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The Insulin-Related Ovarian Regulatory System in Health and Disease
Abstract
I. Introduction II. Insulin and Insulin Receptor A. Structures of insulin and insulin receptor B. Presence of insulin and insulin receptor in the ovary C. Insulin action and the ovary D. Summary III. IGFs and Their Receptors A. IGF peptides and receptors B. Expression of IGFs and IGF receptors in the ovary C. Role of IGFs in ovulatory function and steroidogenesis D. Summary IV. IGF-Binding Proteins (IGFBPs) and Proteases A. Structural relationships among IGFBPs B. IGFBP expression in the ovary C. IGFBP proteases in the ovary D. IGFBP actions in the ovary E. Role of IGFBPs in follicular development and atresia F. Summary V. Polycystic Ovary Syndrome (PCOS) A. Clinical features B. Theories of pathogenesis C. Insulin resistance in PCOS D. Alterations of IGFs and IGFBPs in PCOS E. Summary VI. The Insulin-Related Ovarian Regulatory System: Implications for Therapy A. Treatment of PCOS B. Therapeutic use of IGF-I and IGF-II C. Use of GH in ovulation induction VII. Summary and Conclusions
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Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., & Spiegelman, B. M. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117936 · Cited by 3,543
Franks, S. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509283331307 · Cited by 2,463
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346
Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508
Kiddy, D. S., Hamilton‐Fairley, D., Bush, A., Short, F., Anyaoku, V., Reed, M. J., & Franks, S. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb02909.x · Cited by 921
Velazquez, E. M., Mendoza, S., Hamer, T., Sosa, F., & Glueck, C. J. (1994) · Metabolism · doi:10.1016/0026-0495(94)90209-7 · Cited by 865
NESTLER, J. E., POWERS, L. P., MATT, D. W., STEINGOLD, K. A., PLYMATE, S. R., RITTMASTER, R. S., CLORE, J. N., & BLACKARD, W. G. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-72-1-83 · Cited by 815
Nestler, J. E., & Jakubowicz, D. J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199608293350902 · Cited by 743
Acute stimulation of glucose metabolism in mice by leptin treatment
Kamohara, S., Burcelin, R., Halaas, J. L., Friedman, J. M., & Charron, M. J. (1997) · Nature · doi:10.1038/38717 · Cited by 708
Cited by
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
Calle, E. E., & Kaaks, R. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1408 · Cited by 3,613
The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113
Dumesic, D. A., Oberfield, S. E., Stener-Victorin, E., Marshall, J. C., Laven, J. S., & Legro, R. S. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1018 · Cited by 1,020
Inoue, M. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.17.1871 · Cited by 561
The effect of obesity on polycystic ovary syndrome: a systematic review and meta‐analysis
Lim, S. S., Norman, R. J., Davies, M. J., & Moran, L. J. (2013) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01053.x · Cited by 539
Moran, L. J., Noakes, M., Clifton, P. M., Tomlinson, L., & Norman, R. J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020815 · Cited by 530
Ovarian antral folliculogenesis during the human menstrual cycle: A review
Baerwald, A. R., Adams, G. P., & Pierson, R. A. (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr039 · Cited by 487
Genetic, hormonal and metabolic aspects of PCOS: an update
De Leo, V., Musacchio, M. C., Cappelli, V., Massaro, M. G., Morgante, G., & Petraglia, F. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0173-x · Cited by 484
Obesity and androgens: facts and perspectives
Pasquali, R. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.10.054 · Cited by 469
Abdominal adiposity and the polycystic ovary syndrome
Escobar-Morreale, H. F., & Millán, J. L. S. (2007) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2007.07.003 · Cited by 386
