Regulation of efferocytosis as a novel cancer therapy

Tumour-educated macrophages promote tumour progression and metastasis

Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,413

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321

Calreticulin exposure dictates the immunogenicity of cancer cell death

Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166

Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl.

Martin, S. J., Reutelingsperger, C. P., McGahon, A. J., Rader, J. A., van Schie, R. C., LaFace, D. M., & Green, D. R. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.5.1545 · Cited by 2,824

Inhibitory Fc receptors modulate in vivo cytoxicity against tumor targets

Clynes, R. A., Towers, T. L., Presta, L. G., & Ravetch, J. V. (2000) · Nature Medicine · doi:10.1038/74704 · Cited by 2,768

Distinct role of macrophages in different tumor microenvironments

Lewis, C. E., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4005 · Cited by 2,225

The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

Bingle, L., Brown, N. J., & Lewis, C. E. (2002) · The Journal of Pathology · doi:10.1002/path.1027 · Cited by 2,022

Immunosuppressive effects of apoptotic cells

Voll, R. E., Herrmann, M., Roth, E. A., Stach, C., Kalden, J. R., & Girkontaite, I. (1997) · Nature · doi:10.1038/37022 · Cited by 1,787

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

Majeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.045 · Cited by 1,752

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P. D., Mitra, S. S., Wang, J., Contreras-Trujillo, H., Martin, R. K., Cohen, J. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121623109 · Cited by 1,706

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

Elliott, M. R., Chekeni, F. B., Trampont, P. C., Lazarowski, E. R., Kadl, A., Walk, S. F., Park, D., Woodson, R. I., Ostankovich, M., Sharma, P., et al. (2009) · Nature · doi:10.1038/nature08296 · Cited by 1,654

Cell-Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through trans-Activation of LRP on the Phagocyte

Gardai, S. J., McPhillips, K. A., Frasch, S. C., Janssen, W. J., Starefeldt, A., Murphy-Ullrich, J. E., Bratton, D. L., Oldenborg, P.-A., Michalak, M., & Henson, P. M. (2005) · Cell · doi:10.1016/j.cell.2005.08.032 · Cited by 1,473

Annexins: linking Ca2+ signalling to membrane dynamics

Gerke, V., Creutz, C. E., & Moss, S. E. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1661 · Cited by 1,412

Identification of a factor that links apoptotic cells to phagocytes

Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., & Nagata, S. (2002) · Nature · doi:10.1038/417182a · Cited by 1,401

Therapeutic antibodies: successes, limitations and hopes for the future

Chames, P., Van Regenmortel, M., Weiss, E., & Baty, D. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00190.x · Cited by 1,382

Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation.

Huynh, M.-L. N., Fadok, V., & Henson, P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci11638 · Cited by 1,333

Identification of Tim4 as a phosphatidylserine receptor

Miyanishi, M., Tada, K., Koike, M., Uchiyama, Y., Kitamura, T., & Nagata, S. (2007) · Nature · doi:10.1038/nature06307 · Cited by 1,180

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

Vergadi, E., Ieronymaki, E., Lyroni, K., Vaporidi, K., & Tsatsanis, C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601515 · Cited by 1,148

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

Chao, M. P., Alizadeh, A. A., Tang, C. Z., Myklebust, J. H., Varghese, B., Gill, S. I., Jan, M., Cha, A. C., Chan, C. K. F., Tan, B. T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.044 · Cited by 1,124

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

Wyckoff, J. B., Wang, Y., Lin, E. Y., Li, J.-F., Goswami, S. K., Stanley, E. R., Segall, J. E., Pollard, J. W., & Condeelis, J. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1823 · Cited by 1,089

Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., & Nagata, S. (2004) · Science · doi:10.1126/science.1094359 · Cited by 992

Apoptotic Cells Induce Migration of Phagocytes via Caspase-3-Mediated Release of a Lipid Attraction Signal

Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y.-J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00422-7 · Cited by 967

