Structural connectivity of the developing human amygdala
Open accessAbstract
A large corpus of research suggests that there are changes in the manner and degree to which the amygdala supports cognitive and emotional function across development. One possible basis for these developmental differences could be the maturation of amygdalar connections with the rest of the brain. Recent functional connectivity studies support this conclusion, but the structural connectivity of the developing amygdala and its different nuclei remains largely unstudied. We examined age related changes in the DWI connectivity fingerprints of the amygdala to the rest of the brain in 166 individuals of ages 5-30. We also developed a model to predict age based on individual-subject amygdala connectivity, and identified the connections that were most predictive of age. Finally, we segmented the amygdala into its four main nucleus groups, and examined the developmental changes in connectivity for each nucleus. We observed that with age, amygdalar connectivity becomes increasingly sparse and localized. Age related changes were largely localized to the subregions of the amygdala that are implicated in social inference and contextual memory (the basal and lateral nuclei). The central nucleus' connectivity also showed differences with age but these differences affected fewer target regions than the basal and lateral nuclei. The medial nucleus did not exhibit any age related changes. These findings demonstrate increasing specificity in the connectivity patterns of amygdalar nuclei across age.
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Weaker or less organized functional and structural connectivity between these brain regions in childhood may contribute to increased difficulty with emotion regulation.
“Weaker or less organized functional and structural connectivity between these brain regions in childhood may also be contributing toward increased difficulty with emotion regulation [55–57].”
From The neuroscience of emotion regulation development: Implications for education (2016) · cites this paper as [56]
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The neuroscience of emotion regulation development: Implications for education
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- Authors
- Saygin, Z. M., Osher, D. E., Koldewyn, K., Martin, R. E., Finn, A., Saxe, R., Gabrieli, J. D. E., & Sheridan, M.
- Affiliations
- McGovern Institute for Brain Research (US)
- Boston University (US)
- Boston Children's Hospital (US)
- Corresponding author
- Saygin, Zeynep M.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-04-15
- Volume
- 10
- Issue
- 4
- Pages
- e0125170
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4398350
- OpenAlex
- W2011068063
- Cited by
- 45
- References
- 79
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 1
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Bangor University Research Portal (Bangor University) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Bangor University Research Portal (Bangor University) (submittedVersion, other-oa)
- Funders
- Ellison Medical Foundation
- Simons Center for the Social Brain, Massachusetts Institute of Technology
- McGovern Institute for Brain Research, Massachusetts Institute of Technology
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- amygdala, structural connectivity, brain development, amygdala nuclei, diffusion-weighted imaging, age prediction, basal amygdala, lateral amygdala, central amygdala, medial amygdala, social inference, contextual memory
- MeSH terms
- Adolescent, Adult, Amygdala, Brain Mapping, Child, Child, Preschool, Emotions, Female, Humans, Male, Models, Anatomic, Nerve Net, Organ Size, Diffusion Magnetic Resonance Imaging, Young Adult
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