The DOI matches its Crossref record; 52 of the 57 references it cites were found in a registry or an index.
Testosterone Inhibits Adipogenic Differentiation in 3T3-L1 Cells: Nuclear Translocation of Androgen Receptor Complex with β-Catenin and T-Cell Factor 4 May Bypass Canonical Wnt Signaling to Down-Regulate Adipogenic Transcription Factors
Open accessAbstract
Testosterone supplementation in men decreases fat mass; however, the mechanisms by which it inhibits fat mass are unknown. We hypothesized that testosterone inhibits adipogenic differentiation of preadipocytes by activation of androgen receptor (AR)/β-catenin interaction and subsequent translocation of this complex to the nucleus thereby bypassing canonical Wnt signaling. We tested this hypothesis in 3T3-L1 cells that differentiate to form fat cells in adipogenic medium. We found that these cells express AR and that testosterone and dihydrotestosterone dose-dependently inhibited adipogenic differentiation as analyzed by Oil Red O staining and down-regulation of CCAAT/enhancer binding protein-α and -δ and peroxisome proliferator-activated receptor-γ2 protein and mRNA. These inhibitory effects of androgens were partially blocked by flutamide or bicalutamide. Androgen treatment was associated with nuclear translocation of β-catenin and AR. Immunoprecipitation studies demonstrated association of β-catenin with AR and T-cell factor 4 (TCF4) in the presence of androgens. Transfection of TCF4 cDNA inhibited adipogenic differentiation, whereas a dominant negative TCF4 cDNA construct induced adipogenesis and blocked testosterone’s inhibitory effects. Our gene array analysis indicates that testosterone treatment led to activation of some Wnt target genes. Expression of constitutively activated AR fused with VP-16 did not inhibit the expression of CCAAT/enhancer binding protein-α in the absence of androgens. Testosterone and dihydrotestosterone inhibit adipocyte differentiation in vitro through an AR-mediated nuclear translocation of β-catenin and activation of downstream Wnt signaling. These data provide evidence for a regulatory role for androgens in inhibiting adipogenic differentiation and a mechanistic explanation consistent with the observed reduction in fat mass in men treated with androgens.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Testosterone inhibits the expression of the activity of lipoprotein lipase, the main enzymatic regulator of triglyceride uptake in the fat cell, preferentially in abdominal fat (28, 29).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Polakis, P. (2000) · Genes & Development · doi:10.1101/gad.14.15.1837 · Cited by 3,183
Wnt signaling: a common theme in animal development
Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,537
Understanding Adipocyte Differentiation
Gregoire, F. M., Smas, C. M., & Sul, H. S. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.3.783 · Cited by 2,406
Inhibition of Adipogenesis by Wnt Signaling
Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., & MacDougald, O. A. (2000) · Science · doi:10.1126/science.289.5481.950 · Cited by 1,876
Secreted antagonists of the Wnt signalling pathway
Kawano, Y., & Kypta, R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00623 · Cited by 1,584
C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint
Rosen, E. D., Hsu, C.-H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., & Spiegelman, B. M. (2002) · Genes & Development · doi:10.1101/gad.948702 · Cited by 1,497
Biological Actions of Androgens
MOORADIAN, A. D., MORLEY, J. E., & KORENMAN, S. G. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-1-1 · Cited by 1,080
TRANSCRIPTIONAL REGULATION OF GENE EXPRESSION DURING ADIPOCYTE DIFFERENTIATION
MacDougald, O. A., & Lane, M. D. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.002021 · Cited by 1,064
Research works printed but not linked: 1
- Jaubert, 1993, Androgen receptors in hamster white adipocytes and their precursor cells: regional variations and modulation by androgens., Endocrine, 1, 535
Cited by
Sorted by citations
Adipocyte differentiation from the inside out
Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607
Pope, H. G., Wood, R. I., Rogol, A. D., Nyberg, F., Bowers, L. D., & Bhasin, S. (2013) · Endocrine Reviews · doi:10.1210/er.2013-1058 · Cited by 703