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

Staunton, D. E., Marlin, S. D., Stratowa, C., Dustin, M. L., & Springer, T. A. (1988) · Cell · doi:10.1016/0092-8674(88)90434-5 · Cited by 954

BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module

Park, D., Tosello‐Trampont, A., Elliott, M. R., Lu, M., Haney, L. B., Ma, Z., Klibanov, A. L., Mandell, J. W., & Ravichandran, K. S. (2007) · Nature · doi:10.1038/nature06329 · Cited by 885

Integrin-associated protein (CD47) and its ligands

Brown, E. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01906-1 · Cited by 880

TAM Receptor Tyrosine Kinases: Biologic Functions, Signaling, and Potential Therapeutic Targeting in Human Cancer

Linger, R. M. A., Keating, A. K., Earp, H. S., & Graham, D. K. (2008) · Advances in cancer research · doi:10.1016/s0065-230x(08)00002-x · Cited by 750

Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

Birge, R. B., Boeltz, S., Kumar, S., Carlson, J., Wanderley, J. L. M., Calianese, D. C., Barcinski, M. A., Brekken, R. A., Huang, X., Hutchins, J., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.11 · Cited by 744

Homeostatic Regulation of the Immune System by Receptor Tyrosine Kinases of the Tyro 3 Family

Lu, Q., & Lemke, G. (2001) · Science · doi:10.1126/science.1061663 · Cited by 699

CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis

Kojima, Y., Volkmer, J.-P., McKenna, K., Civelek, M., Lusis, A. J., Miller, C. L., Direnzo, D., Nanda, V., Ye, J., Connolly, A. J., et al. (2016) · Nature · doi:10.1038/nature18935 · Cited by 683

TIM-1 and TIM-4 Glycoproteins Bind Phosphatidylserine and Mediate Uptake of Apoptotic Cells

Kobayashi, N., Karisola, P., Peña‐Cruz, V., Dorfman, D. M., Jinushi, M., Umetsu, S. E., Butte, M. J., Nagumo, H., Chernova, I., Zhu, B., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.11.011 · Cited by 669

Intercellular adhesion molecule-1 (ICAM-1) expression and cell signaling cascades

Hubbard, A. K., & Rothlein, R. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00223-9 · Cited by 594

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

Ravichandran, K. S. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101157 · Cited by 572

Clearance of Apoptotic Cells

Lauber, K., Blumenthal, S. G., Waibel, M., & Wesselborg, S. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00237-0 · Cited by 571

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

Ravichandran, K. S. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.004 · Cited by 559

Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer

Kurahara, H., Shinchi, H., Mataki, Y., Maemura, K., Noma, H., Kubo, F., Sakoda, M., Ueno, S., Natsugoe, S., & Takao, S. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2009.05.026 · Cited by 555

AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications

Zhu, C., Wei, Y., & Wei, X. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1090-3 · Cited by 507

Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL

Liu, L., Greger, J., Shi, H., Liu, Y., Greshock, J., Annan, R., Halsey, W., Sathe, G. M., Martin, A.-M., & Gilmer, T. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4490 · Cited by 495

Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment

Myers, K. V., Amend, S. R., & Pienta, K. J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1022-2 · Cited by 490

Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis

Obeid, M., Panaretakis, T., Joza, N., Tufi, R., Tesniere, A., van Endert, P., Zitvogel, L., & Kroemer, G. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402201 · Cited by 474

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

Truman, L. A., Ford, C. A., Pasikowska, M., Pound, J. D., Wilkinson, S. J., Dumitriu, I. E., Melville, L., Melrose, L. A., Ogden, C. A., Nibbs, R., et al. (2008) · Blood · doi:10.1182/blood-2008-06-162404 · Cited by 473

Increased exposure of anionic phospholipids on the surface of tumor blood vessels.

