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The Response-to-Retention Hypothesis of Early Atherogenesis
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“The retention of lipoproteins in the arterial extracellular matrix is a critical step in atherogenesis in which lipoproteins with higher affinity for arterial proteoglycans are more atherogenic (55, 56).”
From Role of the N- and C-Terminal Domains in Binding of Apolipoprotein E Isoforms to Heparan Sulfate and Dermatan Sulfate: A Surface Plasmon Resonance Study (2008) · cites this paper as [55]
In the citing paper
“The ECM has a central role in initiation of atherosclerosis, primarily through the interaction between the negatively charged side chains of proteoglycans (particularly chondroitin sulphate of biglycan and versican and heparin sulphate of perlecan 110 ) with positively charged apolipoproteins (especially apolipoprotein B) , which leads to the retention of plasma-derived lipoproteins 101,111 - as”
From Vascular smooth muscle cells in atherosclerosis (2019) · cites this paper as [113]
In the citing paper
“the interaction of apoB-containing lipoproteins (the non-HDL lipoproteins) with intimal extracellular proteoglycans (referred to as retention)1,43,44 inhibits the movement of the lipoproteins, thereby resulting in much higher subendothelial concentrations of these lipoproteins in the intima than in any other tissue45.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [1]
In the citing paper
“Atherosclerosis is a disease characterized by low-grade, chronic inflammation of the arterial wall and is triggered by the subendothelial retention of plasma-derived, apolipoprotein B (apoB)-containing lipoproteins in the affected inner layer of the arterial wall, the intima1–3.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [1]
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Citations
Cites
The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Role of oxidized low density lipoprotein in atherogenesis.
Witztum, J. L., & Steinberg, D. H. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115499 · Cited by 2,675
The Pathogenesis of Atherosclerosis
Ross, R., & Glomset, J. A. (1976) · New England Journal of Medicine · doi:10.1056/nejm197608122950707 · Cited by 2,017
Ylä‐Herttuala, S., Palinski, W., Rosenfeld, M. E., Parthasarathy, S., Carew, T. E., Butler, S. S., Witztum, J. L., & Steinberg, D. H. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114271 · Cited by 1,877
Atherogenesis: a postprandial phenomenon.
Zilversmit, D. B. (1979) · Circulation · doi:10.1161/01.cir.60.3.473 · Cited by 1,701
ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.
Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693
Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk
Austin, M. A., King, M. C., Vranizan, K. M., & Krauss, R. M. (1990) · Circulation · doi:10.1161/01.cir.82.2.495 · Cited by 1,411
The pathogenesis of atherosclerosis
(1972) · American Heart Journal · doi:10.1016/0002-8703(72)90090-7 · Cited by 1,329
Research works printed but not linked: 64
- 1949, Arch Pathol, 48, 342
- 1991, Adv Exp Med Biol, 285, 373
- 1991, Atheroscler Rev, 23, 91
- 10.1161/atv91.14.5.8172861 · DOI
- 1977, Am J Pathol, 86, 675
- 1992, Am J Pathol, 140, 907
- 10.1161/atv91.12.9.1525124 · DOI
- 1992, Arch Pathol Lab Med, 116, 1301
- 10.1161/atv91.13.8.8343497 · DOI
- 1992, Arch Pathol Lab Med, 116, 1292
- 1957, Arch Pathol, 64, 303
- 10.1161/atv91.12.12.1450173 · DOI
- 10.1161/atv91.13.8.8343494 · DOI
- 10.1161/atv91.14.2.8305425 · DOI
- 1913, Zentralbl Allg Pathol, 24, 1
- 1989, Ann Cardiol Angeiol (Paris), 38, 631
- 10.1161/atv91.13.9.8364021 · DOI
- 1984, Am J Pathol, 114, 112
- 10.1161/atv91.12.4.1558836 · DOI
- 10.1161/atv91.12.11.1420090 · DOI
- 10.1161/atv91.12.11.1420091 · DOI
- 1994, Am J Pathol, 144, 952
- 10.1161/atv91.13.2.7678986 · DOI
- 10.1161/atv91.11.6.1931881 · DOI
- 10.1161/atv91.14.3.8123647 · DOI
- 1993, Lab Invest, 68, 369
- 1991, Am J Pathol, 139, 101
- 10.1161/res.72.2.8418981 · DOI
- 10.1161/res.74.1.8261591 · DOI
- 10.1161/atv91.12.11.1420084 · DOI
- 10.1161/atv91.14.1.8274468 · DOI
- 1983, Am J Pathol, 113, 156
- 10.1161/atv91.14.1.8274466 · DOI
- 1988, Am J Pathol, 131, 73
- 1986, Am J Pathol, 123, 109
- 10.1161/circ.85.6.1591855 · DOI
- 10.1161/atv91.12.5.1576119 · DOI
- 10.1161/atv91.13.11.7692957 · DOI
- 10.1161/atv91.14.1.7506053 · DOI
- 1994, Am J Med, 97, 3A
- Lund G Beisiegel U Seeber N Nikutta P Hamm CW. Effect of probucol on progression/regression of coronary artery disease. In: Abstracts Submitted to the Council on Arteriosclerosis for the 66th Scientific Sessions of the American Heart Association . Dallas Tex: American Heart Association Inc; 1993:124.
- 10.1161/atv91.14.5.8172860 · DOI
- 10.1161/atv91.11.5.1911712 · DOI
- 10.1161/atv91.12.5.1576122 · DOI
- 10.1161/atv91.13.12.8241102 · DOI
- 10.1161/atv91.14.7.8018672 · DOI
- 10.1161/circ.60.3.222498 · DOI
- 10.1161/atv91.13.2.8427855 · DOI
- 1986, Lab Invest, 54, 402
- 1994, Am J Pathol, 144, 538
- 10.1161/atv91.12.2.1543697 · DOI
- 10.1161/atv91.12.8.1637798 · DOI
- 1993, Am J Pathol, 142, 1787
- 10.1161/atv91.11.6.1931877 · DOI
- 10.1161/atv91.13.9.8364022 · DOI
- 10.1161/atv91.14.8.8049196 · DOI
- 1990, Eur J Cell Biol, 52, 98
- 1992, Eur J Cell Biol, 59, 314
- 1994, Am J Pathol, 144, 1348
- 10.1161/circ.82.2.2372896 · DOI
- 10.1161/atv91.14.3.8123657 · DOI
- 1993, Am J Pathol, 143, 1551
- 10.1161/atv91.14.9.8068605 · DOI
- 10.1161/atv91.13.5.8485115 · DOI
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Metadata
- Authors
- Williams, K. J., & Tabas, I.
- Affiliations
- Thomas Jefferson University (US)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 1995-05
- Volume
- 15
- Issue
- 5
- Pages
- 551-561
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC2924812
- OpenAlex
- W1968171440
- Cited by
- 1,413
- References
- 240
- Citations by year
- 2026: 27 · 2025: 34 · 2024: 37 · 2023: 40 · 2022: 42 · 2021: 39 · 2020: 55 · 2019: 47 · 2018: 42 · 2017: 41 · 2016: 59 · 2015: 73 · 2014: 60 · 2013: 56 · 2012: 60
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institutes of Health (5p50hl021006-17, 5r01hl039703-08)
- Genentech
- National Heart, Lung, and Blood Institute (HL 38956, HL-39703, HL 21006, R01HL038956)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- atherosclerosis initiation, plaque retention, endothelial dysfunction
- MeSH terms
- Animals, Arteries, Arteriosclerosis, Humans, Lipoproteins, LDL, Models, Biological, Proteoglycans
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