Cited by 251Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Telomeres and lifestyle factors: Roles in cellular aging.

Lin, Jue, Epel, Elissa, Blackburn, Elizabeth·2012·Mutation research. Fundamental and molecular mechanisms of mutagenesis

Abstract

Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effects of genetic, environmental and lifestyle factors on aging and aging-related diseases. It is timely to 'take stock' of where this work has led the field. This review summarizes studies that have examined associations between lifestyle factors and telomere length and telomerase activity. In most of the studies described in this chapter, telomere length was measured in leukocytes (LTL) or peripheral blood mononuclear cells (PBMCs), taken from blood draws from the study subjects. Much of this chapter focuses on psychological stress, a widespread factor often intimately tied in with lifestyle or behavioral factors that in turn are related to risks of clinical diseases. Together, these findings suggest that cellular aging is linked to a range of influences, with an individual's life events and lifestyle parameters playing significant roles. Lastly, we propose possible biochemical mechanisms that mediate these associations and discuss future directions.

Integrity signals

Registry

Crossref · 10.1016/j.mrfmmm.2011.08.003

Cites

83 of 83 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Lin, J., Epel, E., & Blackburn, E.
Affiliations
University of California, San Francisco (US)
Corresponding author
Lin, Jue
Venue
Mutation research. Fundamental and molecular mechanisms of mutagenesis
Publisher
Elsevier BV
Published
2012-02
Volume
730
Issue
1-2
Pages
85-89
ISSN
  • 0027-5107 (ISSN-L)
  • 1386-1964
OpenAlex
W1993467061
Cited by
251
References
83
Citations by year
2026: 6 · 2025: 11 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 20 · 2019: 24 · 2018: 21 · 2017: 25 · 2016: 25 · 2015: 26 · 2014: 24 · 2013: 16 · 2012: 16
FWCI
12.44
Type
journal article
Language
en
Open access
closed
Locations
  • Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords
telomeres, telomere length, telomerase activity, cellular aging, lifestyle factors, psychological stress, leukocyte telomere length, peripheral blood mononuclear cells, age-related diseases, biochemical mechanisms
MeSH terms
Aging, Diet, Humans, Leukocytes, Life Style, Stress, Psychological, Temperament, Telomere, Cellular Senescence, Telomere Homeostasis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review