The DOI matches its Crossref record; 128 of the 129 references it cites were found in a registry or an index.
Gastrointestinal regulation of food intake
Open accessAbstract
Despite substantial fluctuations in daily food intake, animals maintain a remarkably stable body weight, because overall caloric ingestion and expenditure are exquisitely matched over long periods of time, through the process of energy homeostasis. The brain receives hormonal, neural, and metabolic signals pertaining to body-energy status and, in response to these inputs, coordinates adaptive alterations of energy intake and expenditure. To regulate food consumption, the brain must modulate appetite, and the core of appetite regulation lies in the gut-brain axis. This Review summarizes current knowledge regarding the neuroendocrine regulation of food intake by the gastrointestinal system, focusing on gastric distention, intestinal and pancreatic satiation peptides, and the orexigenic gastric hormone ghrelin. We highlight mechanisms governing nutrient sensing and peptide secretion by enteroendocrine cells, including novel taste-like pathways. The increasingly nuanced understanding of the mechanisms mediating gut-peptide regulation and action provides promising targets for new strategies to combat obesity and diabetes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is evidence that enteric neurons link glucose sensing in EEC to glucose transport function in enterocytes (50).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [50]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
Ghrelin induces adiposity in rodents
Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949
Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395
Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503
Self-citationGhrelin enhances appetite and increases food intake in humans
Wren, A. M., Seal, L. J., Cohen, M. A., Brynes, A. E., Frost, G. S., Murphy, K. G., Dhillo, W. S., Ghatei, M. A., & Bloom, S. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.12.8111 · Cited by 2,494
Gut hormone PYY3-36 physiologically inhibits food intake
Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351
Plasma Ghrelin Levels after Diet-Induced Weight Loss or Gastric Bypass Surgery
Cummings, D. E., Weigle, D. S., Frayo, R. S., Breen, P. A., Marina, K., Dellinger, E. P., & Purnell, J. Q. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012908 · Cited by 2,271
Self-citationThe biology of incretin hormones
Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210
A role for glucagon-like peptide-1 in the central regulation of feeding
Turton, M. D., O'Shea, D., Gunn, I., Beak, S. A., Edwards, C. M. B., Meeran, K., Choi, S. J., Taylor, G. M., Heath, M. M., Lambert, P. D., et al. (1996) · Nature · doi:10.1038/379069a0 · Cited by 1,950
Inhibition of Food Intake in Obese Subjects by Peptide YY 3–36
Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604
Flagged first, then by citations
1 of the 129 references couldn’t be matched to a known paper.
Research works printed but not linked: 18
- Grill, 1988, Am. J. Physiol., 254, R853
- Davis, 1990, Am. J. Physiol., 259, R1228
- Kaplan, 1992, Am. J. Physiol., 263, R813
- Phillips, 1996, Am. J. Physiol., 271, R766
- Schwartz, 1999, Am. J. Physiol., 276, R1623
- Moran, 1998, Am. J. Physiol., 274, R618
- Edwards, 1986, Am. J. Physiol., 251, R971
- Schwartz, 1993, Am. J. Physiol., 265, R872
- Moran, 1982, Am. J. Physiol., 242, R491
- Moran, 1993, Am. J. Physiol., 265, R620
- Reidelberger, 1989, Am. J. Physiol., 257, R1512
- West, 1984, Am. J. Physiol., 246, R776
- Verdich, 2001, J. Clin. Endocrinol. Metab., 86, 4382
- Okada, 1992, Am. J. Physiol., 262, R1111
- Lutz, 1998, Am. J. Physiol., 274, R1777
- Margolskee, 2006, Diabetes., 55(Suppl. 1), 35
- Meyer, 1998, Am. J. Physiol., 275, R1293
- Wang, 1997, Am. J. Physiol., 273, R833
Cited by
Sorted by citations
Items 101–200 of 997
Parra, D., Ramel, A., Bandarra, N., Kiely, M., Martinez, J., & Thorsdottir, I. (2008) · Appetite · doi:10.1016/j.appet.2008.06.003 · Cited by 155
