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Gut microbiome variation modulates the effects of dietary fiber on host metabolism

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Murga-Garrido, Sofia M., Hong, Qilin, Cross, Tzu-Wen L., Hutchison, Evan R., Han, Jessica, Thomas, Sydney P., Vivas, Eugenio I., Denu, John, Ceschin, Danilo G., Tang, Zheng-Zheng, Rey, Federico E.·2021·Microbiome
DOI 10.1186/s40168-021-01061-6

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Abstract

Background: There is general consensus that consumption of dietary fermentable fiber improves cardiometabolic health, in part by promoting mutualistic microbes and by increasing production of beneficial metabolites in the distal gut. However, human studies have reported variations in the observed benefits among individuals consuming the same fiber. Several factors likely contribute to this variation, including host genetic and gut microbial differences. We hypothesized that gut microbial metabolism of dietary fiber represents an important and differential factor that modulates how dietary fiber impacts the host. Results: We examined genetically identical gnotobiotic mice harboring two distinct complex gut microbial communities and exposed to four isocaloric diets, each containing different fibers: (i) cellulose, (ii) inulin, (iii) pectin, (iv) a mix of 5 fermentable fibers (assorted fiber). Gut microbiome analysis showed that each transplanted community preserved a core of common taxa across diets that differentiated it from the other community, but there were variations in richness and bacterial taxa abundance within each community among the different diet treatments. Host epigenetic, transcriptional, and metabolomic analyses revealed diet-directed differences between animals colonized with the two communities, including variation in amino acids and lipid pathways that were associated with divergent health outcomes. Conclusion: This study demonstrates that interindividual variation in the gut microbiome is causally linked to differential effects of dietary fiber on host metabolic phenotypes and suggests that a one-fits-all fiber supplementation approach to promote health is unlikely to elicit consistent effects across individuals. Overall, the presented results underscore the importance of microbe-diet interactions on host metabolism and suggest that gut microbes modulate dietary fiber efficacy.

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Metadata

Authors
Murga-Garrido, S. M., Hong, Q., Cross, T.-W. L., Hutchison, E. R., Han, J., Thomas, S. P., Vivas, E. I., Denu, J., Ceschin, D. G., Tang, Z.-Z., & Rey, F. E.
Venue
Microbiome
Publisher
Springer Science and Business Media LLC
Published
2021-05-20
Volume
9
Issue
1
Pages
117-117
ISSN
2049-2618 (ISSN-L)
DOI
10.1186/s40168-021-01061-6
OpenAlex
W3161190141
Cited by
185
References
35
FWCI
7.45
Type
journal article
Language
en
Open access
gold
Licence
Funders
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK108259)
  • Foundation for the National Institutes of Health (GM140464)
  • Food and Nutrition Service (2018-08000)
  • Fondation Leducq
  • Agencia Nacional de Promoción Científica y Tecnológica (PICT-2017-4497)

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CoChat. (2026). Citation check: Gut microbiome variation modulates the effects of dietary fiber on host metabolism. https://app.cochat.ai/papers/10.1186/s40168-021-01061-6
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Murga-Garrido, S. M., Hong, Q., Cross, T.-W. L., Hutchison, E. R., Han, J., Thomas, S. P., Vivas, E. I., Denu, J., Ceschin, D. G., Tang, Z.-Z., & Rey, F. E. (2021). Gut microbiome variation modulates the effects of dietary fiber on host metabolism. Microbiome. https://doi.org/10.1186/s40168-021-01061-6

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