Self-citationPower, M. L., & Schulkin, J. A. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507853347 · Cited by 645
Sanchez-Garrido, M. A., & Tena-Sempere, M. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.01.001 · Cited by 557
Transcriptional Regulation of Adipogenesis
de Sá, P. M., Richard, A. J., Hang, H., & Stephens, J. M. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160022 · Cited by 406
Wnt/β-catenin signaling in adipogenesis and metabolism
Prestwich, T. C., & MacDougald, O. A. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.09.014 · Cited by 364
Testosterone deficiency, insulin resistance and the metabolic syndrome
Zitzmann, M. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.212 · Cited by 359
Kalinchenko, S. Y., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J., Giltay, E. J., & Saad, F. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03845.x · Cited by 348
Brand, J. S., van der Tweel, I., Grobbee, D. E., Emmelot-Vonk, M. H., & van der Schouw, Y. T. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyq158 · Cited by 334
Mauvais-Jarvis, F. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.10.002 · Cited by 335
Sarjeant, K., & Stephens, J. M. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008417 · Cited by 328
Androgens and body fat distribution
Blouin, K., Boivin, A., & Tchernof, A. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.09.001 · Cited by 321
Bhasin, S., Calof, O. M., Storer, T. W., Lee, M. L., Mazer, N. A., Jasuja, R., Montori, V. M., Gao, W., & Dalton, J. T. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0120 · Cited by 298
Self-citationTestosterone and insulin resistance in the metabolic syndrome and T2DM in men
Rao, P. M., Kelly, D. M., & Jones, T. H. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.122 · Cited by 292
The role of androgens in metabolism, obesity, and diabetes in males and females
Navarro, G., Allard, C., Xu, W., & Mauvais‐Jarvis, F. (2015) · Obesity · doi:10.1002/oby.21033 · Cited by 289
Sex dimorphism and depot differences in adipose tissue function
White, U. A., & Tchoukalova, Y. D. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.006 · Cited by 296
Traish, A. M., Goldstein, I., & Kim, N. N. (2007) · European Urology · doi:10.1016/j.eururo.2007.02.034 · Cited by 268
Onset of effects of testosterone treatment and time span until maximum effects are achieved
Saad, F., Aversa, A., Isidori, A. M., Zafalon, L., Zitzmann, M., & Gooren, L. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0221 · Cited by 232
Selective androgen receptor modulators as function promoting therapies
Bhasin, S., & Jasuja, R. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32832a3d79 · Cited by 223
Self-citationEndocrine Aspects of Male Sexual Dysfunctions
Buvat, J., Maggi, M., Gooren, L., Guay, A. T., Kaufman, J., Morgentaler, A., Schulman, C., Tan, H. M., Torres, L. O., Yassin, A., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01780.x · Cited by 221
White adipocyte dysfunction and obesity-associated pathologies in humans
Hagberg, C. E., & Spalding, K. L. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00680-1 · Cited by 236
Traish, A. M., Miner, M. M., Morgentaler, A., & Zitzmann, M. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.12.027 · Cited by 206
Bone and muscle loss after spinal cord injury: organ interactions
Qin, W., Bauman, W. A., & Cardozo, C. P. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05806.x · Cited by 194
Traish, A. M., Haider, A., Doros, G. D., & Saad, F. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12319 · Cited by 188
Corbould, A. (2007) · Journal of Endocrinology · doi:10.1677/joe.1.07070 · Cited by 184
A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities
Handeli, S., & Simon, J. A. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2063 · Cited by 183
Recovery responses of testosterone, growth hormone, and IGF-1 after resistance exercise
Kraemer, W. J., Ratamess, N. A., & Nindl, B. C. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00599.2016 · Cited by 181
Endocrinology of the aging male
de Araújo, A. B., & Wittert, G. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.11.004 · Cited by 184
Understanding androgen action in adipose tissue