Gastrointestinal targets of appetite regulation in humans
Delzenne, N. M., Blundell, J. E., Brouns, F. J. P. H., Cunningham, K., de Graaf, K. C., Erkner, A., Lluch, A., Mars, M., Peters, H. P. F., & Westerterp‐Plantenga, M. S. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00707.x · Cited by 172
Obesity: A Review of Pathophysiology and Classification
Busebee, B. T., Ghusn, W., Cifuentes, L., & Acosta, A. J. (2023) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2023.05.026 · Cited by 192
Ghrelin is a physiological regulator of insulin release in pancreatic islets and glucose homeostasis
Dezaki, K., Sone, H., & Yada, T. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.02.008 · Cited by 157
Ultraprocessed Foods and Obesity Risk: A Critical Review of Reported Mechanisms
Valicente, V. M., Peng, C.-H., Pacheco, K., Lin, L., Kielb, E., Dawoodani, E., Abdollahi, A., & Mattes, R. D. (2023) · Advances in Nutrition · doi:10.1016/j.advnut.2023.04.006 · Cited by 166
Mechanisms of CCK signaling from gut to brain
Raybould, H. E. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.09.006 · Cited by 151
Murashita, K., Kurokawa, T., Nilsen, T. O., & Rønnestad, I. (2008) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2008.11.024 · Cited by 154
Kral, J. G., & Näslund, E. B. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0563 · Cited by 151
Weight Regain After Gastric Bypass: Influence of Gut Hormones
Santo, M. A., Riccioppo, D., Pajecki, D., Kawamoto, F., de Cleva, R., Antonangelo, L., Marçal, L., & Cecconello, I. (2016) · Obesity Surgery · doi:10.1007/s11695-015-1908-z · Cited by 145
Taste, olfactory and food texture reward processing in the brain and the control of appetite
Rolls, E. T. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000821 · Cited by 149
Duarte, A. I., Candeias, E., Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Plácido, A. I., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.01.008 · Cited by 149
Emerging Therapeutic Strategies for Obesity
Foster‐Schubert, K. E., & Cummings, D. E. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0041 · Cited by 140
Self-citationRole of the bypassed proximal intestine in the anti-diabetic effects of bariatric surgery
Cummings, D. E., Overduin, J., Foster-Schubert, K. E., & Carlson, M. J. (2007) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2007.02.003 · Cited by 140
Self-citationBiological Control of Appetite: A Daunting Complexity
MacLean, P. S., Blundell, J. E., Mennella, J. A., & Batterham, R. L. (2017) · Obesity · doi:10.1002/oby.21771 · Cited by 140
Glucose sensing and signalling; regulation of intestinal glucose transport
Shirazi-Beechey, S. P., Moran, A. W., Batchelor, D. J., Daly, K., & Al-Rammahi, M. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111000103 · Cited by 139
The metabolic role of vagal afferent innervation
Waise, T. M. Z., Dranse, H. J., & Lam, T. K. T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0062-1 · Cited by 140
T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach
Hass, N., Schwarzenbacher, K., & Breer, H. (2010) · Cell and Tissue Research · doi:10.1007/s00441-009-0907-6 · Cited by 143
Roche, J. R., Blache, D., Kay, J. K., Miller, D. R., Sheahan, A. J., & Miller, D. W. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138744 · Cited by 154
Modulation of Taste Sensitivity by GLP‐1 Signaling in Taste Buds
Martin, B., Dotson, C. D., Shin, Y., Ji, S., Drucker, D. J., Maudsley, S., & Munger, S. D. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.03920.x · Cited by 137
Connecting metabolism and reproduction: roles of central energy sensors and key molecular mediators
Roa, J., & Tena-Sempere, M. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.09.027 · Cited by 136
Diet‐induced adaptation of vagal afferent function
Kentish, S. J., Li, H., Philp, L., O’Donnell, T. A., Isaacs, N. J., Young, R. L., Wittert, G., Blackshaw, L. A., & Page, A. J. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.222158 · Cited by 136
