A Preliminary Longitudinal Magnetic Resonance Imaging Study of Brain Volume and Cortical Thickness in Autism
Open accessAbstract
Background Autism is a developmental neurobiologic disorder associated with structural and functional abnormalities in several brain regions including the cerebral cortex. This longitudinal study examined developmental changes in brain volume and cortical thickness (CT) using magnetic resonance imaging (MRI) in children with autism.Methods MRI scans and behavioral measures were obtained at baseline and after a 30-month interval in a sample of male subjects with autism (n = 18) and healthy age-, and sex-matched control subjects (n = 16) between ages 8 and 12 years at baseline.Results No differences in brain volumes were observed between the autism and control subjects at baseline or follow-up. However, differences in total gray matter volumes were observed over time with significantly greater decreases in the autism group compared with control subjects. Differences in CT were observed over time with greater decreases in the autism group compared with control subjects in several brain regions including the frontal lobe. When accounting for multiple comparisons, differences between the two groups became nonsignificant except for changes in occipital CT. Furthermore, associations were observed between several clinical features and changes in CT with greater thinning of the cortex being correlated with more severe symptomatology.Conclusions Findings from this study provide preliminary evidence for age-related changes in gray matter volume and CT in children with autism that are associated with symptoms severity. Future longitudinal studies of larger sample sizes are needed to evaluate developmental changes and examine the relationships between structural abnormalities and clinical expressions of the disorder.
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These findings agree with the reduction of gray matter volume over time in ASD, which is associated with increased severity of symptoms.
“These findings agree with the reduction of gray matter volume over time in ASD, which is associated with increased severity of symptoms [143].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [143]
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,406 · see citing works
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065 · see citing works
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565 · see citing works
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520 · see citing works
Four Factor Index of Social Status
Paschou, R. (1975) · Cited by 6,989 · see citing works
Four Factor Index of Social Status [1975]
Hollingshead, A. B. (1975) · Cited by 5,151 · see citing works
Statistical Power Analysis for the Behavioral Sciences
(1977) · doi:10.1016/c2013-0-10517-x · Cited by 2,457 · see citing works
Dapretto, M., Davies, M. S., Pfeifer, J. H., Scott, A. A., Sigman, M., Bookheimer, S. Y., & Iacoboni, M. (2006) · Nature Neuroscience · doi:10.1038/nn1611 · Cited by 1,694 · see citing works
Just, M. A. (2004) · Brain · doi:10.1093/brain/awh199 · Cited by 1,589 · see citing works
Amaral, D. G., Schumann, C. M., & Nordahl, C. W. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.12.005 · Cited by 1,492 · see citing works
Unusual brain growth patterns in early life in patients with autistic disorder: An MRI study
Courchesne, E., Karns, C. M., Davis, H. R., Ziccardi, R., Carper, R. A., Tigue, Z. D., Chisum, H. J., Moses, P., Pierce, K., Lord, C., et al. (2001) · Neurology · doi:10.1212/wnl.57.2.245 · Cited by 1,487 · see citing works
Longitudinal Mapping of Cortical Thickness and Brain Growth in Normal Children
Sowell, E. R., Thompson, P. M., Leonard, C. M., Welcome, S. E., Kan, E., & Toga, A. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1798-04.2004 · Cited by 1,481 · see citing works
Wide Range Achievement Test-Revised
McCloskey, G. (1987) · Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine) · Cited by 1,391 · see citing works
On the adaptive control of the false discovery rate in multiple testing with independent statistics
Benjamini, Y., & Hochberg, Y. (2000) · Journal of Educational and Behavioral Statistics · doi:10.3102/10769986025001060 · Cited by 1,349 · see citing works
A clinicopathological study of autism
Bailey, A. (1998) · Brain · doi:10.1093/brain/121.5.889 · Cited by 1,083 · see citing works
Genetic influences on brain structure
Thompson, P. M., Cannon, T. D., Narr, K. L., van Erp, T. G. M., Poutanen, V.-P., HUTTUNEN, M. O., Lönnqvist, J. K., Standertskjöld-Nordenstam, C.-G., Kaprio, J. A., Khaledy, M., et al. (2001) · Nature Neuroscience · doi:10.1038/nn758 · Cited by 1,033 · see citing works
Brain structural abnormalities in young children with autism spectrum disorder
Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., Maravilla, K. R., Giedd, J. N., Munson, J., Dawson, G., et al. (2002) · Neurology · doi:10.1212/wnl.59.2.184 · Cited by 961 · see citing works
Maturation of white matter in the human brain: A review of magnetic resonance studies.
