Cited by 264Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesMicrobial Metabolites in Food Biotechnology

Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?

Brahe, L. K., Astrup, A., Larsen, L. H.·2013·Obesity Reviews

Abstract

It is increasingly recognized that there is a connection between diet, intestinal microbiota, intestinal barrier function and the low-grade inflammation that characterizes the progression from obesity to metabolic disturbances, making dietary strategies to modulate the intestinal environment relevant. In this context, the ability of some Gram-positive anaerobic bacteria to produce the short-chain fatty acid butyrate is interesting. A lower abundance of butyrate-producing bacteria has been associated with metabolic risk in humans, and recent studies suggest that butyrate might have an anti-inflammatory potential that can alleviate obesity-related metabolic complications, possibly due to its ability to enhance the intestinal barrier function. Here, we review and discuss the potential of butyrate as an anti-inflammatory mediator in metabolic diseases, and the potential for dietary interventions increasing the intestinal availability of butyrate.

Integrity signals

Registry

Crossref · 10.1111/obr.12068

Cites

115 of 115 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • SCFAs are estimated to account for ~60-70% of the energy requirements of colon epithelial cells and 5-15% of the total caloric requirements of humans.

    “SCFAs are estimated to account for ~60–70% of the energy requirements of colon epithelial cells and 5–15% of the total caloric requirements of humans [251].”
  • Fewer butyrate-producing bacteria are found in stool samples from patients with type 2 diabetes than in healthy controls, suggesting a possible protective role of butyrate in obesity-related metabolic diseases.

    “Studies on the human gut microbiota have shown that fewer butyrate-producing bacteria are found in stool samples from patients with type 2 diabetes than in healthy controls, thus suggesting a possible protective role of butyrate in obesity-related metabolic diseases [251].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Brahe, L. K., Astrup, A., & Larsen, L. H.
Affiliations
University of Copenhagen (DK)
Corresponding author
Brahe, L. K.
Venue
Obesity Reviews
Publisher
Wiley
Published
2013-08-16
Volume
14
Issue
12
Pages
950-959
ISSN
  • 1467-7881 (ISSN-L)
  • 1467-789X
OpenAlex
W1866784611
Cited by
264
References
114
Citations by year
2026: 14 · 2025: 17 · 2024: 26 · 2023: 23 · 2022: 26 · 2021: 31 · 2020: 23 · 2019: 20 · 2018: 25 · 2017: 19 · 2016: 13 · 2015: 18 · 2014: 9
FWCI
1.25
Type
journal article
Language
en
Open access
closed
Locations
  • Obesity Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
butyrate, short-chain fatty acids, gut microbiota, obesity, metabolic disorders, low-grade inflammation, intestinal barrier function, anaerobic Gram-positive bacteria, dietary intervention, anti-inflammatory activity
MeSH terms
Anti-Inflammatory Agents, Bacteria, Anaerobic, Butyrates, Diet, Humans, Intestines, Metabolic Diseases, Obesity, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review