Catechin- and caffeine-rich teas for control of body weight in humans
Hursel, R., & Westerterp‐Plantenga, M. S. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.058396 · Cited by 138
Review article: the gastrointestinal tract: neuroendocrine regulation of satiety and food intake
Maljaars, J., Peters, H. P. F., & Masclee, A. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03550.x · Cited by 139
A Metagenomic Investigation of the Duodenal Microbiota Reveals Links with Obesity
Angelakis, E., Armougom, F., Carrière, F., Bachar, D., Laugier, R., Lagier, J., Robert, C., Michelle, C., Henrissat, B., & Raoult, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137784 · Cited by 131
Effects of dietary fibre on behaviour and satiety in pigs
de Leeuw, J. A., Bolhuis, J. E., Bosch, G., & Gerrits, W. J. J. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s002966510800863x · Cited by 130
A neural circuit mechanism for mechanosensory feedback control of ingestion
Kim, D.-Y., Heo, G., Kim, M., Kim, H., Jin, J. A., Kim, H. K., Jung, S., An, M., Ahn, B. H., Park, J. H., et al. (2020) · Nature · doi:10.1038/s41586-020-2167-2 · Cited by 133
Intestinal lipoprotein overproduction in insulin-resistant states
Adeli, K., & Lewis, G. F. (2008) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e3282ffaf82 · Cited by 130
Regional brain response to visual food cues is a marker of satiety that predicts food choice
Mehta, S. H., Melhorn, S. J., Smeraglio, A., Tyagi, V., Grabowski, T. J., Schwartz, M. W., & Schur, E. A. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.042341 · Cited by 133
Metabolic signals in human puberty: Effects of over and undernutrition
Martos‐Moreno, G. Á., Chowen, J. A., & Argente, J. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.017 · Cited by 132
Leptin and Ghrelin in Relation toHelicobacter pyloriStatus in Adult Males
Roper, J., François, F., Shue, P. L., Mourad, M. S., Pei, Z., de Perez, A. Z. O., Perez-Perez, G. I., Tseng, C., & Blaser, M. J. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2057 · Cited by 128
Neuronal regulation of homeostasis by nutrient sensing
Lam, T. K. T. (2010) · Nature Medicine · doi:10.1038/nm0410-392 · Cited by 125
Food texture influences on satiety: systematic review and meta-analysis
Stribițcaia, E., Evans, C., Gibbons, C., Blundell, J. E., & Sarkar, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-69504-y · Cited by 133
Glucose Homeostasis During Short-term and Prolonged Exposure to High Altitudes
Woolcott, O. O., Ader, M., & Bergman, R. N. (2015) · Endocrine Reviews · doi:10.1210/er.2014-1063 · Cited by 129
Alterations in Gut Hormones After Laparoscopic Sleeve Gastrectomy
Dimitriadis, E., Daskalakis, M., Kampa, M., Peppe, A., Papadakis, J. A., & Melissas, J. (2012) · Annals of Surgery · doi:10.1097/sla.0b013e31826e1846 · Cited by 122
Thammacharoen, S., Lutz, T. A., Geary, N., & Asarian, L. (2007) · Endocrinology · doi:10.1210/en.2007-0340 · Cited by 121
van Jaarsveld, C. H. M., Boniface, D. R., Llewellyn, C. H., & Wardle, J. (2014) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2013.4951 · Cited by 119
Beaulieu, K., Hopkins, M., Blundell, J. E., & Finlayson, G. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.12.032 · Cited by 130
Non-Nutritive Sweeteners and Their Implications on the Development of Metabolic Syndrome
Liauchonak, I., Qorri, B., Dawoud, F., Riat, Y., & Szewczuk, M. R. (2019) · Nutrients · doi:10.3390/nu11030644 · Cited by 126
Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat
Beutler, L. R., Corpuz, T. V., Ahn, J. S., Kosar, S., Song, W., Chen, Y., & Knight, Z. A. (2020) · eLife · doi:10.7554/elife.55909 · Cited by 113
Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity
de Lartigue, G., Ronveaux, C. C., & Raybould, H. E. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.06.003 · Cited by 120
Endoscopic Bariatric and Metabolic Therapies: Surgical Analogues and Mechanisms of Action
Jirapinyo, P., & Thompson, C. C. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.10.021 · Cited by 116