Paus, T., Collins, D. L., Evans, A. C., Leonard, G., Pike, B., & Zijdenbos, A. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00434-2 · Cited by 863 · see citing works
Minicolumnar pathology in autism
Casanova, M. F., Buxhoeveden, D. P., Switala, A. E., & Roy, E. (2002) · Neurology · doi:10.1212/wnl.58.3.428 · Cited by 846 · see citing works
White matter structure in autism: preliminary evidence from diffusion tensor imaging
Barnea‐Goraly, N., Kwon, H., Menon, V., D, S. E. M., Lotspeich, L. J., & Reiss, A. L. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.022 · Cited by 780 · see citing works
Contribution of SHANK3 Mutations to Autism Spectrum Disorder
Moessner, R., Marshall, C. R., Sutcliffe, J. S., Skaug, J., Pinto, D., Vincent, J., Zwaigenbaum, L., Fernandez, B., Roberts, W., Szatmari, P., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/522590 · Cited by 681 · see citing works
Localization of white matter volume increase in autism and developmental language disorder
Herbert, M. R., Ziegler, D. A., Makris, N., Filipek, P. A., Kemper, T. L., Normandin, J. J., Sanders, H. A., Kennedy, D. N., & Caviness, V. S. (2004) · Annals of Neurology · doi:10.1002/ana.20032 · Cited by 663 · see citing works
Diffusion tensor imaging of the corpus callosum in Autism
Alexander, A. L., Lee, J. E., Lazar, M., Boudos, R., DuBray, M. B., Oakes, T. R., Miller, J. N., Lu, J. K., Jeong, E., McMahon, W. M., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.08.032 · Cited by 593 · see citing works
Cerebral Lobes in Autism: Early Hyperplasia and Abnormal Age Effects
Carper, R. (2002) · NeuroImage · doi:10.1006/nimg.2002.1099 · Cited by 566 · see citing works
Anatomical Differences in the Mirror Neuron System and Social Cognition Network in Autism
Hadjikhani, N., Joseph, R. M., Snyder, J., & Tager-Flusberg, H. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj069 · Cited by 554 · see citing works
Abnormal functional connectivity in autism spectrum disorders during face processing
Kleinhans, N. M., Richards, T., Sterling, L., Stegbauer, K. C., Mahurin, R., Johnson, L. C., Greenson, J., Dawson, G., & Aylward, E. (2008) · Brain · doi:10.1093/brain/awm334 · Cited by 498 · see citing works
Effects of age on brain volume and head circumference in autism
Aylward, E., Minshew, N. J., Field, K., Sparks, B. F., & Singh, N. (2002) · Neurology · doi:10.1212/wnl.59.2.175 · Cited by 496 · see citing works
Self-citationKana, R. K., Keller, T. A., Minshew, N. J., & Just, M. A. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.004 · Cited by 470 · see citing works
Self-citationLocalized enlargement of the frontal cortex in early autism
Carper, R. A., & Courchesne, E. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.005 · Cited by 456 · see citing works
Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation
Nelson, K. B., Grether, J. K., Croen, L., Dambrosia, J. M., Dickens, B. F., Jelliffe‐Pawlowski, L. L., Hansen, R. L., & Phillips, T. M. (2001) · Annals of Neurology · doi:10.1002/ana.1024 · Cited by 435 · see citing works
Brain anatomy and development in autism: review of structural MRI studies
Brambilla, P., Hardan, A., di Nemi, S. U., Perez, J., Soares, J. C., & Barale, F. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.06.001 · Cited by 418 · see citing works
Self-citationAn MRI study of brain size in autism
Piven, J., Arndt, S. V., Bailey, J. N., Havercamp, S. M., Andreasen, N. C., & Palmer, P. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.8.1145 · Cited by 417 · see citing works
Rojas, D. C., Peterson, E., Winterrowd, E., Reite, M. L., Rogers, S. J., & Tregellas, J. R. (2006) · BMC Psychiatry · doi:10.1186/1471-244x-6-56 · Cited by 360 · see citing works