Ran, S., Downes, A., & Thorpe, P. E. (2002) · PubMed · Cited by 471

Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor

Park, S.-Y., Jung, M.-Y., Kim, H.-J., Lee, S., Kim, S.-Y., Lee, B.-H., Kwon, T.-H., Park, R. W., & Kim, I. T. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402242 · Cited by 464

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

Paolino, M., Choidas, A., Wallner, S., Pranjic, B., Uribesalgo, I., Loeser, S., Jamieson, A. M., Langdon, W. Y., Ikeda, F., Fededa, J. P., et al. (2014) · Nature · doi:10.1038/nature12998 · Cited by 456

Burying the Dead

Vandivier, R. W., Henson, P. M., & Douglas, I. S. (2006) · CHEST Journal · doi:10.1378/chest.129.6.1673 · Cited by 450

Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment

Brown, S., Heinisch, I., Ross, E., Shaw, K., Buckley, C. D., & Savill, J. (2002) · Nature · doi:10.1038/nature00811 · Cited by 390

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine‐1‐phosphate as a “come‐and‐get‐me” signal

Gude, D., Alvarez, S. E., Paugh, S. W., Mitra, P., Yu, J., Griffiths, R., Barbour, S. E., Milstien, S., & Spiegel, S. (2008) · The FASEB Journal · doi:10.1096/fj.08-107169 · Cited by 385

αvβ5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells

Albert, M. L., Kim, J.-I., & Birge, R. B. (2000) · Nature Cell Biology · doi:10.1038/35046549 · Cited by 381

TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis

van der Meer, J. H. M., van der Poll, T., & Veer, C. V. ′. (2014) · Blood · doi:10.1182/blood-2013-09-528752 · Cited by 350

A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock.

Camenisch, T. D., Koller, B. H., Earp, H. S., & Matsushima, G. K. (1999) · PubMed · Cited by 321

A Novel Receptor Tyrosine Kinase, Mer, Inhibits TNF-α Production and Lipopolysaccharide-Induced Endotoxic Shock

Camenisch, T. D., Koller, B. H., Earp, H. S., & Matsushima, G. K. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3498 · Cited by 290

The role of efferocytosis in atherosclerosis

Kojima, Y., Weissman, I. L., & Leeper, N. J. (2017) · Circulation · doi:10.1161/circulationaha.116.025684 · Cited by 289

The immune response to secondary necrotic cells

Sachet, M., Liang, Y. Y., & Oehler, R. (2017) · Apoptosis · doi:10.1007/s10495-017-1413-z · Cited by 282

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

Lew, E. D., Oh, J., Burrola, P., Lax, I., Zagórska, A., Través, P. G., Schlessinger, J., & Lemke, G. (2014) · eLife · doi:10.7554/elife.03385 · Cited by 281

Macrophages as mediators of tumor immunosurveillance

Jaiswal, S., Chao, M. P., Majeti, R., & Weissman, I. L. (2010) · Trends in Immunology · doi:10.1016/j.it.2010.04.001 · Cited by 249

Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells

Kim, D., Wang, J., Willingham, S. B., Martin, R. K., Wernig, G., & Weissman, I. L. (2012) · Leukemia · doi:10.1038/leu.2012.141 · Cited by 249

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells

He, M. T., Kubo, H., Morimoto, K., Fujino, N., Suzuki, T., Takahasi, T., Yamada, M., Yamaya, M., Maekawa, T., Yamamoto, Y., et al. (2011) · EMBO Reports · doi:10.1038/embor.2011.28 · Cited by 232

The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity

Ramirez‐Ortiz, Z. G., Pendergraft, W. F., Prasad, A., Byrne, M. H., Iram, T., Blanchette, C. J., Luster, A. D., Hacohen, N., Khoury, J. B. E., & Means, T. K. (2013) · Nature Immunology · doi:10.1038/ni.2670 · Cited by 227

Cancer Neoantigens and Applications for Immunotherapy

Desrichard, A., Snyder, A., & Chan, T. A.-T. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-3175 · Cited by 219

Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor

Sainaghi, P. P., Castello, L. M., Bergamasco, L., Galletti, M., Bellosta, P., & Avanzi, G. C. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20265 · Cited by 217

Differences between the clearance of apoptotic cells by professional and non-professional phagocytes

Parnaik, R., RAFF, M. C., & Scholes, J. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00598-4 · Cited by 216

