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Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism
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Caloric restriction results in changes in molecular processes associated with aging, including DNA methylation.
“Caloric restriction (CR), defined as lessening caloric intake without depriving essential nutrients4, results in changes in molecular processes that have been associated with aging, including DNA methylation (DNAm)5–7, and is established to increase healthy lifespan in multiple species8,9.”
From Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial (2023) · cites this paper as [6]
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DNA methylation aging clocks: challenges and recommendations
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Metadata
- Authors
- Hahn, O., Grönke, S., Stubbs, T. M., Ficz, G., Hendrich, O., Krueger, F., Andrews, S., Zhang, Q., Wakelam, M. J., Beyer, A., Reik, W., & Partridge, L.
- Venue
- Genome Biology
- Published
- 2017-03-28
- Volume
- 18
- Issue
- 1
- ISSN
- 1474-760X
- PMC
- PMC5370449
- Cited by
- 226
- References
- 26
- Language
- en
- Funders
- Max-Planck-Gesellschaft
- Bundesministerium für Bildung und Forschung (SyBACol 0315893A-B)
- European Research Council (268739)
- Biotechnology and Biological Sciences Research Council
- Wellcome Trust
- EpiGeneSys
- Blueprint
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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