O’Reilly, M. W., House, P. J., & Tomlinson., J. W. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.04.008 · Cited by 180
Androgens inhibit adipogenesis during human adipose stem cell commitment to preadipocyte formation
Chazenbalk, G. D., Singh, P., Irge, D., Shah, A., Abbott, D. H., & Dumesic, D. A. (2013) · Steroids · doi:10.1016/j.steroids.2013.05.001 · Cited by 167
Cellular models for understanding adipogenesis, adipose dysfunction, and obesity
Armani, A., Mammi, C., Marzolla, V., Calanchini, M., Antelmi, A., Rosano, G. M. C., Fabbri, A., & Caprio, M. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22598 · Cited by 166
Gupta, V., Bhasin, S., Guo, W., Singh, R., Miki, R., Chauhan, P., Choong, K., Tchkonia, T., Lebrasseur, N. K., Flanagan, J. N., et al. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.08.019 · Cited by 162
Self-citationTestosterone in men with advanced liver disease: Abnormalities and implications
Sinclair, M. J., Grossmann, M., Gow, P. J., & Angus, P. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12695 · Cited by 163
Phenotypic heterogeneity of mutations in androgen receptor gene
Rajender, S., Singh, L., & Kumarasamy Thangaraj, K. (2007) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2007.00250.x · Cited by 160
Risks and benefits of testosterone therapy in older men
Spitzer, M., Huang, G., Basaria, S., Travison, T. G., & Bhasin, S. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.73 · Cited by 154
Self-citationObesity and late-onset hypogonadism
Corona, G., Vignozzi, L., Sforza, A., Mannucci, E., & Maggi, M. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.06.031 · Cited by 154
Saad, F., Aversa, A., M. Isidori, A., & J. Gooren, L. (2012) · Current Diabetes Reviews · doi:10.2174/157339912799424573 · Cited by 148
Androgen metabolism in adipose tissue: Recent advances
Blouin, K., Veilleux, A., Luu-The, V., & Tchernof, A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.035 · Cited by 147
Lin, W., Xiang, L., Shi, H., Zhang, J., Jiang, L., Cai, P., Lin, Z., Lin, B., Huang, Y., Zhang, H., et al. (2015) · BioMed Research International · doi:10.1155/2015/730139 · Cited by 151
Corbould, A. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.872 · Cited by 143
Caprio, M., Antelmi, A., Chetrite, G., Muscat, A., Mammi, C., Marzolla, V., Fabbri, A., Zennaro, M., & Fève, B. (2010) · Endocrinology · doi:10.1210/en.2010-0674 · Cited by 139
Position Stand on Androgen and Human Growth Hormone Use
Hoffman, J. R., Kraemer, W. J., Bhasin, S., Storer, T. W., Ratamess, N. A., Haff, G. G., Willoughby, D. S., & Rogol, A. D. (2009) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e31819df2e6 · Cited by 143
Self-citationAdiponectin protects against development of metabolic disturbances in a PCOS mouse model
Benrick, A., Chanclón, B., Micallef, P., Wu, Y., Hadi, L., Shelton, J. M., Stener‐Victorin, E., & Asterholm, I. W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708854114 · Cited by 140
Singh, R., Bhasin, S., Braga, M., Artaza, J. N., Pervin, S., Taylor, W. E., Krishnan, V., Sinha, S. K., Rajavashisth, T. B., & Jasuja, R. (2008) · Endocrinology · doi:10.1210/en.2008-0858 · Cited by 131
Self-citationBlouin, K., Nadeau, M., Perreault, M., Veilleux, A., Drolet, R., Marceau, P., Mailloux, J. R., Luu‐The, V., & Tchernof, A. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03645.x · Cited by 131
Recent advances in the biology and therapy of muscle wasting
Glass, D. J., & Roubenoff, R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05809.x · Cited by 130
McInnes, K. J., Smith, L. B., Hunger, N. I., Saunders, P. T. K., Andrew, R., & Walker, B. R. (2012) · Diabetes · doi:10.2337/db11-1136 · Cited by 124
A plural role for lipids in motor neuron diseases: energy, signaling and structure
Schmitt, F., Hussain, G., Dupuis, L., Loeffler, J., & Henriques, A. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00025 · Cited by 120
Follistatin Promotes Adipocyte Differentiation, Browning, and Energy Metabolism
Braga, M., Reddy, S. T., Vergnes, L., Pervin, S., Grijalva, V., Stout, D., David, J., Li, X., Tomasian, V., Reid, C. B., et al. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m039719 · Cited by 111
Self-citationWhich patients with sexual dysfunction are suitable for testosterone replacement therapy?
