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Cited by 559

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

A Comparison of Lithium and T 3 Augmentation Following Two Failed Medication Treatments for Depression: A STAR*D Report

Nierenberg, Andrew A., Fava, Maurizio, Trivedi, Madhukar H., Wisniewski, Stephen R., Thase, Michael E., McGrath, Patrick J., Alpert, Jonathan E., Warden, Diane, Luther, James F., Niederehe, George, Lebowitz, Barry, Shores-Wilson, Kathy, Rush, A. John, STAR*D Study Team·2006·American Journal of Psychiatry
DOI 10.1176/ajp.2006.163.9.1519
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Abstract

OBJECTIVE: More than 40% of patients with major depressive disorder do not achieve remission even after two optimally delivered trials of antidepressant medications. This study compared the effectiveness of lithium versus triiodothyronine (T(3)) augmentation as a third-step treatment for patients with major depressive disorder. METHOD: A total of 142 adult outpatients with nonpsychotic major depressive disorder who had not achieved remission or who were intolerant to an initial prospective treatment with citalopram and a second switch or augmentation trial were randomly assigned to augmentation with lithium (up to 900 mg/day; N=69) or with T(3) (up to 50 mug/day; N=73) for up to 14 weeks. The primary outcome measure was whether participants achieved remission, which was defined as a score < or =7 on the 17-item Hamilton Depression Rating Scale. RESULTS: After a mean of 9.6 weeks (SD=5.2) of treatment, remission rates were 15.9% with lithium augmentation and 24.7% with T(3) augmentation, although the difference between treatments was not statistically significant. Lithium was more frequently associated with side effects (p=0.045), and more participants in the lithium group left treatment because of side effects (23.2% versus 9.6%; p=0.027). CONCLUSIONS: Remission rates with lithium and T(3) augmentation for participants who experienced unsatisfactory results with two prior medication treatments were modest and did not differ significantly. The lower side effect burden and ease of use of T(3) augmentation suggest that it has slight advantages over lithium augmentation for depressed patients who have experienced several failed medication trials.

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Cites

Show all 13 references

Research works printed but not linked: 35

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Cited by

Metadata

Authors
Nierenberg, A. A., Fava, M., Trivedi, M. H., Wisniewski, S. R., Thase, M. E., McGrath, P. J., Alpert, J. E., Warden, D., Luther, J. F., Niederehe, G., Lebowitz, B., Shores-Wilson, K., Rush, A. J., & STAR*D Study Team
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2006-09
Volume
163
Issue
9
Pages
1519-1530
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.2006.163.9.1519
OpenAlex
W2170273380
Cited by
559
References
13
FWCI
20.00
Type
journal article
Language
en
Open access
closed

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