Cold pleasure. Why we like ice drinks, ice-lollies and ice cream
Eccles, R., Du-Plessis, L., Dommels, Y. E. M., & Wilkinson, J. E. (2013) · Appetite · doi:10.1016/j.appet.2013.09.011 · Cited by 114
Romijn, J. A., Corssmit, E. P. M., Havekes, L. M., & Pijl, H. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328302c9b0 · Cited by 112
Douglas, J. A., King, J. A., Clayton, D. J., Jackson, A. P., Sargeant, J. A., Thackray, A. E., Davies, M. J., & Stensel, D. J. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.181 · Cited by 123
Li, Y., Hu, M., Xiao, H., Du, Y., Decker, E. A., & McClements, D. J. (2010) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2010.05.004 · Cited by 112
Visceral Mechano-sensing Neurons Control Drosophila Feeding by Using Piezo as a Sensor
Wang, P., Jia, Y., Liu, T., Jan, Y. N., & Zhang, W. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.017 · Cited by 114
Anti-obesity drugs and neural circuits of feeding
Adan, R. A. H., Vanderschuren, L. J. M. J., & ELAFLEUR, S. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.01.008 · Cited by 110
The effects of whey protein on cardiometabolic risk factors
Pal, S., & Radavelli‐Bagatini, S. (2012) · Obesity Reviews · doi:10.1111/obr.12005 · Cited by 111
Rodenfels, J., Lavrynenko, O., Ayciriex, S., Sampaio, J. L., Carvalho, M., Shevchenko, A., & Eaton, S. (2014) · Genes & Development · doi:10.1101/gad.249763.114 · Cited by 109
Li, Y., & McClements, D. J. (2010) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2010.09.024 · Cited by 106
Coupé, B., Grit, I., Darmaun, D., & Parnet, P. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00201.2009 · Cited by 106
Gut Hormones in Health and Obesity: The Upcoming Role of Short Chain Fatty Acids
Alhabeeb, H., AlFaiz, A., Kutbi, E., AlShahrani, D. A., Alsuhail, A., Alrajhi, S., Alotaibi, N., Alotaibi, K., Alamri, S. S., Alghamdi, S. A. A., et al. (2021) · Nutrients · doi:10.3390/nu13020481 · Cited by 114
Review article: a comparison of glucagon‐like peptides 1 and 2
Janssen, P., Rotondò, A., Mulè, F., & Tack, J. F. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12092 · Cited by 105
Insulin Activates Erk1/2 Signaling in the Dorsal Vagal Complex to Inhibit Glucose Production
Filippi, B., Yang, C. S., Tang, C., & Lam, T. K. T. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.09.005 · Cited by 112
Melanocortin signaling in the CNS directly regulates circulating cholesterol
Pérez–Tilve, D., Hofmann, S. M., Basford, J. E., Nogueiras, R., Pfluger, P. T., Patterson, J. T., Grant, E., Wilson, H., Granholm, N. A., Arnold, M., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2569 · Cited by 103
Review: Enteroendocrine cells: Neglected players in gastrointestinal disorders?
Moran, G. W., Leslie, F. C., Levison, S., & McLaughlin, J. T. (2008) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x08093943 · Cited by 112
Bose, M., Machineni, S., Oliván, B., Teixeira, J., McGinty, J. J., Bawa, B., Koshy, N., Colarusso, A., & Laferrère, B. (2010) · Obesity · doi:10.1038/oby.2009.473 · Cited by 102
Changes in gut hormones after bariatric surgery
Vincent, R. P., & Le Roux, C. W. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03164.x · Cited by 100
Ghrelin as a pleotrophic modulator of gonadal function and reproduction
Tena‐Sempere, M. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet1003 · Cited by 101
Islam, H., Townsend, L. K., McKie, G. L., Medeiros, P. J., Gurd, B. J., & Hazell, T. J. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00218.2017 · Cited by 100
Homeostatic regulation of protein intake: in search of a mechanism
Morrison, C. D., Reed, S. D., & Henagan, T. M. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00609.2011 · Cited by 99
Homeostatic regulation of food intake
Cifuentes, L., & Acosta, A. J. (2021) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2021.101794 · Cited by 117
Asarian, L., & Geary, N. (2007) · Endocrinology · doi:10.1210/en.2007-0341 · Cited by 100
Lipids, CHOs, proteins: Can all macronutrients put a ‘brake’ on eating?
