PIN-FORMED1 and PINOID regulate boundary formation and cotyledon development in Arabidopsis embryogenesis

Furutani, Masahiko; Vernoux, Teva; Traas, Jan; Kato, Takehide; Tasaka, Masao; Aida, Mitsuhiro

doi:10.1242/dev.01388

Cited by 271Plant Molecular Biology ResearchDevelopmental Biology and Gene RegulationPlant Parasitism and Resistance

PIN-FORMED1 and PINOID regulate boundary formation and cotyledon development in Arabidopsis embryogenesis

Furutani, Masahiko, Vernoux, Teva, Traas, Jan, Kato, Takehide, Tasaka, Masao, Aida, Mitsuhiro·2004·Development

DOI 10.1242/dev.01388

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Abstract

In dicotyledonous plants, two cotyledons are formed at bilaterally symmetric positions in the apical region of the embryo. Single mutations in the PIN-FORMED1 (PIN1) and PINOID (PID)genes, which mediate auxin-dependent organ formation, moderately disrupt the symmetric patterning of cotyledons. We report that the pin1 piddouble mutant displays a striking phenotype that completely lacks cotyledons and bilateral symmetry. In the double mutant embryo, the expression domains of CUP-SHAPED COTYLEDON1 (CUC1), CUC2 and SHOOT MERISTEMLESS (STM), the functions of which are normally required to repress growth at cotyledon boundaries, expand to the periphery and overlap with a cotyledon-specific marker, FILAMENTOUS FLOWER. Elimination of CUC1, CUC2 or STM activity leads to recovery of cotyledon growth in the double mutant, suggesting that the negative regulation of these boundary genes by PIN1 and PID is sufficient for primordium growth. We also show that PID mRNA is localized mainly to the boundaries of cotyledon primordia and early expression of PID mRNA is dependent on PIN1. Our results demonstrate the redundant roles of PIN1 and PID in the establishment of bilateral symmetry, as well as in the promotion of cotyledon outgrowth, the latter of which involves the negative regulation of CUC1, CUC2 and STM genes, which are boundary-specific downstream effectors.

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PIN1 reorientation depends on the kinase PINOID (PID).
“This reorientation depends on the kinase PINOID (PID) that controls basal-apical localization of PIN1 (Furutani et al., 2004).”
From Shaping plant architecture (2015) · cites this paper as Furutani et al., 2004
Boundaries between cotyledons and between developing leaflets are correlated with low auxin concentrations.
“Furthermore, the boundaries between cotyledons (Furutani et al., 2004) and between developing leaflets (Koenig et al., 2009) have been correlated with low auxin concentrations.”
From Divide et impera: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Furutani et al., 2004
CUC gene expression is linked to auxin-dependent organ initiation.
“An earlier study demonstrated a link between CUC gene expression and auxin-dependent organ initiation (Furutani et al., 2004).”
From Divide et impera: boundaries shape the plant body and initiate new meristems (2016) · cites this paper as Furutani et al., 2004

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Authors: Furutani, M., Vernoux, T., Traas, J., Kato, T., Tasaka, M., & Aida, M.
Affiliations: Nara Institute of Science and Technology (JP)
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Corresponding author: Aida, Mitsuhiro
ORCID: Furutani, Masahiko
Vernoux, Teva
Traas, Jan
Kato, Takehide
Tasaka, Masao
Aida, Mitsuhiro
Venue: Development
Publisher: The Company of Biologists
Published: 2004-10-15
Volume: 131
Issue: 20
Pages: 5021-5030
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.01388
OpenAlex: W2033325050
Cited by: 271
References: 34
Citations by year: 2026: 5 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 11 · 2021: 7 · 2020: 6 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 21 · 2014: 13 · 2013: 12 · 2012: 14
FWCI: 18.05
Type: journal article
Language: en
Open access: closed
Locations: Development (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Parasitism and Resistance
Keywords: PINOID, auxin transport, cotyledon development, bilateral symmetry, SHOOT MERISTEMLESS, mRNA localization, embryonic development, Arabidopsis thaliana
MeSH terms: Indoleacetic Acids, Mutation, Down-Regulation, Protein Serine-Threonine Kinases, Arabidopsis, Homeodomain Proteins, Cotyledon, Membrane Transport Proteins, Arabidopsis Proteins

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PIN-FORMED1 and PINOID regulate boundary formation and cotyledon development in Arabidopsis embryogenesis

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