & Davidge, S. T. (1999) · Circulation Research · doi:10.1161/01.res.85.10.906 · Cited by 366

The collagenase gene family in humans consists of at least four members

Muller, D., Quantin, B., Gesnel, M. C., Millon-Collard, R., Abecassis, J., & Breathnach, R. (1988) · Biochemical Journal · doi:10.1042/bj2530187 · Cited by 365

Mechanotransduction through growth-factor shedding into the extracellular space

Tschumperlin, D. J., Dai, G., Maly, I. V., Kikuchi, T., Laiho, L. H., McVittie, A. K., Haley, K. J., Lilly, C. M., So, P. T. C., Lauffenburger, D. A., et al. (2004) · Nature · doi:10.1038/nature02543 · Cited by 353

Stimulation of Matrix Metalloproteinase Production by Recombinant Extracellular Matrix Metalloproteinase Inducer from Transfected Chinese Hamster Ovary Cells

Guo, H., Zucker, S., Gordon, M. K., Toole, B. P., & Biswas, C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.24 · Cited by 341

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

Will, H., & Hinzmann, B. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0602d.x · Cited by 336

Matrix metalloproteinases in destructive pulmonary pathology

Elkington, P. T. G. (2006) · Thorax · doi:10.1136/thx.2005.051979 · Cited by 330

Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease

Ning, W., Li, C.-J., Kaminski, N., Feghali-Bostwick, C. A., Alber, S. M., Di, Y. P., Otterbein, S. L., Song, R., Hayashi, S., Zhou, Z., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401168101 · Cited by 328

Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.

Puente, X. S., Pendás, A. M., Llano, E., Velasco, G., & López-Otı́n, C. (1996) · PubMed · Cited by 327

A Key Role for Mast Cell Chymase in the Activation of Pro-matrix Metalloprotease-9 and Pro-matrix Metalloprotease-2

Tchougounova, E., Lundequist, A., Fajardo, I., Winberg, J.-O., Åbrink, M., & Pejler, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410396200 · Cited by 323

Matrilysin (Matrix Metalloproteinase-7) Mediates E-Cadherin Ectodomain Shedding in Injured Lung Epithelium

McGuire, J. K., Li, Q., & Parks, W. C. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64318-0 · Cited by 322

New Functions for Non-collagenous Domains of Human Collagen Type IV

Petitclerc, E., Boutaud, A., Prestayko, A., Xu, J., Sado, Y., Ninomiya, Y., Sarras, M. P., Hudson, B. G., & Brooks, P. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.8051 · Cited by 315

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling

Lanone, S., Zheng, T., Zhu, Z., Liu, W., Lee, C. G., Ma, B., Chen, Q., Homer, R. J., Wang, J., Rabach, L. A., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14136 · Cited by 299

Gelatinase B/MMP‐9 and neutrophil collagenase/MMP‐8 process the chemokines human GCP‐2/CXCL6, ENA‐78/CXCL5 and mouse GCP‐2/LIX and modulate their physiological activities

Van den Steen, P. E., Wuyts, A., Husson, S. J., Proost, P., Van Damme, J., & Opdenakker, G. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03760.x · Cited by 288

Vascular Endothelial Growth Factor Increases Release of Gelatinase A and Decreases Release of Tissue Inhibitor of Metalloproteinases by Microvascular Endothelial Cellsin Vitro

Lamoreaux, W. J., Fitzgerald, M. E. C., Reiner, A., Hasty, K. A., & Charles, S. T. (1998) · Microvascular Research · doi:10.1006/mvre.1997.2056 · Cited by 278

Epilysin, a Novel Human Matrix Metalloproteinase (MMP-28) Expressed in Testis and Keratinocytes and in Response to Injury

Lohi, J., Wilson, C. L., Roby, J. D., & Parks, W. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m001599200 · Cited by 273

Matrilysin expression and function in airway epithelium.

