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Cited by 762

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Vitamin C Improves Endothelium-Dependent Vasodilation by Restoring Nitric Oxide Activity in Essential Hypertension

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Taddei, Stefano, Virdis, Agostino, Ghiadoni, Lorenzo, Magagna, Armando, Salvetti, Antonio·1998·Circulation
DOI 10.1161/01.cir.97.22.2222
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Abstract

Background —Essential hypertension is associated with impaired endothelium-dependent vasodilation. Inactivation of endothelium-derived nitric oxide by oxygen free radicals participates in endothelial dysfunction in experimental hypertension. To test this hypothesis in humans, we evaluated the effect of antioxidant vitamin C on endothelium-dependent responses in essential hypertensive patients. Methods and Results —In 14 healthy subjects (47.1±4.8 years; blood pressure, 120.6±4.5/80.9±3.5 mm Hg) and 14 essential hypertensive patients (47.3±5.1 years; blood pressure, 153.9±7.1/102.3±4.1 mm Hg), we studied forearm blood flow (strain-gauge plethysmography) modifications induced by intrabrachial acetylcholine (0.15, 0.45, 1.5, 4.5, and 15 μg · 100 mL −1 · min −1 ) or sodium nitroprusside (1, 2, and 4 μg/100 mL forearm tissue per minute), an endothelium-dependent and -independent vasodilator, respectively, in basal conditions and during infusion of intrabrachial vitamin C (2.4 mg/100 mL forearm tissue per minute). In hypertensive patients but not in control subjects, vitamin C increased ( P <0.01) the impaired vasodilation to acetylcholine, whereas the response to sodium nitroprusside was unaffected. Moreover, in another 14 hypertensive patients (47.1±5.2 years; blood pressure, 155.2±6.9/103.7±4.5 mm Hg), the facilitating effect of vitamin C on vasodilation to acetylcholine was reversed by N G -monomethyl- l -arginine (100 μg/100 mL forearm tissue per minute), a nitric oxide synthase inhibitor, suggesting that in essential hypertension superoxide anions impair endothelium-dependent vasodilation by nitric oxide breakdown. Finally, because in adjunctive 7 hypertensive patients (47.8±6.1 years; blood pressure, 155.3±6.8/103.5±4.3 mm Hg), indomethacin (50 μg/100 mL forearm tissue per minute), a cyclooxygenase inhibitor, prevented the potentiating effect of vitamin C on vasodilation to acetylcholine, it is possible that in essential hypertension a main source of superoxide anions could be the cyclooxygenase pathway. Conclusions —In essential hypertensive patients, impaired endothelial vasodilation can be improved by the antioxidant vitamin C, an effect that can be reversed by the nitric oxide synthase inhibitor N G -monomethyl- l -arginine. These findings support the hypothesis that nitric oxide inactivation by oxygen free radicals contributes to endothelial dysfunction in essential hypertension.

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Metadata

Authors
Taddei, S., Virdis, A., Ghiadoni, L., Magagna, A., & Salvetti, A.
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-06-09
Volume
97
Issue
22
Pages
2222-2229
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.97.22.2222
OpenAlex
W2164382299
Cited by
762
References
5
FWCI
27.10
Type
journal article
Language
en
Open access
bronze

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