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy

Chao, M. P., Tang, C. Z., Pachynski, R. K., Chin, R., Majeti, R., & Weissman, I. L. (2011) · Blood · doi:10.1182/blood-2011-02-338020 · Cited by 196

MFG-E8–mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF

Jinushi, M., Nakazaki, Y., Dougan, M. L., Carrasco, D. R., Mihm, M. C., & Dranoff, G. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30966 · Cited by 195

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

Cook, R. S., Jacobsen, K. M., Wofford, A., DeRyckere, D., Stanford, J. C., Prieto, A. L., Redente, E. F., Sandahl, M. A., Hunter, D. M., Strunk, K. E., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67655 · Cited by 191

Polarization of Prostate Cancer-associated Macrophages Is Induced by Milk Fat Globule-EGF Factor 8 (MFG-E8)-mediated Efferocytosis

Soki, F. N., Koh, A. J., Jones, J., Kim, Y. W., Dai, J., Keller, E. T., Pienta, K. J., Atabai, K., Roca, H., & McCauley, L. K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.571620 · Cited by 173

Opportunities and challenges in the development of kinase inhibitor therapy for cancerPreprint

Sawyers, C. L. (2003) · Genes & Development · doi:10.1101/gad.1152403 · Cited by 170

Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6

Loges, S., Schmidt, T., Tjwa, M., Geyte, K. V., Lievens, D., Lutgens, E., Vanhoutte, D., Borgel, D., Plaisance, S., Hoylaerts, M., et al. (2009) · Blood · doi:10.1182/blood-2009-06-228684 · Cited by 168

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance

Miller, M. A., Oudin, M. J., Sullivan, R. J., Wang, S. J., Meyer, A. S., Im, H., Frederick, D. T., Tadros, J., Griffith, L. G., Lee, H., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0933 · Cited by 168

Tim4- and MerTK-Mediated Engulfment of Apoptotic Cells by Mouse Resident Peritoneal Macrophages

Nishi, C., Toda, S., Segawa, K., & Nagata, S. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01394-13 · Cited by 161

Spontaneous tumor rejection by cbl-b –deficient CD8+ T cells

Loeser, S., Loser, K., Bijker, M. S., Rangachari, M., van der Burg, S. H., Wada, T., Beissert, S., Melief, C. J. M., & Penninger, J. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061699 · Cited by 161

Epithelial Cells Remove Apoptotic Epithelial Cells During Post-Lactation Involution of the Mouse Mammary Gland1

Monks, J., Smith-Steinhart, C., Kruk, E. R., Fadok, V. A., & Henson, P. M. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.065045 · Cited by 158

TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy

Akalu, Y. T., Rothlin, C. V., & Ghosh, S. (2017) · Immunological Reviews · doi:10.1111/imr.12522 · Cited by 158

Autophosphorylation Docking Site Tyr-867 in Mer Receptor Tyrosine Kinase Allows for Dissociation of Multiple Signaling Pathways for Phagocytosis of Apoptotic Cells and Down-modulation of Lipopolysaccharide-inducible NF-κB Transcriptional Activation

Tibrewal, N., Wu, Y., D’Mello, V., Akakura, R., George, T. C., Varnum, B. C., & Birge, R. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706906200 · Cited by 156

Efferocytosis in the tumor microenvironment

Werfel, T. A., & Cook, R. S. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0698-5 · Cited by 156

Axl Mediates Acquired Resistance of Head and Neck Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Erlotinib

Giles, K. M., Kalinowski, F. C., Candy, P. A., Epis, M. R., Zhang, P. M., Redfern, A. D., Stuart, L. M., Goodall, G. J., & Leedman, P. J. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0170 · Cited by 155

Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer

Bosurgi, L., Bernink, J. H., Cuevas, V. D., Gagliani, N., Joannas, L. D., Schmid, E. T., Booth, C. J., Ghosh, S., & Rothlin, C. V. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302507110 · Cited by 152