Shin, H.-S., Ingram, J. R., McGill, A., & Poppitt, S. D. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.07.008 · Cited by 98
Nutritional toxicology of mammals: regulated intake of plant secondary compounds
Torregrossa, A., & Dearing, M. D. (2009) · Functional Ecology · doi:10.1111/j.1365-2435.2008.01523.x · Cited by 98
Reward Systems in the Brain and Nutrition
Rolls, E. T. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050725 · Cited by 102
Stewart, J. E., Feinle‐Bisset, C., & Keast, R. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.02.002 · Cited by 100
Borrelli, F., & Izzo, A. A. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.10.003 · Cited by 100
Influence of Running and Walking on Hormonal Regulators of Appetite in Women
Larson‐Meyer, D. E., Palm, S. M., Bansal, A., Austin, K. J., Hart, A. M., & Alexander, B. M. (2012) · Journal of Obesity · doi:10.1155/2012/730409 · Cited by 96
Do SCFA have a role in appetite regulation?
Darzi, J., Frost, G. S., & Robertson, M. D. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665110004039 · Cited by 94
Ileal brake activation: macronutrient-specific effects on eating behavior?
van Avesaat, M. H. P., Troost, F. J., Ripken, D., Hendriks, H., & Masclee, A. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.112 · Cited by 93
The effects of gut microbiota on appetite regulation and the underlying mechanisms
Yu, M., Yu, B., & Chen, D. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2414796 · Cited by 100
Recent advances in clinical practice challenges and opportunities in the management of obesity
Acosta, A., Abu Dayyeh, B. K., Port, J. D., & Camilleri, M. (2014) · Gut · doi:10.1136/gutjnl-2013-306235 · Cited by 91
van Kleef, E., van Trijp, J. C. M., van den Borne, J. J. G. C., & Zondervan, C. (2012) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.504901 · Cited by 98
Itô, J., Ito, M., Nambu, H., Fujikawa, T., Tanaka, K., Iwaasa, H., & Tokita, S. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0859-x · Cited by 93
Ghrelin increases the motivation to eat, but does not alter food palatability
Overduin, J., Figlewicz, D. P., Jay, J. L., Kittleson, S., & Cummings, D. E. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00488.2011 · Cited by 93
Self-citationCholecystokinin Regulates Expression of Y2 Receptors in Vagal Afferent Neurons Serving the Stomach
Burdyga, G., de Lartigue, G., Raybould, H. E., Morris, R., Dimaline, R., Varró, A., Thompson, D. G., & Dockray, G. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2493-08.2008 · Cited by 98
Steinert, R. E., Poller, B., Castelli, M., Drewe, J., & Beglinger, C. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29663 · Cited by 94
Central and peripheral control of food intake
Abdalla, M. M. I. (2017) · Endocrine Regulations · doi:10.1515/enr-2017-0006 · Cited by 101
Odunsi, S. T., Vázquez‐Roque, M. I., Camilleri, M., Papathanasopoulos, A. A., Clark, M. M., Wodrich, L., Lempke, M. B., McKinzie, S., Ryks, M. D., Burton, D. D., et al. (2009) · Obesity · doi:10.1038/oby.2009.421 · Cited by 92
Etiologies of Obesity in Children: Nature and Nurture
Skelton, J. A., Irby, M. B., Grzywacz, J. G., & Miller, G. (2011) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2011.09.006 · Cited by 102
Yi, Z., Li, X., Luo, W., Xu, Z., Ji, C., Zhang, Y., Nie, Q., Zhang, D., & Zhang, X. (2018) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-018-0261-1 · Cited by 91
Ghrelin Levels Increase After Pictures Showing Food
SCHÜSSLER, P., Kluge, M., Yassouridis, A., Dresler, M., Uhr, M., & Steiger, A. (2012) · Obesity · doi:10.1038/oby.2011.385 · Cited by 91
The Gut Hormones in Appetite Regulation
Suzuki, K., Jayasena, C. N., & Bloom, S. R. (2011) · Journal of Obesity · doi:10.1155/2011/528401 · Cited by 98
Release of Endogenous Opioids From Duodenal Enteroendocrine Cells Requires Trpm5
Kokrashvili, Z., Rodriguez, D., Yevshayeva, V., Zhou, H., Margolskee, R. F., & Mosinger, B. J. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.070 · Cited by 90
