The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Microbial Symbionts Accelerate Wound Healing via the Neuropeptide Hormone Oxytocin
Open accessAbstract
Wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. Impact of the microbiome upon the mammalian wound healing process is poorly understood. We discover that supplementing the gut microbiome with lactic acid microbes in drinking water accelerates the wound-healing process to occur in half the time required for matched control animals. Further, we find that Lactobacillus reuteri enhances wound-healing properties through up-regulation of the neuropeptide hormone oxytocin, a factor integral in social bonding and reproduction, by a vagus nerve-mediated pathway. Bacteria-triggered oxytocin serves to activate host CD4+Foxp3+CD25+ immune T regulatory cells conveying transplantable wound healing capacity to naive Rag2-deficient animals. This study determined oxytocin to be a novel component of a multi-directional gut microbe-brain-immune axis, with wound-healing capability as a previously unrecognized output of this axis. We also provide experimental evidence to support long-standing medical traditions associating diet, social practices, and the immune system with efficient recovery after injury, sustained good health, and longevity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Indeed, administration of L. reuteri, to mice resulted in an increase in the circulation levels and expression of oxytocin, which was associated with an increase in social behavior (Buffington et al., 2016;Poutahidis et al., 2013).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Poutahidis et al., 2013
Experimental — accuracy not yet measuredIn the citing paper
“Interestingly, the effects observed above are dependent on vagal signaling, which blunted the effects of Lactobacillus on host plasma and hypothalamic oxytocin [132,133].”
From Anxiety, depression, and the microbiome: A role for gut peptides (2018) · cites this paper as [132]
In the citing paper
“We and others have shown that L. reuteri increases oxytocin levels (Buffington et al., 2016; Poutahidis et al., 2013).”
From Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder (2019) · cites this paper as Poutahidis et al., 2013
In the citing paper
“We and others have previously provided correlational evidence that L. reuteri increases oxytocin levels (Buffington et al., 2016; Poutahidis et al., 2013)”
From Mechanisms underlying microbial-mediated changes in social behavior in mouse models of autism spectrum disorder (2019) · cites this paper as Poutahidis et al., 2013
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992
Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008) · Nature · doi:10.1038/nature07039 · Cited by 6,542
Singer, A. J., & Clark, R. A. F. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909023411006 · Cited by 6,106
Wound Healing--Aiming for Perfect Skin Regeneration
Martin, P. B. (1997) · Science · doi:10.1126/science.276.5309.75 · Cited by 4,842
Host-gut microbiota metabolic interactions
Nicholson, J. K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., & Pettersson, S. (2012) · Science · doi:10.1126/science.1223813 · Cited by 4,760
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
Cryan, J. F., & Dinan, T. G. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3346 · Cited by 4,572
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · cited 1×
“The processes of re-epithelialization and granulation tissue formation with collagen deposition and successive influx of different subsets of immune cells match the classical wound healing timeline previously described in C57BL/6 mice [33,48,56].”
BackgroundVagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Borovikova, L. V., Ivanova, S., Zhang, M., Yang, H., Botchkina, G. I., Watkins, L. R., Wang, H., Abumrad, N., Eaton, J. W., & Tracey, K. J. (2000) · Nature · doi:10.1038/35013070 · Cited by 4,211
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
FOXP3+ regulatory T cells in the human immune system
Sakaguchi, S., Miyara, M., Costantino, C. M., & Hafler, D. A. (2010) · Nature reviews. Immunology · doi:10.1038/nri2785 · Cited by 2,524
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460
Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645
Reciprocal interactions of the intestinal microbiota and immune system
Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598
Gut immune maturation depends on colonization with a host-specific microbiota
Chung, H., Pamp, S. J., Hill, J. A., Surana, N. K., Edelman, S. M., Troy, E. B., Reading, N. C., Villablanca, E. J., Wang, S., Mora, J. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.037 · Cited by 1,241
The X-files in immunity: sex-based differences predispose immune responses
Fish, E. N. (2008) · Nature reviews. Immunology · doi:10.1038/nri2394 · Cited by 1,164
The Neuropeptide Oxytocin Regulates Parochial Altruism in Intergroup Conflict Among Humans
De Dreu, C. K. W., Greer, L. L., Handgraaf, M. J. J., Shalvi, S., Van Kleef, G. A., Baas, M., Ten Velden, F. S., Van Dijk, E., & Feith, S. W. W. (2010) · Science · doi:10.1126/science.1189047 · Cited by 1,148
Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?