Phosphatidylserine-Targeting Antibody Induces M1 Macrophage Polarization and Promotes Myeloid-Derived Suppressor Cell Differentiation

Yin, Y., Huang, X., Lynn, K. D., & Thorpe, P. E. (2013) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-13-0073 · Cited by 150

The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

Goyette, M.-A., Duhamel, S., Aubert, L., Pelletier, A., Savage, P., Thibault, M.-P., Johnson, R. M., Carmeliet, P., Basik, M., Gaboury, L. A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.019 · Cited by 148

An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis

Kariolis, M. S., Miao, Y. R., Jones, D. S., Kapur, S., Mathews, I. I., Giaccia, A. J., & Cochran, J. R. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1636 · Cited by 143

Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during experimental autoimmune encephalomyelitis

Weinger, J. G., Brosnan, C. F., Loudig, O., Goldberg, M. F., Macian, F., Arnett, H. A., Prieto, A. L., Tsiperson, V., & Shafit-Zagardo, B. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-49 · Cited by 134

Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer

Sen, T., Tong, P., Diao, L., Li, L., Fan, Y.-H., Hoff, J. A., Heymach, J. V., Wang, J., & Byers, L. A. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-17-1284 · Cited by 134

A Monoclonal Antibody that Binds Anionic Phospholipids on Tumor Blood Vessels Enhances the Antitumor Effect of Docetaxel on Human Breast Tumors in Mice

Huang, X., Bennett, M. A., & Thorpe, P. E. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0031 · Cited by 133

HMGB1 inhibits macrophage activity in efferocytosis through binding to the αvβ3-integrin

Friggeri, A., Yang, Y., Banerjee, S., Park, Y.-J., Liu, G., & Abraham, E. H. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00152.2010 · Cited by 132

TIM-4 Glycoprotein-Mediated Degradation of Dying Tumor Cells by Autophagy Leads to Reduced Antigen Presentation and Increased Immune Tolerance

Baghdadi, M., Yoneda, A., Yamashina, T., Nagao, H., Komohara, Y., Nagai, S., Akiba, H., Foretz, M., Yoshiyama, H., Kinoshita, I., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.09.014 · Cited by 131

ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis

Yang, M. H., Liu, J., Piao, C., Shao, J., & Du, J. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.144 · Cited by 130

Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression

Kasikara, C., Kumar, S., Kimani, S. G., Tsou, W., Geng, K., Davra, V., Sriram, G., Devoe, C., Nguyen, K.-Q. N., Lewis-Antes, A., et al. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0350 · Cited by 129

The phosphatidylserine receptor TIM4 utilizes integrins as coreceptors to effect phagocytosis

Flannagan, R. S., Canton, J., Furuya, W., Glogauer, M., & Grinstein, S. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-04-0212 · Cited by 126

Milk Fat Globule EGF-8 Promotes Melanoma Progression through Coordinated Akt and Twist Signaling in the Tumor Microenvironment

Jinushi, M., Nakazaki, Y., Carrasco, D. R., Draganov, D., Souders, N. C., Johnson, M., Mihm, M. C., & Dranoff, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2147 · Cited by 125

Ablation of Cbl-b provides protection against transplanted and spontaneous tumors

Chiang, J. Y., Jang, I. K., Hodes, R., & Gu, H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29472 · Cited by 124

Resistance to CD4+CD25+ Regulatory T Cells and TGF-β in Cbl-b−/− Mice

Wohlfert, E. A., Callahan, M. K., & Clark, R. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1059 · Cited by 121

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Joseph, M., & Enting, D. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01270 · Cited by 120

Signaling cross-talk in the resistance to HER family receptor targeted therapy

Yamaguchi, H., Chang, S. H., Hsu, J. L., & Hung, M. (2013) · Oncogene · doi:10.1038/onc.2013.74 · Cited by 118

Axl, A Receptor Tyrosine Kinase, Mediates Flow-Induced Vascular Remodeling

Korshunov, V. A., Mohan, A. M., Georger, M. A., & Berk, B. C. (2006) · Circulation Research · doi:10.1161/01.res.0000223322.16149.9a · Cited by 116

Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK)

Rochlitz, C. F., Lohri, A., Bacchi, M., Schmidt, M., Nagel, S., Fopp, M., Fey, M., Herrmann, R., & Neubauer, A. (1999) · Leukemia · doi:10.1038/sj.leu.2401484 · Cited by 115

Acquired Resistance to Small Molecule ErbB2 Tyrosine Kinase Inhibitors

Chen, F. L., Xia, W., & Spector, N. L. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0581 · Cited by 114

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Leconet, W., Larbouret, C., Chardès, T., Thomas, G., Neiveyans, M., Busson, M., Jarlier, M., Radosevic‐Robin, N., Pugnière, M., Bernex, F., et al. (2013) · Oncogene · doi:10.1038/onc.2013.487 · Cited by 107

Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells

Vouri, M., Croucher, D. R., Kennedy, S. P., An, Q., Pilkington, G. J., & Hafizi, S. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.66 · Cited by 106

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Nguyen, K.-Q. N., Tsou, W., Calarese, D. A., Kimani, S. G., Singh, S., Hsieh, S., Liu, Y., Lü, B., Wu, Y., Garforth, S., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.570838 · Cited by 101

p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression

Tian, L., Choi, S., Murakami, Y., Allen, J. N., Morse, H. C., Qi, C., Krzewski, K., & Coligan, J. E. (2014) · Nature Communications · doi:10.1038/ncomms4146 · Cited by 100

Efferocytosis: molecular mechanisms and pathophysiological perspectives

Hayat, S. M. G., Bianconi, V., Pirro, M., & Sahebkar, A. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12206 · Cited by 100

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Balaji, K., Vijayaraghavan, S., Diao, L., Tong, P., Fan, Y.-H., Carey, J. P. W., Bui, T. N., Warner, S. L., Heymach, J. V., Hunt, K. K., et al. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0157 · Cited by 98

Crosstalk between ERK, AKT, and cell survival

Dent, P. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.27541 · Cited by 97

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Neutzner, M., Lopez, T., Xu, F., Bergmann‐Leitner, E. S., Leitner, W. W., & Udey, M. C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0165 · Cited by 96

CD300b regulates the phagocytosis of apoptotic cells via phosphatidylserine recognition

Murakami, Y., Tian, L., Voss, O. H., Margulies, D. H., Krzewski, K., & Coligan, J. E. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.86 · Cited by 95

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Jinushi, M., Sato, M., Kanamoto, A., Itoh, A., Nagai, S., Koyasu, S., Dranoff, G., & Tahara, H. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082614 · Cited by 95

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Werfel, T. A., Elion, D. L., Rahman, B., Hicks, D. J., Sanchez, V. M., Ericsson, P. I. G., Nixon, M. J., James, J. L., Balko, J. M., Scherle, P., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1106 · Cited by 94

Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment

Kumar, S., Calianese, D. C., & Birge, R. B. (2017) · Immunological Reviews · doi:10.1111/imr.12587 · Cited by 93

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Stach, C. M., Turnay, J., Voll, R. E., Kern, P. M., Kolowos, W., Beyer, T. D., Kalden, J. R., & i, M. H. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400715 · Cited by 89

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Yamada, K., Uchiyama, A., Uehara, A., Perera, B., Ogino, S., Yokoyama, Y., Takeuchi, Y., Udey, M. C., Ishikawa, O., & Motegi, S. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2812 · Cited by 87

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Paccez, J. D., Duncan, K., Sekar, D., Correa, R. G., Wang, Y., Gu, X., Bashin, M., Chibale, K., Libermann, T. A., & Zerbini, L. F. (2019) · Oncogenesis · doi:10.1038/s41389-019-0122-6 · Cited by 81

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Hamaï, A., Meslin, F., Benlalam, H., Jalil, A., Mehrpour, M., Faure, F., Lécluse, Y., Vielh, P., Avril, M., Robert, C., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0719 · Cited by 81

