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IKK/NF- B signaling: balancing life and death - a new approach to cancer therapy
Open accessAbstract
IkappaB kinase/NF-kappaB (IKK/NF-kappaB) signaling pathways play critical roles in a variety of physiological and pathological processes. One function of NF-kappaB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-kappaB can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin, use NF-kappaB to achieve resistance to anticancer drugs, radiation, and death cytokines. Hence, inhibition of IKK-driven NF-kappaB activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression.
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Metadata
- Authors
- Luo, J.-L.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-10-01
- Volume
- 115
- Issue
- 10
- Pages
- 2625-2632
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2145028653
- Cited by
- 878
- References
- 11
- FWCI
- 19.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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