Lee, Y. K., & Mazmanian, S. K. (2010) · Science · doi:10.1126/science.1195568 · Cited by 1,147
Oxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941
Smits, H. H., Engering, A. J., van der Kleij, D., de Jong, E. C., Schipper, K., van Capel, T. M. M., Zaat, B. A. J., Yazdanbakhsh, M., Wierenga, E. A., & van Kooyk, Y. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.03.036 · Cited by 778
CD4+CD25+ TR Cells Suppress Innate Immune Pathology Through Cytokine-dependent Mechanisms
Maloy, K. J., Salaün, L., Cahill, R., Dougan, G., Saunders, N. J. S. G., & Powrie, F. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021345 · Cited by 740
Neuropeptidergic regulation of affiliative behavior and social bonding in animals
Lim, M. M., & Young, L. J. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.028 · Cited by 624
Wetzler, C., Kämpfer, H., Stallmeyer, B., Pfeilschifter, J., & Frank, S. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00029.x · Cited by 584
Fries, A. B. W., Ziegler, T. E., Kurian, J. R., Jacoris, S., & Pollak, S. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504767102 · Cited by 570
Giacinto, C. D., Marinaro, M., Sanchez, M., Strober, W., & Boirivant, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.6.3237 · Cited by 522
Hofmann, U., Beyersdorf, N., Weirather, J., Podolskaya, A., Bauersachs, J. K., Ertl, G., Kerkau, T., & Frantz, S. (2012) · Circulation · doi:10.1161/circulationaha.111.044164 · Cited by 508
Tyzio, R., Cossart, R., Khalilov, I., Minlebaev, M., Hübner, C. A., Represa, A., Ben-Ari, Y., & Khazipov, R. (2006) · Science · doi:10.1126/science.1133212 · Cited by 485
Impaired cutaneous wound healing in interleukin‐6‐deficient and immunosuppressed mice
Gallucci, R. M., Simeonova, P. P., Matheson, J. M., Kommineni, C., Guriel, J. L., Sugawara, T., & Luster, M. I. (2000) · The FASEB Journal · doi:10.1096/fj.00-0073com · Cited by 405
Karimi, K., Inman, M. D., Bienenstock, J., & Forsythe, P. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200806-951oc · Cited by 361
(1999) · PubMed · Cited by 354
Skrundz, M., Bolten, M., Nast, I., Hellhammer, D. H., & Meinlschmidt, G. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.74 · Cited by 349
Novel Insights into Wound Healing Sequence of Events
Braiman, L., Solomonik, I., Spira, R. M., & Tennenbaum, T. (2007) · Toxicologic Pathology · doi:10.1080/01926230701584189 · Cited by 313
CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice
Erdman, S. E., Poutahidis, T., Tomczak, M. F., Rogers, A. B., Cormier, K. S., Plank, B., Horwitz, B. H., & Fox, J. G. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63863-1 · Cited by 303
Davari, S., Talaei, S. A., Alaei, H., & salami, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.055 · Cited by 290
Israel, S., Lerer, E., Shalev, I., Uzefovsky, F., Riebold, M., Laiba, E., Bachner-Melman, R., Maril, A., Bornstein, G., Knafo, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005535 · Cited by 278 · cited 1×
“In fact, in humans, specific SNPs in the 39 untranslated region of the oxytocin receptor gene correlate with prosocial behavior, suggesting that modulation of these hormones at the levels of transcription and translation can have profound influence on these phenotypes [81].”