Morelli, A., Corona, G., Filippi, S., Ambrosini, S., Forti, G., Vignozzi, L., & Maggi, M. (2007) · Journal of Endocrinological Investigation · doi:10.1007/bf03349232 · Cited by 109
Testosterone and type 2 diabetes
Grossmann, M., Gianatti, E. J., & Zajac, J. D. (2010) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e32833919cf · Cited by 108
Adipose tissue expandability and the early origins of PCOS
de Zegher, F., López‐Bermejo, A., & Ibáñez, L. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.06.003 · Cited by 108
The triad of erectile dysfunction, hypogonadism and the metabolic syndrome
Shabsigh, R., Arver, S., Channer, K. S., Ian Eardley, C., Fabbri, A., Gooren, L. J., Heufelder, A. E., Jones, H., Meryn, S., & Zitzmann, M. (2008) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01696.x · Cited by 105
Gebhardt, R., & Hovhannisyan, A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22041 · Cited by 104
Androgens and metabolic syndrome: Lessons from androgen receptor knock out (ARKO) mice
Yanase, T., Fan, W., Kyoya, K., Min, L., Takayanagi, R., Kato, S., & Nawata, H. (2008) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2008.03.017 · Cited by 101
Regulation of Adipocyte Differentiation via MicroRNAs
Son, Y. H., Ka, S., Kim, A., & Kim, J. B. (2014) · Endocrinology and Metabolism · doi:10.3803/enm.2014.29.2.122 · Cited by 101
The Alliance of Mesenchymal Stem Cells, Bone, and Diabetes
Napoli, N., Strollo, R., Paladini, A., Briganti, S., Pozzilli, P., & Epstein, S. (2014) · International Journal of Endocrinology · doi:10.1155/2014/690783 · Cited by 105
Obesity phenotypes: depot-differences in adipose tissue and their clinical implications
Guglielmi, V., & Sbraccia, P. (2017) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-017-0467-9 · Cited by 103
Fetal origins of the metabolic syndrome
Xita, N., & Tsatsoulis, A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05658.x · Cited by 96
Kaur, H., & Werstuck, G. H. (2021) · CJC Open · doi:10.1016/j.cjco.2021.05.007 · Cited by 98
Braga, M., Bhasin, S., Jasuja, R., Pervin, S., & Singh, R. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.11.019 · Cited by 96
Self-citationAndrogens and Adipose Tissue in Males: A Complex and Reciprocal Interplay
Mammi, C., Calanchini, M., Antelmi, A., Cinti, F., Rosano, G. M. C., Lenzi, A., Caprio, M., & Fabbri, A. (2012) · International Journal of Endocrinology · doi:10.1155/2012/789653 · Cited by 95
Rehan, V. K., Asotra, K., & Torday, J. S. (2009) · Lung · doi:10.1007/s00408-009-9158-2 · Cited by 93
Traish, A. M. (2014) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000086 · Cited by 95
Artaza, J. N., Sirad, F., Ferrini, M. G., & Norris, K. C. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.01.001 · Cited by 93
Self-citationKitagawa, T., Matsuda, K., Inui, S., Takenaka, H., Katoh, N., Itami, S., Kishimoto, S., & Kawata, M. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1053 · Cited by 95
Blouin, K., Nadeau, M., Mailloux, J. R., Daris, M., Lebel, S., Luu-The, V., & Tchernof, A. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2008 · Cited by 90
Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men
Blouin, K., Richard, C., Brochu, G., Hould, F.-S., Lebel, S., Marceau, S., Biron, S., Luu-The, V., & Tchernof, A. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06365 · Cited by 90
Zhao, J., Yue, W., Zhu, M. J., Sreejayan, N., & Du, . (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.161 · Cited by 91
Testosterone treatment improves metabolic syndrome-induced adipose tissue derangements
Maneschi, E., Morelli, A., Filippi, S., Cellai, I., Comeglio, P., Mazzanti, B., Mello, T., Calcagno, A., Sarchielli, E., Vignozzi, L., et al. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0333 · Cited by 89
Impact of testosterone on body fat composition
Maddalena, C. D., Vodo, S., Petroni, A., & Aloisi, A. M. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24096 · Cited by 89
