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Cited by 165Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeural and Behavioral Psychology StudiesChild and Adolescent Psychosocial and Emotional Development

Striatal functional alteration during incentive anticipation in pediatric anxiety disorders

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Guyer, Amanda E., Choate, Victoria R., Detloff, Allison, Benson, Brenda, Nelson, Eric E., Perez-Edgar, Koraly, Fox, Nathan A., Pine, Daniel S. +1 more·2012·American Journal of Psychiatry
DOI 10.1176/appi.ajp.2011.11010006PMC PMC3307369
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Abstract

OBJECTIVE: Behavioral inhibition is an early childhood temperament recently associated with altered striatal response in adolescence to incentives of increasing magnitudes. Since early childhood behavioral inhibition is also associated with risk for adolescent social phobia, a similar pattern of striatal activation may manifest in social phobia. The present study compares striatal function in healthy adolescents, adolescents with social phobia, and adolescents with generalized anxiety disorder. METHOD: Blood-oxygen-level-dependent signal in striatal regions was examined in 58 medication-free adolescents—14 with social phobia, 18 with generalized anxiety disorder but not social phobia, and 26 with no psychiatric disorder—matched on sex, age, puberty, IQ, and socioeconomic status. During functional magnetic resonance imaging, participants responded to incentive cues depicting potential monetary gains or losses of varying magnitudes. RESULTS: While anticipating incentives of increasing magnitude, adolescents with social phobia showed increasingly heightened caudate and putamen activation at a level greater than that seen in the healthy comparison and generalized anxiety disorder groups. The generalized anxiety disorder group showed a unique valence-specific putamen response relative to the healthy comparison or social phobia group. Both patient groups displayed more complex patterns in the nucleus accumbens than in the caudate or putamen. CONCLUSIONS: Caudate and putamen hypersensitivity to incentives of increasing magnitudes characterizes adolescent social phobia, relative to activation in this region in adolescents with generalized anxiety disorder as well as healthy adolescents. Thus, these findings resemble the pattern previously found in adolescents with early childhood behavioral inhibition, thereby implicating similar neural responses to anticipation of incentives in both early childhood behavioral inhibition and adolescent social phobia.

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Crossref · 10.1176/appi.ajp.2011.11010006

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  • Youth with anxiety and at temperamental risk for anxiety exhibit heightened neural responses to the anticipation and receipt of monetary and social rewards, especially when rewards are contingent on performance.

    “youth with anxiety and at temperamental risk for anxiety exhibit heightened neural responses to the anticipation and receipt of monetary and social rewards, especially when rewards are contingent on performance (Guyer et al., 2006, 2012; Bar-Haim et al., 2009; Benson et al., 2015).”

    From Neural Activation to Parental Praise Interacts With Social Context to Predict Adolescent Depressive Symptoms (2019) · cites this paper as Guyer et al., 2012

    The Conclusions and Discussion report heightened striatal responses to anticipated incentives in adolescents with social phobia and describe similar findings in adolescents with early childhood behavioral inhibition. The Method’s Task Paradigm specifies performance-dependent monetary gains and losses, but says the imaging analysis focused on anticipation, not receipt; this study did not test social rewards. The finding for clinically anxious youth is also specific to social phobia rather than generalized anxiety disorder. (LLM, conf=0.88)

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  • Human imaging studies show neural circuits affected by anxiety change during puberty.

    “Human imaging studies show that neural circuits affected by anxiety change during puberty (29, 30), and gonadal hormones are thought to contribute to these changes (31).”

    From Sexual differentiation of neural mechanisms of stress sensitivity during puberty (2023) · cites this paper as [29]

    The Discussion (page not provided) reports altered striatal circuitry in adolescents with anxiety disorders, supporting the claim that imaging identifies anxiety-related neural differences. It does not show that those circuits change during puberty; the authors instead call for longitudinal imaging to investigate developmental shifts. The citation is attached to the neural-circuit claim, not the separate statement about gonadal hormones. (LLM, conf=0.84)

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  • Several studies have examined reward systems in adolescent depression, anxiety and anxiety risk, substance use, and ADHD.

    “A number of studies have already emerged, examining reward systems in different pathologies, such as depression (Forbes et al., 2010a), anxiety and risk for anxiety disorders (Guyer et al., 2012), substance use (Peters et al., 2011), and ADHD (Rubia et al., 2009) in adolescence.”

    From A systematic review of fMRI reward paradigms used in studies of adolescents vs. adults: The impact of task design and implications for understanding neurodevelopment (2013) · cites this paper as Guyer et al., 2012

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Research works printed but not linked: 1

  1. [35]Talairach J Tournoux P Co-planar Stereotaxic Altas of the Human Brain 1988 Stuttgart, Germany Georg Thieme Verlag

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Authors
Guyer, A. E., Choate, V. R., Detloff, A., Benson, B., Nelson, E. E., Perez-Edgar, K., Fox, N. A., Pine, D. S., & Ernst, M.
Affiliations
  • George Mason University (US)
  • From the Department of Human and Community Development, Center for Mind and Brain, University of California Davis, Davis, Calif.; the Mood and Anxiety Program, National Institute of Mental Health, Bethesda, Md.; the Department of Psychology, George Mason University, Fairfax, Va.; and the Department of Human Development, University of Maryland, College Park, Md.
ORCID
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
2012-02
Volume
169
Issue
2
Pages
205-212
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/appi.ajp.2011.11010006
PMC
PMC3307369
OpenAlex
W2100440238
Cited by
165
References
41
Citations by year
2026: 4 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 15 · 2021: 11 · 2020: 14 · 2019: 13 · 2018: 7 · 2017: 4 · 2016: 15 · 2015: 17 · 2014: 23 · 2013: 16 · 2012: 4
FWCI
18.89
Type
journal article
Language
en
Open access
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (R00MH080076, K99/R00MH-080076, K99 MH080076)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
striatum, social anxiety disorder, generalized anxiety disorder, adolescents, behavioral inhibition, caudate nucleus, putamen, nucleus accumbens, early childhood temperament
MeSH terms
Adolescent, Adolescent Behavior, Anxiety Disorders, Behavioral Symptoms, Caudate Nucleus, Child, Child Behavior, Humans, Inhibition, Psychological, Magnetic Resonance Imaging, Putamen, Research Design, Risk Factors, Functional Neuroimaging

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