BackgroundOxytocin/vasopressin-related peptides have an ancient role in reproductive behavior
Garrison, J. L., Macosko, E. Z., Bernstein, S., Pokala, N., Albrecht, D. R., & Bargmann, C. I. (2012) · Science · doi:10.1126/science.1226201 · Cited by 266
Social facilitation of wound healing
Detillion, C. E., Craft, T. K. S., Glasper, E. R., Prendergast, B. J., & DeVries, A. C. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.10.003 · Cited by 259
Culture‐independent analysis of the gut microbiota in colorectal cancer and polyposis
Scanlan, P. D., Shanahan, F., Clune, Y., Collins, J. K., O'Sullivan, G. C., O'Riordan, M., Holmes, E., Wang, Y., & Marchesi, J. R. (2008) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01503.x · Cited by 245
Low sympathetic tone and obese phenotype in oxytocin-deficient mice
Camerino, C. (2009) · Obesity · doi:10.1038/oby.2009.12 · Cited by 235
Erdman, S. E., Rao, V. P., Poutahidis, T., Ihrig, M. M., Ge, Z., Feng, Y., Tomczak, M. F., Rogers, A. B., Horwitz, B. H., & Fox, J. G. (2003) · PubMed · Cited by 210
Recommendations for Probiotic Use—2011 Update
Floch, M. H., Walker, W. A., Madsen, K. L., Sanders, M. E., Macfarlane, G. T., Flint, H. J., Dieleman, L. A., Ringel, Y., Guandalini, S., Kelly, C. P., et al. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318230928b · Cited by 208
Cytokines and the immunomodulatory function of the vagus nerve
Johnston, G. R., & Webster, N. R. (2009) · British Journal of Anaesthesia · doi:10.1093/bja/aep037 · Cited by 205
Probiotic Bacteria Induce a ‘Glow of Health’
Levkovich, T., Poutahidis, T., Smillie, C. S., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., Alm, E. J., & Erdman, S. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053867 · Cited by 201
Wound-Healing Studies in Transgenic and Knockout Mice
Grose, R., & Werner, S. (2004) · Molecular Biotechnology · doi:10.1385/mb:28:2:147 · Cited by 197
Rao, V. P., Poutahidis, T., Ge, Z., Nambiar, P. R., Boussahmain, C., Wang, Y. Y., Horwitz, B. H., Fox, J. G., & Erdman, S. E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0558 · Cited by 185
Erdman, S. E., Rao, V. P., Poutahidis, T., Rogers, A. B., Taylor, C. L., Jackson, E. A., Ge, Z., Lee, C. W., Schauer, D. B., Wogan, G. N., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812347106 · Cited by 183
Saulnier, D. M. A., dos Santos, F. B., Roos, S., Mistretta, T., Spinler, J. K., Molenaar, D., Teusink, B., & Versalovic, J. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018783 · Cited by 181
Gordon, J. I. (2012) · Science · doi:10.1126/science.1224686 · Cited by 172
Ansell, D. M., Kloepper, J. E., Thomason, H. A., Paus, R., & Hardman, M. J. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.291 · Cited by 171
The intestinal microbiota in health and disease
Young, V. B. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32834d61e9 · Cited by 164
Microbial Reprogramming Inhibits Western Diet-Associated Obesity
Poutahidis, T., Kleinewietfeld, M., Smillie, C., Levkovich, T., Perrotta, A., Bhela, S., Varian, B. J., Ibrahim, Y. M., Lakritz, J. R., Kearney, S. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068596 · Cited by 164
Self-citationPowrie, F. M., & Maloy, K. J. (2003) · Science · doi:10.1126/science.1082031 · Cited by 138
Inducing Tolerance to Pregnancy
Williams, Z. (2012) · New England Journal of Medicine · doi:10.1056/nejmcibr1207279 · Cited by 107
Johnson, H. M., & Torres, B. A. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.2.773 · Cited by 102
The gut microbiota—a clinical perspective on lessons learned
Shanahan, F. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.145 · Cited by 100
Mast-Cell Degranulation in Human Hearts
Dvořàk, A. M. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610093151515 · Cited by 94
A reliable method of determining wound healing rate
Cukjati, D., Rebersek, S., & Miklavčič, D. (2001) · Medical & Biological Engineering & Computing · doi:10.1007/bf02344811 · Cited by 93
Liu, Y., Fatheree, N. Y., Dingle, B. M., Tran, D. Q., & Rhoads, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056547 · Cited by 87
Unifying roles for regulatory T cells and inflammation in cancer
Erdman, S. E., Rao, V. P., Olipitz, W., Taylor, C. L., Jackson, E. A., Levkovich, T., Lee, C.-W., Horwitz, B. H., Fox, J. G., Ge, Z., et al. (2009) · International Journal of Cancer · doi:10.1002/ijc.24923 · Cited by 87
Breast Cancer: Should Gastrointestinal Bacteria Be on Our Radar Screen?
