Cited by 451Circadian rhythm and melatoninBlood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic Control

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Daily Nighttime Melatonin Reduces Blood Pressure in Male Patients With Essential Hypertension

Scheer, Frank A.J.L., Van Montfrans, Gert A., van Someren, Eus J.W., Mairuhu, Gideon, Buijs, Ruud M.·2004·Hypertension

DOI 10.1161/01.hyp.0000113293.15186.3b

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Abstract

Patients with essential hypertension have disturbed autonomic cardiovascular regulation and circadian pacemaker function. Recently, the biological clock was shown to be involved in autonomic cardiovascular regulation. Our objective was to determine whether enhancement of the functioning of the biological clock by repeated nighttime melatonin intake might reduce ambulatory blood pressure in patients with essential hypertension. We conducted a randomized, double-blind, placebo-controlled, crossover trial in 16 men with untreated essential hypertension to investigate the influence of acute (single) and repeated (daily for 3 weeks) oral melatonin (2.5 mg) intake 1 hour before sleep on 24-hour ambulatory blood pressure and actigraphic estimates of sleep quality. Repeated melatonin intake reduced systolic and diastolic blood pressure during sleep by 6 and 4 mm Hg, respectively. The treatment did not affect heart rate. The day-night amplitudes of the rhythms in systolic and diastolic blood pressures were increased by 15% and 25%, respectively. A single dose of melatonin had no effect on blood pressure. Repeated (but not acute) melatonin also improved sleep. Improvements in blood pressure and sleep were statistically unrelated. In patients with essential hypertension, repeated bedtime melatonin intake significantly reduced nocturnal blood pressure. Future studies in larger patient group should be performed to define the characteristics of the patients who would benefit most from melatonin intake. The present study suggests that support of circadian pacemaker function may provide a new strategy in the treatment of essential hypertension.

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Authors: Scheer, F. A. J. L., Van Montfrans, G. A., van Someren, E. J. W., Mairuhu, G., & Buijs, R. M.
Affiliations: Amsterdam UMC Location University of Amsterdam (NL)
From Netherlands Institute for Brain Research (F.A.J.L.S., E.J.W.v.S., R.M.B.), the Department of Internal Medicine, Academic Medical Center (G.A.V.M., G.A.), and VU University Medical Center (E.J.W.v.S.), Amsterdam, The Netherlands.
ORCID: Scheer, Frank A.J.L.
Buijs, Ruud M.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-02
Volume: 43
Issue: 2
Pages: 192-197
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/01.hyp.0000113293.15186.3b
OpenAlex: W2122583624
Cited by: 451
References: 49
Citations by year: 2026: 6 · 2025: 17 · 2024: 20 · 2023: 28 · 2022: 25 · 2021: 24 · 2020: 22 · 2019: 18 · 2018: 22 · 2017: 18 · 2016: 22 · 2015: 15 · 2014: 29 · 2013: 33 · 2012: 16
FWCI: 7.22
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Pure Amsterdam UMC (submittedVersion)
KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords: melatonin, essential hypertension, nocturnal blood pressure, circadian rhythm, biological clock, autonomic cardiovascular regulation, ambulatory blood pressure, sleep quality, heart rate, circadian pacemaker
MeSH terms: Adult, Aged, Antihypertensive Agents, Blood Pressure, Circadian Rhythm, Double-Blind Method, Humans, Hypertension, Male, Melatonin, Middle Aged, Sleep, Wakefulness, Cross-Over Studies, Blood Pressure Monitoring, Ambulatory

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Daily Nighttime Melatonin Reduces Blood Pressure in Male Patients With Essential Hypertension

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