Relationships between IQ and Regional Cortical Gray Matter Thickness in Healthy Adults
Narr, K. L., Woods, R. P., Thompson, P. M., Szeszko, P. R., Robinson, D. G., Dimtcheva, T., Gurbani, M. N., Toga, A. W., & Bilder, R. M. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl125 · Cited by 339 · see citing works
Lenroot, R. K., Schmitt, J. E., Ordaz, S. J., Wallace, G. L., Neale, M. C., Lerch, J. P., Kendler, K. S., Evans, A. C., & Giedd, J. N. (2009) · Human Brain Mapping · doi:10.1002/hbm.20494 · Cited by 320 · see citing works
Villalobos, M. E., Mizuno, A., Dahl, B. C., Kemmotsu, N., & Müller, R.-A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.022 · Cited by 312 · see citing works
Structural MR image processing using the brains2 toolbox
Magnotta, V. A., Harris, G., Andreasen, N. C., OʼLeary, D. S., Yuh, W. T. C., & Heckel, D. (2002) · Computerized Medical Imaging and Graphics · doi:10.1016/s0895-6111(02)00011-3 · Cited by 301 · see citing works
Delayed maturation of the frontal cortex in childhood autism
Zilbovicius, M., Garreau, B., Samson, Y., Rémy, P., Barthélémy, C., Syrota, A., & Lelord, G. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.2.248 · Cited by 275 · see citing works
An MRI Study of Increased Cortical Thickness in Autism
Hardan, A. Y., Muddasani, S., Vemulapalli, M., Keshavan, M. S., & Minshew, N. J. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.7.1290 · Cited by 253 · see citing works
Self-citationCorpus callosum size in autism
Hardan, A. Y., Minshew, N. J., & Keshavan, M. S. (2000) · Neurology · doi:10.1212/wnl.55.7.1033 · Cited by 243 · see citing works
Self-citationMagnetic resonance imaging in autism: measurement of the cerebellum, pons, and fourth ventricle
Piven, J., Nehme, E., Simon, J., Barta, P. E., Pearlson, G. D., & Folstein, S. E. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90260-7 · Cited by 237 · see citing works
Multiple Bases of Human Intelligence Revealed by Cortical Thickness and Neural Activation
Choi, Y. Y., Shamosh, N. A., Cho, S. H., DeYoung, C. G., Lee, M.-J., Lee, J., Kim, S. I., Cho, Z., Kim, K., Gray, J. R., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3259-08.2008 · Cited by 215 · see citing works
Gyrification abnormalities in childhood- and adolescent-onset schizophrenia
White, T. J. H., Andreasen, N. C., Nopoulos, P., & Magnotta, V. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00065-9 · Cited by 189 · see citing works
Magnotta, V. A., Heckel, D., Andreasen, N. C., Cizadlo, T., Corson, P. W., Ehrhardt, J. C., & Yuh, W. T. C. (1999) · Radiology · doi:10.1148/radiology.211.3.r99ma07781 · Cited by 179 · see citing works
Serum neurotrophin concentrations in autism and mental retardation: a pilot study
Miyazaki, K., Narita, N., Sakuta, R., Miyahara, T., Naruse, H., Okado, N., & Narita, M. (2003) · Brain and Development · doi:10.1016/s0387-7604(03)00168-2 · Cited by 173 · see citing works
Hardan, A. Y., Minshew, N. J., Mallikarjuhn, M., & Keshavan, M. S. (2001) · Journal of Child Neurology · doi:10.1177/088307380101600607 · Cited by 171 · see citing works
Self-citationKatoh‐Semba, R., Wakako, R., Komori, T., Shigemi, H., Miyazaki, N., Ito, H., Kumagai, T., Tsuzuki, M., Shigemi, K., Yoshida, F., et al. (2007) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2007.07.002 · Cited by 155 · see citing works
Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism
Hashimoto, K., Iwata, Y., Nakamura, K., Tsujii, M., Tsuchiya, K. J., Sekine, Y., Suzuki, K., Minabe, Y., Takei, N., Iyo, M., et al. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.018 · Cited by 131 · see citing works
Voxel-Based Morphometry Study of Gray Matter Abnormalities in Obsessive-Compulsive Disorder