Rao, V. P., Poutahidis, T., Fox, J. G., & Erdman, S. E. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3468 · Cited by 77
Dreifuss, J. J., Raggenbass, M., Charpak, S., Dubois‐Dauphin, M., & Tribollet, E. (1988) · Brain Research Bulletin · doi:10.1016/0361-9230(88)90089-5 · Cited by 76
Coming Full Circle: Contributions of Central and Peripheral Oxytocin Actions to Energy Balance
Ho, J. M., & Blevins, J. E. (2012) · Endocrinology · doi:10.1210/en.2012-1751 · Cited by 67
Poutahidis, T., Haigis, K. M., Rao, V. P., Nambiar, P. R., Taylor, C. L., Ge, Z., Watanabe, K., Davidson, A., Horwitz, B. H., Fox, J. G., et al. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm180 · Cited by 64
Novel role of regulatory T cells in limiting early neutrophil responses in skin
Richards, H. E., Williams, A. S., Jones, E., Hindley, J. P., Godkin, A. J., Simon, A. K., & Gallimore, A. (2010) · Immunology · doi:10.1111/j.1365-2567.2010.03333.x · Cited by 60
Oxytocin Affects Nitric Oxide and Cytokine Production by Sepsis-Sensitized Macrophages
Oliveira‐Pelegrin, G. R., Saia, R. S., Cárnio, E. C., & Rocha, M. J. A. (2012) · NeuroImmunoModulation · doi:10.1159/000345044 · Cited by 59
A Neuro-Endocrine-Immune Symphony
Pittman, Q. J. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02176.x · Cited by 58
Chow, J., & Mazmanian, S. K. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2008.12.006 · Cited by 54
Differential Evaluation of Excisional Non-occluded Wound Healing in db/db Mice
Tkalčević, V. I., Čužić, S., Parnham, M. J., Pašalić, I., & Brajša, K. (2009) · Toxicologic Pathology · doi:10.1177/0192623308329280 · Cited by 49
Expression and Regulation of Functional Oxytocin Receptors in Bovine T Lymphocytes1
Ndiaye, K., Poole, D. H., & Pate, J. L. (2007) · Biology of Reproduction · doi:10.1095/biolreprod.107.065938 · Cited by 47
Low frequency pulsed current and pressure ulcer healing
Jerčinović, A., Karba, R., Vodovnik, L., Stefanovska, A., Krošelj, P., Turk, R., Džidić, I., Benko, H., & Šavrin, R. (1994) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.340876 · Cited by 43
Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance
Nomura, T., & Sakaguchi, S. (2007) · Nature Immunology · doi:10.1038/ni0407-333 · Cited by 42
Macciò, A., Madeddu, C., Chessa, P., Panzone, F., Lissoni, P., & Mantovani, G. (2010) · PubMed · Cited by 40
Excisional Wound Healing: An Experimental Approach
Frank, S., & Kämpfer, H. (2003) · Humana Press eBooks · doi:10.1385/1-59259-332-1:003 · Cited by 33
Indirect effects of oral tolerance improve wound healing in skin
Costa, R. A., Ruiz‐de‐Souza, V., Azevedo, G. M., Gava, E., Kitten, G. T., Vaz, N. M., & Carvalho, C. R. (2011) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2011.00700.x · Cited by 27
Impact of the Neuroendocrine System on Thymus and Bone Marrow Function
Barnard, A., Layton, D., Hince, M. N., Sakkal, S., Bernard, C. C. A., Chidgey, A. P., & Boyd, R. L. (2008) · NeuroImmunoModulation · doi:10.1159/000135619 · Cited by 26
Aire and Foxp3 Expression in a Particular Microenvironment for T Cell Differentiation
