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Cited by 944

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Regular Physical Activity Improves Endothelial Function in Patients With Coronary Artery Disease by Increasing Phosphorylation of Endothelial Nitric Oxide Synthase

Open access
Hambrecht, R., Adams, V., Erbs, S., Linke, A., Kränkel, N., Shu, Y., Baither, Y., Gielen, S., Thiele, H., Gummert, J.F., Mohr, F.W., Schuler, G.·2003·Circulation
DOI 10.1161/01.cir.0000074229.93804.5c
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Abstract

Background— In stable coronary artery disease (CAD), exercise training has well-documented positive effects on arterial endothelial function. NO derived from endothelial NO synthase (eNOS) is regarded as a protective factor against atherosclerosis. The aim of the present study was to investigate the effects of exercise training on the endothelial function in relation to the expression of eNOS and Akt-dependent eNOS phosphorylation in the left internal mammary artery (LIMA) of patients with stable CAD. Methods and Results— In 17 training patients (T) and 18 control patients (C), endothelium-dependent vasodilation and average peak flow velocity (APV) in response to acetylcholine were measured invasively at study beginning and after 4 weeks in the LIMA. In LIMA tissue sampled during bypass surgery, eNOS expression and content of pospho-eNOS-Ser 1177 , Akt, and phospho-Akt were determined by Western blot and quantitative reverse transcriptase–polymerase chain reaction. After exercise training, LIMA APV in response to acetylcholine was increased by 56±8% (from +48±8% at beginning to +104±11% after 4 weeks, P <0.001). Patients in T had a 2-fold higher eNOS protein expression (T 1.0±0.7 versus C 0.5±0.3 arbitrary units, P <0.05) and 4-fold higher eNOS Ser 1177 -phosphorylation levels in LIMA-endothelium (1.2±0.9 versus 0.3±0.2 arbitrary units, P <0.01). A linear correlation was confirmed between Akt phosphorylation and phospho-eNOS levels ( R =0.80, P <0.05) and between phospho-eNOS and Δ APV ( R =0.59, P <0.05). Conclusions— Exercise training in stable CAD leads to an improved agonist-mediated endothelium-dependent vasodilatory capacity. The change in acetylcholine-induced vasodilatation was closely related to a shear stress–induced/Akt-dependent phosphorylation of eNOS on Ser 1177 .

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Metadata

Authors
Hambrecht, R., Adams, V., Erbs, S., Linke, A., Kränkel, N., Shu, Y., Baither, Y., Gielen, S., Thiele, H., Gummert, J. F., Mohr, F. W., & Schuler, G.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-07
Volume
107
Issue
25
Pages
3152-3158
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.0000074229.93804.5c
OpenAlex
W2101047147
Cited by
944
References
3
FWCI
20.99
Type
journal article
Language
en
Open access
bronze

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