Androgens and the Regulation of Adiposity and Body Fat Distribution in Humans
Tchernof, A., Brochu, D., Maltais‐Payette, I., Mansour, M. F., Marchand, G. B., Carreau, A., & Kapeluto, J. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170009 · Cited by 113
Sex Hormones and Macronutrient Metabolism
Comitato, R., Saba, A., Turrini, A., Arganini, C., & Virgili, F. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.651177 · Cited by 86
Sex Steroid Hormone Levels and Body Composition in Men
Gates, M. A., Mekary, R. A., Chiu, G. R., Ding, E. L., Wittert, G., & de Araújo, A. B. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2582 · Cited by 85
Moreno‐Navarrete, J. M., & Fernández‐Real, J. M. (2011) · Springer eBooks · doi:10.1007/978-1-4614-0965-6_2 · Cited by 87
Saad, F., & Gooren, L. J. (2010) · Journal of Obesity · doi:10.1155/2011/471584 · Cited by 82
Mechanisms underlying the metabolic actions of testosterone in humans: A narrative review
Dandona, P., Dhindsa, S., Ghanim, H., & Saad, F. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14206 · Cited by 90
Ibebunjo, C., Eash, J. K., Li, C., Ma, Q., & Glass, D. J. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00402.2010 · Cited by 81
Sarcopenia and Androgens: A Link between Pathology and Treatment
Basualto-Alarcón, C., Varela, D., Duran, J., Maass, R., & Estrada, M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00217 · Cited by 83
Amelioration of Penile Fibrosis: Myth or Reality
El‐Sakka, A. I., & Yassin, A. A. (2010) · Journal of Andrology · doi:10.2164/jandrol.109.008730 · Cited by 80
Androgen Effects on Adipose Tissue Architecture and Function in Nonhuman Primates
Varlamov, O., White, A. E., Carroll, J. M., Bethea, C. L., Reddy, A. P., Slayden, O. D., O’Rourke, R. W., & Roberts, C. T. (2012) · Endocrinology · doi:10.1210/en.2011-2111 · Cited by 74
Androgens Play a Pivotal Role in Maintaining Penile Tissue Architecture and Erection: A Review
Traish, A. M. (2009) · Journal of Andrology · doi:10.2164/jandrol.108.006007 · Cited by 75
Barbonetti, A., Caterina Vassallo, M. R., Cotugno, M., Felzani, G., Francavilla, S., & Francavilla, F. (2016) · The Journal of Spinal Cord Medicine · doi:10.1179/2045772314y.0000000288 · Cited by 75
Adiposopathy: why do adiposity and obesity cause metabolic disease?
Bays, H. E., & Ballantyne, C. M. (2006) · Future Lipidology · doi:10.2217/17460875.1.4.389 · Cited by 75
The use of phosphodiesterase 5 inhibitors with concomitant medications
Corona, G., Razzoli, E., Forti, G., & Maggi, M. (2008) · Journal of Endocrinological Investigation · doi:10.1007/bf03349261 · Cited by 74
Updated survey of the steroid-converting enzymes in human adipose tissues
Tchernof, A., Mansour, M. F., Pelletier, M., Boulet, M.-M., Nadeau, M., & Luu-The, V. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.011 · Cited by 73
Nuclear receptor regulation of stemness and stem cell differentiation
Jeong, Y., & Mangelsdorf, D. J. (2009) · Experimental & Molecular Medicine · doi:10.3858/emm.2009.41.8.091 · Cited by 74
Testosterone metabolites differentially regulate obesogenesis and fat distribution
Sebo, Z. L., & Rodeheffer, M. S. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101141 · Cited by 71
Hypogonadism as a possible link between metabolic diseases and erectile dysfunction in aging men
Corona, G., Bianchini, S., Sforza, A., Vignozzi, L., & Maggi, M. (2015) · HORMONES · doi:10.14310/horm.2002.1635 · Cited by 70
Myocyte Androgen Receptors Increase Metabolic Rate and Improve Body Composition by Reducing Fat Mass
Fernando, S. M., Rao, P., Niel, L., Chatterjee, D., Stagljar, M., & Monks, D. A. (2010) · Endocrinology · doi:10.1210/en.2010-0018 · Cited by 69
Androgen activates β-catenin signaling in bladder cancer cells
Li, Y., Zheng, Y., Izumi, K., Ishiguro, H., Ye, B., Li, F., & Miyamoto, H. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0328 · Cited by 67
