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The fundamental basis of inflammatory bowel disease

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Strober, Warren, Fuss, Ivan, Mannon, Peter·2007·Journal of Clinical Investigation

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Two broad hypotheses have arisen regarding the fundamental nature of the pathogenesis of inflammatory bowel diseases (IBDs, which include ulcerative colitis and Crohn disease). The first contends that primary dysregulation of the mucosal immune system leads to excessive immunologic responses to normal microflora. The second suggests that changes in the composition of gut microflora and/or deranged epithelial barrier function elicits pathologic responses from the normal mucosal immune system. Here we examine these hypotheses and conclude that IBD is indeed characterized by an abnormal mucosal immune response but that microbial factors and epithelial cell abnormalities can facilitate this response.

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Authors: Strober, W., Fuss, I., & Mannon, P.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2007-03-01
Volume: 117
Issue: 3
Pages: 514-521
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci30587
OpenAlex: W1991081070
Cited by: 1,319
References: 4
FWCI: 49.74
Type: journal article
Language: en
Open access: bronze

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The fundamental basis of inflammatory bowel disease

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