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Identify Changes of Brain Regional Homogeneity in Bipolar Disorder and Unipolar Depression Using Resting-State fMRI
Open accessAbstract
BACKGROUND: To identify changes in brain activation patterns in bipolar disorder (BD) and unipolar depression (UD) patients. METHODOLOGY/PRINCIPAL FINDINGS: Resting-state fMRI scans of 16 healthy controls, 17 BD and 16 UD patients were obtained. T-test of normalized regional homogeneity (ReHo) was performed in a voxel-by-voxel manner. A combined threshold of á = 0.05, minimum cluster volume of V = 10503 mm(3) (389 voxels) were used to determine ReHo differences between groups. In UD group, fMRI revealed ReHo increases in the left middle occipital lobe, right inferior parietal lobule, right precuneus and left convolution; and ReHo decreases in the left parahippocampalgyrus, right precentralgyrus, left postcentralgyrus, left precentralgyrus and left cingulated. In BD group, ReHo increases in the right insular cortex, left middle frontal gyrus, left precuneus, left occipital lobe, left parietal, left superior frontal gyrus and left thalamus; and ReHo decreases in the right anterior lobe of cerebellum, pons, right precentralgyrus, left postcentralgyrus, left inferior frontal gyrus, and right cingulate. There were some overlaps in ReHo profiles between UD and BD groups, but a marked difference was seen in the thalamus of BD. CONCLUSIONS/SIGNIFICANCE: The resting-state fMRI and ReHo mapping are a promising tool to assist the detection of functional deficits and distinguish clinical and pathophysiological signs of BD and UD.
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“In bipolar disorder, subjects show reduced cerebellar volumes (Baldacara et al., 2011; DelBello et al., 1999; Mills et al., 2005), abnormal cerebellar functional connectivity (Liang et al., 2013), and abnormal cerebellar metabolism (Johnson et al., 2018; Magnotta et al., 2022) compared to neuronormative populations.”
From A double-blind, randomized, sham-controlled clinical trial of cerebellar intermittent theta burst stimulation for bipolar disorder: Safety, tolerability, mood and cognitive effects (2025) · cites this paper as Liang et al., 2013
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Metadata
- Authors
- Liang, M.-J., Zhou, Q., Yang, K.-R., Yang, X.-L., Fang, J., Chen, W.-L., & Huang, Z.
- Affiliations
- First Affiliated Hospital of Jinan University (CN)
- Corresponding author
- Zhou, Quan
- ORCID
- Zhou, Quan
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-12-04
- Volume
- 8
- Issue
- 12
- Pages
- e79999
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3851159
- OpenAlex
- W2001770029
- Cited by
- 135
- References
- 76
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 11 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 13 · 2019: 13 · 2018: 19 · 2017: 13 · 2016: 14 · 2015: 13 · 2014: 5
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Capital Medical University
- Jinan University
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- bipolar disorder, major depressive disorder, regional homogeneity, resting-state brain activity, thalamus, brain activation patterns, functional deficits, neuroimaging biomarkers
- MeSH terms
- Adolescent, Adult, Bipolar Disorder, Brain Mapping, Cerebellum, Depressive Disorder, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Occipital Lobe, Parietal Lobe, Thalamus, Case-Control Studies
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