Cardoso, R. C., Veiga‐Lopez, A., Moeller, J., Beckett, E. M., Pease, A. P., Keller, E., Madrigal, V., Chazenbalk, G. D., Dumesic, D. A., & Padmanabhan, V. (2015) · Endocrinology · doi:10.1210/en.2015-1565 · Cited by 67
Yarrow, J. F., McCoy, S. C., & Borst, S. E. (2010) · Steroids · doi:10.1016/j.steroids.2010.01.019 · Cited by 69
Noh, T., Gabet, Y., Cogan, J. P., Shi, Y., Tank, A., Sasaki, T., Criswell, B., Dixon, A., Lee, C. S., Tam, J., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005438 · Cited by 65
Liu, X., Allen, J. D., Arnold, J. T., & Blackman, M. R. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn011 · Cited by 65
Obesity attenuates gender differences in cardiovascular mortality
for the DECODE Study Group, Song, X., Tabák, Á. G., Zethelius, B., Yudkin, J. S., Söderberg, S., Laatikainen, T. K., Stehouwer, C. D. A., Dankner, R. S., Jousilahti, P., et al. (2014) · Cardiovascular Diabetology · doi:10.1186/s12933-014-0144-5 · Cited by 62
Inhibition of in vitro and in vivo brown fat differentiation program by myostatin
Braga, M., Pervin, S., Norris, K. C., Bhasin, S., & Singh, R. (2013) · Obesity · doi:10.1002/oby.20117 · Cited by 65
Self-citationDeciphering the selective androgen receptor modulators paradigm
Zhang, X., & Sui, Z. (2012) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2013.741582 · Cited by 66
Kuo, D., Yeh, C., Shieh, P., Cheng, K., Chen, F., & Cheng, J. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.05.005 · Cited by 63
Veiga‐Lopez, A., Moeller, J., Patel, D., Ye, W., Pease, A. P., Kinns, J., & Padmanabhan, V. (2013) · Endocrinology · doi:10.1210/en.2012-2145 · Cited by 64
Metadata
- Authors
- Singh, R., Artaza, J. N., Taylor, W. E., Braga, M., Yuan, X., Gonzalez-Cadavid, N. F., & Bhasin, S.
- Affiliations
- Charles R. Drew University of Medicine and Science (US)
- Beth Israel Deaconess Medical Center (US)
- Division of Endocrinology, Metabolism, and Molecular Medicine (R.S., J.N.A., W.E.T., M.B., N.F.G.-C., S.B.), Charles R. Drew University of Medicine and Science, Los Angeles, California 90059
- Boston Medical Center (US)
- Corresponding author
- Singh, Rajan
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2006-01-01
- Volume
- 147
- Issue
- 1
- Pages
- 141-154
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- PMC
- PMC4417624
- OpenAlex
- W2064549818
- Cited by
- 369
- References
- 57
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 13 · 2023: 5 · 2022: 14 · 2021: 6 · 2020: 17 · 2019: 7 · 2018: 13 · 2017: 27 · 2016: 9 · 2015: 30 · 2014: 20 · 2013: 29 · 2012: 21
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1p20md000545-01, 5u01dk070431-11)
- National Institute on Aging (SC1AG033407)
- National Institute of General Medical Sciences (S06GM068510)
- National Institute of Diabetes and Digestive and Kidney Diseases (1R01 DK 59627-01, U01-DK-070431, R01DK070534, R01DK059627, 1R01DK70431-01)
- National Center for Research Resources (G12 RR 03026, G12RR003026)
- National Institute on Minority Health and Health Disparities (1P20MD000545-02, P20 MD000545)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD041748-0, U54HD041748, R01HD043348)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- testosterone, adipogenesis, androgen receptor, β-catenin, T-cell factor 4, Wnt signaling, 3T3-L1 cells, preadipocytes, C/EBPα, C/EBPδ, PPARγ, nuclear translocation, flutamide, bicalutamide, fat mass, androgen supplementation
- MeSH terms
- Adipose Tissue, Animals, Cell Differentiation, Cell Nucleus, Gene Expression Regulation, Receptors, Androgen, RNA, Messenger, Testosterone, Transcription Factors, Transcription, Genetic, Signal Transduction, 3T3 Cells, Adipocytes, Reverse Transcriptase Polymerase Chain Reaction, Protein Transport, Wnt Proteins, beta Catenin, Mice, TCF Transcription Factors, Transcription Factor 7-Like 2 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