Dunsmore, S. E., Saarialho-Kere, U. K., Roby, J. D., Wilson, C. L., Matrisian, L. M., Welgus, H. G., & Parks, W. C. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1516 · Cited by 270

Mechanical stress is communicated between different cell types to elicit matrix remodeling

Swartz, M. A., Tschumperlin, D. J., Kamm, R. D., & Drazen, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111133298 · Cited by 267

Mouse macrophage elastase. Purification and characterization as a metalloproteinase

Banda, M. J., & Werb, Z. (1981) · Biochemical Journal · doi:10.1042/bj1930589 · Cited by 264

Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiency

Corry, D. B., Rishi, K., Kanellis, J., Kiss, A., Song, L.-Z., Xu, J., Feng, L., Werb, Z., & Kheradmand, F. (2002) · Nature Immunology · doi:10.1038/ni773 · Cited by 263

The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function

Joos, L. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.5.569 · Cited by 261

Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors.

Llano, E., Pendás, A. M., Freije, J. M. P., Nakano, A., Knäuper, V., Murphy, G., & López-Otín, C. (1999) · PubMed · Cited by 258

Membrane-Bound Matrix Metalloproteinase-8 on Activated Polymorphonuclear Cells Is a Potent, Tissue Inhibitor of Metalloproteinase-Resistant Collagenase and Serpinase

Owen, C. A., Hu, Z., Lopez-Otin, C., & Shapiro, S. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.12.7791 · Cited by 257

Monocyte Chemoattractant Protein-1 Enhances Gene Expression and Synthesis of Matrix Metalloproteinase-1 in Human Fibroblasts by an Autocrine IL-1α Loop

Yamamoto, T., Eckes, B., Mauch, C., Hartmann, K., & Krieg, T. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6174 · Cited by 255

Drosophila Matrix Metalloproteinases Are Required for Tissue Remodeling, but Not Embryonic Development

Page-McCaw, A., Serano, J., Santé, J. M., & Rubin, G. M. (2003) · Developmental Cell · doi:10.1016/s1534-5807(02)00400-8 · Cited by 254

An endopeptidase from rheumatoid synovial tissue culture

Harris, E. D., & Krane, S. M. (1972) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(72)90249-5 · Cited by 254

Immune gene discovery by expressed sequence tags generated from hemocytes of the bacteria-challenged oyster, Crassostrea gigas

Gueguen, Y., Cadoret, J., Flament, D., Barreau, C., Girardot, A.-L., Garnier, J., Hoareau, A., Bachère, E., & Escoubas, J.-M. (2003) · Gene · doi:10.1016/s0378-1119(02)01149-6 · Cited by 253

Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease

Molet, S., Belleguic, C., Lena, H., Germain, N., Bertrand, C. P., Shapiro, S. D., Planquois, J. M., Delaval, P., & Lagente, V. (2005) · Inflammation Research · doi:10.1007/s00011-004-1319-4 · Cited by 252

Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13–induced inflammation and remodeling

Lanone, S., Zheng, T., Zhu, Z., Liu, W., Lee, C. G., Ma, B., Chen, Q., Homer, R. J., Wang, J., Rabach, L. A., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0214136 · Cited by 248

Balance of Matrix Metalloprotease-9 and Tissue Inhibitor of Metalloprotease-1 from Alveolar Macrophages in Cigarette Smokers

Lim, S., Roche, N., Oliver, B. G. G., de Mattos, W. L. L. D., Barnes, P. J., & Chung, K. F. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.4.9910097 · Cited by 247

Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis

Herman, M. P., Sukhova, G. K., Kisiel, W., Foster, D., Kehry, M. R., Libby, P., & Schönbeck, U. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10403 · Cited by 246

Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence

Park, P. W., Pier, G. B., Hinkes, M. T., & Bernfield, M. (2001) · Nature · doi:10.1038/35075100 · Cited by 243

Molecular Regulation of Lung Development

Cardoso, W. V. (2001) · Annual Review of Physiology · doi:10.1146/annurev.physiol.63.1.471 · Cited by 241

Chronic exposure to high levels of particulate air pollution and small airway remodeling.

