The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Recycling of Apolipoprotein(a) After PlgRKT-Mediated Endocytosis of Lipoprotein(a)
Abstract
Rationale: Lipoprotein(a) [Lp(a)] is a low-density lipoprotein–like lipoprotein and important cardiovascular risk factor whose cognate receptor and intracellular fate remains unknown. Objective: Our study aimed to determine the intracellular trafficking pathway for Lp(a) and the receptor responsible for its uptake in liver cells. Methods and Results: Human hepatoma cells were treated with Lp(a) purified from human plasma and Lp(a) uptake studied using Western blot analysis and intracellular localization of Lp(a) by confocal microscopy. Lp(a) was maximally internalized by 2 hours and was detected by an antiapo(a) antibody to be localized to Rab5-positive early endosomes, the trans-Golgi network, and subsequently Rab11-positive recycling endosomes. In human hepatoma cells, the apo(a) component from the internalized Lp(a) was resecreted back into the cellular media, whereas the low-density lipoprotein component was localized to the lysosomal compartment. Lp(a) internalization was reduced 0.35-fold in HAP1 and 0.33-fold in human hepatoma cells in which the plasminogen receptor (KT) was knocked out. Conversely, Lp(a) internalization was enhanced 2-fold in HAP1 and 1.6-fold in human hepatoma cells in which plasminogen receptor (KT) was overexpressed, showing for the first time the role of a specific plasminogen receptor in Lp(a) uptake. Conclusions: The novel findings that Lp(a) is internalized by the plasminogen receptor, plasminogen receptor (KT), and the apo(a) component is recycled may have important implications for the catabolism and function of Lp(a).
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Multiple studies of the LDL receptor (LDLR) in cells27-34, animal models25,32,35,36, and humans10,28,37-48 have provided inconsistent or conflicting results.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [33]
In the citing paper
“However, other studies have found no influence of LDLR on cellular Lp(a) binding or uptake in vitro31-34.”
From Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening (2025) · cites this paper as [33]
Citations
Cites
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703
cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
McLean, J. W., Tomlinson, J. E., Kuang, W.-J., Eaton, D. L., Chen, E. Y., Fless, G. M., Scanu, A. M., & Lawn, R. M. (1987) · Nature · doi:10.1038/330132a0 · Cited by 1,886
Khera, A. V., Everett, B. M., Caulfield, M. P., Hantash, F. M., Wohlgemuth, J., Ridker, P. M., & Mora, S. (2014) · Circulation · doi:10.1161/circulationaha.113.004406 · Cited by 461
Tsimikas, S., Viney, N. J., Hughes, S. G., Singleton, W., Graham, M. J., Baker, B. F., Burkey, J. L., Yang, Q., Marcovina, S. M., Geary, R. S., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(15)61252-1 · Cited by 460
Research works printed but not linked: 46
- 10.1093/eurheartj/ehq386 · DOI · Paper page
- 10.1126/science.2530631 · DOI · Paper page
- 10.1002/pro.5560031222 · DOI
- 10.1097/00041433-199906000-00010 · DOI
- 10.1016/S0022-2275(20)32192-1 · DOI
- 10.1016/j.atherosclerosis.2012.09.031 · DOI
- 10.1172/JCI117292 · DOI
- 10.1194/jlr.M500249-JLR200 · DOI · Paper page
- 10.1194/jlr.M038877 · DOI · Paper page
- 10.1194/jlr.M056150 · DOI · Paper page
- 10.1172/JCI110896 · DOI · Paper page
- 10.1038/sj.ejhg.5200152 · DOI · Paper page
- 10.1016/j.jacc.2014.01.006 · DOI
- 10.1016/j.amjcard.2014.05.060 · DOI
- 10.1074/jbc.M114.611988 · DOI · Paper page
- 10.1016/0021-9150(91)90025-X · DOI · Paper page
- 10.1161/01.ATV.16.1.129 · DOI · Paper page
- 10.1016/S0022-2275(20)37140-6 · DOI · Paper page
- 10.1016/j.atherosclerosissup.2004.08.027 · DOI
- 10.1172/JCI119753 · DOI · Paper page
- 10.1161/01.ATV.19.3.552 · DOI
- 10.1042/BJ20030932 · DOI · Paper page
- 10.1055/s-0038-1653797 · DOI
- 10.1161/01.ATV.17.10.2036 · DOI
- 10.1016/S0022-2275(20)37595-7 · DOI · Paper page
- 10.1155/2012/141806 · DOI
- 10.1093/clinchem/41.2.246 · DOI
- 10.1016/S0021-9258(19)40266-4 · DOI
- 10.1099/mic.0.2007/005769-0 · DOI
- 10.1016/0092-8674(91)90533-5 · DOI
- 10.1083/jcb.106.6.1821 · DOI
- 10.1182/blood-2008-11-188938 · DOI
- 10.1016/j.jacbts.2016.06.006 · DOI · Paper page
- 10.1016/S0022-2275(20)40742-4 · DOI
- 10.1073/pnas.0601455103 · DOI
- 10.1074/jbc.M310425200 · DOI
- 10.1021/bi00142a024 · DOI
- 10.1016/j.jprot.2011.07.008 · DOI
- 10.1194/jlr.M400418-JLR200 · DOI
- 10.1016/S1050-1738(00)00033-5 · DOI
- 10.1016/j.metabol.2004.10.001 · DOI
- 10.1016/j.metabol.2015.10.031 · DOI
- 10.1016/S0021-9150(00)00732-2 · DOI
- Su W, Campos H, Judge H, Walsh BW, Sacks FM. Distinct metabolism of apolipoproteins (a) and B-100 within plasma lipoprotein(a). J Clin Endocrinol Metab. 1998;83:3267–3276.
- 10.1161/01.ATV.16.8.905 · DOI
- 10.1016/S010-6736(15)61252-1 · DOI
Cited by
Sorted by citations
Reyes-Soffer, G., Ginsberg, H. N., Berglund, L., Duell, P. B., Heffron, S. P., Kamstrup, P. R., Lloyd-Jones, D. M., Marcovina, S. M., Yeang, C., Koschinsky, M. L., et al. (2022) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atv.0000000000000147 · Cited by 836
Thedrez, A., Blom, D. J., Ramin-Mangata, S., Blanchard, V., Croyal, M., Chemello, K., Nativel, B., Pichelin, M., Cariou, B., Bourane, S., et al. (2018) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.310217 · Cited by 105
Thomas, T., Zhou, H., Karmally, W., Ramakrishnan, R., Holleran, S., Liu, Y., Jumes, P., Wagner, J. A., Hubbard, B., Previs, S. F., et al. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.117.309549 · Cited by 96
Functional interrogation of cellular Lp(a) uptake by genome-scale CRISPR screening
Khan, T. G., Bragazzi Cunha, J., Raut, C., Burroughs, M., Vyas, H. S., Leix, K., Goonewardena, S. N., Smrcka, A. V., Speliotes, E. K., & Emmer, B. T. (2025) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2025.119174 · Cited by 6
Metadata
- Authors
- Sharma, M., Redpath, G. M., Williams, M. J. A., & McCormick, S. P. A.
- Affiliations
- From the Department of Biochemistry, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand (M.S., G.M.R., S.P.A.M.); and Department of Medicine, Dunedin School of Medicine, University of Otago, New Zealand (M.J.A.W.).
- Venue
- Circulation Research
- Published
- 2017-03-31
- Volume
- 120
- Issue
- 7
- Pages
- 1091-1102
- ISSN
- 0009-7330
- 1524-4571
- Cited by
- 97
- References
- 4
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
