The DOI matches its Crossref record; 64 of the 65 references it cites were found in a registry or an index.
MicroRNA-Regulated Pathways Associated with Endometriosis
Open accessAbstract
Endometriosis is a prevalent gynecological disease characterized by growth of endometriotic tissue outside the uterine cavity. MicroRNAs (miRNAs) are naturally occurring posttranscriptional regulatory molecules that potentially play a role in endometriotic lesion development. We assessed miRNA expression by microarray analysis in paired ectopic and eutopic endometrial tissues and identified 14 up-regulated (miR-145, miR-143, miR-99a, miR-99b, miR-126, miR-100, miR-125b, miR-150, miR-125a, miR-223, miR-194, miR-365, miR-29c and miR-1) and eight down-regulated (miR-200a, miR-141, miR-200b, miR-142-3p, miR-424, miR-34c, miR-20a and miR-196b) miRNAs. The differential expression of six miRNAs was confirmed by quantitative RT-PCR. An in silico analysis identified 3851 mRNA transcripts as putative targets of the 22 miRNAs. Of these predicted targets, 673 were also differentially expressed in ectopic vs. eutopic endometrial tissue, as determined by microarray. Functional analysis suggested that the 673 miRNA targets constitute molecular pathways previously associated with endometriosis, including c-Jun, CREB-binding protein, protein kinase B (Akt), and cyclin D1 (CCND1) signaling. These pathways appeared to be regulated both transcriptionally as well as by miRNAs at posttranscriptional level. These data are a rich and novel resource for endometriosis and miRNA research and suggest that the 22 miRNAs and their cognate mRNA target sequences constitute pathways that promote endometriosis. Accordingly, miRNAs are potential therapeutic targets for treating this disease.
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“Using arrays probing 377 miRNAs to compare eutopic and ectopic (peritoneal) endometrium from seven women with stage II–IV endometriosis, Teague et al., detected dysregulation of 22 miRNAs, with predicted cognate mRNA targets known to be involved in endometriosis pathogenesis [121].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [121]
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“Global differential expression of miRNAs in eutopic compared with ectopic endometrium has been evaluated by several groups [120–124].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [121]
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“Interestingly, the dysregulation of miRNAs was cycle phase independent, though the relatively small sample size limited definitive correlation.”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [121]
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Metadata
- Authors
- Ohlsson Teague, E. M. C., Van der Hoek, K. H., Van der Hoek, M. B., Perry, N., Wagaarachchi, P., Robertson, S. A., Print, C. G., & Hull, L. M.
- Affiliations
- The University of Adelaide (AU)
- Women's and Children's Hospital (AU)
- University of Auckland (NZ)
- Venue
- Molecular Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2009-02
- Volume
- 23
- Issue
- 2
- Pages
- 265-275
- ISSN
- 0888-8809 (ISSN-L)
- 1944-9917
- PMC
- PMC5419313
- OpenAlex
- W1993162436
- Cited by
- 357
- References
- 65
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 17 · 2023: 11 · 2022: 24 · 2021: 21 · 2020: 22 · 2019: 22 · 2018: 26 · 2017: 25 · 2016: 23 · 2015: 22 · 2014: 20 · 2013: 25 · 2012: 18
- FWCI
- 23.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Endocrinology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- endometriosis, microRNA, miRNA expression profiling, ectopic endometrium, eutopic endometrium, miRNA target prediction, CREB-binding protein, Akt signaling, cyclin D1, post-transcriptional regulation, therapeutic target
- MeSH terms
- Endometriosis, Female, Gene Expression Regulation, Multigene Family, Humans, Molecular Sequence Data, Signal Transduction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MicroRNAs, JNK Mitogen-Activated Protein Kinases
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