Churg, A., Brauer, M., del Carmen Avila-Casado, M., Fortoul, T. I., & Wright, J. L. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.6042 · Cited by 240

Matrix Metalloproteinases: Matrix Degradation and More

Shapiro, S. D., & Senior, R. M. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.6.f151 · Cited by 240

Is There a Link Between DNA Polymerase Beta and Cancer?

Starcevic, D., Dalal, S., & Sweasy, J. B. (2004) · Cell Cycle · doi:10.4161/cc.3.8.1062 · Cited by 239

Eosinophils as a source of matrix metalloproteinase-9 in asthmatic airway inflammation.

Ohno, I., Ohtani, H., Nitta, Y., Suzuki, J., Hoshi, H., Honma, M., Isoyama, S., Tanno, Y., Tamura, G., Yamauchi, K., et al. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.16.3.9070604 · Cited by 232

Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients

Finlay, G. A., Russell, K. J., McMahon, K. J., D'ARCY, E. M., Masterson, J., FitzGerald, M. X., & O'CONNOR, C. M. (1997) · Thorax · doi:10.1136/thx.52.6.502 · Cited by 231

Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3

Eickelberg, O., Köhler, E., Reichenberger, F., Bertschin, S., Woodtli, T., Erne, P., Perruchoud, A. P., & Roth, M. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.276.5.l814 · Cited by 226

The Th2 Lymphocyte Products IL-4 and IL-13 Rapidly Induce Airway Hyperresponsiveness Through Direct Effects on Resident Airway Cells

Venkayya, R., Lam, M., Willkom, M., Grünig, G., Corry, D. B., & Erle, D. J. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.2.4600 · Cited by 223

Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis*

Heine, U. I., Munoz, E. F., Flanders, K. C., Roberts, A. B., & Sporn, M. B. (1990) · Development · doi:10.1242/dev.109.1.29 · Cited by 220

Extracellular Cyclophilins Contribute to the Regulation of Inflammatory Responses

Arora, K., Gwinn, W. M., Bower, M. A., Watson, A. M., Okwumabua, I., MacDonald, H. R., Bukrinsky, M., & Constant, S. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.1.517 · Cited by 219

Pneumonitis and Emphysema in sp-C Gene Targeted Mice

Glasser, S. W., Detmer, E. A., Ikegami, M., Na, C.-L., Stahlman, M. T., & Whitsett, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210909200 · Cited by 218

Guidebook to the extracellular matrix and adhesion proteins

(1994) · General Pharmacology: The Vascular System · doi:10.1016/0306-3623(94)90275-5 · Cited by 212

Human Neutrophils Secrete Gelatinase B In Vitro and In Vivo in Response to Endotoxin and Proinflammatory Mediators

Pugin, J., Widmer, M.-C., Kossodo, S., Liang, C.-M., Preas, H. L., & Suffredini, A. F. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.3.3311 · Cited by 212

Normal newt limb regeneration requires matrix metalloproteinase function

Vinarsky, V., Atkinson, D. L., Stevenson, T. J., Keating, M. T., & Odelberg, S. J. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.12.003 · Cited by 211

Surfactant-associated proteins: functions and structural variation

Haagsman, H. P., & Diemel, R. V. (2001) · Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology · doi:10.1016/s1095-6433(01)00308-7 · Cited by 209

Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokines

Corry, D. B., Kiss, A., Song, L.-Z., Song, L., Xu, J., Lee, S.-H., Werb, Z., & Kheradmand, F. (2004) · The FASEB Journal · doi:10.1096/fj.03-1412fje · Cited by 209

Molecular cloning and mRNA tissue distribution of a novel matrix metalloproteinase isolated from porcine enamel organ

Bartlett, J. D., Simmer, J. P., Xue, J., Margolis, H. C., & Moreno, E. C. (1996) · Gene · doi:10.1016/s0378-1119(96)00525-2 · Cited by 205

Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines

Koshy, P. J., Henderson, N., Logan, C., Life, P. F., Cawston, T. E., & Rowan, A. D. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.8.704 · Cited by 205

Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase.