Hansenne, I., Louis, C., Martens, H., Dorban, G., Charlet-Renard, C., Peterson, P., & Geenen, V. G. (2008) · NeuroImmunoModulation · doi:10.1159/000179665 · Cited by 21
Gajendrareddy, P. K., Engeland, C. G., Junges, R., Horan, M. P., Rojas, I. G., & Marucha, P. T. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.10.016 · Cited by 21
Belkaid, Y., Liesenfeld, O., & Maizels, R. M. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04131.x · Cited by 17
Regulatory T cells prevent non-B non-T colitis
Erdman, S. E., Fox, J. G., Sheppard, B. J., Feldman, D., & Horwitz, B. H. (2001) · Gastroenterology · doi:10.1016/s0016-5085(08)82601-7 · Cited by 4
Hair and Wound Healing: Anagen Gets an “A”
Aber, C., Jimenez, J. J., & Kirsner, R. S. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.409 · Cited by 3
Flagged first, then by citations
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Microbiota in health and diseases
Hou, K., Wu, Z.-X., Chen, X.-Y., Wang, J.-Q., Zhang, D., Xiao, C., Zhu, D., Koya, J. B., Wei, L., Li, J., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00974-4 · Cited by 3,171
The gut microbiota–brain axis in behaviour and brain disorders
Morais, L. H., Schreiber, H. L., & Mazmanian, S. K. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00460-0 · Cited by 2,149
Microbial reconstitution reverses maternal diet-induced social and synaptic deficits in offspring
Buffington, S. A., Di Prisco, G. V., Auchtung, T. A., Ajami, N. J., Petrosino, J. F., & Costa-Mattioli, M. (2016) · Cell · doi:10.1016/j.cell.2016.06.001 · Cited by 1,163
Metadata
- Authors
- Poutahidis, T., Kearney, S. M., Levkovich, T., Qi, P., Varian, B. J., Lakritz, J. R., Ibrahim, Y. M., Chatzigiagkos, A., Alm, E. J., & Erdman, S. E.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Massachusetts Institute of Technology (US)
- Broad Institute (US)
- Corresponding author
- Erdman, Susan E.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-10-30
- Volume
- 8
- Issue
- 10
- Pages
- e78898
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3813596
- OpenAlex
- W2068527256
- Cited by
- 310
- References
- 85
- Citations by year
- 2026: 19 · 2025: 29 · 2024: 33 · 2023: 25 · 2022: 31 · 2021: 32 · 2020: 31 · 2019: 21 · 2018: 22 · 2017: 18 · 2016: 24 · 2015: 10 · 2014: 14 · 2013: 1
- FWCI
- 17.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by)
- Figshare (submittedVersion, cc-by)
- Funders
- National Institutes of Health
- National Cancer Institute (U01CA164337, R01CA108854)
- National Institute of Environmental Health Sciences (P30ES002109)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- wound healing, gut microbiota, Lactobacillus reuteri, oxytocin, vagus nerve, regulatory T cells, gut-brain-immune axis, lactic acid bacteria, drinking water supplementation, microbial symbionts
- MeSH terms
- Animals, Collagen, DNA-Binding Proteins, Female, Oxytocin, Symbiosis, Time Factors, Wound Healing, CD4-Positive T-Lymphocytes, Up-Regulation, Mice, Limosilactobacillus reuteri, Drinking Water
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
