Telomeres and lifestyle factors: Roles in cellular aging.
Abstract
Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effects of genetic, environmental and lifestyle factors on aging and aging-related diseases. It is timely to 'take stock' of where this work has led the field. This review summarizes studies that have examined associations between lifestyle factors and telomere length and telomerase activity. In most of the studies described in this chapter, telomere length was measured in leukocytes (LTL) or peripheral blood mononuclear cells (PBMCs), taken from blood draws from the study subjects. Much of this chapter focuses on psychological stress, a widespread factor often intimately tied in with lifestyle or behavioral factors that in turn are related to risks of clinical diseases. Together, these findings suggest that cellular aging is linked to a range of influences, with an individual's life events and lifestyle parameters playing significant roles. Lastly, we propose possible biochemical mechanisms that mediate these associations and discuss future directions.
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HIV-associated inflammation and/or exposure to nucleoside analogues have been associated with changes in telomere-related and other key biologic pathways.
“HIV-associated inflammation and/or exposure to nucleoside analogues have been associated with changes in these and other key biologic pathways (33–40).”
From HIV and Aging: State of Knowledge and Areas of Critical Need for Research. A Report to the NIH Office of AIDS Research by the HIV and Aging Working Group (2012) · cites this paper as [39]
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- Authors
- Lin, J., Epel, E., & Blackburn, E.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Lin, Jue
- Venue
- Mutation research. Fundamental and molecular mechanisms of mutagenesis
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 730
- Issue
- 1-2
- Pages
- 85-89
- ISSN
- 0027-5107 (ISSN-L)
- 1386-1964
- OpenAlex
- W1993467061
- Cited by
- 251
- References
- 83
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 8 · 2023: 9 · 2022: 8 · 2021: 11 · 2020: 20 · 2019: 24 · 2018: 21 · 2017: 25 · 2016: 25 · 2015: 26 · 2014: 24 · 2013: 16 · 2012: 16
- FWCI
- 12.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Mutation research. Fundamental and molecular mechanisms of mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- telomeres, telomere length, telomerase activity, cellular aging, lifestyle factors, psychological stress, leukocyte telomere length, peripheral blood mononuclear cells, age-related diseases, biochemical mechanisms
- MeSH terms
- Aging, Diet, Humans, Leukocytes, Life Style, Stress, Psychological, Temperament, Telomere, Cellular Senescence, Telomere Homeostasis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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