Shapiro, S. D., Griffin, G. L., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., Welgus, H. G., Senior, R. M., & Ley, T. J. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42885-2 · Cited by 204

C‐C chemokine receptor 2 (CCR2) deficiency improves bleomycin‐induced pulmonary fibrosis by attenuation of both macrophage infiltration and production of macrophage‐derived matrix metalloproteinases

Okuma, T., Terasaki, Y., Kaikita, K., Kobayashi, H., Kuziel, W. A., Kawasuji, M., & Takeya, M. (2004) · The Journal of Pathology · doi:10.1002/path.1667 · Cited by 199

Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2

Kheradmand, F., Rishi, K., & Werb, Z. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.4.839 · Cited by 197

Mutations in the Surfactant Protein C Gene Associated With Interstitial Lung Disease

Nogee, L. M., Dunbar, A. E., Wert, S., Askin, F., Hamvas, A., & Whitsett, J. A. (2002) · Chest · doi:10.1378/chest.121.3_suppl.20s · Cited by 197

Identification and Characterization of Human Endometase (Matrix Metalloproteinase-26) from Endometrial Tumor

Park, H. I., Ni, J., Gerkema, F. E., Liu, D., Belozerov, V. E., & Sang, Q.-X. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002349200 · Cited by 195

Egr-1 Mediates Extracellular Matrix-driven Transcription of Membrane Type 1 Matrix Metalloproteinase in Endothelium

Haas, T. L., Stitelman, D., Davis, S. J., Apte, S. S., & Madri, J. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22679 · Cited by 188

Matrix Metalloproteinase-9 Deficiency Results in Enhanced Allergen-Induced Airway Inflammation

McMillan, S. J., Kearley, J., Campbell, J. D., Zhu, X., Larbi, K. Y., Shipley, J. M., Senior, R. M., Nourshargh, S., & Lloyd, C. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2586 · Cited by 186

Gelatinase B Is Required for Alveolar Bronchiolization after Intratracheal Bleomycin

Betsuyaku, T., Fukuda, Y., Parks, W. C., Shipley, J. M., & Senior, R. M. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64563-4 · Cited by 185

Proteomic Identification of In Vivo Substrates for Matrix Metalloproteinases 2 and 9 Reveals a Mechanism for Resolution of Inflammation

Greenlee, K. J., Corry, D. B., Engler, D. A., Matsunami, R. K., Tessier, P., Cook, R. G., Werb, Z., & Kheradmand, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7312 · Cited by 182

Matrix Metalloproteinase-3 Genotype Contributes to Age-Related Aortic Stiffening Through Modulation of Gene and Protein Expression

Medley, T. L., Kingwell, B. A., Gatzka, C. D., Pillay, P., & Cole, T. J. (2003) · Circulation Research · doi:10.1161/01.res.0000076891.24317.ca · Cited by 180

STIMULATION BY ENDOCYTOSIS OF THE SECRETION OF COLLAGENASE AND NEUTRAL PROTEINASE FROM RABBIT SYNOVIAL FIBROBLASTS

Werb, Z., & Reynolds, J. J. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.140.6.1482 · Cited by 180

HGF reduces advancing lung fibrosis in mice: a potential role for MMP‐dependent myofibroblast apoptosis

Mizuno, S., Matsumoto, K., Li, M.-Y., & Nakamura, T. (2005) · The FASEB Journal · doi:10.1096/fj.04-1535fje · Cited by 177

Respiratory-related neuronal activity in the nucleus ambiguus-retroambigualis complex and their responses to peripheral and central stimulation in the rat

Balnave, R., Huang, Z., Subramanian, S., & Turman, A. (2001) · Respiratory Research · doi:10.1186/rr126 · Cited by 177

Neutral proteinases of human mononuclear phagocytes. Cellular differentiation markedly alters cell phenotype for serine proteinases, metalloproteinases, and tissue inhibitor of metalloproteinases

Campbell, E. J., Cury, J. D., Shapiro, S. D., Goldberg, G. I., & Welgus, H. G. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.4.1286 · Cited by 176

Increased and Prolonged Pulmonary Fibrosis in Surfactant Protein C-Deficient Mice Following Intratracheal Bleomycin