Review article: The impact of obesity on reproduction in women with polycystic ovary syndrome
Pasquali, R., Gambineri, A., & Pagotto, U. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00990.x · Cited by 359
Molecular mechanisms of insulin resistance in polycystic ovary syndrome
Diamanti-Kandarakis, E., & Papavassiliou, A. G. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.05.006 · Cited by 301
The origins and sequelae of abnormal neuroendocrine function in polycystic ovary syndrome
Blank, S. K., McCartney, C. R., & Marshall, J. C. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml017 · Cited by 301
Polycystic ovarian syndrome: Pathophysiology, molecular aspects and clinical implications
Diamanti-Kandarakis, E. (2008) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399408000598 · Cited by 294
Silfen, M. E., Denburg, M. R., Manibo, A. M., Lobo, R. A., Jaffe, R., Ferin, M., Levine, L. S., & Oberfield, S. E. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030617 · Cited by 269
Imani, B., Eijkemans, M. J. C., te Velde, E. R., Habbema, J. D. F., & Fauser, B. C. J. M. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02929-6 · Cited by 262
Environment, lifestyle, and female infertility
Bala, R., Singh, V., Rajender, S., & Singh, K. (2021) · Reproductive Sciences · doi:10.1007/s43032-020-00279-3 · Cited by 242
New Approach to Polycystic Ovary Syndrome and Other Forms of Anovulatory Infertility
Laven, J. S. E., Imani, B., Eijkemans, M. J. C., & Fauser, B. C. J. M. (2002) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-200211000-00022 · Cited by 235
Gambineri, A., Patton, L., Vaccina, A., Cacciari, M., Morselli-Labate, A. M., Cavazza, C., Pagotto, U., & Pasquali, R. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2250 · Cited by 221
Gambineri, A., Pelusi, C., Genghini, S., Morselli‐Labate, A. M., Cacciari, M., Pagotto, U., & Pasquali, R. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.01973.x · Cited by 216
Sex hormone-binding globulin and type 2 diabetes mellitus
Le, T. N., Nestler, J. E., Strauss, J. F., & Wickham, E. P. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.09.005 · Cited by 191
Female reproduction and type 1 diabetes: From mechanisms to clinical findings
Codner, E., Merino, P. M., & Tena-Sempere, M. (2012) · Human Reproduction Update · doi:10.1093/humupd/dms024 · Cited by 182
Calcaterra, V., Verduci, E., Cena, H., Magenes, V. C., Todisco, C. F., Tenuta, E., Gregorio, C., De Giuseppe, R., Bosetti, A., Di Profio, E., et al. (2021) · Nutrients · doi:10.3390/nu13061848 · Cited by 183
Neuroendocrine dysfunction in polycystic ovary syndrome
Burt Solorzano, C. M., Beller, J. P., Abshire, M. Y., Collins, J. S., McCartney, C. R., & Marshall, J. C. (2012) · Steroids · doi:10.1016/j.steroids.2011.12.007 · Cited by 173
“Hyperinsulinemia is also associated with a decrease in SHBG levels leading to increased free testosterone levels [29].”
BackgroundGenetics of polycystic ovary syndrome: searching for the way out of the labyrinth
Diamanti-Kandarakis, E., & Piperi, C. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi025 · Cited by 167
Sensitization to Insulin Induces Ovulation in Nonobese Adolescents with Anovulatory Hyperandrogenism
Ibáñez, L., Valls, C., Ferrer, A., Marcos, M. V., Rodriguez-Hierro, F., & de Zegher, F. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7756 · Cited by 162
Genetics of the polycystic ovary syndrome
Kosova, G., & Urbanek, M. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.10.009 · Cited by 156
Mehrabani, H. H., Salehpour, S., Amiri, Z., Farahani, S. J., Meyer, B. J., & Tahbaz, F. (2012) · Journal of the American College of Nutrition · doi:10.1080/07315724.2012.10720017 · Cited by 141
Kaaks, R., Bellati, C., Venturelli, E., Rinaldi, S., Secreto, G., Biessy, C., Pala, V, Sieri, S., & Berrino, F. (2003) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601647 · Cited by 120
Female infertility: which role for obesity?