Yoo, S. Y., Roh, M., Choi, J., Kang, D.-H., Ha, T. H., Lee, J., Kim, I. Y., Kim, S. I., & Kwon, J. S. (2008) · Journal of Korean Medical Science · doi:10.3346/jkms.2008.23.1.24 · Cited by 107 · see citing works
Hutsler, J. J., Love, T., & Zhang, H. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.015 · Cited by 105 · see citing works
Wassink, T. H., Hazlett, H. C., Epping, E. A., Arndt, S. V., Dager, S. R., Schellenberg, G. D., Dawson, G., & Piven, J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.6.709 · Cited by 101 · see citing works
Altamura, C., Dell'Acqua, M., Moessner, R., Murphy, D., Lesch, K., & Persico, A. M. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhl051 · Cited by 79 · see citing works
Is autism caused by early hyperactivity of brain-derived neurotrophic factor?
Tsai, S. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.01.034 · Cited by 69 · see citing works
Cortical enlargement in autism is associated with a functional VNTR in the monoamine oxidase A gene
Davis, L. K., Hazlett, H. C., Librant, A. L., Nopoulos, P., Sheffield, V. C., Piven, J., & Wassink, T. H. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30738 · Cited by 66 · see citing works
Cortical thinning in obsessive compulsive disorder
Shin, Y., Yoo, S. Y., Lee, J. K., Ha, T. H., Lee, K. J., Lee, J. M., Kim, I. Y., Kim, S. I., & Kwon, J. S. (2007) · Human Brain Mapping · doi:10.1002/hbm.20338 · Cited by 64 · see citing works
Price (1999) · doi:10.1002/1531-8249(199903)45:3
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Consensus Paper: Pathological Role of the Cerebellum in Autism
Fatemi, S. H., Aldinger, K. A., Ashwood, P., Bauman, M. L., Blaha, C. D., Blatt, G. J., Chauhan, A., Chauhan, V., Dager, S. R., Dickson, P. E., et al. (2012) · The Cerebellum · doi:10.1007/s12311-012-0355-9 · Cited by 723 · see citing works
Wolff, J. J., Gu, H., Gerig, G., Elison, J. T., Styner, M., Gouttard, S., Botteron, K. N., Dager, S. R., Dawson, G., Estes, A. M., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11091447 · Cited by 671 · see citing works
Salience Network–Based Classification and Prediction of Symptom Severity in Children With Autism
Uddin, L. Q., Supekar, K., Lynch, C. J., Khouzam, A., Phillips, J., Feinstein, C., Ryali, S., & Menon, V. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.104 · Cited by 621 · see citing works
Autism spectrum disorder: neuropathology and animal models
Varghese, M., Keshav, N., Jacot-Descombes, S., Warda, T., Wicinski, B., Dickstein, D. L., Harony-Nicolas, H., De Rubeis, S., Drapeau, E., Buxbaum, J. D., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1736-4 · Cited by 536 · see citing works
Hazlett, H. C., Poe, M. D., Gerig, G., Styner, M., Chappell, C., Smith, R. G., Vachet, C., & Piven, J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.39 · Cited by 481 · see citing works
Rommelse, N. N. J., Geurts, H. M., Franke, B., Buitelaar, J. K., & Hartman, C. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.02.015 · Cited by 429 · see citing works
Longitudinal changes in cortical thickness in autism and typical development
Zielinski, B. A., Prigge, M. B. D., Nielsen, J. A., Froehlich, A. L., Abildskov, T. J., Anderson, J. S., Fletcher, P. T., Zygmunt, K. M., Travers, B. G., Lange, N., et al. (2014) · Brain · doi:10.1093/brain/awu083 · Cited by 378 · see citing works
Review of neuroimaging in autism spectrum disorders: what have we learned and where we go from here
Anagnostou, E., & Taylor, M. J. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-4 · Cited by 321 · see citing works
Changes in the Development of Striatum Are Involved in Repetitive Behavior in Autism
