fMRI reveals two distinct cerebral networks subserving speech motor control
Abstract
BACKGROUND: There are few data on the cerebral organization of motor aspects of speech production and the pathomechanisms of dysarthric deficits subsequent to brain lesions and diseases. The authors used fMRI to further examine the neural basis of speech motor control. METHODS AND RESULTS: In eight healthy volunteers, fMRI was performed during syllable repetitions synchronized to click trains (2 to 6 Hz; vs a passive listening task). Bilateral hemodynamic responses emerged at the level of the mesiofrontal and sensorimotor cortex, putamen/pallidum, thalamus, and cerebellum (two distinct activation spots at either side). In contrast, dorsolateral premotor cortex and anterior insula showed left-sided activation. Calculation of rate/response functions revealed a negative linear relationship between repetition frequency and blood oxygen level-dependent (BOLD) signal change within the striatum, whereas both cerebellar hemispheres exhibited a step-wise increase of activation at approximately 3 Hz. Analysis of the temporal dynamics of the BOLD effect found the various cortical and subcortical brain regions engaged in speech motor control to be organized into two separate networks (medial and dorsolateral premotor cortex, anterior insula, and superior cerebellum vs sensorimotor cortex, basal ganglia, and inferior cerebellum). CONCLUSION: These data provide evidence for two levels of speech motor control bound, most presumably, to motor preparation and execution processes. They also help to explain clinical observations such as an unimpaired or even accelerated speaking rate in Parkinson disease and slowed speech tempo, which does not fall below a rate of 3 Hz, in cerebellar disorders.
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Left lateralized activation during overt articulation is observed in the insula and dorsolateral premotor cortex, contrasted with bilateral activation in sensorimotor cortex.
“Left lateralized activation during overt articulation was observed in the insula and the dorsolateral premotor cortex and this was contrasted to the bilateral activation in sensorimotor cortex (Riecker et al., 2005).”
From A review and synthesis of the first 20years of PET and fMRI studies of heard speech, spoken language and reading (2012) · cites this paper as Riecker et al., 2005
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- Authors
- Riecker, A., Mathiak, K., Wildgruber, D., Erb, M., Hertrich, I., Grodd, W., & Ackermann, H.
- Affiliations
- Hertie Institute for Clinical Brain Research (DE)
- Venue
- Neurology
- Published
- 2005-02-22
- Volume
- 64
- Issue
- 4
- Pages
- 700-706
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2030232282
- Cited by
- 327
- References
- 43
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 9 · 2023: 14 · 2022: 8 · 2021: 9 · 2020: 10 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 22 · 2015: 26 · 2014: 16 · 2013: 22 · 2012: 20
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Physiology › Voice and Speech Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Phonetics and Phonology Research
- Keywords
- speech motor control, syllable repetition, click trains, anterior insula, cerebellum, basal ganglia, sensorimotor cortex, dysarthria
- MeSH terms
- Adolescent, Adult, Brain Mapping, Cerebellum, Cerebral Cortex, Dominance, Cerebral, Female, Frontal Lobe, Globus Pallidus, Humans, Magnetic Resonance Imaging, Male, Motor Cortex, Phonation, Putamen, Reference Values, Somatosensory Cortex, Speech, Subtraction Technique, Thalamus, Artifacts, Prefrontal Cortex
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