Lawson, W. E., Polosukhin, V. V., Stathopoulos, G. T., Zoia, O., Han, W., Lane, K. B., Li, B., Donnelly, E. F., Holburn, G. E., Lewis, K. G., et al. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61214-x · Cited by 174

Matrix metalloproteinases in asthma and COPD

Demedts, I., Brusselle, G., Bracke, K. R., Vermaelen, K. Y., & PAUWELS, R. A. (2005) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.12.005 · Cited by 172

Role of matrix metalloproteinases in the development of airway inflammation and remodeling

Lagente, V., Manoury, B., Nénan, S., Quément, C. L., Martin‐Chouly, C., & Boichot, E. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005001000009 · Cited by 163

Surfactant Protein D Regulates NF-κB and Matrix Metalloproteinase Production in Alveolar Macrophages via Oxidant-Sensitive Pathways

Yoshida, M., Korfhagen, T. R., & Whitsett, J. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7514 · Cited by 162

Mechanisms and Limits of Induced Postnatal Lung Growth

(2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200209-1062st · Cited by 161

Matrix Metalloproteinase-8 Deficiency Promotes Granulocytic Allergen-Induced Airway Inflammation

Gueders, M. M., Balbı́n, M., Rocks, N., Foidart, J.-M., Gosset, P., Louis, R. E., Shapiro, S. D., López-Otı́n, C., Noël, A., & Cataldo, D. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2589 · Cited by 158

Determinants of Progression in Idiopathic Pulmonary Fibrosis

Schwartz, D. A., Fossen, D. S. V., Davis, C. S., Helmers, R. A., Dayton, C. S., Burmeister, L. F., & Hunninghake, G. W. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.2.8306043 · Cited by 156

Pulmonary alveolar proteinosis: CT findings.

Godwin, J. D., Müller, N. L., & Takasugi, J. E. (1988) · Radiology · doi:10.1148/radiology.169.3.3186983 · Cited by 155

Matrix Metalloproteinase-9 Promoter Polymorphism Associated with Upper Lung Dominant Emphysema

Ito, I., Nagai, S., Handa, T., Muro, S., Hirai, T., Tsukino, M., & Mishima, M. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200506-953oc · Cited by 155

The Matrix Metalloproteinase-14 (MMP-14) Gene Is Structurally Distinct from Other MMP Genes and Is Co-expressed with the TIMP-2 Gene during Mouse Embryogenesis

Apte, S., Fukai, N., Beier, D. R., & Olsen, B. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25511 · Cited by 148

Immune modulation of metalloproteinase production in human macrophages. Selective pretranslational suppression of interstitial collagenase and stromelysin biosynthesis by interferon-gamma.

Shapiro, S. D., Campbell, E. J., Kobayashi, D. K., & Welgus, H. G. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114826 · Cited by 148

A Protective Role for Matrix Metalloproteinase-3 in Squamous Cell Carcinoma

McCawley, L. J., Crawford, H. C., King, L. E., Mudgett, J. S., & Matrisian, L. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0910 · Cited by 148

Functional and Analytical Evidence for Scavenging of Oxygen Radicals by l-Arginine

Lass, A., Suessenbacher, A., Wölkart, G., Mayer, B., & Brünner, F. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.5.1081 · Cited by 148

Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastat

Corbel, M., Caulet-Maugendre, S., Germain, N., Molet, S., Lagente, V., & Boichot, E. (2001) · The Journal of Pathology · doi:10.1002/path.826 · Cited by 145

CHRONIC EFFECTS OF MECHANICAL FORCE ON AIRWAYS

Tschumperlin, D. J., & Drazen, J. M. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.072304.113102 · Cited by 143

Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM)

Wang, H., Parry, S. I., Macones, G. A., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh287 · Cited by 142

Membrane-type Matrix Metalloproteinase-1 (MT1-MMP) Is a Processing Enzyme for Human Laminin γ2 Chain

Koshikawa, N., Minegishi, T., Sharabi, A. B., Quaranta, V., & Seiki, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411824200 · Cited by 140

Identification and characterization of a novel collagenase in Xenopus laevis: possible roles during frog development.

