CoChat
Sign Up
Cited by 162

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

Sproul, Andrew A., Jacob, Samson, Pre, Deborah, Kim, Soong Ho, Nestor, Michael W., Navarro-Sobrino, Miriam, Santa-Maria, Ismael, Zimmer, Matthew, Aubry, Soline, Steele, John W., Kahler, David J., Dranovsky, Alex, Arancio, Ottavio, Crary, John F., Gandy, Sam, Noggle, Scott A.·2014·PLoS ONE
DOI 10.1371/journal.pone.0084547PMC PMC3885572
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0084547

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Studies using human iPSC-derived neurons demonstrate that the PSEN1 M146L mutation significantly elevates the Aβ42/Aβ40 ratio by selectively increasing Aβ42 production without altering Aβ40 levels, a biochemical signature strongly linked to amyloid aggregation and neurotoxicity in AD.

    “Moreover, studies utilizing human induced pluripotent stem cell (iPSC)-derived neurons demonstrate that the M146L mutation significantly elevates the Aβ42/Aβ40 ratio by selectively increasing Aβ42 production without altering Aβ40 levels, a biochemical signature strongly linked to amyloid aggregation and neurotoxicity in AD (Liu et al. 2014), (Sproul et al. 2014), (Schrank et al. 2020).”

    From TMEM55B downregulation promotes neurodegeneration in Alzheimer’s disease models (2026) · cites this paper as Sproul et al. 2014