Langen, M., Bos, D., Noordermeer, S. D. S., Nederveen, H., van Engeland, H., & Durston, S. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.013 · Cited by 256 · see citing works
Langen, M., Leemans, A., Johnston, P., Ecker, C., Daly, E., Murphy, C. M., dell’Acqua, F., Durston, S., & Murphy, D. G. M. (2012) · Cortex · doi:10.1016/j.cortex.2011.05.018 · Cited by 234 · see citing works
EEG hyper-connectivity in high-risk infants is associated with later autism
The BASIS Team, Orekhova, E. V., Elsabbagh, M., Jones, E. J., Dawson, G., Charman, T., & Johnson, M. H. (2014) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-6-40 · Cited by 210 · see citing works
Structural and functional magnetic resonance imaging of autism spectrum disorders
Stigler, K. A., McDonald, B. C., Anand, A., Saykin, A. J., & McDougle, C. J. (2011) · Brain Research · doi:10.1016/j.brainres.2010.11.076 · Cited by 197 · see citing works
Autism As a Disorder of High Intelligence
Crespi, B. J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00300 · Cited by 156 · see citing works
The comorbidity of ADHD and autism spectrum disorder
Antshel, K. M., Zhang-James, Y., & Faraone, S. V. (2013) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2013.840417 · Cited by 147 · see citing works
Dodero, L., Damiano, M., Galbusera, A., Bifone, A., Tsaftsaris, S. A., Scattoni, M. L., & Gozzi, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076655 · Cited by 116 · see citing works
Dougherty, C. C., Evans, D. W., Myers, S. M., Moore, G. J., & Michael, A. M. (2016) · Neuropsychology Review · doi:10.1007/s11065-015-9300-2 · Cited by 104 · see citing works
Review: Cortical construction in autism spectrum disorder: columns, connectivity and the subplate
Hutsler, J. J., & Casanova, M. F. (2016) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12227 · Cited by 94 · see citing works
Wallace, G. L., Eisenberg, I. W., Robustelli, B., Dankner, N., Kenworthy, L., Giedd, J. N., & Martin, A. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.03.007 · Cited by 85 · see citing works
Effects of Rat Prenatal Exposure to Valproic Acid on Behaviour and Neuro-Anatomy
Mychasiuk, R., Richards, S., Nakahashi, A., Kolb, B., & Gibb, R. (2012) · Developmental Neuroscience · doi:10.1159/000341786 · Cited by 82 · see citing works
Cortical thickness change in autism during early childhood: CT in Early Childhood ASD
Smith, E., Thurm, A., Greenstein, D., Farmer, C., Swedo, S., Giedd, J., & Raznahan, A. (2016) · Human Brain Mapping · doi:10.1002/hbm.23195 · Cited by 53 · see citing works
- Authors
- Hardan, A. Y., Libove, R. A., Keshavan, M. S., Melhem, N. M., & Minshew, N. J.
- Affiliations
- Stanford University (US)
- Beth Israel Deaconess Medical Center (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 66
- Issue
- 4
- Pages
- 320-326
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2905654
- OpenAlex
- W1997254625
- Cited by
- 173
- References
- 58
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 11 · 2017: 15 · 2016: 14 · 2015: 15 · 2014: 14 · 2013: 17 · 2012: 16
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K23MH064027, MH-64027)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD055748)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- autism spectrum disorder, brain volume, cortical thickness, gray matter volume, cortical thinning, brain development, children, symptom severity, frontal lobe, occipital cortex, longitudinal MRI
- MeSH terms
- Affective Symptoms, Autistic Disorder, Brain, Cerebral Cortex, Child, Humans, Intelligence Tests, Longitudinal Studies, Magnetic Resonance Imaging, Male, Organ Size, Severity of Illness Index, Stereotyped Behavior, Case-Control Studies
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