on behalf of the Obesity Programs of nutrition, E., Gambineri, A., Laudisio, D., Marocco, C., Radellini, S., Colao, A., & Savastano, S. (2019) · International Journal of Obesity Supplements · doi:10.1038/s41367-019-0009-1 · Cited by 114
Hyperandrogenism and Polycystic Ovary Syndrome in Women with Type 1 Diabetes Mellitus
Codner, E., & Escobar-Morreale, H. F. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2641 · Cited by 112
Indices of low-grade inflammation in polycystic ovary syndrome
DIAMANTI‐KANDARAKIS, E., PATERAKIS, T., & KANDARAKIS, H. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1365.015 · Cited by 112
Obesity and assisted reproductive technology outcomes
Bellver, J., Busso, C., Pellicer, A., Remohí, J., & Simón, C. (2006) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)61181-9 · Cited by 100
de Melo, A. S., Dias, S. V., Cavalli, R. D. C., Cardoso, V. C., Bettiol, H., Barbieri, M. A., Ferriani, R. A., & Vieira, C. S. (2015) · Reproduction · doi:10.1530/rep-14-0499 · Cited by 99
Kamenov, Z., & Gateva, A. (2020) · Molecules · doi:10.3390/molecules25235566 · Cited by 100
“Decreasing insulin levels on the other hand has no significant effect on LH secretion [53].”
BackgroundMechanisms IN endocrinology: metabolic syndrome through the female life cycle
Vryonidou, A., Paschou, S. A., Muscogiuri, G., Orio, F., & Goulis, D. G. (2015) · European Journal of Endocrinology · doi:10.1530/eje-15-0275 · Cited by 88
Kosidou, K., Dalman, C., Widman, L., Arver, S., Lee, B. K., Magnusson, C., & Gardner, R. M. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.09.022 · Cited by 78
Agnoli, C., Grioni, S., Sieri, S., Sacerdote, C., Ricceri, F., Tumino, R., Frasca, G., Pala, V., Mattiello, A., Chiodini, P., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0128891 · Cited by 76
Sex-dependent role of glucocorticoids and androgens in the pathophysiology of human obesity
Pasquali, R., Vicennati, V, Gambineri, A., & Pagotto, U. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.129 · Cited by 74
Gaete, X., Vivanco, M., Eyzaguirre, F. C., López, P., Rhumie, H. K., Unanue, N., & Codner, E. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.08.039 · Cited by 73
Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood
Abbott, D. H., & Bacha, F. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.05.023 · Cited by 67
Corbett, S. J., McMichael, A. J., & Prentice, A. M. (2009) · American Journal of Human Biology · doi:10.1002/ajhb.20937 · Cited by 64
Pregnancy outcomes in women with growth hormone deficiency
Vila, G., Akerblad, A.-C., Mattsson, A. F., Riedl, M., Webb, S. M., Hána, V., Nielsen, E. H., Biller, B. M. K., & Luger, A. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.07.1132 · Cited by 50
THERAPY OF ENDOCRINE DISEASE: Treatment of hirsutism in the polycystic ovary syndrome
Pasquali, R., & Gambineri, A. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-0585 · Cited by 49
Herriot, A. M., Whitcroft, S., & Jeanes, Y. (2008) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2008.00890.x · Cited by 46
Bayona, A., Martínez-Vaello, V., Zamora, J., Nattero-Chávez, L., Luque-Ramírez, M., & Escobar-Morreale, H. F. (2022) · Human Reproduction Update · doi:10.1093/humupd/dmac011 · Cited by 44
Nteeba, J., Sanz-Fernandez, M. V., Rhoads, R. P., Baumgard, L. H., Ross, J. W., & Keating, A. F. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.114.126714 · Cited by 44
Graham, E. J., & Selgrade, J. F. (2017) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2017.01.007 · Cited by 25
Spaczynski, R. Z., Tilly, J. L., Mansour, A., & Duleba, A. J. (2005) · MHR: Basic science of reproductive medicine · doi:10.1093/molehr/gah168 · Cited by 24
Metadata
- Authors
- Poretsky, L., Cataldo, N. A., Rosenwaks, Z., & Giudice, L. C.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 1999-08-01
- Volume
- 20
- Issue
- 4
- Pages
- 535-582
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2077815106
- Cited by
- 818
- References
- 48
- FWCI
- 26.69
- Type
- journal article
- Language
- en
- Open access
- closed
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