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Cited by 629

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Physical Activity and Coronary Heart Disease in Men: The Harvard Alumni Health Study

Open access
Sesso, Howard D., Paffenbarger, Ralph S., Lee, I-Min·2000·Circulation
DOI 10.1161/01.cir.102.9.975
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Abstract

Background —The quantity and intensity of physical activity required for the primary prevention of coronary heart disease (CHD) remain unclear. Therefore, we examined the association of the quantity and intensity of physical activity with CHD risk and the impact of other coronary risk factors. Methods and Results —We followed 12 516 middle-aged and older men (mean age 57.7 years, range 39 to 88 years) from 1977 through 1993. Physical activity was assessed at baseline in kilojoules per week (4.2 kJ=1 kcal) from blocks walked, flights climbed, and participation in sports or recreational activities. During follow-up, 2135 cases of incident CHD, including myocardial infarction, angina pectoris, revascularization, and coronary death, occurred. Compared with men expending <2100 kJ/wk, men expending 2100 to 4199, 4200 to 8399, 8400 to 12 599, and ≥12 600 kJ/wk had multivariate relative risks of 0.90, 0.81, 0.80, and 0.81, respectively ( P for trend=0.003). When we considered the independent effects of specific physical activity components, only total sports or recreational activities ( P for trend=0.042) and vigorous activities ( P for trend=0.02) were inversely associated with the risk of CHD. These associations did not differ within subgroups of men defined by coronary risk factors. Finally, among men with multiple coronary risk factors, those expending ≥4200 kJ/wk had reduced CHD risk compared with men expending <4200 kJ/wk. Conclusions —Total physical activity and vigorous activities showed the strongest reductions in CHD risk. Moderate and light activities, which may be less precisely measured, showed nonsignificant inverse associations. The association between physical activity and a reduced risk of CHD also extends to men with multiple coronary risk factors.

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Metadata

Authors
Sesso, H. D., Paffenbarger, R. S., & Lee, I.-M.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-08-29
Volume
102
Issue
9
Pages
975-980
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.102.9.975
OpenAlex
W2097978321
Cited by
629
References
7
FWCI
13.42
Type
journal article
Language
en
Open access
bronze

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