Stolow, M. A., Bauzon, D. D., Li, J., Sedgwick, T., Liang, V. C.-T., Sang, Q. A., & Shi, Y. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.10.1471 · Cited by 140

MMP-28, a new human matrix metalloproteinase with an unusual cysteine-switch sequence is widely expressed in tumors

Marchenko, G. N., & Strongin, A. Y. (2001) · Gene · doi:10.1016/s0378-1119(01)00360-2 · Cited by 137

Post-translational Proteolytic Processing of Procollagen C-terminal Proteinase Enhancer Releases a Metalloproteinase Inhibitor

Mott, J. D., Thomas‐Virnig, C. L., Rosenbach, M. T., Takahara, K., Greenspan, D. S., & Banda, M. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1384 · Cited by 136

The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant.

Banda, M. J., Rice, A. G., Griffin, G. L., & Senior, R. M. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.5.1608 · Cited by 136

Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation

Oblander, S. A., Zhou, Z., Gálvez, B. G., STARCHER, B. C., Shannon, J. M., Durbeej, M., Arroyo, A. G., Tryggvason, K., & Apte, S. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.09.033 · Cited by 131

Ventilator-Induced Lung Injury Upregulates and Activates Gelatinases and EMMPRIN

Foda, H. D., Rollo, E. E., Drews, M., Conner, C. E., Appelt, K., Shalinsky, D. R., & Zucker, S. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.6.4558f · Cited by 130

Matrix metalloproteinases regulate neutrophil‐endothelial cell adhesion through generation of endothelin‐1[1–32]

Fernández-Patrón, C., Zouki, C., Whittal, R. M., Chan, J. S. D., Davidge, S. T., & Filep, J. G. (2001) · The FASEB Journal · doi:10.1096/fj.01-0178com · Cited by 129

Induced sputum matrix metalloproteinase‐9 correlates with lung function and airway inflammation in children with cystic fibrosis

Sagel, S. D., Kapsner, R. K., & Osberg, I. M. (2005) · Pediatric Pulmonology · doi:10.1002/ppul.20165 · Cited by 128

Tryptase, the Dominant Secretory Granular Protein in Human Mast Cells, is a Potent Mitogen for Cultured Dog Tracheal Smooth Muscle Cells

Brown, J. K., Tyler, C. L., Jones, C. A., Ruoss, S. J., Hartmann, T., & Caughey, G. H. (1995) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.13.2.7626290 · Cited by 128

Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene

Breathnach, R., Matrisian, L. M., Gesnel, M.-C., Staub, A., & Leroy, P. (1987) · Nucleic Acids Research · doi:10.1093/nar/15.3.1139 · Cited by 128

A novel hydra matrix metalloproteinase (HMMP) functions in extracellular matrix degradation, morphogenesis and the maintenance of differentiated cells in the foot process

Leontovich, A. A., Zhang, J., Shimokawa, K., Nagase, H., & Sarras, M. P. (2000) · Development · doi:10.1242/dev.127.4.907 · Cited by 128

Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process?

DeMayo, F. J., Minoo, P., Plopper, C. G., Schuger, L. A., Shannon, J., & Torday, J. S. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00144.2002 · Cited by 124

Identification of MMP-18, a Putative Novel Human Matrix Metalloproteinase

Cossins, J., Dudgeon, T. J., Catlin, G., Gearing, A. J. H., & Clements, J. M. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1688 · Cited by 122

A study of reactive oxygen species in mainstream of cigarette

Huang, M. F., Lin, W., & Ma, Y. C. (2005) · Indoor Air · doi:10.1111/j.1600-0668.2005.00330.x · Cited by 121

MMP13 mutation causes spondyloepimetaphyseal dysplasia, Missouri type (SEMDMO)

Kennedy, A. M., Inada, M., Krane, S. M., Christie, P. T., Harding, B., López-Otı́n, C., Sánchez, L. M., Pannett, A. A. J., Dearlove, A., Hartley, C. L., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22900 · Cited by 120

Matrix metalloproteinase expression and function during fin regeneration in zebrafish: Analysis of MT1-MMP, MMP2 and TIMP2