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Fens, M. H. A. M., Mastrobattista, E., de Graaff, A. M., Flesch, F. M., Ultee, A., Rasmussen, J. T., Molema, G., Storm, G., & Schiffelers, R. M. (2008) · Blood · doi:10.1182/blood-2007-06-094763 · Cited by 80

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Roy, S., Bag, A. K., Dutta, S., Polavaram, N. S., Islam, R., Schellenburg, S., Banwait, J., Guda, C., Ran, S., Hollingsworth, M. A., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0562 · Cited by 80

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Lin, J., Wang, Z., De, W., Zheng, M., Xu, W., Wu, H., Armstrong, A., & Zhu, J. (2017) · Oncotarget · doi:10.18632/oncotarget.17026 · Cited by 79

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Gerber, D. E., Stopeck, A., Wong, L., Rosen, L. S., Thorpe, P. E., Shan, J. S., & Ibrahim, N. K. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1074 · Cited by 73

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Knocke, S., Fleischmann-Mundt, B., Saborowski, M., Manns, M. P., Kühnel, F., Wirth, T. C., & Woller, N. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.086 · Cited by 71

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Banerjee, S., de Freitas, A., Friggeri, A., Zmijewski, J. W., Liu, G., & Abraham, E. H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101500 · Cited by 68

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Tian, Y., Zhang, Z., Miao, L., Yang, Z., Yang, J., Wang, Y., Qian, D., Cai, H., & Wang, Y. (2016) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504016x14648701447814 · Cited by 61

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Kawada, I., Hasina, R., Arif, Q., Mueller, J. S., Smithberger, E., Husain, A. N., Vokes, E. E., & Salgia, R. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3583 · Cited by 59

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Onken, J., Torka, R., Korsing, S., Radke, J., Krementeskaia, I., Nieminen-Kelhä, M., Bai, X., Ullrich, A., Heppner, F. L., & Vajkoczy, P. (2016) · Oncotarget · doi:10.18632/oncotarget.7130 · Cited by 59

Milk fat globule—epidermal growth factor—factor VIII (MFGE8)/lactadherin promotes bladder tumor development

Sugano, G., Bernard‐Pierrot, I., Lae, M. E., Battail, C., Allory, Y., Stransky, N., Krumeich, S., Lepage, M.-L., Maille, P., Donnadieu, M.-H., et al. (2010) · Oncogene · doi:10.1038/onc.2010.446 · Cited by 57

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Nishimura, T., Horino, K., Nishiura, H., Shibuya, Y., Hiraoka, T., Tanase, S., & Yamamoto, T. (2001) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a002876 · Cited by 57

Development of Bavituximab, a Vascular Targeting Agent with Immune-Modulating Properties, for Lung Cancer Treatment

DeRose, P. M., Thorpe, P. E., & Gerber, D. E. (2011) · Immunotherapy · doi:10.2217/imt.11.87 · Cited by 56

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Munoz, L. E., Franz, S., Pausch, F., Fürnrohr, B. G., Sheriff, A., Vogt, B., Kern, P. M., Baum, W., Stach, C. M., von Laer, D., et al. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306166 · Cited by 55

Identification of MFG-E8 as a novel therapeutic target for diseases

Li, B., Zhang, H.-Y., Pan, H., & Ye, D. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.829455 · Cited by 53

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Chalasani, P., Marron, M., Roe, D. J., Clarke, K., Iannone, M., Livingston, R. B., Shan, J. S., & Stopeck, A. (2015) · Cancer Medicine · doi:10.1002/cam4.447 · Cited by 45

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Tian, L., Choi, S.-C., Lee, H., Murakami, Y., Qi, C.-F., Sengottuvelu, M., Voss, O., Krzewski, K., & Coligan, J. E. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.161 · Cited by 45

TIM-4 promotes the growth of non-small-cell lung cancer in a RGD motif-dependent manner

Zhang, Q., Wang, H., Wu, X., Liu, B., Liu, W., Wang, R., Liang, X., Ma, C., & Gao, L. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.323 · Cited by 44

