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A local Wnt-3a signal is required for development of the mammalian hippocampus
Abstract
The mechanisms that regulate patterning and growth of the developing cerebral cortex remain unclear. Suggesting a role for Wnt signaling in these processes, multiple Wnt genes are expressed in selective patterns in the embryonic cortex. We have examined the role of Wnt-3a signaling at the caudomedial margin of the developing cerebral cortex, the site of hippocampal development. We show that Wnt-3a acts locally to regulate the expansion of the caudomedial cortex, from which the hippocampus develops. In mice lacking Wnt-3a, caudomedial cortical progenitor cells appear to be specified normally, but then underproliferate. By mid-gestation, the hippocampus is missing or represented by tiny populations of residual hippocampal cells. Thus, Wnt-3a signaling is crucial for the normal growth of the hippocampus. We suggest that the coordination of growth with patterning may be a general role for Wnts during vertebrate development.
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Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Eiraku, M., Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., & Sasai, Y. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.002 · Cited by 1,522
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Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431
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Sur, M., & Rubenstein, J. L. R. (2005) · Science · doi:10.1126/science.1112070 · Cited by 677
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Hirabayashi, Y., Itoh, Y., Tabata, H., Nakajima, K., Akiyama, T., Masuyama, N., & Gotoh, Y. (2004) · Development · doi:10.1242/dev.01165 · Cited by 600
Tiwari, S. K., Agarwal, S., Seth, B., Yadav, A., Nair, S., Bhatnagar, P., Karmakar, M., Kumari, M., Chauhan, L. K. S., Patel, D. K., et al. (2014) · ACS Nano · doi:10.1021/nn405077y · Cited by 558
Sakaguchi, H., Kadoshima, T., Soen, M., Narii, N., Ishida, Y., Ohgushi, M., Takahashi, J., Eiraku, M., & Sasai, Y. (2015) · Nature Communications · doi:10.1038/ncomms9896 · Cited by 542
The origin of mind: Evolution of brain, cognition, and general intelligence.
Geary, D. C. (2005) · doi:10.1037/10871-000 · Cited by 551
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Ciani, L., & Salinas, P. C. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1665 · Cited by 543
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Ruiz i Altaba, A., Palma, V., & Dahmane, N. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn704 · Cited by 376
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Chen, J., Park, C. S., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511920200 · Cited by 298
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Munji, R. N., Choe, Y., Li, G., Siegenthaler, J. A., & Pleasure, S. J. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5404-10.2011 · Cited by 275
Chenn, A. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.599 · Cited by 253
Lavado, A., Lagutin, O. V., Chow, L. M. L., Baker, S. J., & Oliver, G. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000460 · Cited by 238
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Freese, J. L., Pino, D., & Pleasure, S. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.09.003 · Cited by 180
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Wexler, E. M., Paucer, A., Kornblum, H. I., Palmer, T. D., & Geschwind, D. H. (2009) · Stem Cells · doi:10.1002/stem.36 · Cited by 174
Frozza, R. L., Bernardi, A., Hoppe, J. B., Meneghetti, A. B., Matté, A., Battastini, A. M. O., Pohlmann, A. R., Guterres, S. S., & Salbego, C. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8401-2 · Cited by 165
Iwano, T., Masuda, A., Kiyonari, H., Enomoto, H., & Matsuzaki, F. (2012) · Development · doi:10.1242/dev.080002 · Cited by 155
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Mallamaci, A., & Stoykova, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04634.x · Cited by 95
Pomeshchik, Y., Klementieva, O., Gil, J., Martinsson, I., Hansen, M. G., de Vries, T., Sancho-Balsells, A., Russ, K., Savchenko, E., Collin, A., et al. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.06.001 · Cited by 95
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Xu, H.-T., Han, Z., Gao, P., He, S., Li, Z., Shi, W., Kodish, O., Shao, W., Brown, K. N., Huang, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.067 · Cited by 80
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Aghaizu, N. D., Jin, H., & Whiting, P. J. (2020) · Brain Sciences · doi:10.3390/brainsci10120902 · Cited by 70
Seki, T., Sato, T., Toda, K., Osumi, N., Imura, T., & Shioda, S. (2014) · Journal of Comparative Neurology · doi:10.1002/cne.23460 · Cited by 60
Nielsen, J. V., Thomassen, M., Møllgård, K., Noraberg, J., & Jensen, N. A. (2014) · Cerebral Cortex · doi:10.1093/cercor/bhs400 · Cited by 59
Metadata
- Authors
- Lee, S. M. K., Tole, S., Grove, E. A., & McMahon, A. P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-02-01
- Volume
- 127
- Issue
- 3
- Pages
- 457-467
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1892599478
- Cited by
- 636
- References
- 0
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- closed
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