BAI, S., Thummel, R., Godwin, A. R. F., Nagase, H., Itoh, Y., Li, T., EVANS, R., McDermott, J. P., Seiki, M., & SARRASJR, M. (2005) · Matrix Biology · doi:10.1016/j.matbio.2005.03.007 · Cited by 117

Animal Models of Cigarette Smoke-Induced COPD*

Wright, J. L., & Churg, A. (2002) · CHEST Journal · doi:10.1378/chest.122.6_suppl.301s · Cited by 116

Inducible Expression of Tissue Inhibitor of Metalloproteinases–Resistant Matrix Metalloproteinase-9 on the Cell Surface of Neutrophils

Owen, C. A., Hu, Z., Barrick, B., & Shapiro, S. D. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0034oc · Cited by 114

Role of reactive oxygen and nitrogen species in acute respiratory distress syndrome

Fink, M. P. (2002) · Current Opinion in Critical Care · doi:10.1097/00075198-200202000-00002 · Cited by 113

MMP20 Active-site Mutation in Hypomaturation Amelogenesis Imperfecta

Özdemır, D., Hart, P. S., Ryu, O. H., Choi, S. J., Karataş, M. Ö., Fıratlı, E., Piesco, N. P., & Hart, T. C. (2005) · Journal of Dental Research · doi:10.1177/154405910508401112 · Cited by 113

Cg‐TIMP, an inducible tissue inhibitor of metalloproteinase from the Pacific oyster Crassostrea gigas with a potential role in wound healing and defense mechanisms1

Montagnani, C., Roux, F. L., Berthe, F. C. J., & Escoubas, J.-M. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02559-5 · Cited by 113

Mycobacterium tuberculosis Up-Regulates Matrix Metalloproteinase-1 Secretion from Human Airway Epithelial Cells via a p38 MAPK Switch

Elkington, P. T., Emerson, J. E., LOPEZ‐PASCUA, L. D. C., O’Kane, C. M., Horncastle, D. E., Boyle, J. J., & Friedland, J. S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5333 · Cited by 112

Primary structure and expression of a gamete lytic enzyme in Chlamydomonas reinhardtii: similarity of functional domains to matrix metalloproteases.

Kinoshita, T., Fukuzawa, H., Shimada, T., Saito, T., & Matsuda, Y. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4693 · Cited by 107

αvβ3 Integrin Interacts with the Transforming Growth Factor β (TGFβ) Type II Receptor to Potentiate the Proliferative Effects of TGFβ1 in Living Human Lung Fibroblasts

Scaffidi, A. K., Petrovic, N., Moodley, Y. P., Fogel‐Petrovic, M., Kroeger, K. M., Seeber, R. M., Eidne, K. A., Thompson, P. J., & Knight, D. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403010200 · Cited by 107

MMPs - Role in Cardiovascular Development and Disease

Philip, R. B. (2006) · Frontiers in bioscience · doi:10.2741/1810 · Cited by 105

Matrix Metalloproteinase Homologues from Arabidopsis thaliana

Maidment, J. M., Moore, D., Murphy, G. P., Murphy, G., & Clark, I. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.49.34706 · Cited by 104

Molecular mechanism for activation and regulation of matrix metalloproteinases during bacterial infections and respiratory inflammation

Okamoto, T., Akuta, T., Tamura, F., van der Vliet, A., & Akaike, T. (2004) · Biological Chemistry · doi:10.1515/bc.2004.130 · Cited by 104

Membrane Type 1-Matrix Metalloproteinase Is Regulated by Chemokines Monocyte-Chemoattractant Protein-1/CCL2 and Interleukin-8/CXCL8 in Endothelial Cells during Angiogenesis

Gálvez, B. G., Genı́s, L., Matı́as-Román, S., Oblander, S. A., Tryggvason, K., Apte, S., & Arroyo, A. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408673200 · Cited by 103

Bcl-2 Promotes Invasion and Lung Metastasis by Inducing Matrix Metalloproteinase-2