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Akitake, R., Seno, H., Nakatsuji, M., Kimura, Y., Nakanishi, Y., Yoshioka, T., Kanda, K., Kawada, M., Kawada, K., Sakai, Y., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt069 · Cited by 42

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Digumarti, R., Bapsy, P. P., Suresh, A. V., Bhattacharyya, G. S., Dasappa, L., Shan, J. S., & Gerber, D. E. (2014) · Lung Cancer · doi:10.1016/j.lungcan.2014.08.010 · Cited by 41

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Ksantini, M., Lafont, E., Bocquet, B., Meunier, I., & Hamel, C. (2011) · European Journal of Ophthalmology · doi:10.5301/ejo.5000096 · Cited by 39

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Mancini, M., Gaborit, N., Lindzen, M., Salame, T. M., Dall’Ora, M., Sevilla-Sharon, M., Abdul‐Hai, A., Downward, J., & Yarden, Y. (2015) · Science Signaling · doi:10.1126/scisignal.aaa0725 · Cited by 38

MERTK Promotes Resistance to Irreversible EGFR Tyrosine Kinase Inhibitors in Non–small Cell Lung Cancers Expressing Wild-type EGFR Family Members

Yan, D., Parker, R. E., Wang, X., Frye, S. V., Earp, H. S., DeRyckere, D., & Graham, D. K. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-0040 · Cited by 33

Expression of milk fat globule epidermal growth factor-VIII may be an indicator of poor prognosis in malignant melanoma

Oba, J., Moroi, Y., Nakahara, T., Abe, T., Hagihara, A., & Furue, M. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10409.x · Cited by 32

Efferocytosis of apoptotic human papillomavirus‐positive cervical cancer cells by human primary fibroblasts

Hermetet, F., Jacquin, É., Launay, S., Gaiffe, É., Couturier, M., Hirchaud, F., Sandoz, P., Prétet, J., & Mougin, C. (2016) · Biology of the Cell · doi:10.1111/boc.201500090 · Cited by 32

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Duan, Y., Luo, L., Qiao, C., Li, X., Wang, J., Liu, H., Zhou, T., Shen, B., Lv, M., & Feng, J. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12777 · Cited by 26

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Jia, M., Yao, H., Chen, C., Wang, Y., Wang, H., Cui, T., & Zhu, J. (2017) · Archives of Medical Research · doi:10.1016/j.arcmed.2017.06.003 · Cited by 24

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Gerber, D. E., Spigel, D. R., Giorgadze, D., Shtivelband, M. I., Ponomarova, O. V., Shan, J. S., Menander, K. B., & Belani, C. P. (2016) · Clinical Lung Cancer · doi:10.1016/j.cllc.2016.02.003 · Cited by 23

Expression of milk fat globule epidermal growth factor-VIII may be an indicator of poor prognosis in malignant melanoma

大場, 純. (2012) · Cited by 21

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Kanemura, T., Miyata, H., Makino, T., Tanaka, K., Sugimura, K., Hamada‐Uematsu, M., Mizote, Y., Uchida, H., Miyazaki, Y., Takahashi, T., et al. (2018) · Cancer Science · doi:10.1111/cas.13785 · Cited by 18

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Yu, L., Zhao, L., Jia, Z., Bi, J., Wei, Q., Song, X., Jiang, L., Lin, S., & Wei, M. (2018) · Pathology - Research and Practice · doi:10.1016/j.prp.2018.12.036 · Cited by 17

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Lee, Y., Kim, S., & Lee, C. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.9957 · Cited by 13

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Zhao, J., Ma, X., Li, Z., Deng, R., Wang, S.-M., Shen, G., Zhang, J., Wang, F., Zhang, B., & Wei, Y.-Q. (2014) · Clinical and Experimental Medicine · doi:10.1007/s10238-014-0277-6 · Cited by 9

Untitled work

Good (1996) · doi:10.1002/(sici)1097-4652(199609)168:3

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(2015) · Cancer Cell & Microenvironment · doi:10.14800/ccm.666 · Cited by 44

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