Chandarana, K., Drew, M. E., Emmanuel, J. J., Karra, E., Gelegen, Ç., Chan, P., Cron, N., & Batterham, R. L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.047 · Cited by 89
Hypothalamus as an Endocrine Organ
Clarke, I. J. (2014) · Comprehensive physiology · doi:10.1002/cphy.c140019 · Cited by 114
Glucocorticoids, stress and eating: The mediating role of appetite‐regulating hormones
Kuckuck, S., van der Valk, E. S., Scheurink, A. J. W., van der Voorn, B., Iyer, A. M., Visser, J. A., Delhanty, P. J. D., van den Berg, S. A. A., & van Rossum, E. F. C. (2022) · Obesity Reviews · doi:10.1111/obr.13539 · Cited by 99
Bariatric surgery and bone disease: from clinical perspective to molecular insights
Folli, F. B., Sabowitz, B., Schwesinger, W. H., Fanti, P., Guardado‐Mendoza, R., & Muscogiuri, G. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.115 · Cited by 89
Nutrient sensing and signalling by the gut
Rasoamanana, R., Darcel, N., Fromentin, G., & Tomé, D. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000110 · Cited by 99
Nevé, B. L., Foltz, M., Daniel, H., & Gouka, R. J. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00135.2010 · Cited by 87
Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity
Song, Z., Wang, Y., Zhang, F., Yao, F., & Sun, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112768 · Cited by 89
Effect of viscosity on appetite and gastro-intestinal hormones
Zijlstra, N., Mars, M., de Wijk, R. A., Westerterp‐Plantenga, M. S., Holst, J. J., & de Graaf, C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.001 · Cited by 87
Opportunities for the replacement of animals in the study of nausea and vomiting
Holmes, A., Rudd, J. A., Tattersall, F., Aziz, Q., & Andrews, P. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00176.x · Cited by 86
Changes in Gastrointestinal Hormones and Leptin After Roux‐en‐Y Gastric Bypass Surgery
Beckman, L. M., Beckman, T. R., Sibley, S. D., Thomas, W. T. B., Ikramuddin, S., Kellogg, T. A., Ghatei, M. A., Bloom, S. R., le Roux, C. W., & Earthman, C. P. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607110381403 · Cited by 87
The effects of bulking, viscous and gel-forming dietary fibres on satiation
Wanders, A. J., Jonathan, M. C., van den Borne, J. J. G. C., Mars, M., Schols, H. A., Feskens, E. J. M., & de Graaf, C. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512003145 · Cited by 86
Dayyeh, B. K. A., Jirapinyo, P., Weitzner, Z. N., Barker, C. L., Flicker, M. S., Lautz, D. B., & Thompson, C. C. (2012) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2012.03.1407 · Cited by 85
Mans, E., Serra‐Prat, M., Palomera, E., Suñol, X., & Clavé, P. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.104307 · Cited by 85
(2010) · PubMed
Aguirre, V., Stylopoulos, N., Grinbaum, R., & Kaplan, L. M. (2008) · Obesity · doi:10.1038/oby.2008.502 · Cited by 85
Metadata
- Authors
- Cummings, D. E., & Overduin, J.
- Affiliations
- University of Washington (US)
- Corresponding author
- Cummings, David E.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-01-02
- Volume
- 117
- Issue
- 1
- Pages
- 13-23
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1716217
- OpenAlex
- W2082113374
- Cited by
- 1,216
- References
- 129
- Citations by year
- 2026: 34 · 2025: 46 · 2024: 35 · 2023: 36 · 2022: 44 · 2021: 64 · 2020: 52 · 2019: 54 · 2018: 61 · 2017: 54 · 2016: 67 · 2015: 76 · 2014: 88 · 2013: 66 · 2012: 93
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Washington
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases (P01DK68384, R01DK-61516, R01DK061516, P01DK068384)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- food intake regulation, energy homeostasis, gut-brain axis, appetite, gastric distension, satiety peptides, ghrelin, enteroendocrine cells, nutrient sensing, obesity, diabetes mellitus
- MeSH terms
- Adipose Tissue, Energy Intake, Homeostasis, Humans, Models, Biological, Satiety Response, Peptide YY, Peptide Hormones, Gastrointestinal Tract, Ghrelin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review