Choi, J., Choi, K., Benveniste, E. N., Hong, Y.-S., Lee, J., Kim, J., & Park, K. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4570 · Cited by 103

Emphysema and Metalloelastase Expression in Mouse Lung Induced by Cigarette Smoke

Valença, S. S., da Hora, K., Castro, P., Moraes, V. G., de Carvalho, L., & Pôrto, L. C. (2004) · Toxicologic Pathology · doi:10.1080/01926230490431466 · Cited by 103

The plasmin system in airway remodeling

Kucharewicz, I., Kowal, K., Buczko, W., & Bodzenta‐Łukaszyk, A. (2003) · Thrombosis Research · doi:10.1016/j.thromres.2003.10.011 · Cited by 102

Cyclic mechanical strain‐induced proliferation and migration of human airway smooth muscle cells: role of EMMPRIN and MMPs

Hasaneen, N. A., Zucker, S., Cao, J. P., Chiarelli, C., Panettieri, R. A., & Foda, H. D. (2005) · The FASEB Journal · doi:10.1096/fj.04-3350fje · Cited by 101

Structural and Enzymatic Characterization of Drosophila Dm2-MMP, a Membrane-bound Matrix Metalloproteinase with Tissue-specific Expression

Llano, E., Adam, G., Pendás, A. M., Quesada, V., Sánchez, L. M., Santamarı́a, I., Noselli, S., & López-Otı́n, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200121200 · Cited by 100

Asthma: Pathology and Pathophysiology

Barrios, R. J., Kheradmand, F., Batts, L. M., & Corry, D. B. (2006) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2006-130-447-apap · Cited by 100

The involvement of matrix metalloproteinase‐9 in airway inflammation of patients with acute asthma

Lee, Y. C., Lee, H. B., Rhee, Y. K., & Song, C. H. (2001) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2001.01211.x · Cited by 100

Matrix Metalloproteinase-12 and Cathepsin D Expression in Pulmonary Macrophages and Dendritic Cells of Cigarette Smoke-Exposed Mice

Bracke, K. R., Cataldo, D. D., Maes, T., Gueders, M. M., Noël, A., Foidart, J., Brusselle, G., & PAUWELS, R. A. (2005) · International Archives of Allergy and Immunology · doi:10.1159/000088439 · Cited by 99

Vascular endothelial growth factor, epidermal growth factor and fibroblast growth factor-4 and -10 stimulate trophoblast plasminogen activator system and metalloproteinase-9

Anteby, E. Y. (2004) · Molecular Human Reproduction · doi:10.1093/molehr/gah031 · Cited by 99

Mechanical stretch induces MMP-2 release and activation in lung endothelium: role of EMMPRIN

Haseneen, N. A., Vaday, G. G., Zucker, S., & Foda, H. D. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00290.2002 · Cited by 98

Proteinases and Oxidants as Targets in the Treatment of Chronic Obstructive Pulmonary Disease

Owen, C. A. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200504-029sr · Cited by 97

A null mutation for Tissue Inhibitor of Metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis

Gill, S. E., Pape, M. C., Khokha, R., Watson, A. J., & Leco, K. J. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00318-x · Cited by 94

The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases

Cabral-Pacheco, G. A., Garza-Veloz, I., Castruita-De la Rosa, C., Ramirez-Acuña, J. M., Perez-Romero, B. A., Guerrero-Rodriguez, J. F., Martinez-Avila, N., & Martinez-Fierro, M. L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249739 · Cited by 1,820

Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development

Morrisey, E. E., & Hogan, B. L. M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.010 · Cited by 964

The role of TIMPs in regulation of extracellular matrix proteolysis

Arpino, V., Brock, M., & Gill, S. E. (2015) · Matrix Biology · doi:10.1016/j.matbio.2015.03.005 · Cited by 734

Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis

Craig, V. J., Zhang, L., Hagood, J. S., & Owen, C. A. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2015-0020tr · Cited by 507

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

Volkman, H. E., Pozos, T. C., Zheng, J., Davis, J. M., Rawls, J. F., & Ramakrishnan, L. (2010) · Science · doi:10.1126/science.1179663 · Cited by 448