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 43

  1. C Ballard, 2011, Alzheimer's disease, The Lancet, 377, 1019, 10.1016/S0140-6736(10)61349-9 · DOI · Paper page
  2. GA Elder, 2010, Presenilin transgenic mice as models of Alzheimer's disease, Brain Struct Funct, 214, 127, 10.1007/s00429-009-0227-3 · DOI
  3. O Quintero-Monzon, 2011, Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations, Biochemistry, 50, 9023, 10.1021/bi2007146 · DOI · Paper page
  4. S Hata, 2009, Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction, Journal of Biological Chemistry, 284, 36024, 10.1074/jbc.M109.057497 · DOI
  5. JBJ Kwok, 2003, Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy, J Biol Chem, 278, 6748, 10.1074/jbc.M211827200 · DOI
  6. M Thambisetty, 2013, Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype, Biol Psychiatry, 73, 422, 10.1016/j.biopsych.2012.08.015 · DOI · Paper page
  7. L Qiang, 2011, Directed conversion of Alzheimer's disease patient skin fibroblasts into functional neurons, Cell, 146, 359, 10.1016/j.cell.2011.07.007 · DOI
  8. O Lazarov, 2010, Neurogenesis and Alzheimer's disease: at the crossroads, Exp Neurol, 223, 267, 10.1016/j.expneurol.2009.08.009 · DOI
  9. Y Mu, 2011, Adult hippocampal neurogenesis and its role in Alzheimer's disease, Mol Neurodegener, 6, 85, 10.1186/1750-1326-6-85 · DOI · Paper page
  10. L Verret, 2007, Alzheimer's-type amyloidosis in transgenic mice impairs survival of newborn neurons derived from adult hippocampal neurogenesis, J Neurosci, 27, 6771, 10.1523/JNEUROSCI.5564-06.2007 · DOI
  11. EM Reiman, 2012, Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study, Lancet Neurol, 11, 1048, 10.1016/S1474-4422(12)70228-4 · DOI · Paper page
  12. JT Dimos, 2008, Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons, Science, 321, 1218, 10.1126/science.1158799 · DOI
  13. C Bock, 2011, Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines, Cell, 144, 439, 10.1016/j.cell.2010.12.032 · DOI · Paper page
  14. J Nielsen, 1976, Autosomal reciprocal translocations and 13/14 translocations: a population study, Clin Genet, 10, 161, 10.1111/j.1399-0004.1976.tb00029.x · DOI
  15. I Santa-Maria, 2012, The MAPT H1 haplotype is associated with tangle-predominant dementia, Acta Neuropathologica, 124, 693, 10.1007/s00401-012-1017-1 · DOI
  16. Ozair MZ, Noggle S, Warmflash A, Krzyspiak JE, Brivanlou AH (2012) SMAD7 Directly Converts Human Embryonic Stem Cells to Telencephalic Fate by a Default Mechanism. Stem Cells. doi:10.1002/stem.1246. · DOI
  17. J Pruszak, 2007, Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations, Stem Cells, 25, 2257, 10.1634/stemcells.2006-0744 · DOI
  18. I Bezprozvanny, 2008, Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease, Trends Neurosci, 31, 454, 10.1016/j.tins.2008.06.005 · DOI · Paper page
  19. MCN Marchetto, 2010, A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells, Cell, 143, 527, 10.1016/j.cell.2010.10.016 · DOI · Paper page
  20. TH Murphy, 1992, Spontaneous synchronous synaptic calcium transients in cultured cortical neurons, J Neurosci, 12, 4834, 10.1523/JNEUROSCI.12-12-04834.1992 · DOI
  21. K Duff, 1996, Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1, Nature, 383, 710, 10.1038/383710a0 · DOI
  22. M Bentahir, 2006, Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms, J Neurochem, 96, 732, 10.1111/j.1471-4159.2005.03578.x · DOI
  23. BP Imbimbo, 2011, γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes, Curr Top Med Chem, 11, 1555, 10.2174/156802611795860942 · DOI
  24. DW Huang, 2009, Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists, Nucleic Acids Res, 37, 1, 10.1093/nar/gkn923 · DOI · Paper page
  25. DW Huang, 2009, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nat Protoc, 4, 44, 10.1038/nprot.2008.211 · DOI · Paper page
  26. JM Bruey, 2004, PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages, J Biol Chem, 279, 51897, 10.1074/jbc.M406741200 · DOI
  27. Dagenais M, Skeldon A, Saleh M (2012) The inflammasome: in memory of Dr. Jurg Tschopp. <volume>8</volume> pp. doi:10.1038/cdd.2011.159. · DOI
  28. JM Rubio-Perez, 2012, A review: inflammatory process in Alzheimer's disease, role of cytokines, ScientificWorldJournal, 2012, 756357
  29. MA Debrincat, 2007, Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation, J Biol Chem, 282, 4728, 10.1074/jbc.M609164200 · DOI
  30. S Kwon, 2010, ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function, BMC Biol, 8, 23, 10.1186/1741-7007-8-23 · DOI
  31. MF Beal, 2011, Neuroprotective effects of creatine, Amino Acids, 40, 1305, 10.1007/s00726-011-0851-0 · DOI
  32. SE Arnold, 1994, Neuropathologic changes of the temporal pole in Alzheimer“s disease and Pick”s disease, Arch Neurol, 51, 145, 10.1001/archneur.1994.00540140051014 · DOI
  33. WS Liang, 2008, Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set, Physiol Genomics, 33, 240, 10.1152/physiolgenomics.00242.2007 · DOI · Paper page
  34. WS Liang, 2010, Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology, Neurobiol Aging, 31, 549, 10.1016/j.neurobiolaging.2008.05.013 · DOI
  35. J-H Kim, 2012, Amyloid neurotoxicity is attenuated by metallothionein: dual mechanisms at work, J Neurochem, 121, 751, 10.1111/j.1471-4159.2012.07725.x · DOI
  36. BM Braunger, 2012, The different functions of Norrin, Adv Exp Med Biol, 723, 679, 10.1007/978-1-4614-0631-0_86 · DOI
  37. Q Xu, 2004, Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair, Cell, 116, 883, 10.1016/S0092-8674(04)00216-8 · DOI · Paper page
  38. P He, 2009, Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease, J Neurosci, 29, 6545, 10.1523/JNEUROSCI.0421-09.2009 · DOI
  39. DA Lim, 2000, Noggin antagonizes BMP signaling to create a niche for adult neurogenesis, Neuron, 28, 713, 10.1016/S0896-6273(00)00148-3 · DOI
  40. T Kuwabara, 2009, Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis, Nat Neurosci, 12, 1097, 10.1038/nn.2360 · DOI · Paper page
  41. AA Sproul, 2009, Cbl negatively regulates JNK activation and cell death, Cell Res, 19, 950, 10.1038/cr.2009.74 · DOI
  42. J-PG Vonsattel, 2008, Twenty-first century brain banking: practical prerequisites and lessons from the past: the experience of New York Brain Bank, Taub Institute, Columbia University, Cell Tissue Bank, 9, 247, 10.1007/s10561-008-9079-y · DOI
  43. J-PG Vonsattel, 2008, Twenty-first century brain banking. Processing brains for research: the Columbia University methods, Acta Neuropathologica, 115, 509, 10.1007/s00401-007-0311-9 · DOI

Cited by

Sorted by citations

Metadata

Authors
Sproul, A. A., Jacob, S., Pre, D., Kim, S. H., Nestor, M. W., Navarro-Sobrino, M., Santa-Maria, I., Zimmer, M., Aubry, S., Steele, J. W., Kahler, D. J., Dranovsky, A., Arancio, O., Crary, J. F., Gandy, S., & Noggle, S. A.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-01-08
Volume
9
Issue
1
Pages
e84547
ISSN
1932-6203
DOI
10.1371/journal.pone.0084547
PMC
PMC3885572
Cited by
162
References
9
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review