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Cited by 345

The DOI matches its Crossref record; 432 of the 432 references it cites were found in a registry or an index.

Regulation of the Pulmonary Circulation in the Fetus and Newborn

Gao, Yuansheng, Raj, J. Usha·2010·Physiological Reviews
DOI 10.1152/physrev.00032.2009
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Abstract

During the development of the pulmonary vasculature in the fetus, many structural and functional changes occur to prepare the lung for the transition to air breathing. The development of the pulmonary circulation is genetically controlled by an array of mitogenic factors in a temporo-spatial order. With advancing gestation, pulmonary vessels acquire increased vasoreactivity. The fetal pulmonary vasculature is exposed to a low oxygen tension environment that promotes high intrinsic myogenic tone and high vasocontractility. At birth, a dramatic reduction in pulmonary arterial pressure and resistance occurs with an increase in oxygen tension and blood flow. The striking hemodynamic differences in the pulmonary circulation of the fetus and newborn are regulated by various factors and vasoactive agents. Among them, nitric oxide, endothelin-1, and prostaglandin I 2 are mainly derived from endothelial cells and exert their effects via cGMP, cAMP, and Rho kinase signaling pathways. Alterations in these signaling pathways may lead to vascular remodeling, high vasocontractility, and persistent pulmonary hypertension of the newborn.

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Metadata

Authors
Gao, Y., & Raj, J. U.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2010-10
Volume
90
Issue
4
Pages
1291-1335
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00032.2009
OpenAlex
W2004886793
Cited by
345
References
432
FWCI
3.03
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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